
	Where results make sense

Topic: Cofactor (biochemistry)

Related Topics

Active site

Phenylketonuria

Ireland

Finland

In the News (Thu 17 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Encyclopedia :: encyclopedia : Biochemistry (Site not responding. Last check: 2007-10-08)
		Biochemistry is the chemistry of life, a bridge between biology and chemistry that studies how complex chemical reactions give rise to life.
		Biochemistry is the study of the structure and function of cellular components, such as proteins, carbohydrates, lipids, nucleic acids, and other biomolecules.
		Biochemistry is the study of the chemical substances and vital processes occurring in living organisms.
	www.hallencyclopedia.com /topic/Biochemistry.html (2616 words)

	Cofactor - Wikipedia, the free encyclopedia
		Cofactor (biochemistry) is a substance that needs to be present in addition to an enzyme for a certain reaction to take place.
		Shannon cofactor is a derived function of another function, a notion useful in computer science and mathematics.
		In epidemiology, a cofactor is a condition that exacerbates the effects of another condition; for instance, while chlamydia infection on its own will not cause cervical cancer, it increases the risk that HPV infection will do so.
	en.wikipedia.org /wiki/Cofactor (166 words)

	Requirement of NifX and Other nif Proteins for In Vitro Biosynthesis of the Iron-Molybdenum Cofactor of Nitrogenase -- ... (Site not responding. Last check: 2007-10-08)
		Implications for the synthesis of the iron-molybdenum cofactor of dinitrogenase.
		In vitro synthesis of the iron-molybdenum cofactor of nitrogenase.
		Biosynthesis of iron-molybdenum cofactor in the absence of nitrogenase.
	jb.asm.org /cgi/content/full/181/9/2797 (4215 words)

	arthritis pain relief - Cofactor (biochemistry)
		A cofactor is any substance that needs to be present in addition to an enzyme to catalyse a certain reaction.
		Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in certain forms.
		Cofactors generally are either bound tightly to active sites, or may bind loosely with the substrate.
	www.painreliefchat.com /arthritis-pain-relief/Cofactor_(biochemistry) (106 words)

	Cofactor (biochemistry) - Wikipedia, the free encyclopedia
		(However, more or less ubiquitous substances such as water do not qualify.) Some cofactors are inorganic, such as the metal atoms zinc, magnesium, iron, and copper in certain forms.
		Some cofactors undergo chemical changes during the course of a reaction (i.e.
		Cofactors vary in location and tightness of binding.
	en.wikipedia.org /wiki/Cofactor_(biochemistry) (262 words)

	Britain.tv Wikipedia - Enzymes
		Organic cofactors (coenzymes) are usually prosthetic groups, which are tightly bound to the enzymes that they assist.
		These tightly-bound cofactors are distinguished from other coenzymes, such as NADH, since they are not released from the active site during the reaction.
		The International Union of Biochemistry and Molecular Biology and the International Union of Pure and Applied Chemistry have developed a nomenclature for enzymes, the EC numbers; each enzyme is described by a sequence of four numbers preceded by "EC".
	www.britain.tv /wikipedia.php?title=Enzymes (5740 words)

	Blood Coagulation
		Tissue factor is a cofactor in the factor VIIa-catalyzed activation of factor X. Factor VIIa, a gla residue containing serine protease, cleaves factor X to factor Xa in a manner identical to that of factor IXa of the intrinsic pathway.
		Factor V is a cofactor in the formation of the prothrombinase complex, similar to the role of factor VIII in tenase complex formation.
		Factor VIII is a cofactor in the activation of factor X to factor Xa in a reaction catalyzed by factor IXa.
	web.indstate.edu /thcme/mwking/blood-coagulation.html (4046 words)

	Factor V: a combination of Dr Jekyll and Mr Hyde -- Mann and Kalafatis 101 (1): 20 -- Blood
		-thrombin, the active cofactor is a heterodimer composed of a heavy chain divalent cation associated with light chain.
		The B region of the cofactor is released as 2 fragments.
		-thrombin in the presence of the vascular cofactor thrombomodulin.
	www.bloodjournal.org /cgi/content/full/101/1/20 (6814 words)

	Structural studies of Mo-nitrogenase component I (Site not responding. Last check: 2007-10-08)
		Arber, J.M., Flood, A.C., Garner, C.D., Gormal, C.A., Hasnain, S.S. and Smith, B.E. Iron Kedge Xray absorption spectroscopy of the iron-molybdenum cofactor of nitrogenase from Klebsiella pneumoniae.
		Conradson, S.D., Burgess, B.K. and Holm, R.H. Fluorine19 chemical shifts as probes of the structure and reactivity of the iron-molybdenum cofactor of nitrogenase.
		Shah, V.K., Allen, J.R., Spangler, N.J. and Ludden, P.W. In vitro synthesis of the iron-molybdenum cofactor of nitrogenase.
	metallo.scripps.edu /promise/NITROGENASE1_REF.html (1906 words)

	Hermann Schindelin (Site not responding. Last check: 2007-10-08)
		The molybdenum cofactor (Moco) is an essential component of a diverse group of enzymes catalyzing important redox transformations in the global carbon, nitrogen and sulfur cycles.
		The cofactor consists of a mononuclear molybdenum coordinated by the dithiolene moiety of a family of tricyclic pyrano-pterins containing a cis-dithiolene group in their pyran ring.
		Enzymes containing a pyranopterin cofactor and either Mo or W are found in all phyla and some of these catalyze important transformations in the global carbon, nitrogen and sulfur cycle.
	www.sunysb.edu /biochem/BIOCHEM/facultypages/schindelin (2051 words)

	References - molybdate or molybdenum or molybdo - HORT640 - Metabolic Plant Physiology - Department of Horticulture and ...
		Boxer DH 1989 Involvement of the chlorate resistance loci and the molybdenum cofactor in the biosynthesis of the Escherichia coli nitrate reductase.
		Heck IS, Ninnemann H 1995 Molybdenum cofactor biosynthesis in Neurospora crassa: biochemical characterization of pleiotropic molybdoenzyme mutants nit-7, nit-8, nit-9A, B and C. Photochem.
		Neubauer H, Pantel I, Gotz F 1998 Characterization of moeB--part of the molybdenum cofactor biosynthesis gene cluster in Staphylococcus carnosus.
	web.ics.purdue.edu /~drhodes/hort640c/referen/molybd.htm (5871 words)

	Elisabetta Fasella, Ph.D. (Site not responding. Last check: 2007-10-08)
		Broadly speaking our objective is to gain a better understanding of molecular recognition and of enzymatic catalysis through the design, preparation and evaluation of synthetic models of the usually complex structures involved in these important biological processes.
		At present our attention is focused on the elucidation of the role of the cofactor 4-methylidene-5-imidazolone (MIO) in the deamination of the amino acids histidine and phenylalanine.
		The transformation promoted by this cofactor is unprecedented with synthetic reagents and it constitutes a potential pathway for the reduction of blood phenylalanine levels in phenylketonurics.
	www.usip.edu /chemistry/faculty/biography.asp?id=27 (170 words)

	Glossary: Organic and biochemistry
		For enzyme-catalyzed reactions, a cofactor is something other than the enzyme itself that is required.
		A cofactor may be organic or inorganic (e.g., metal ions), and may be loosely or tightly (even covalently) bound to the enzyme.
		A protein kinase phosphorylates a protein, using ATP; this is an important type of reaction in biochemistry, as the phosphorylation modulates the shape -- and hence the activity -- of proteins.
	www.geocities.com /athens/thebes/5118/obc/glossary.htm (1865 words)

	thesis-ref
		Biochem J. Richards,A.J., Lowe,D.J., Richards,R.L., Thomson,A.J. and Smith,B.E. Electron-paramagnetic-resonance and magnetic-circular-dichroism studies of the binding of cyanide and thiols to the thiols to the iron-molybdenum cofactor from Klebsiella pneumoniae nitrogenase.
		Gavini,N. and Burgess, B.K. (1992) FeMo Cofactor Synthesis by a nifH Mutant with Altered MgATP Reactivity.
		Hoover,T.R., Robertson,A.D., Cerny,R.L., Hayes,R.N., Imperial,J., Shah,V.K., Ludden,P.W. (1987) Identification of the V factor needed for synthesis of the iron-molybdenum cofactor of nitrogenase as homocitrate.
	myweb.tiscali.co.uk /chengqi/ref.htm (8727 words)

	[No title]
		Lipoic acid is the free form of a catalytic cofactor important in the generation and transfer of acyl groups formed by the pyruvate dehydrogenase and
		Lipoamide aquires a hydroxyalkyl group from the thiamine pyrophosphate cofactor at an active site of the dehydrogenase component of the complex, and concomitantly is reduced as the hydroxyalkyl group is oxidized to an acyl group.
		Dihydrolipoamide then swings into a third active site, that of the flavoprotein component of the complex, dihydrolipoyl dehydrogenase, where it is oxidized by an FAD cofactor.
	guweb2.gonzaga.edu /faculty/cronk/biochem/L-index.cfm?definition=lipoamide (218 words)

	Scientists Take 'snapshots' Of Enzyme Action
		Previously, it had been believed that all the "players" -- the enzyme, cofactor, and substrate -- came together at a particular time to perform the function of transferring an oxygen atom from the enzyme to the substrate.
		First, the cofactor (known as NADPH) binds to a molecule known as FAD, which is a coenzyme attached to the FMO, and transfers a hydride ion to it.
		At this moment an oxygen atom from molecular oxygen is attached to the substrate, and the hydride ion obtained from the cofactor combines with the other oxygen atom to form a water molecule, which is released.
	www.medicalnewstoday.com /medicalnews.php?newsid=45081 (702 words)

	ADP Ribosylation Factor-like Protein 2 (Arl2) Regulates the Interaction of Tubulin-folding Cofactor D with Native ...
		F, An Arl2 variant containing a mutation in the putative effector loop fails to bind cofactor D. HA-tagged wild-type Arl2 and the corresponding mutations T47A and F50A were translated in vitro, incubated with cofactor D, and immunoprecipitated with an anticofactor D antibody, and the immunoprecipitated material resolved by SDS-PAGE.
		S-labeled in the ß-subunit by in vitro translation were incubated with cofactor D in the absence or presence of either GST (as a control) or a 5- or 15-fold molar excess (with respect to cofactor D) of purified Arl2.
		Tian, G., Bhamidipati, A., Cowan, N.J., Lewis, S.A. Tubulin folding cofactors as GTPase activating proteins: GTP hydrolysis and the assembly of the alpha/beta tubulin heterodimer.
	www.jcb.org /cgi/content/full/149/5/1087 (6172 words)

	Vitamins and Coenzymes
		Pyridoxal phosphate functions as a cofactor in enzymes involved in transamination reactions required for the synthesis and catabolism of the amino acids as well as in glycogenolysis as a cofactor for glycogen phosphorylase.
		Biotin is the cofactor required of enzymes that are involved in carboxylation reactions, e.g.
		This modification is a carboxylation and the enzyme responsible requires vitamin K as a cofactor.
	web.indstate.edu /thcme/mwking/vitamins.html (4135 words)

	BIOCHEMISTRY
		Cofactors are non-protein atoms or molecules which bind to the apoenzyme.
		This allows the cofactor to act like a switch turning the enzyme either on or off.
		If the cofactor turns the enzyme on it can be called an activator.
	www2.hawaii.edu /~johnb/micro/m130/m130lect7.html (643 words)

	PierreNeuenschwander (Site not responding. Last check: 2007-10-08)
		Clotting ensues only when damage to blood vessels causes a cofactor protein, tissue factor, to be exposed to the circulation thus binding to and "activating" fVIIa.
		The results are aimed at elucidating the ability of cofactors to effectively mediate the hemostatic response, as well as elucidating their roles in thrombosis.
		Each of these areas involves understanding the roles of cofactors in the regulation of either of the two factor X activating complexes that are central in blood clotting; the factor VIIa-tissue factor complex and the factor IXa-factor VIIIa complex.
	www.uthct.edu /BIRE/Faculty/PierreNeuenschwander.htm (595 words)

	Sulfate uptake, reduction and the synthesis of cysteine and methionine in plants - Sulfate uptake and assimilation - ...
		The recently determined crystallographic structure of the sulfite reductase hemoprotein from Escherichia coli (Crane et al, 1995) reveals structural features that are key for the catalytic mechanisms and suggest a common symmetric structural unit for this diverse family of enzymes (Crane and Getzoff, 1996).
		Siroheme, is a cofactor of both sulfite and nitrite reductase in Salmonella typhimurium, and requires the cysG gene for its synthesis (Goldman and Roth, 1993).
		Note that in humans, cystathionine is synthesized by cystathionine beta-synthase; an unusual enzyme that requires the cofactors heme and pyridoxal phosphate (PLP) to catalyze the condensation of homocysteine and serine to generate cystathionine (Taoka et al, 1999).
	www.hort.purdue.edu /rhodcv/hort640c/sulfate/su00005.htm (3311 words)

	Publications
		Synthesis and characterization of model compounds of the lysine tyrosyl quinone cofactor of lysyl oxidase.
		Kinetic analysis of oxygen utilization during cofactor biogenesis in a copper-containing amine oxidase from yeast.
		Mutation of a strictly conserved, active-site residue alters substrate specificity and cofactor biogenesis in a copper amine oxidase.
	www.cchem.berkeley.edu /~jukgrp/publications.html (1126 words)

	Abstract List
		Protein conformational changes upon binding of cognate DNA and cofactor Mg were monitored by tryptophan fluorescence of the single tryptophan mutant and wild-type endonuclease.
		Binding of Mg cofactor or DNA substrate did not affect the location or flexibility of the N-terminal region as sensed by pyrene fluorescence and cross-linking, indicating that substrate binding is not accompanied by folding or unfolding of the N-terminus.
		Specific-site binding is stimulated about 700-fold by Ca (not a cofactor for cleavage), but with non-cleavable 3'-phosphorothiolate and 4'-thiodeoxyribose derivatives whose response to Ca is similar to that of the parent oligonucleotide, Mg stimulates binding only fourfold and twofold, respectively.
	www.pitt.edu /~biohome/Dept/Frame/Faculty/jen-jacobsonabstract.htm (5245 words)

	Dr. Thomas Wiese
		Because of the close relationship between biochemistry and medicine, I have included in this glossary a collection of prefixes, suffixes and root words typically found in medical dictionaries in hopes that some words I may have forgotten to define can be figured out.
		The protein portion of an enzyme, absent any organic or inorganic cofactors or prosthetic groups that might be required for catalytic activity.
		An enzymatic cofactor derived from pterin and involved in certain oxidation-reduction reactions.
	www.fhsu.edu /chemistry/twiese/glossary/biochemglossary.htm (9936 words)

	Structure of a quinohemoprotein amine dehydrogenase with an uncommon redox cofactor and highly unusual crosslinking -- ...
		whereas for MADH, the cofactor is tryptophan tryptophylquinone
		of the cofactor (the oxidative half-reaction) (26, 27).
		cofactor in CAO (35) and the Cys-Tyr crosslinked cofactor in
	www.pnas.org /cgi/content/full/98/25/14268 (4428 words)

	cofactor - OneLook Dictionary Search
		Cofactor : Drug Discovery and Development [home, info]
		Cofactor : AGRICULTURAL AND ENVIRONMENTAL BIOTECHNOLOGY [home, info]
		Phrases that include cofactor: platelet cofactor i, platelet cofactor ii, cofactor expansion, molybdenum cofactor, membrane cofactor p, more...
	www.onelook.com /?w=cofactor (201 words)

	CSU Chemistry Homepage
		Biochemistry of blood coagulation and thrombosis; identification of binding sites for protein-protein interaction; regulation of blood clotting and thrombosis at the surface of platelets and endothelial cell;, phosphorylation of blood clotting proteins by platelet kinases and significance of phosphorylation; signal transduction; identification of the molecular defect in patients with blood coagulation disorders.
		The Journal of Biological Chemistry; Biochemistry; The Journal of Clinical Investigation; Blood; Arteriosclerosis Thrombosis, and Vascular Biology; Thrombosis and Haemostasis; The Journal of Laboratory and Clinical Medicine; Protein Science.
		Camire, R.M., Kalafatis, M., Simioni, P., Girolami, A., and Tracy, P.B. Platelet-derived factor Va/VaLeiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C. Blood 1998, 91, 2818-2829.
	www.csuohio.edu /chemistry/kalafatis.htm (5446 words)

Try your search on: Qwika (all wikis)