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| | Necrotizing nasal lesions |
 | | Skin testing and/or complement fixation titers for tuberculosis, histoplasmosis, coccidiodomycosis, and blastomycosis may be obtained. |
 | | Biopsies and Immunohistochemical studies are very helpful, and special stains and cultures for acid-fast bacilli, fungi, spirochetes, and rhinoscleroma should be performed. |
 | | Nasal lesions in histoplasmosis, coccidiodomycosis, blastomycosis, and cryptococcosis are almost invariably the result of systemic spread from a primary pulmonary infection. |
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