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Topic: Contractility

In the News (Sun 27 Dec 09)

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	CiteULike: Mechanoelectrical feedback: independent role of preload and contractility in modulation of canine ... (Site not responding. Last check: 2007-11-03)
		An increase in preload or contractility was associated with shortening of the action potential.
		A threefold increase in preload and twofold increase in contractility were associated with a decrease in action potential duration of 22 and 24 ms, respectively.
		The similar effects of either increased preload or contractility on excitability may be mediated by a common cellular mechanism which results in a rise in intracellular free Ca2+ and secondary abbreviation of the action potential.
	www.citeulike.org /user/weihuil/article/732224 (823 words)

	CiteULike: Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from ... (Site not responding. Last check: 2007-11-03)
		We investigated the effects of pharmacological inhibitors of acto-myosin contractility on growth and differentiation of C2C12 myogenic cells.
		Thus, as with suspension-arrest, inhibition of acto-myosin contractility in adherent cells led to arrest uncoupled from differentiation.
		We suggest that in myoblasts, the Rho pathway and regulation of acto-myosin contractility may define a control point for conditional uncoupling of differentiation and the cell cycle.
	www.citeulike.org /user/catcremona/article/851237 (643 words)

	Cytokinetics Contractility
		Contractility has evolved from simple cytokinetic events in prokaryotic life to include muscle contractility and more complex intracellular events in higher eukaryotic organisms where contractile tissues play a role in a variety of physiologic processes including cardiac contractility, blood pressure maintenance, airflow regulation and bladder control.
		However, regardless of muscle type or regulation, muscle contractility derives fundamentally from the interaction of a force generating motor, myosin, with a filamentous polymer, actin.
		Given that the contractile proteins are not only the final effectors of contractility but also are restricted in expression to their specific muscle types, they make ideal targets for the generation of specific modulators of muscle contractility.
	www.cytokinetics.com /cyto/research_contractility (206 words)

	Cardiovascular Ultrasound \| Full text \| Myocardial contractility in the echo lab: molecular, cellular and ...
		In the standard accepted concept, contractility is the intrinsic ability of heart muscle to generate force and to shorten, independently of changes in the preload or afterload with fixed heart rates.
		Contractility is quantified by the angular coefficient (or slope) of the ESPVR relation: the Ees (end systolic elastance) (Fig.
		This proposed approach allows the assessment of a theoretically robust and sophisticated index of left ventricular contractility with an absolute minimum extra-burden of data acquisition and analysis, since all the basic parameters (heart rate, blood pressure and left ventricular volumes) are routinely acquired during exercise stress echo testing [34].
	www.cardiovascularultrasound.com /content/3/1/27 (5247 words)

	Tromethamine Buffer Modifies the Depressant Effect of Permissive Hypercapnia on Myocardial Contractility in Patients ...
		Reversible impairment of myocardial contractility due to hypercarbic acidosis in the isolated perfused rat heart.
		Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relations.
		Influence of high thoracic epidural anesthesia on left ventricular contractility assessed using the end-systolic pressure-length relationship.
	ajrccm.atsjournals.org /cgi/content/full/162/4/1361 (2753 words)

	High-dose colforsin daropate increases diaphragmatic contractility in dogs: [De fortes doses de daropate de colforsine ...
		contractility of the diaphragm was evaluated by measuring the
		Colforsin daropate improves contractility in fatigued canine diaphragm.
		Effect of sevoflurane on diaphragmatic contractility in dogs.
	www.cja-jca.org /cgi/content/full/49/8/877 (1040 words)

	Microtubule-Dependent Effect of Phorbol Ester on the Contractility of Cytoskeleton of Cultured Fibroblasts -- Lyass et ...
		The effect of the tumor promoter phorbol 12-myristate 13-acetate (PMA) upon the contractility of permeabilized cell models (cytoskeletons) of mouse fibroblasts was examined.
		Normal high contractility was characteristic of the models from the cells preincubated with PMA in combination with Colcemid.
		It is suggested that protein kinase C regulates contractility of actin cortex and that the pathway of this regulation has a microtubule-dependent stage blocked by Colcemid.
	www.pnas.org /cgi/content/abstract/85/24/9538 (325 words)

	Effects of changes in left ventricular contractility on indexes of contractility in mice -- Nemoto et al. 283 (6): 2504 ...
		inotropy, and 3) esmolol infusion to decrease contractility.
		The goal of this study was to address the effects of a change in contractility on indexes of LV contractility in mice.
		as a cardiac contractile parameter in murine cardiac physiology,
	ajpheart.physiology.org /cgi/content/full/283/6/H2504 (4019 words)

	Glucocorticoid-induced contractility and F-actin content of human lung fibroblasts in three-dimensional culture -- Miki ...
		Glucocorticoid-induced contractility and F-actin content of human lung fibroblasts in three-dimensional culture -- Miki et al.
		The contractility of fibroblasts in a collagen lattice is reduced by corticosteroids.
		Cytoplasmic actomyosin fibrils in tissue culture cells: direct proof of contractility by visualization of ATP-induced contraction in fibrils isolated by laser micro-beam dissection.
	ajplung.physiology.org /cgi/content/full/278/1/L13 (3488 words)

	Stimulation of Integrin-mediated Cell Contractility by Fibronectin Polymerization -- Hocking et al. 275 (14): 10673 -- ...
		matrices and triggers a significant increase in cytoskeletal contractility.
		is not involved in the contractile response of cells to fibronectin.
		Previous studies have defined a role for Rho-mediated contractility in fibronectin polymerization (16, 71, 75).
	www.jbc.org /cgi/content/full/275/14/10673 (6203 words)

	AGING AND EXERCISE (Site not responding. Last check: 2007-11-03)
		Reduced sensitivity to catecholamines blunts the inotropic increase of myocardial contractility during vigorous exercise.
		After-loading of the ventricle also rises more than in a younger individual, in part because of hypertension and a loss of arterial elasticity, and in part because weakened skeletal muscles must contract at a larger fraction of their peak voluntary force.
		Finally, ventricular contractility may be impaired by the development of silent myocardial ischemia.
	www.sportsci.org /encyc/agingex/agingex.html (3149 words)

	Increased smooth muscle contractility of intestine in the genetic null of the endothelin ETB receptor: a rat model for ...
		Figure 2 Contractile effect of carbachol on the proximal (A) and distal (B) parts of the ileum in the homozygous endothelin ETB receptor null rat (ETB(-/-)R) compared with the homozygous wild type ETB(+/+)R. Contractile responses are expressed in mN per mg tissue wet weight (mN/mg ww).
		Figure 3 Contractile effects of KCl on the proximal (A) and distal (B) parts of the ileum in the homozygous endothelin ETB receptor null rat (ETB(-/-)R) compared with the homozygous wild type ETB(+/+)R. Contractile responses are expressed in mN per mg tissue wet weight (mN/mg ww).
		Figure 4 Contractile effects of endothelin-1 on the proximal (A) and distal (B) parts of the ileum in the homozygous endothelin ETB receptor null rat (ETB(-/-)R) compared with the homozygous wild type ETB(+/+)R. Contractile responses are expressed in mN per mg tissue wet weight (mN/mg ww).
	gut.bmjjournals.com /cgi/content/full/50/3/355 (3992 words)

	Caldesmon Inhibits Nonmuscle Cell Contractility and Interferes with the Formation of Focal Adhesions -- Helfman et al. ...
		Contractility of nonmuscle cells has recently been demonstrated to be intimately associated with adhesion and adhesion-dependent
		The contractility of caldesmon-transfected cells was assessed by examining the ability of substrate-attached cells to generate
		Danowski, B. Fibroblast contractility and actin organization are stimulated by microtubule inhibitors.
	www.molbiolcell.org /cgi/content/full/10/10/3097 (7367 words)

	Roles of IL-1 and TNF in the decreased ileal muscle contractility induced by lipopolysaccharide -- Lodato et al. 276 ...
		Roles of IL-1 and TNF in the decreased ileal muscle contractility induced by lipopolysaccharide -- Lodato et al.
		in contractility of skeletal (15), cardiac (3, 33), and
		For the contractility studies, strips of longitudinal muscle ~1 cm long were peeled from segments of ileum that were removed
	ajpgi.physiology.org /cgi/content/full/276/6/G1356 (4123 words)

	Delayed rectifier potassium channels contribute to the depressed pulmonary artery contractility in pneumonia -- Yaghi ...
		Delayed rectifier potassium channels contribute to the depressed pulmonary artery contractility in pneumonia -- Yaghi et al.
		Contractility of intrapulmonary arteries from pneumonia and control rats was studied by using three different agonists: KCl,
		Either KCl or PE was added in incremental concentrations (arrows) to the organ bath, and responses of PA rings were recorded before and after incubation with 4-AP.
	jap.physiology.org /cgi/content/full/93/3/957 (5003 words)

	Nitric Oxide-Mediated Effects on Myometrial Contractility at Term During Prelabor and Labor -- EKERHOVD et al. 93 (6): ...
		Effects of sodium nitroprusside on contractile activity in myometrial strips obtained from the upper and the lower uterine body (UB) before the onset of labor.
		Effects of spermine NONOate on contractile activity in myometrial strips obtained from the upper and lower uterine body (UB) during emergency cesarean delivery after the onset of labor.
		Contrasting effects of diethylenetriamine-nitric oxide, a spontaneously releasing nitric oxide donor, on pregnant rat uterine contractility in vitro versus in vivo.
	www.greenjournal.org /cgi/content/full/93/6/987 (3958 words)

	Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation -- ...
		Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation -- Dhawan and Helfman 117 (17): 3735 -- Journal of Cell Science
		Thus, as with suspension-arrest, inhibition of acto-myosin contractility
		The contractility of non-muscle myosin II is regulated by myosin
	jcs.biologists.org /cgi/content/full/117/17/3735 (7218 words)

	VEGF-PLC{gamma}1 pathway controls cardiac contractility in the embryonic heart -- Rottbauer et al. 19 (13): 1624 -- ...
		contractile function normalized to the diameters of the heart.
		contractility in the zebrafish, we suspected the existence of
		Effects of VEGF on zebrafish cardiac ventricular contractility are not mediated by the receptor FLK-1.
	www.genesdev.org /cgi/content/full/19/13/1624 (5136 words)

	Differential Regulation of Contractility and Nitric Oxide Sensitivity in Gravid and Nongravid Myometrium during Late ...
		Differential Regulation of Contractility and Nitric Oxide Sensitivity in Gravid and Nongravid Myometrium during Late Pregnancy in a Marsupial -- Ingram et al.
		Differential Regulation of Contractility and Nitric Oxide Sensitivity in Gravid and Nongravid Myometrium during Late Pregnancy in a Marsupial
		in contractile behavior of nongravid and gravid myometrium from
	endo.endojournals.org /cgi/content/full/142/6/2244 (4761 words)

	Amazon.com: Contractility (Site not responding. Last check: 2007-11-03)
		Electrogenesis and contractility in skeletal muscle cells by Jozef Zachar (Unknown Binding - 1971)
		Dietary fish oil increases acetylcholine- and eicosanoid-induced contractility of isolated rat ileum : An article from: The Journal of Nutrition by Glen S Patten, Mahinda Y Abeywardena, Edward J McMurchie, and Anisa Jahangiri (Sep 30, 2002)
		Esophageal contractility synchronous with expiration : An article from: The Annals of Otology, Rhinology & Laryngology by Mitsuhiro Mohri, Naoki Ohtsuki, and Mutsuo Amatsu (Aug 31, 1999)
	www.amazon.com /s?ie=UTF8&keywords=Contractility&tag=icongroupinterna&index=blended&link_code=qs&page=1 (424 words)

	Excitability and contractility of skeletal muscle engineered from primary cultures and cell lines -- Dennis et al. 280 ...
		The methods for measuring the excitability and contractility of myooids have been described in detail previously (5).
		For measurements of excitability and contractility, one of the artificial tendons of each myooid was affixed to a force transducer.
		CSA, excitability, and time-dependant isometric contractility of myooids
	ajpcell.physiology.org /cgi/content/full/280/2/C288 (5419 words)

	Experimental Human Endotoxemia Is Associated With Depression of Load-Independent Contractility Indices: Prevention by ...
		Indices of ventricular contractility (EF, Vcfc, SBP/ESVI, Pes/ESVI,
		respect to the increased apparent contractility at 3 h is unclear.
		myocardial contractility in the subsequent phase of the response
	www.chestjournal.org /cgi/content/full/126/3/860 (3951 words)

	A novel mechanism of regulation of cardiac contractility by mitochondrial functional state -- KAASIK et al. 18 (11): ...
		A novel mechanism of regulation of cardiac contractility by mitochondrial functional state -- KAASIK et al.
		Contractile response to mitochondrial energization (MITO) in conditions where potassium is substituted.
		Contractile response to mitochondrial energization (MITO) during osmotic compression of intracellular structures with 10% dextran or with fiber shortening.
	www.fasebj.org /cgi/content/full/18/11/1219 (4468 words)

	Left Ventricular Systolic Performance, Function, and Contractility in Patients With Diastolic Heart Failure -- Baicu et ...
		preload, afterload, and contractility and influenced by remodeling.
		Reduced left ventricular systolic pump performance and depressed myocardial contractile function in patients >65 years of age with normal ejection fraction and a high relative wall thickness.
		Myocardial contractility by strain echocardiography: comparison with physiological measurements in an in vitro model.
	circ.ahajournals.org /cgi/content/full/111/18/2306 (4161 words)

	Effects of Load Manipulations, Heart Rate, and Contractility on Left Ventricular Apical Rotation : An Experimental ...
		ED and ES values for individual interventions (contractility changes, aortic constriction [increased afterload], and heart rate changes [tachycardia], respectively) are shown as open circles (one point per dog).
		Plot of mean pressure–apex rotation for contractility changes by the paired-pacing model (n=8).
		Because twist and volume are interrelated, an end-systolic pressure–apex rotation relation has been postulated from contractility data to be similar to end-systolic pressure–volume relation.
	circ.ahajournals.org /cgi/content/full/92/1/130 (6688 words)

	Effect of MyBP-C Binding to Actin on Contractility in Heart Muscle -- Kulikovskaya et al. 122 (6): 761 -- The Journal ...
		Effect of extraction of myosin binding protein C on contractility of rat heart.
		A physiological basis for variation in the contractile properties of isolated rat heart.
		Structural and functional responses of the contractile proteins to changes in calcium concentration in the heart.
	www.jgp.org /cgi/content/full/122/6/761 (8407 words)

	Novel regulatory mechanism of cardiomyocyte contractility involving ICAM-1 and the cytoskeleton -- Davani et al. 287 ...
		Novel regulatory mechanism of cardiomyocyte contractility involving ICAM-1 and the cytoskeleton -- Davani et al.
		This effect is prevented by disruption of the actin cytoskeleton by cytochalasin D or latrunculin A. To demonstrate that PMN binding and the decrease in contractility
		Leukocytes and decreased left-ventricular contractility during endotoxemia in rabbits.
	ajpheart.physiology.org /cgi/content/full/287/3/H1013 (5010 words)

	Optimizer™ III: Cardiac Contractility Modulation Therapy for CHF - Medgadget - www.medgadget.com
		Vanderbilt University Medical Center is reporting that it is "one of 40 centers nationwide to enroll patients in a study to determine the efficacy and safety of a new
		Impulse Dynamics' core technology involves the control of individual cell activity during a time period when the cell is already electrically active.
		CCM is a unique method for treating the failing heart; nonstimulatory impulses are delivered during the absolute refractory period (ARP) and are intended to enhance contractility and overall cardiac performance...
	www.medgadget.com /archives/2006/01/optimizer_iii_c.html (459 words)

	Different effects of olprinone on contractility in nonfatigued and fatigued diaphragm in dogs -- Fujii and Toyooka 47 ...
		Different effects of olprinone on contractility in nonfatigued and fatigued diaphragm in dogs -- Fujii and Toyooka 47 (12): 1243 -- Canadian Journal of Anesthesia
		III inhibitor, on contractility and its mechanism in nonfatigued and
		contractility in nonfatigued diaphragm, but increases contractility in
	www.cja-jca.org /cgi/content/abstract/47/12/1243 (339 words)

	Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide -- Eu et al. 100 ...
		Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide -- Eu et al.
		contractility and on myocyte calcium flux and sarcomere shortening.
		Superoxide scavengers augment contractile but not energetic responses to hypoxia in rat diaphragm
	www.pnas.org /cgi/content/abstract/100/25/15229 (696 words)

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