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Topic: Colchicine

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	Colchicine - Wikipedia, the free encyclopedia
		Colchicine is a highly poisonous alkaloid, originally extracted from plants of the genus Colchicum (Autumn crocus, also known as the "Meadow saffron").
		Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules.
		Colchicine is Food and Drug Administration (FDA)-approved for the treatment of gout and also for familial Mediterranean fever, secondary amyloidosis(AA), and scleroderma.
	en.wikipedia.org /wiki/Colchicine (678 words)

	Data Sheet
		Colchicine is not an analgesic, though it relieves pain in acute attacks of gout.
		Colchicine is contraindicated in patients with a known hypersensitivity to the medicine, in those with serious gastrointestinal, renal, hepatic or cardiac disorders, or in those with blood dyscrasias.
		Colchicine should be administered with caution to aged or debilitated patients, and to those with early manifestations of gastrointestinal, renal, hepatic, cardiac or hematological disorders.
	www.medsafe.govt.nz /profs/Datasheet/c/Colchicinetab.htm (1739 words)

	Colchicine (PIM 141)
		Colchicine is an alkaloid of Colchicum autumnale (autumn crocus, meadow saffron).
		Colchicine is excreted unchanged (10 to 20 percent) or as metabolites.
		50 to 70% of colchicine is excreted unchanged and 30 to 50% as metabolites.
	www.inchem.org /documents/pims/pharm/colchic.htm (5872 words)

	colchicine.html
		Colchicine had no discernible effect on regneration when administered so as to miss the period of greatest cell division among cells of the wound coagulum posited to be myoblasts.
		The objective was to apply equal amounts of colchicine (or vehicle) but at different time relative to the three-day increase in mitotic activity among cells in the wound coagulum.
		In colchicine treated three-day tissues 50 to 60 % of the round cells were in division; approximately 11 % of round cells were dividing in normal and vehicle treated regenerates.
	www.indiana.edu /~pietsch/colchicine.html (2011 words)

	Colchicine for dermatologic diseases Journal of Drugs in Dermatology - Find Articles
		Colchicine is an alkaloid extracted from the seeds and tubes of Colchicum autumnale (meadow saffron).
		Colchicine is the drug of choice in the prevention and treatment of the amyloidosis associated with familial Mediterranean fever.
		Colchicine may exert its prophylactic effects on cytokine-provoked inflammation by diminishing the qualitative expression of E-selectin on endothelium, and its therapeutic effects by diminishing the quantitative expression of L-selectin on neutrophils.
	www.findarticles.com /p/articles/mi_m0PDG/is_2_4/ai_n13559188 (869 words)

	Pharmacy Times: Life-threatening Colchicine Drug Interactions
		Colchicine is a known substrate for Pglycoprotein (PGP), a transmembrane protein that acts to eliminate drugs by expelling them into the bile, urine, and intestine and acting as a blood-brain barrier.
		Colchicine toxicity is not a pretty sight, and the reported reactions have been life-threatening or fatal.
		Colchicine should not be used with clarithromycin or erythromycin, and given the potential for fatal outcomes, it would be prudent to avoid all PGP inhibitors with colchicine (Table).
	www.pharmacytimes.com /article.cfm?ID=3466 (596 words)

	Colchicine - Feature Molecule Molecule of the Month
		The goal of most colchicine research is a more thorough understanding of the cause of gout, which is often thought of as a disease of rich living.
		The precise mechanism by which colchicine relieves the intense pain of gout is not known.[5] However, it is believed that the major relief of pain involves colchicine's major pharmacological action: binding to tubulin dimers.
		The energy barrier of rotation in colchicine, approximately 22-24 kcal/mol [8], is large enough to allow the synthesis and isolation of the conformations as stereoisomers.
	www.phc.vcu.edu /Feature/oldfeature/colchicine/colchicine.html (1492 words)

	Colchicine Poisoning \| Poison Control Center - Children's Hospital of Philadelphia
		Deacetylation of colchicine occurs in the liver with large amounts of the drug and its metabolites undergoing enterohepatic circulation.
		Once absorbed, colchicine cannot be removed from the body by hemodialysis or charcoal hemoperfusion, and aggressive care including endotracheal intubation, timely fluid management guided by pulmonary artery pressure monitoring and pressor support is frequently required for the patient to survive.
		Colchicine overdose: report of two cases and review of the literature.
	www.chop.edu /consumer/jsp/division/generic.jsp?id=73057 (1464 words)

	Colchicine
		The ability of colchicines to interfere with this sort of structural protein formation has led to its use in scarring diseases such as hepatic cirrhosis, and abnormal protein depositions such as amyloidosis.
		Because of colchicine’s ability to interfere with cell division, it should not be used in animals for breeding.
		Colchicine cannot be used in pregnancy and is probably best not used in animals intended for breeding.
	www.marvistavet.com /html/colchicine.html (550 words)

	Healthopedia.com Drugs Information - Colchicine : Proper Use
		Colchicine can build up in the body and cause serious side effects if too much of it is taken or if it is taken too often.
		If you are taking colchicine to prevent gout attacks, and you are also taking another medicine to reduce the amount of uric acid in your body, you probably will be able to stop taking colchicine after a while.
		Also, stop taking colchicine when you have taken the largest amount that your doctor ordered for each attack, even if the pain is not relieved or none of these side effects occurs.
	www.healthopedia.com /drugs/detailed/colchicine/proper-use.html (1218 words)

	MedlinePlus Drug Information: Colchicine (Systemic) (Site not responding. Last check: 2007-10-11)
		Colchicine (KOL-chi-seen) is used to prevent or treat attacks of gout (also called gouty arthritis).
		Colchicine does not cure gout or take the place of other medicines that lower the amount of uric acid in the body.
		Colchicine may also be used for other conditions as determined by your doctor.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202160.html (2583 words)

	Colchicine for gout (Site not responding. Last check: 2007-10-11)
		The study was a randomised comparison colchicine and placebo in patients with acute gout confirmed by joint aspiriation and demonstration of negatively birefringent needle shaped crystals.
		Colchicine (N=22) and placebo groups (N=21) were the same at baseline.
		It is sobering that the sum total of randomised patients that could be found for the evidence on use of colchicine in acute gout was 43.
	www.jr2.ox.ac.uk /bandolier/booth/gout/colchrct.html (577 words)

	Patient Education - Drugs - colchicine
		Colchicine is only available in a generic form.
		Colchicine is used to treat or prevent acute gouty arthritis.
		In gastroenterology it may be used to slow the formation of fibrous tissue in the liver that occurs with conditions such as cirrhosis and primary biliary cirrhosis.
	www.gicare.com /pated/colchicine.htm (714 words)

	Colchicine Therapy (Site not responding. Last check: 2007-10-11)
		Colchicine has been regarded by some as the most powerful anti-inflammatory agent known to man. The beneficial effects of colchicine in the treatment of gout are apparently secondary to its ability to inhibit both the metabolic and phagocytic activity and migration of granulocytes.
		Colchicine's inhibition of the release of histamine containing granules from mast cells is also believed secondary to its interference with granule transportation by the microtubular system.
		Adverse effects from colchicine administration were documented in only one patient in the form of a burn at the IV site.
	members.aol.com /IntegrativeHC/Cochicine_nn4.html (896 words)

	colchicine,colchicine dosage (Site not responding. Last check: 2007-10-11)
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	colchicine.sunxe.com (403 words)

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		Colchicine has been proposed as a treatment for amyloidosis in animals.
		Colchicine should be used with caution in geriatric or debilitated animals.
		If problems develop on colchicines therapy I stop the drug for a few days and then reinstitute therapy using a once a day dose or use half the dose twice a day.
	www.drjwv.com /faq/?view=8 (282 words)

	Healthopedia.com Drugs Information - Colchicine : Before Using
		Treatment with colchicine does not increase, and may actually decrease, the occurrence of these problems in women with this condition.
		However, colchicine is used in children 3 years of age and older who need preventive treatment for other medical conditions.
		Also, colchicine may stay in the body longer in older patients than it does in younger adults.
	www.healthopedia.com /drugs/detailed/colchicine/before-using.html (719 words)

	Suspected Toxic Chemical Colchicine is Not Found in Ginkgo
		Farnsworth was emphatic that colchicine is not a constituent of ginkgo.
		Based on biogenetic considerations, colchicine should never be found outside of the Monocotyledoneae (e.g., Araceae, Liliaceae) and thus the report of its occurrence in Saussurea sacra (Asteraceae) is an anomaly that has not been duplicated by other reports on the chemistry of this species.
		"Anyone who thinks that colchicine can be found naturally in ginkgo is not qualified to be a peer reviewer of this paper," he said, referring to the editorial process for scientific journals in which papers are reviewed by independent experts to determine their scientific merit and the accuracy of their conclusions prior to publication.
	www.herbalgram.org /default.asp?c=083001press (1226 words)

	colchicine (Site not responding. Last check: 2007-10-11)
		The precise mechanism by which colchicine relieves the pain associated with gout is not known.
		However, it is believed that major relief involves colchicine's major pharmacological action: binding to tubulin dimers.
		Colchicine binding prevents curved tubulin from adopting a straight structure, which inhibits assembly.
	www.tufts.edu /med/biochemistry/faculty/baleja/colchicine.html (44 words)

	Safety of colchicine therapy during pregnancy
		Less frequently, colchicine is used for treating liver cirrhosis; biliary cirrhosis; and certain skin disorders, such as psoriasis, palmoplantar pustulosis, Behçet’s disease, dermatitis herpetiformis, scleroderma, and condyloma acuminatum.
		Colchicine was introduced in the early 1970s to prevent and decrease the severity of FMF attacks.
		If colchicine is to be used during pregnancy, caution should be exercised, and amniocentesis with karyotyping9 should be considered due to the mutagenic risk shown in animals.
	www.cfpc.ca /cfp/2003/Aug/vol49-aug-clinical-1.asp (1572 words)

	colchicine - [Medication]
		If you are taking colchicine to treat an acute attack of gout, therapy should be stopped as soon as the pain is relieved, when the maximum amount of medicine has been taken, or at the first sign of nausea, vomiting, diarrhea, or abdominal pain.
		Colchicine is in the FDA pregnancy category C. This means that it is not known whether colchicine will harm an unborn baby.
		To treat an attack, colchicine may be taken up to once every hour until the pain is relieved, until the maximum amount of medicine has been taken, or until nausea, vomiting, or diarrhea occurs.
	www.peacehealth.org /kbase/multum/d00150a1.htm (941 words)

	Colchicine for gout
		Colchicine can be given intravenously for acute attacks or for people who cannot tolerate the stomach problems associated with oral colchicine.
		Colchicine is usually effective in relieving a gout attack within 12 to 24 hours.
		Colchicine is usually avoided or the dose adjusted in people who have reduced kidney function.
	www.webmd.com /hw/arthritis/hw66568.asp (448 words)

	Cyberbotanica: Colchicine
		With colchicine present, the spindle fibers don't form, and so the cell can't move its chromosomes around.
		Researchers aren't sure exactly how colchicine works against gout, but it does seem to reduce the frequency of severe attacks and relieves residual pain.
		Colchicine poisoning resembles arsenic poisoning; the symptoms (which, because it is a mitotic poison, occur 2 to 5 hours after the toxic dose has been ingested) include burning in the mouth and throat, diarrhea, stomach pain, vomiting, and kidney failure.
	biotech.icmb.utexas.edu /botany/colch.html (331 words)

	Colchicine (Systemic)
		Colchicine is not an ordinary pain reliever and will not relieve most kinds of pain.
		Even if you think the colchicine is not working, do not stop taking it and do not increase the dose.
		Colchicine helps prevent other serious problems, such as kidney disease, that can occur in people with this condition.
	allnutritionals.com /drugs/c/colchicine-systemic.shtml (2654 words)

	Preparing Colchicine Solutions
		The colchicine solutions for inducing polyploidy are usually 0.25%, 0.5% or 1%, depending on species and tissue.
		Colchicine can be purchased from scientific supply houses as a white powder.
		I'd dissolve the colchicine in half (roughly) of the water, transferring that solution to the storage vial, then use the rest of the water to rinse the mixing container, adding that to the solution in the storage vial.
	members.tripod.com /h_syriacus/colchicine.html (741 words)

	3D QSAR Analysis of Colchicine Analogs
		In this work, two series of colchicine analogues were synthesized and their biological activities assessed by the concentration at which they inhibited 50 % of the in vitro assembly of tubulin into microtubules (I50).
		Photograph D illustrates the alignment of all 33 colchicine analogues, in the presence of the CoMFA field.
		After alignment of the trimethoxy ring, it is apparent that the only difference between colchicine (1) and isocolchicine (19) is the inversion of the carbonyl oxygen and methoxy group at the C-9 and C-10 positions respectively.
	chemistry.binghamton.edu /BANE/QSAR_POSTER/qsar_poster.html (1347 words)

	Colchicine
		As mentioned previously, the main drug prescribed for PBC is Ursodeoxycholic Acid, however it has also been noted that Urso might be less effective in some PBC sufferers or in some rare cases, the sufferer might not be able to tolerate the medicine.
		Colchicine is a drug that was created to originally to treat and prevent gout.
		It is important that Colchicine be taken as your doctor instructs as this medicine can accumulate and cause an overdose.
	www.suite101.com /article.cfm/living_with_pbc/108920 (472 words)

	CDC \| Case Definition: Colchicine Poisoning
		Ingestion of colchicine typically leads to profuse vomiting and diarrhea, which can be bloody, followed by hypovolemic shock and multisystem organ failure within 24-72 hours.
		Biologic: A case in which colchicine is detected in urine, serum, or plasma (2), as determined by a commercial laboratory.
		The case can be confirmed if laboratory testing was not performed because either a predominant amount of clinical and nonspecific laboratory evidence of a particular chemical was present or a 100% certainty of the etiology of the agent is known.
	www.bt.cdc.gov /agent/colchicine/casedef.asp (327 words)

	Buy Colchicine. No Prescription US Pharmacy. Order without Delay.
		Colchicine is used to treat attacks of gout.
		Some of the side effects that may occur while taking Colchicine include: difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; fever; rash; numbness or tingling.
		Symptoms of a colchicine overdose include nausea; vomiting; stomach pain; diarrhea; muscle weakness; burning in your throat, stomach, or skin; difficulty breathing; delirium; and seizures.
	www.readingtarget.com /shop/colchicine.htm (511 words)

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