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| | eMedicine - Hyperbilirubinemia, Conjugated : Article Excerpt by: Richard A Weisiger, MD |
 | | Accumulation of bilirubin or its conjugates in body tissues produces jaundice (ie, icterus), which is characterized by high plasma bilirubin levels and deposition of yellow bilirubin pigments in skin, sclerae, mucous membranes, and other less visible tissues. |
 | | Diseases that reduce the rate of secretion of conjugated bilirubin into the bile or the flow of bile into the intestine produce a mixed or predominantly conjugated hyperbilirubinemia due to reflux of conjugates back into the plasma. |
 | | Pathophysiology: Conjugated hyperbilirubinemia results from reduced secretion of conjugated bilirubin into the bile, such as occurs in patients with hepatitis, or it results from impaired flow of bile into the intestine, such as occurs in patients with biliary obstruction. |
| www.emedicine.com /med/byname/hyperbilirubinemia-conjugated.htm (601 words) |
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