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Sloan-Kettering - Projects: Merlin/NF-2 Contact Inhibition of Growth and Tumor Suppression Cancer cells are refractory to this contact inhibition of growth. We are using biochemistry and optical imaging to examine the signaling mechanisms underlying contact inhibition. Biochemical and imaging studies indicate that de-phosphorylated Merlin mediates contact inhibition of growth by suppressing Rac signaling. www.mskcc.org /mskcc/html/56840.cfm   (261 words)

Jahrbuch-CD der MPG 2003 - Contact inhibition of VEGF-indu β-Catenin-null endothelial cells are not contact inhibited by VE-cadherin and are still responsive to VEGF, indicating that this protein is required to restrain growth factor signaling. Overall the data indicate that VE-cadherin-β-catenin complex participates in contact inhibition of VEGF signaling. In sparse cells or in VE-cadherin-null cells, this phenomenon cannot occur and the receptor is fully activated by the growth factor. www.mpg.de /forschungsergebnisse/wissVeroeffentlichungen/archivListenJahrbuch/2003/20/publZIM68.html   (236 words)

Merlin tells when to grow and when to stop Overcoming this contact growth inhibition is an integral aspect of cancer induction. Although previous studies have identified merlin as a negative regulator of cell growth, this paper is the first documentation of merlin’s specific role in the contact inhibition of growth. Although contact inhibition is only one form of cell growth regulation, the insight that Dr. Herrlich and colleagues have provided into the mechanism of contact growth inhibition will undoubtedly improve our understanding of cancer development. www.eurekalert.org /pub_releases/2001-04/CSHL-Mtwt-1404101.php   (329 words)

Hair Loss Forums :: View topic - The scalp inflamation question? My opinion on the role of contact inhibition in anagen follicle size, and the advantages of this in the evolution and function of hair, can be seen here http://www.biohydraulic.co.uk A slightly modified version of this paper was published in Medical Hypotheses (2002) 59 (5), 522-526. Contact inhibition ensures that organs can only be as large as the available space allows. A role of contact inhibition mediated through hydraulic changes in MPB, does not conflict with in-vitro observations, or the donor dominance observed in transplanted grafts. www.morphollica.com /forums/viewtopic.php?p=392   (1430 words)

Contact with Isolated Sclerotome Cells Steers Sensory Growth Cones by Altering Distinct Elements of Extension -- ... F, The growth cone reestablishes contact, reiterating the response; veil extension is inhibited on contacting filopodia (arrowhead), whereas noncontacting filopodia support extension. Contact with PS cells disrupts three discrete elements of veil extension that are quantitative measures of the ability of Contact with PS does not alter (D) veil initiation frequency or (E) the rate of veil extension on either contacting or noncontacting filopodia. www.jneurosci.org /cgi/content/full/19/9/3495   (6829 words)

Integrin and Cadherin Synergy Regulates Contact Inhibition of Migration and Motile Activity -- Huttenlocher et al. 141 ... N-cadherins all implicate N-cadherin in the contact inhibition This contact- mediated inhibition of migration is mediated by Contact inhibition of cell migration was originally described in fibroblasts by Abercrombie and Heaysman (1953) www.jcb.org /cgi/content/full/141/2/515   (5726 words)

Impact of Cell Growth Morphology on Retroviral Transduction: Effect of Contact Inhibition   (Site not responding. Last check: 2007-09-16) In this study, we focused on the effect of cell-cell contact inhibition on the efficiency of retroviral transduction with two anchorage-dependent cell lines: NIH 3T3 and 293 cells. Experimental data indicate that the abatement of the transduction rate of 293 cells was initiated in the early stage of the culture, whereas effect of contact inhibition of NIH 3T3 cells on the transduction rate became dominating at the end of the culture period. The implication drawn from this study is that contact inhibition effect on retroviral transduction should be taken into account for large-scale gene transfer systems such as the microcarrier bioreactor. pubs.acs.org /cgi-bin/abstract.cgi/bipret/2001/17/i02/abs/bp000168o.html   (325 words)

Contact inhibition/collapse and pathfinding of neural crest cells in the zebrafish trunk -- Jesuthasan 122 (1): 381 -- ... Contact inhibition/collapse and pathfinding of neural crest cells in the zebrafish trunk -- Jesuthasan 122 (1): 381 -- Development Contact inhibition/collapse and pathfinding of neural crest cells in the zebrafish trunk inhibition or collapse) when the medial surface does not. dev.biologists.org /cgi/content/abstract/122/1/381   (293 words)

Cell-cell contact changes the dynamics of lamellar activity in nontransformed epitheliocytes but not in their ... inhibited at the free lamellar edges adjacent to the zone of contact. While contact inhibition of movement is a well known phenomenon, the cellular mechanisms underlying this activity remain unknown. contact detected the presence of an enrichment of E-cadherin (Fig. www.pnas.org /cgi/content/full/94/3/879   (3429 words)

UW Pediatrics: Active Grants   (Site not responding. Last check: 2007-09-16) Interestingly, preliminary studies suggest that although these cells show less contact inhibition, they display enhanced cell-cell adhesiveness, suggesting that the adhesive and signaling characteristics of cadherin may be functionally uncoupled in calpain deficient embryonic fibroblasts. We propose to test the hypothesis that p120 catenin is a critical mediator of calpain’s effect on cell-cell adhesive function and contact-mediated inhibition of migration. Define the relationship between p120/cadherin interaction and calpain’s effects on contact inhibition of cell migration. www.pediatrics.wisc.edu /research/activegrants/ahuttenlocher_ardcm.html   (548 words)

glossary A type of disease in which normal cells lose contact inhibition, and grow profusely to form a malignant tumour, which invades surrounding tissue and sometimes spreads to other locations; there are many different causes, including carcinogenic chemicals, certain forms of radiation and some viruses. A disease of adult fruit flies (Drosophlia), sensitivity caused by Sigma virus; a very brief contact with pure carbon dioxide gas is lethal to infected (sensitive) flies; the virus is transmitted to the off-spring by the gametes of one or both parents. Harbouring of or contact with micro-organisms (or other organisms such as insect parasites) in absence of a relationship which may be considered commensalistic, mutualistic or parasitic or the presence of an unwanted pesticide or other material in or on a plant, animal or their by-products. www.pestmanagement.co.uk /lib/glossary/glossary_c.shtml   (9944 words)

IL-10 Contributes to the Inhibition of Contact Hypersensitivity in Mice Treated with Photodynamic Therapy -- Simkin et ... Inhibition of contact hypersensitivity with different analogs of benzoporphyrin derivative. Interleukin-10 inhibits the elicitation phase of allergic contact hypersensitivity. IL-12 as a mediator and adjuvant for the induction of contact sensitivity in vivo. www.jimmunol.org /cgi/content/full/164/5/2457   (4652 words)

APStracts 2:0210L, 1995.   (Site not responding. Last check: 2007-09-16) Cell-cycle arrest in g0/g1 phase by contact inhibition and transforming growth factor-[beta]1 in mink mv1lu lung epithelial cells. Release of Mv1Lu cells from contact inhibition in the presence of TGF-[beta]1 prevented both the re-expression of p45 and cell cycle progression. Our results indicate that inhibition of G1 progression in Mv1Lu cells is mediated, at least in part, by suppression of p45, cyclin D2/Cdk4, and cyclin B1/Cdc2 expression and/or their activities, and hypophosphorylation of pRb. www.uth.tmc.edu /apstracts/1995/lung/November/210l.html   (381 words)

MSN Encarta - Search Results - contact inhibition Advice: So then Dr Froyd said…, Alcohol: Candy Is dandy But liquor…, Alcohol: "It releases your inhibitions, Lets you be…, Creativity: Endings are... Contact mines were the earliest successful types of naval mines. Search for books about your topic, "contact inhibition" encarta.msn.com /contact+inhibition.html   (109 words)

George Lipkin M.D. Nabi ZF; Zucker-Franklin D; Lipkin G; Rosenberg M."Susceptibility to NK cell lysis is abolished in tumor cells by a factor which restores their contact inhibited growth". Lipkin G; Knecht ME."Contact inhibition of growth is restored to malignant melanocytes of man and mouse by a hamster protein". Lipkin G; Knecht ME."[Restoration of growth contact inhibition in malignant melanocytes from man, mice, and hamsters]". www.med.nyu.edu /pubs/lipkig01.html   (925 words)

[No title] However, this inhibition of growth cone motility is dependent on the level of maturity of the oligodendrocyte. The inhibition of growth cone motility that results from contact with Stage 3 and 4 oligodendrocytes can be blocked by pertussis toxin. This is a particularly appealing approach because it defines the cellular mechanisms that underlie growth cone inhibition that results from the growth coneÕs integration of many signals. www2.umdnj.edu /~moormasj/Research2.html   (853 words)

Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain -- Bhatt et al. 115 ... Effects of calpain inhibition on the cellular morphology of CHO cells plated on fibronectin. Effects of calpain inhibition on focal adhesion disassociation during nocodozole recovery in cells plated on fibronectin. and that inhibiting calpain with calpastatin, stabilizes peripheral jcs.biologists.org /cgi/content/full/115/17/3415   (5396 words)

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44 -- ... inhibition of growth as it occurs at high cell density. Takahashi, K. and Suzuki, K. Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion. Whittenberger, B. and Glaser, L. Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface membranes. www.genesdev.org /cgi/content/full/15/8/968   (7561 words)

Hairsite4.com - Viewing topic #27324 - Lets Brainstorm! Contact inhibition only comes into play in physiology when a tissue is `growing' as in the anagen phase of hair follicles. Contact inhibition is triggered by cell to cell contact to prevent cellular growth where there is a `certain' degree of resistence. This makes contact inhibition `pressure responsive' the greater the pressure from existing tissues, the more resistence to the growth of other tissues, the earlier the `switch of' threshold is reached. www.hairsite4.com /dc/dcboard.php?az=show_topic&forum=8&topic_id=27324&mode=full   (10421 words)

Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact ... synthesis irrespective of the presence of cell-cell contact. In the absence of cell-cell contact, the S262-Cx43 mutations Myocyte cultures infected with adenoviral vectors expressing (A) 262A-Cx43 or (B) 262D-Cx43 were labelled for N-cadherin (green; rabbit polyclonal antibodies to delineate cell-cell contact cardiomyocyte areas), Ki-67 (green; rabbit polyclonal to detect nuclei of proliferating cells; elicits speckled nuclear staining) and Cx43 (red; monoclonal antibodies). jcs.biologists.org /cgi/content/full/117/3/507   (4630 words)

Daniel Lorch - UF Journal of Undergraduate Research Paper   (Site not responding. Last check: 2007-09-16) Transformed cells, identified by loss of contact inhibition and altered morphology, were rescued and cultured, and the integrated provirus retrieved. as a cell line for transformation studies, this mouse fibroblastic cell line is highly regarded for its indefinite growth in culture, retention of contact inhibition, and ease of transformation due to mutations or expression of introduced genes. After three weeks of incubation, clones that once again demonstrated lack of contact inhibition and altered morphological characteristics were considered to be transformed. www.clas.ufl.edu /jur/200212/papers/paper_lorch.html   (2220 words)

Tissue-specific Sorting-out in Two Dimensions in Relation to Contact Inhibition of Cell Movement IT is thought that the monolayering of cells which takes place on a substratum in tissue culture results from "contact inhibition of cell movement", that is inhibition of the movement of a cell in the direction of contact with another If it is the movement of a cell toward a contacted neighbour that is inhibited, cells which are surrounded on all sides by other cells should be immobilized Because of this we wondered whether "contact inhibition of movement" requires a solid substratum. www.nature.com /nature/journal/v244/n5418/abs/244568a0.html   (241 words)

Truncation of the Extracellular Region Abrogrates Cell Contact but Retains the Growth-suppressive Activity of ... to mediate cell-cell contact and contact inhibition presumably Zhu A. J., Watt F. Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes. Zolfaghari A., Djakiew D. Inhibition of chemomigration of a human prostatic carcinoma cell (TSU-pr1) line by inhibition of epidermal growth factor receptor function. cancerres.aacrjournals.org /cgi/content/full/60/24/7057   (5722 words)

Evidence for ERK1/2 phosphorylation controlling contact inhibition of proliferation in Madin-Darby canine kidney ... Evidence for ERK1/2 phosphorylation controlling contact inhibition of proliferation in Madin-Darby canine kidney epithelial cells -- Li et al. Evidence that hepatocyte growth factor abrogates contact inhibition of mitosis in Madin-Darby canine kidney cell monolayers. Role of diffusion boundary layer in contact inhibition of growth. ajpcell.physiology.org /cgi/content/full/287/2/C432   (5262 words)

Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane -- Okada et ... Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane -- Okada et al. Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane contact inhibition of growth by suppressing recruitment of Rac www.jcb.org /cgi/content/abstract/171/2/361   (241 words)

Mechanisms of Mitotic Inhibition in Corneal Endothelium: Contact Inhibition and TGF-{beta}2 -- Joyce et al. 43 (7): ... Mechanisms of Mitotic Inhibition in Corneal Endothelium: Contact Inhibition and TGF-{beta}2 -- Joyce et al. Mechanisms of Mitotic Inhibition in Corneal Endothelium: Contact Inhibition and TGF-ß2 contact on the relative protein and mRNA expression of the CKIs, www.iovs.org /cgi/content/abstract/43/7/2152   (757 words)

Medical Dictionary: Contact inhibition - WrongDiagnosis.com Contact inhibition : arrest of cell locomotion or cell division when two cells come into contact. The main area of interest in this property is that cancer cells do not stop growing when they reach other cells, but will either push these cells, or penetrate into the cell area. Hence, lack of contact inhibition causes tumors to continue growing even when they press on other organs (causing damage or other problems), and also promotes metastasis of the cancer cells. www.wrongdiagnosis.com /medical/contact_inhibition_printer.htm   (200 words)

Respiratory Syncytial Virus Fusion Protein Mediates Inhibition of Mitogen-Induced T-Cell Proliferation by Contact -- ... observed inhibition of PBMC proliferation (18, 30, 32). The responsible RSV contact antigen was identified as the RSV Inhibition of lymphocyte proliferation is more pronounced with PBLs of the specific host. jvi.asm.org /cgi/content/full/76/3/1163   (6090 words)

Notch Activation Induces Endothelial Cell Cycle Arrest and Participates in Contact Inhibition: Role of p21Cip1 ... the phosphorylation and inhibition of the retinoblastoma gene Notch4IC and Notch1IC inhibit S-phase entry and Rb phosphorylation in endothelial cells from veins, arteries, and microvessels. Activated Notch inhibits nuclear localization of cdk4 and cyclin D. HUVEC transduced with MIY (vector), MIY-Notch4IC (Notch4IC), or MIY-Notch1IC (Notch1IC) were immunostained with antibodies for cdk4 and cyclin D, and the proportion of cells expressing nuclear cdk4 and cyclin D was enumerated by fluorescence microscopy. mcb.asm.org /cgi/content/full/24/20/8813   (5635 words)

Nikon MicroscopyU Digital Video Gallery: Live-Cell Imaging - A-549 Cell Motility Epithelial cells experience significant contact inhibition to migration. When two epithelial cells come into contact with one another, the ruffling of their overlapping surface extensions generally halts and the cells adhere to one another. Unlike fibroblasts, which experience a much milder form of contact inhibition, epithelial cells do not usually separate and travel in new directions once they become stuck together. www.microscopyu.com /moviegallery/livecellimaging/a549/t1/a549-dsl3.html   (349 words)

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