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Topic: Commonwealth Serum Laboratories

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	Millions given infected polio vaccine - Health - www.smh.com.au
		Commonwealth Serum Laboratories knew from its own internal research that the monkey virus was a potential cause of cancer in humans.
		Commonwealth Serum Laboratories, which was privatised in 1994, supports the call for further research.
		Minutes of a meeting held at Commonwealth Serum Laboratories on May 1, 1962 record how the organisation's then director, Ron Greville, confirmed that SV40 had been found in vaccine batch number 64, which was being readied for release.
	www.smh.com.au /articles/2004/10/22/1098316861644.html (1269 words)

	HCV News
		The former Commonwealth Serum Laboratories has admitted it knew in the 1980s that there was a risk of contracting hepatitis C through its treatments, but said the virus was considered relatively minor.
		CSL medical and research director Daryl Maher told a national Senate inquiry in Melbourne yesterday that hepatitis C, then known as non-A and non-B hepatitis, was considered an "innocuous" condition in the 1980s - but that its dangers are known now.
		CSL and the Blood Service have also been accused of failing to use screening equipment used in the United States, known as ALT or surrogacy testing, that could have reduced the risk of transmission of hepatitis C by as much as 50 per cent.
	www.hepcsolutions.com /interactive/2004/april5I.htm (515 words)

	Pharmaceutical Technology - Parkville CSL Recombinant Proteins Production Plant, Australia
		CSL is also using the facility to research into the fermentation of various genetically engineered bacteria (E. coli and of mammalian origin) and yeasts to produce biologically active proteins (monoclonal antibodies and other therapeutic compounds) to expand its product range.
		CSL was incorporated in 1991, and in 1992 the company signed an agreement with Merck Sharp and Dohme (Australia) Pty Ltd and Merck and Co Inc to develop combination vaccines for children in Australia, New Zealand and the Asia-Pacific region.
		CSL was incorporated in 1991, and in 1992 the company signed an agreement with Merck Sharp & Dohme (Australia) Pty Ltd and Merck & Co Inc to develop combination vaccines for children in Australia, New Zealand and the Asia-Pacific region.
	www.pharmaceutical-technology.com /projects/parkville/index.html (1186 words)

	Oz Knowingly Used Cancer Virus Salk Vaccines?
		Commonwealth Serum Laboratories, then a government agency, released at least four batches of the vaccine knowing they were contaminated with the virus, called Simian Virus 40 or SV40, the paper said.
		Internal research conducted by the laboratories in 1962, but never made public, reportedly showed the monkey virus was a potential cause of cancer in humans.
		The paper said the laboratories produced more than 18 million doses of the vaccine, enough to vaccinate six million Australians, between 1956 and 1962.
	www.rense.com /general58/dids.htm (320 words)

	serum
		Serum samples from 366 patients who had suspected dengue on the basis of clinical presentation and onset of symptoms 4 during 2001-2004 were submitted to CDC...
		Serum cardiac troponin T was measured serially in 76 of 101 patients in the doxorubicin group and in 82 of 105 patients in the dexrazoxane and doxorubicin group...
		Serial measurements of serum cardiac troponin T were obtained in 76 of 101 patients in the doxorubicin group and 82 of 105 patients in the group given...
	www.mongabay.com /igapo/biotech/serum.html (3937 words)

	Testing Blood vs Serum in DUI Cases
		Serum is the clear yellowish fluid obtained from separating whole blood into its solid and liquid components (usually by centrifuging the sample); the liquid portion of the blood is called plasma, which is similar to serum.
		Thus, for example, evidence of a subject's blood-alcohol analysis indicating a.10 percent BAC may in fact reflect a true.09 percent if the plasma separation method of analysis was used.
		The appellate court agreed, citing the Bartolacci opinion; although that case addressed the use of blood serum rather than plasma, both involved tests on only portions of the blood.
	www.california-drunkdriving.org /blood_vs_serum.html (547 words)

	WCH Clinical Toxinology Resources
		CSL was founded in 1916 as the Commonwealth Serum Laboratories, to meet the demand for locally produced biopharmaceuticals in a country isolated by war.
		CSL's staff numbers are temporarily tripled as the organisation produces 3 million doses of a mixed bacterial vaccine in an attempt to combat the disease.
		CSL is incorporated as a Commonwealth Statutory Authority under the control of a Board of Commissioners.
	www.toxinology.com /fusebox.cfm?staticaction=generic_static_files/avp-csl-01.html (2040 words)

	CSL - Wikipedia, the free encyclopedia
		Central Science Laboratory, a laboratory services agency of the UK Department of Environment, Food and Rural Affairs
		Commonwealth Serum Laboratories (1916-1961), Australian government agency; since privatised to form CSL Limited, an Australian biotechnology company
		Computer Science Laboratory, a laboratory of Xerox's research division, Xerox PARC; both the laboratory and the division are best known for essentially creating the modern personal computer graphical user interface (GUI) paradigm
	en.wikipedia.org /wiki/CSL (297 words)

	Acanthrophis (Site not responding. Last check: 2007-10-26)
		The Commonwealth Serum Laboratory Polyvalent Antivenom is also effective and can be used if the death adder specific antivenom is unavailable or if the snake identification is uncertain.
		The Commonwealth Serum Laboratory Polyvalent Antivenom is also effective and can be used with the same dilution and vial instructions as the death adder specific antivenom or if the snake identification is uncertain.
		It may be necessary or practical to repeat some of the above serum and urine tests periodically over the hospital course to monitor the effects of antivenom therapy or to detect late changes in parametric values previously normal or slightly abnormal.
	www-surgery.ucsd.edu /ent/DAVIDSON/Snake/Acanthop.htm (2325 words)

	Newsletter No.51
		Australia’s founding fathers decided to establish the Commonwealth Serum Laboratories to ensure that Australia was self reliant with regards to the availability of these important medicines.
		CSL has a long history in the field of plasma products and in fact we have been involved in the fractionation of Australian plasma since the early 1950s.
		First, the privatisation of the Commonwealth Serum Laboratories by the Federal Government which led to the establishment of CSL Limited and secondly, the commissioning of our plasma fractionation facility located at Broad-meadows, Victoria.
	home.vicnet.net.au /~ingroup/news51.htm (1984 words)

	CSL Limited
		CSL Limited is a global, specialty biopharmaceutical company that develops, manufactures and markets products to treat and prevent serious human medical conditions.
		The CSL Group has a combined heritage of outstanding contributions to medicine and human health with more than 90 years experience in the development and manufacture of vaccines and plasma protein biotherapies.
		Immunoglobulins to treat infections, autoimmune diseases and for preventing haemolytic disease in the newborn; plasma volume expanders to treat acute blood loss and severe burns; clotting factors to treat bleeding disorders.
	www.csl.com.au (221 words)

	Spiders - Funnel-web Spider antivenom
		An antivenom for the Sydney Funnel-web Spider was first developed for clinical use in 1981 By Dr Struan Sutherland and his team at the Commonwealth Serum Laboratories.
		At the same time Sutherland experimentally established the effectiveness of the compression/immobilisation first aid technique for funnel-web bite.
		Antivenom is held at major city and regional hospitals.
	www.amonline.net.au /spiders/dangerous/funnelweb/antivenom.htm (99 words)

	Technology in Australia 1788-1988, Chapter 9, page 627
		Its Government supported, national role for the supply of some life saving drugs and vaccines which had to be available locally, at short notice, in peace-time and war gave this organisation continuity and status which a totally profit-oriented organisation might not have sustained in periods of recession.
		Smallpox had reached Australia in the 19th century, plague was reported in 1900 and the childhood infectious diseases of diphtheria, whooping cough and measles frequently reached epidemic levels.
		Penfold led the laboratory from 1916 to 1927.
	www.austehc.unimelb.edu.au /tia/627.html (668 words)

	Doctoring the Spin
		On April 30 this year, CSL, the Commonwealth Serum Laboratories, which makes flu vaccines, sent out a press release announcing a new study by the Gallup organisation into the effects of influenza on the community.
		CSL were, for the first time, targeting the young and healthy and highlighting the financial effects of flu on the business community.
		CSL were including those who probably just had bad colds.
	sunday.ninemsn.com.au /sunday/cover_stories/transcript_1121.asp (4207 words)

	VETtech Pty Ltd (Site not responding. Last check: 2007-10-26)
		VETtech are linked with and represent the following Australian manufacturers: CSL LIMITED - Formerly the Australian Commonwealth Serum Laboratories established in 1916 as part of the Australian Ministry of Health.
		CSL's real secret to success throughout the last 82 years has been through its research and development efforts.
		Today CSL is the leading manufacturer of veterinary vaccines and pharmaceuticals in many parts of the world.
	www.austarab.com.au /members/activity.cfm?&ID=94. (290 words)

	Eric Worrel History
		It was from the late Doctor Morgan, then the Director of the Commonwealth Serum Laboratories, in Melbourne.
		Before he died in Cairns Base hospital, he requested that the snake be sent to the Serum Laboratories for venom tests.
		When work began for the Commonwealth Serum Laboratories the first venoms were produced and processed at our Woy Woy Aquarium for several years.
	www.reptilepark.com.au /park_history_eric.asp (1221 words)

	Tiger Snakes (Notechis species) (Site not responding. Last check: 2007-10-26)
		A patient with known sensitivity to horse serum may be pretreated with 1 gm of Solumedrol, administered I.V. push.
		Monitor Signs, Symptoms, and Laboratory data, and administer additional antivenom in 1 vial (3000 units) increments at a rate of 100 units per minute as necessary to control the progession of symptoms.
		It may be necessary or practical to repeat some of the above serum and urine tests periodically over the hospital course to monitor the effects of antivenom therapy or to detect late changes in laboratory values.
	www-surgery.ucsd.edu /ENT/DAVIDSON/snake/Notechis.htm (2280 words)

	Protocol Inland Taipan (Oxyuranus microlepidotus)
		Have the TAIPAN ANTIVENOM (Commonwealth Serum Laboratories) ready for the emergency crew to take with the victim to the hospital.
		Monitor Signs, Symptoms, and Laboratory data, and administer additional antivenom in 1 vial (12000 units) increments at a rate of 400 units per minute as necessary to control the progression of symptoms.
		It may be necessary or practical to repeat some of the above serum and urine tests periodically over the hospital course to monitor the effects of antivenom therapy or to detect late changes in laboratory values previously normal or slightly abnormal.
	sidewinder78.tripod.com /snakebiteprotocol/id19.html (2220 words)

	Orphans experimented on without consent. Selected human guinea pigs.
		Some researchers from the Commonwealth Serum Laboratories admitted at the time that they approached the test, which involved injecting infants in institutions with large doses of experimentally prepared flu vaccine, with some trepidation'' because influenza vaccines had long been known to produce more severe toxic reactions in children than in adults''.
		Production of a whooping cough vaccine used by the CSL on groups in babies' homes was halted only after it failed to pass a safety test in animals.
		Commonwealth Serum Laboratories researchers had taken the commercially available vaccine and mixed it with a detergent, sodium desoxycholate, to try to make it less toxic!
	mc2.vicnet.net.au /home/shortboys/web/broadmeadows.html (1273 words)

	Guinea Pig Serum Contains a Specific High Affinity Growth Hormone-Binding Protein with Novel Ligand Specificity -- Ymer ...
		as ligand, GHBP was undetectable in guinea pig serum (31, 32),
		Serum was stored at -20 C, and liver was stored at -75 C before analysis.
		Baumbach WR, Horner DL, Logan JS 1989 The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.
	endo.endojournals.org /cgi/content/full/138/9/3577 (6377 words)

	Bioline International Official Site (site up-dated regularly)
		The IVI will not be a vaccine producer, but will undertake laboratory, clinical and field studies of new and improved vaccines of particular concern to developing countries.
		The proposed approach calls for establishing a Vaccine Production Consortium and regional Laboratory Control Networks which would be supported by the WHO, CVI and technical resources made available by the various partner institutions of the CVI with an interest in training and capacity-building.
		Behringwerke, Commonwealth Serum Laboratories (CSL, Australia), Connaught, Pasteur Mérieux, Serum Institute of India and Swiss Serum.
	www.bioline.org.br /request?ba98044 (5942 words)

	eMedicine - Snake Envenomations, Sea : Article by James Foster, MD, MS
		Serum glutamic-oxaloacetic transaminase (SGOT) may be elevated because of muscle damage.
		Because of presence of horse serum, agents for emergency treatment of anaphylaxis should be available; in the event of a severe reaction, antivenom administration usually can be restarted at a slower rate with concurrent infusion of IV epinephrine and close patient monitoring
		In severe cases of serum sickness, parenteral steroids may be beneficial to reduce inflammatory effects of this immune-complex mediated disease.
	www.emedicine.com /emerg/topic543.htm (3460 words)

	Commonwealth Serum Laboratories (CSL), Commonwealth of Australia - Australian Science at Work Corporate entry
		In 1916 the Commonwealth Vaccine Depot became the Commonwealth Serum Laboratories.
		The Laboratories also took part in the pioneering of the use of human blood products.
		In 1961 the Commonwealth Serum Laboratories Commission was established, which continued and expanded the work carried out by the Commonwealth Serum Laboratories.
	www.austehc.unimelb.edu.au /asaw/biogs/A000214b.htm (178 words)

	AM - Fed Gov promises investigation into polio vaccine virus SV40
		TONY EASTLEY: The Federal Government has promised an inquiry into reports that the Commonwealth Serum Laboratories knowingly released batches of the polio vaccine contaminated with a virus linked to cancer.
		Newspaper reports say that between 1956 and 1962 at least 700,000 doses of the vaccine were released, by the now privatised CSL, which contained a simian virus called SV40 which has been proven to cause cancers in small animals.
		HAMISH FITZSIMMONS: Stories published in The Age say the Commonwealth Serum Laboratories released 4 batches of polio vaccine it knew were contaminated with a virus that's found in cancers like mesothelioma.
	www.abc.net.au /am/content/2004/s1227032.htm (610 words)

	Parliament of Australia:Senate:Committees:Community Affairs: Hepatitis C and the blood supply in Australia - Report
		Commonwealth officers regularly attended committee meetings and on a least one occasion, representatives from the NSW Department of Health attended.
		In 1961, CSL was incorporated as a statutory authority (the Commonwealth Serum Laboratories Commission).
		In May 1994, the Commonwealth sold CSL by means of a 100 per cent public float.
	www.aph.gov.au /senate/committee/clac_ctte/completed_inquiries/2002-04/hepc/report/c01.htm (2458 words)

	QML Pathology - Queensland's leading pathology provider (Site not responding. Last check: 2007-10-26)
		He had previously been working in the Commonwealth Serum Laboratories in Melbourne, the Australian Institute of Tropical Medicine and Hygiene in Townsville and directing the Commonwealth Health Laboratory in Toowoomba.
		He was a practical active man, who was an experienced builder, enjoying the actual physical construction of some of his laboratories in both city and country.
		They carried on the tradition of their fathers and, as the practice grew, were joined by other pathologists in partnership.
	www.qml.com.au /www/page.cfm?menuitemID=77 (402 words)

	Vaccine contaminated: report - Breaking News (Site not responding. Last check: 2007-10-26)
		At least four batches of vaccine released by the Commonwealth Serum Laboratories, totalling almost 3 million doses, were contaminated by the virus known as Simian Virus 40 or SV40.
		Internal research conducted by the laboratories in 1962, but never made public, showed that the monkey virus was a potential cause of cancer in humans, it was reported.
		The paper said the laboratories produced more than 18 million doses of the Salk polio vaccine, enough to vaccinate 6 million Australians, between 1956 and 1962.
	www.theage.com.au - !http: //www.theage.com.au/articles/2004/10/23/1098474902841.html (325 words)

	Influenza Actvy and Composition of the 1992-93 Flu Vaccine
		In Europe, influenza A(H3N2) virus was the predominant isolate in the Commonwealth of Independent States, Czechoslovakia, Denmark, Finland, France, Greece, Hungary, Italy, the Netherlands, Norway, Portugal, Romania, Spain, Sweden, Switzerland, and the United Kingdom; in some of these countries, it was associated with localized outbreaks.
		Antibody induced by this vaccine component reacted similarly with recent isolates, such as the A/Washington/15/91 virus, in serum from all age groups, and postvaccination geometric mean titers (GMTs) of antibody to the recent isolates were approximately 50%-100% of those to the vaccine virus.
		Postvaccination serum specimens obtained from vaccinees of all age groups reacted well with the vaccine virus B/Panama/45/90, and except for serum from the youngest children, also reacted well with B/Victoria/2/87.
	wonder.cdc.gov /wonder/prevguid/p0000290/p0000290.asp (1320 words)

	Directory of History of Medicine Collections: (146)
		In 2004 the internationally significant Commonwealth Serum Laboratories (CSL) collection finally made its home at Museum Victoria.
		Research equipment and medicinal samples from the internationally significant Commonwealth Serum Laboratories (CSL) (1918-1984).
		The Australian institution, CSL, conducted ground-breaking work in the research and manufacture of medicines for use in public health; these include penicillin, anti-venoms and vaccines.
	www.nlm.nih.gov /hmd/directory/146.html (1085 words)

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