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Topic: Connexon

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	Calcium-dependent Open/Closed Conformations and Interfacial Energy Maps of Reconstituted Hemichannels -- Thimm et al. ... (Site not responding. Last check: 2007-10-09)
		60% of the connexons are of height 1.29 ± 0.44 nm (Fig.
		The model connexon surface contours (A and B, bottom curves) were reconstructed such that convolutions of tip with the model surfaces resemble the measured connexon profiles (red traces), which is effectively the trajectory traced by the tip apex.
		E and F show a model for the mechanism of channel closing; when the tertiary structure of the open connexon (F) is unbalanced by the Ca absorbed on the extramembranous surface, the refolding of the E1 and E2 loops hides the hydrophobic domains and at the same time closes the channel.
	www.jbc.org /cgi/content/full/280/11/10646 (6020 words)

	PRESS RELEASE TCS Signs Reseller Agreement With ConneXon Telecom for TCS VoIP E9-1-1 Service (Site not responding. Last check: 2007-10-09)
		Designed for mobility, TCS VoIP E9-1-1 service enables ConneXon to provide affordable emergency call routing to small- to medium-size VoIP providers and enterprises.
		The ConneXon service is based on TCS VoIP E9-1-1 service for call delivery to Public Safety Answering Points (PSAPs) for effective, real-time call routing of emergency VoIP 9-1-1 calls.
		ConneXon Telecom Inc. is a privately held company specializing in VoIP solutions.
	www.marketwire.com /mw/release_html_b1?release_id=143475 (768 words)

	Assembly of heteromeric connexons in guinea-pig liver en route to the Golgi apparatus, plasma membrane and gap ... (Site not responding. Last check: 2007-10-09)
		Assembly of heteromeric connexons in guinea-pig liver en route to the Golgi apparatus, plasma membrane and gap junctions -- Diez et al.
		Assembly of heteromeric connexons in guinea-pig liver en route to the Golgi apparatus, plasma membrane and gap junctions
		(A) Connexons were solubilized from gap junctions by incubation in dodecyl maltoside and cross-linked with dimethyl suberimidate as described in Experimental procedures.
	content.febsjournal.org /cgi/content/full/262/1/142 (5209 words)

	Professor Kang's Homepage
		One connexon resides in the membrane of one cell and it aligns and joins the connexon of the neighboring cell, froming a continous aquaeous pathway by which these ions and small molecules can freely pass from one cell to the other.
		These connexin proteins consist of specialized regions such that they can be anchored into the lipid bilayer of the cell membrane, have external regions to allow coupling to the opposing connexon and have intracellular regions in the cytoplasm which are regions for specific regulatory control.
		Evidence shows that in some cells the heximeric connexons can be formed by six identical connexins (homologous connexons) or some combination of two expressed connexins (hybrid or heterologous connexons).
	plaza.snu.ac.kr /~kangpub/gap/gap.htm (311 words)

	Roles of Met-34, Cys-64, and Arg-75 in the Assembly of Human Connexin 26. IMPLICATION FOR KEY AMINO ACID RESIDUES FOR ... (Site not responding. Last check: 2007-10-09)
		The M34T-His/WT (H) and the R75W-His/WT (I) exhibit the same elution pattern, where the mutant and WT are co-eluted as hexameric connexons at 550 kDa, indicating that the R75W could form stable connexon with the WT.
		A view of connexon perpendicular to the membrane plane is shown.
		Residue Arg-75 is proposed to lie on the interface between adjacent subunits, where it contributes to the stabilization of the connexon hexamer.
	www.jbc.org /cgi/content/full/278/3/1807 (6932 words)

	[Frontiers in Bioscience, 3, d208-236, February 15, 1998] (Site not responding. Last check: 2007-10-09)
		Each gap junction channel is comprised of two hemichannels or connexons and each connexon is formed by the aggregation of six protein subunits known as connexins (figure 3) (78).
		At this point, the connexons are closed to prevent leakage of cellular contents and entry of extracellular materials.
		At the plasma membrane, the connexons are attracted to those on the adjacent cell by poorly understood forces and two connexons join in an end-to-end manner to form a complete channel.
	www.bioscience.org /1998/V3/d/trosko/3.htm (3190 words)

	Gap junction definition - Medical Dictionary definitions of popular medical terms
		One connexon resides in the membrane of one cell.
		It aligns and joins the connexon of the neighboring cell, forming a continuous aqueous pathway by which ions and small molecules can freely pass (passively) from one cell to the other.
		In some cells the connexons are formed of six identical connexins or of some combination of two different connexins.
	www.medterms.com /script/main/art.asp?articlekey=32536 (210 words)

	Opposing gates model for voltage gating of gap junction channels -- Chen-Izu et al. 281 (5): C1604 -- AJP - Cell ...
		Expression of gap junctions composed of homotypic and heterotypic connexins.
		The connexin RNA was prepared using the in vitro transcription methods previously described (2).
		speculate that the extent of alteration in the connexon voltage
	ajpcell.physiology.org /cgi/content/full/281/5/C1604 (5215 words)

	ConneXon Telecom to Resell TCS VoIP E9-1-1 Service
		ConneXon Telecom in Montreal announced on Thursday that it agreed to resell VoIP E9-1-1 service from
		TCS' VoIP E9-1-1 service is mobile and it will enable ConneXon to provide emergency call routing to small to medium-sized VoIP providers and enterprises.
		The ConneXon service will be based on TCS' VoIP E9-1-1 service for call delivery to Public Safety Answering Points (PSAPs) for real-time call routing of emergency VoIP 9-1-1 calls.
	voipforsmb.tmcnet.com /news/articles/1852-connexon-telecom-resell-tcs-voip-e9-1-1.htm (454 words)

	Fall 2006 VON - Voice, Video and More - brought to you by pulvermedia (Site not responding. Last check: 2007-10-09)
		ConneXon Telecom is the one stop solution for VoIP service providers looking for broad and affordable network access, as well as a fully FCC compliant, cost effective E911 service.
		While ConneXon Telecom focuses on helping VSPs get launched quickly and efficiently, they are equally well suited for the already established VSP looking to further expand their operations.
		ConneXon Telecom offers: Call origination and termination, 911 Enable(TM) (E911 service), and a free class 5 softswitch.
	www.pulvermedia.com /pressroom/06VONfa/911enable.php (449 words)

	Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells -- He et al. 96 ...
		microscopy to be highly enriched for connexons (9).
		decarboxylase (EC 4.1.1.15; 310 kDa) or connexons composed of
		A second band with the same mobility as Cx40 is observed in fractions enriched for connexons (e.g., fraction 12).
	www.pnas.org /cgi/content/full/96/11/6495 (4943 words)

	Assembly of gap junction channels: Mechanism, effects of calmodulin antagonists and identification of connexin ... (Site not responding. Last check: 2007-10-09)
		The approximate positions of connexins, connexons and intermediate oligomers and known molecular mass proteins are indicated.
		Membranes containing connexons were solubilized and immunoprecipitated using Cx32 and Cx26 antibodies as described in the experimental procedures.
		Diez, J.A., Ahmad, S. and Evans, W.H. (1999) Assembly of heteromeric connexons in guinea-pig liver en route to the Golgi apparatus, plasma membrane and gap junctions.
	content.febsjournal.org /cgi/content/full/268/16/4544 (5408 words)

	NCMIR Research Publications Cover 1998 JMB
		With this amount of rotation, the peaks (protrusions) on one connexon fit into the valleys of the apposed connexon in the 3D model, which would make for an ionically tight interface necessary for a functional cell-cell channel.
		Docking appears to be governed by a "lock and key" mechanism via a simple interdigitation of the six protrusions from each connexon.
		The docked connexons were computationally fitted into two gap junction structures, which further confirmed the interdigitated manner of docking.
	ncmir.ucsd.edu /Research/Publications/Cover/1998_JMB.htm (242 words)

	Heterotypic Docking of Cx43 and Cx45 Connexons Blocks Fast Voltage Gating of Cx43 -- Elenes et al. 81 (3): 1406 -- ...
		Such homomeric connexons can pair with themselves to form homotypic channels (right and left panels) or they could pair with connexons formed of a different connexin forming heterotypic channels (center panel).
		Thereafter, the inactivation kinetics for Cx43 connexons heterotypically
		connexons gated with a polarity opposite to that of Cx45 connexons.
	www.biophysj.org /cgi/content/full/81/3/1406 (7207 words)

	Gap junctions and connexon hemichannels in human embryonic stem cells.
		Gap junctions and connexon hemichannels in human embryonic stem cells.
		Dye uptake studies on human ES cell monolayers and recordings from solitary human ES cells gave evidence for the surface expression of connexon hemichannels.
		Human ES cells provide a unique system for the study of human connexin proteins and their potential functions in cellular differentiation and the maintenance of pluripotency.
	stemcells.researchtoday.net /archive/3/7/1529.htm (345 words)

	Connexon - Wikipedia
		Als Connexon bezeichnet man den porenbildenden Komplex aus jeweils sechs Connexin-Molekülen.
		Zwei Connexone bilden einen Gap junction-Kanal, der die Membranen zweier aneinandergrenzender Zellen durchquert und so die Cytoplasmas zweier benachbarter Zellen miteinander verbindet.
		Einige hundert Gap junction-Kanäle bilden gemeinsam die Gap junction, die den Austausch von Ionen und kleinen Molekülen zwischen Nachbarzellen ermöglicht.
	de.wikipedia.org /wiki/Connexon (71 words)

	Connexon - HOME
		Dan is het tijd om professionele hulp in te schakelen.
		Het Web Content Managemet Systeem van Connexon lost al uw problemen op.
		Ik wens meer info over de voordelige, professionele websites van Connexon.
	www.connexon.be (127 words)

	Gap junction - Wikipedia, the free encyclopedia
		When two identical connexons come together to form a Gap junction, it is called a homotypic GJ.
		When one homomeric gap junction and one heteromeric gap junction come together, it is called a heterotypic gap junction.
		When two heteromeric connexons join, it is also called a heteromeric Gap Junction.
	en.wikipedia.org /wiki/Gap_junction (574 words)

	Reconstitution of native-type noncrystalline lens fiber gap junctions from isolated hemichannels -- Kistler et al. 126 ...
		by pairing of two hemichannels or connexons, and are also referred to as
		to separately solubilize hemichannels or connexon pairs from isolated ovine
		connexon pairs were reconstituted with phosphatidylcholines by dialysis
	www.jcb.org /cgi/content/abstract/126/4/1047 (371 words)

	Chemicon - Protein Products - Connexin - CX26
		Gap junctions are composed of a connexon on each of the adjacent cells; docking of connexons on adjacent cells creates a functional Gap junction.
		A single connexon on a nonjunctional membrane permits small molecule exchange between the cell and the extracellular space.
		Connexons are hexamer structures composed of connexin subunits; at least 20 connexins have been identified in humans and mice, and cells usually express multiple isoforms.
	www.chemicon.com /browse/proteinproducts.asp?ProteinID=1317 (239 words)

	InterPro: IPR002268 Gap junction beta-2 protein (Cx26)
		By contrast, the single putative intracellular loop (between TM domains 2 and 3) and the cytoplasmic C-terminus are highly variable among the family members.
		Six connexins are thought to associate to form a hemi-channel, or connexon.
		Two connexons then interact (likely via the extracellular loops of their connexins) to form the complete gap junction channel.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR002268 (3748 words)

	Role of gap junctions during early embryo development -- Houghton 129 (2): 129 -- Reproduction
		A connexon from one cell docks with a connexon from an apposing plasma membrane to form an intercellular channel.
		Connexons may be homomeric, composed of a single connexin protein, or heteromeric, containing multiple connexins.
		Dahl E, Winterhager E, Reuss B, Traub O, Butterweck A and Willecke K 1996 Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extraembryonic tissues and in the gastrulating mouse embryo, respectively.
	www.reproduction-online.org /cgi/content/full/129/2/129 (3926 words)

	VoIP Lowdown: TCS agreement with ConneXon to impact wireless subscribers (Site not responding. Last check: 2007-10-09)
		TeleCommunication Systems, Inc. (TCS), a leading provider of mission-critical wireless communications has signed an agreement with ConneXon Telecom Inc. to resell TCS Voice over Internet Protocol (VoIP) E9-1-1 service.
		ConneXon's strengths to build its channel will be increased through TCS once the integration takes place completely.
		The agreement reached would see ConneXon launching its new service called 11Enable(TM), which will be based on TCS' VoIP E9-1-1 service to deliver for Public Safety Answering Points (PSAPs).
	www.voiplowdown.com /2006/07/tcs_agreement_w.html (412 words)

	News Briefs for July 13, 2006 - 7/13/2006 10:43:00 AM - Wireless Week - CA6352687 (Site not responding. Last check: 2007-10-09)
		The companies first intend to focus on the Japanese and European markets, with future plans in the works to expand globally.
		The deal will enable ConneXon to leverage the service to offer emergency call routing to small- to medium-size VoIP providers and enterprises.
		ConneXon will launch its new service, called 911Enable, which is based on TCS VoIP E9-1-1 service.
	www.wirelessweek.com /article/CA6352687.html (621 words)

	neuro
		Two connexons align between cells to form a channel that spans two plasma membranes.
		The types of connexins used to form the connexon pair have some role in determining specific permeability across the channel.
		Gap junctions are expressed in nearly all mammalian tissues but they are most visibly important in cardiac muscle fibers.
	pharyngula.org /index/neuro/connexin (210 words)

	Clicker Connexon - Trainer Information
		Hello, my name is Heather and I would like to welcome you to the Clicker Connexon Dog Training School website.
		If you choose to train your dog on any of the Clicker Connexon courses, workshops or training days, you are assured of a fun time and masses of easy learning, tips and techniques.
		In February 2005 I will be able to offer Canine Reiki Healing - details will appear on the Diary Page of this website.
	homepages.tesco.net /fourpawdrive/dog-training-courses-yorkshire-clicker-connexons-trainerpage.htm (372 words)

	CONNEXINS (Cx 26-50) ANTIBODIES (Site not responding. Last check: 2007-10-09)
		Absence of intercellular communication mediated by gap junction may lead to transformed or cancerous growth.
		Gap junctional channel is composed of a hemichannel (connexon) in the cell membrane of one cell joined in mirror symmetry with a connexon in the opposing cell.
		Each connexon is an oligomer of six protein subunits that define the axial aqueous pore.
	www.vincibiochem.it /ADI/connexin.html (350 words)

	Zonula Occludens-1 Alters Connexin43 Gap Junction Size and Organization by Influencing Channel Accretion -- Hunter et ...
		Reduction of Cx43-GFP plaque size by coexpression of native Cx43 requires a majority of connexons be composed predominately of native Cx43.
		(D) Distribution of connexon stoichiometries expected when native Cx43 is coexpressed in HeLa Cx43-GFP at levels necessary (MOI 5) and sufficient (MOI 10) to normalize GJ size and distribution.
		Goodenough, D. A., and Paul, D. Beyond the gap: functions of unpaired connexon channels.
	www.molbiolcell.org /cgi/content/full/16/12/5686 (7927 words)

	Clicker Connexon Dog Training School
		You will learn simple, yet very effective training techniques at Clicker Connexon, which will enhance the relationship between you and your dog, building a strong bond for your future together.
		Clicker Connexon Dog Training School promotes only kind, motivational training methods and is committed to responsible dog ownership, with training experience in excess of 25 years.
		Structured 5-week training courses, either Clicker method or play motivation method, for dogs and handlers of all ages, all abilities, and all ambitions.
	homepages.tesco.net /fourpawdrive (97 words)

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