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Expression of a Single Pair of Desmosomal Glycoproteins Renders the Corneal Epithelium Unique Amongst Stratified ... in bovine corneal, limbal, and conjunctival epithelium and desmosomal that Dsg3 is absent from bovine corneal epithelium. Immunofluorescence for Dsc2 and Dsg2 in corneal epithelium was www.iovs.org /cgi/content/full/41/1/8   (4937 words)

Facts About the Cornea and Corneal Disease [NEI Health Information] The epithelium functions primarily to: (1) Block the passage of foreign material, such as dust, water, and bacteria, into the eye and other layers of the cornea; and (2) Provide a smooth surface that absorbs oxygen and cell nutrients from tears, then distributes these nutrients to the rest of the cornea. The part of the epithelium that serves as the foundation on which the epithelial cells anchor and organize themselves is called the basement membrane. A corneal dystrophy is a condition in which one or more parts of the cornea lose their normal clarity due to a buildup of cloudy material. www.nei.nih.gov /health/cornealdisease   (5763 words)

CONFOCAL IN VIVO MICROSCOPY OF THE NORMAL CENTRAL CORNEAL EPITHELIUM   (Site not responding. Last check: 2007-10-20) Methods: We investigated the central corneal epithelium of 50 eyes of 50 otherwise healthy patients (mean age: 46.5 years, sd=19.4, 17-84) with confocal in vivo microscopy (ConfoScan Patients with corneal pathologies, previous intra- or extraocular operations, diabetes or contact lens wearers were excluded. Single frames were evaluated to study different cell populations of the epithelium. www.dog.org /1998/e-abstract98/509.html   (318 words)

Handbook of Ocular Disease Management - Corneal Abrasion and Recurrent Corneal Erosion Recurrent corneal erosion (RCE) is characterized by repeated, spontaneous disruption of the corneal epithelium. Basal cells adhere the epithelium to the stroma in two ways: they secrete the basement membrane and they contain hemidesmosomes, which are essentially linchpins that protrude through the posterior surface of basal cells and into the stroma; each is held in place by an anchoring fibril. If the corneal epithelium is not healing properly within 24 to 48 hours, debride the area to give the epithelium a “clean slate” on which to regenerate. www.revoptom.com /handbook/SECT3F.HTM   (1063 words)

eMedicine - Corneal Erosion, Recurrent : Article by Arun Verma, MD   (Site not responding. Last check: 2007-10-20) Recurrent corneal erosions and epithelial basement membrane dystrophy are usually bilateral and are characterized by various patterns of dots, parallel lines that mimic fingerprints, and patterns that resemble maps, which appear in the epithelium. Recurrent corneal erosions occurring after injury or any corneal insult results because of improper or inadequate healing of the basement membrane, either because the basal epithelial cells fail to produce proper basement membrane complexes to attach to the Bowman layer and stroma or because of faulty basement membrane adherence. Recurrent corneal erosion is an indication for the use of a therapeutic lens. www.emedicine.com /oph/topic113.htm   (5922 words)

Chronic Superficial Corneal Erosions After a corneal epithelial break, no matter how proliferative the new epithelium is, there is a failure of the new epithelium to securely fuse with the anterior stroma which allows the shearing force of the eyelid action to elevate this loosely bound epithelium and fold or roll it back upon itself. Focusing in at the junction of the anterior stroma with the corneal epithelium, the literature describes an incredibly complex physical chemical bond. Corneal neovascularization during healing is not necessarily a good sign or desirable, as it would be with complicated corneal ulcers. www.priory.com /vet/CornealErosions.html   (5291 words)

eMedicine - Corneal Abrasion : Article by Arun Verma, MD   (Site not responding. Last check: 2007-10-20) Corneal epithelial cells are continuously shed into the tear pool, and they are simultaneously replenished by cells moving centrally from the limbus and anteriorly from the basal layer of the epithelium. The magnitude and extent of both the conjunctival and corneal regenerative responses to a corneal abrasion are correlated with the size of the wound. Failure to diagnose the corneal abrasion, failure to treat it adequately, failure to monitor the patient until the abrasion is healed, and failure to diagnose potentially devastating sequelae (eg, corneal ulcers) are pitfalls. www.emedicine.com /oph/topic247.htm   (8227 words)

Corneal Ulcer   (Site not responding. Last check: 2007-10-20) A corneal ulcer is an erosion through the entire epithelium into the stroma. Because a corneal ulcer is quite painful, most cats rub the affected eye with a foot or on the carpet. Corneal ulcers can be seen more frequently in animals that have a lot of facial folds. www.theanimalmedicalclinic.com /corneal_ulcer.htm   (1381 words)

Identification of a Cytosolic NADP+-dependent Isocitrate Dehydrogenase That Is Preferentially Expressed in Bovine ... the corneal epithelium was 31-, 39-, 133-, 230-, and 929-fold ICDH mRNA is detected in basal and wing cells of central corneal epithelium. As the first line of defense against environmental insults, the corneal epithelium is continuously exposed to UV radiation. www.jbc.org /cgi/content/full/274/24/17334   (4600 words)

Requirement for Pax6 in corneal morphogenesis: a role in adhesion -- Davis et al. 116 (11): 2157 -- Journal of Cell ... Localization of Pax6 protein to the corneal epithelium, but not the stroma or endothelium, is shown by bright-field microscopy using an antibody against Pax6 on cryosections from the central (A) and peripheral (B) corneal regions of a 6-week-old wild-type mouse. Laminin was detected by immunofluorescence in the basement membrane underlying the corneal epithelium and the endothelium of wild-type (A) and mutant (+/–) Pax6 The actin cytoskeleton was similar in wild-type (A) and SEY (+/–) (B) corneal epithelium of 6-week-old mice as revealed by rhodamine-phalloidin. jcs.biologists.org /cgi/content/full/116/11/2157   (7130 words)

corneal ulcers   (Site not responding. Last check: 2007-10-20) Below the epithelium is the stroma, and the deepest layer is Descemet's membrane. If a corneal ulcer or descemetocele is present, measures must be taken to protect the eye and to promote healing. It is possible to mistake a corneal abrasion from a corneal ulcer when the latter is very superficial. www.theanimalmedicalclinic.com /corneal_ulcers.htm   (1145 words)

Confocal microscopic study of rabbit and human corneal epithelia using two objectives with different The outermost layer of the human cornea, the corneal epithelium, consists of 5-6 layers of 3 different types of epithelial cells: 2-3 layers of superficial cells, 2-3 layers of intermediate cells (wing cells), and a single layer of collunar basal cells Thus, the corneal epithelium was not touched during the examination, and the corneas were not flattened. The basal layer cells had bright outlines and their contents were dark, unlike the confocal microscope appearance of corneal endothelial cells, in which the cell outlines were dark and contents were bright. www.abonet.com.br /abo/abo62604.htm   (3147 words)

Hypoxia Stimulates the Synthesis of Cytochrome P450-Derived Inflammatory Eicosanoids in Rabbit Corneal Epithelium -- ... Holtzman MJ, Turk J and Pentland A (1989) A regiospecific monooxygenase with a novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells. Hurst JS, Balazy M, Bazan HEP and Bazan NG (1991) The epithelium, endothelium, and stroma of the rabbit cornea generate (12S)-hydroxyeicosatetraenoic acid as the main lipoxygenase metabolite in response to injury. Khatsenko OG, Gross SS, Rifkind AR and Vane JR (1993) Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants. www.jpet.org /cgi/content/full/287/3/903   (5412 words)

Intact corneal epithelium is essential for the prevention of stromal haze after laser assisted in situ keratomileusis ... Intact corneal epithelium is essential for the prevention of stromal haze after laser assisted in situ keratomileusis -- Nakamura et al. Intact corneal epithelium is essential for the prevention of stromal haze after laser assisted in situ keratomileusis Further investigations are needed to reveal the role of epithelium in corneal wound healing. www.bjophthalmol.com /cgi/content/full/85/2/209   (2469 words)

Dr Brenda Tripathi Tripathi, B.J., Tripathi, R.C., Millard, C.B., and Borisuth, N.S.C. Cytotoxicity of hydrogen peroxide to human corneal epithelium in vitro and its clinical implications. Tripathi, B.J., Tripathi, R.C., and Kolli, S.P. Cytotoxicity of ophthalmic preservatives on human corneal epithelium. The authors discuss the possible role of the ciliary epithelium, in addition to retina, in the production of VEGF and the complementary function of basic fibroblast growth factor and other growth factors. pathmicro.med.sc.edu /visbjt.htm   (3961 words)

Adult corneal epithelium basal cells possess the capacity to activate epidermal, pilosebaceous and sweat gland genetic ... Adult corneal epithelium basal cells possess the capacity to activate epidermal, pilosebaceous and sweat gland genetic programs in response to embryonic dermal stimuli -- Ferraris et al. Adult corneal epithelium basal cells possess the capacity to activate epidermal, pilosebaceous and sweat gland genetic programs in response to embryonic dermal stimuli epithelium was thus associated either with a mouse embryonic dorsal, dev.biologists.org /cgi/content/abstract/127/24/5487   (525 words)

Reciprocal transmission of herpes simplex virus type 1 (HSV-1) between corneal epithelium and trigeminal neurites in an ... Reciprocal transmission between epithelia and sensory neurons of the peripheral nervous system is a crucial step in the life cycle of herpes simplex virus type 1 (HSV-1) and related alphaherpesviruses. After direct infection of trigeminal tissues, the virus is transported by anterograde axonal transport to the corneal epithelium, causing a visible cytopathic effect ~48 h postinfection. These results suggest that the organ model presented in this study holds particular promise for the direct observation and molecular analysis of herpes simplex virus spread between primary epithelia and sensory neurons and that it may be an attractive alternative to current experimental approaches based on laboratory animals or human fetal tissues. www.fasebj.org /cgi/content/abstract/01-0803fjev1   (297 words)

Faculty Publications 97   (Site not responding. Last check: 2007-10-20) Sano, Y., Ksander, B.R., and Streilein, J.W.: Murine orthotopic corneal transplantation in high-risk eyes; rejection is dictated primarily by weak rather than strong alloantigens. Smith, J.A. and Azar, D.T.: Corneal diseases of importance to the keratorefractive surgeon. Sugrue, S.P. and Zieske, J.D.: ZO1 in corneal epithelium: association to the zonula occludens and adherens junctions. www.theschepens.org /faculty_publications_97.htm   (3192 words)

Acetic acid kidney dialysis   (Site not responding. Last check: 2007-10-20) A splash of vinegar (4 to 10% acetic acid soln) in the human eye causes immediate pain and conjunctival hyperemia, sometimes with injury of the corneal epithelium. Regeneration of the epithelium took many months, but corneal anesthesia and opacity were permanent. The basis of such an evaluation is the degree of corneal opacification and perilimbal whitening. www.dialysisethics.org /fyi/humanstudies.htm   (14896 words)

Role of Lumican in the Corneal Epithelium during Wound Healing -- Saika et al. 275 (4): 2607 -- Journal of Biological ... Role of Lumican in the Corneal Epithelium during Wound Healing -- Saika et al. Role of Lumican in the Corneal Epithelium during Wound Healing tissues of other organs and embryonic corneal stroma as a glycoprotein. www.jbc.org /cgi/content/abstract/275/4/2607   (1011 words)

Hydrogen chloride   (Site not responding. Last check: 2007-10-20) At high concn, the gas causes necrosis of the bronchial epithelium, constriction of the larynx and bronchi, and closure of the glottis. In support of this, focal superficial ulceration of the respiratory epithelium at its junction with the squamous epithelium of the external nares was reported in mice, 24 hr after a single 10-min exposure to 25-30 mg/cu m (17 ppm). As the exposure was increased to 195.2-417 mg/cu m (131-280 ppm) the adjacent respiratory epithelium underwent mucosal ulceration in a contiguous fashion; and, at 737.6 mg/cu m (493 ppm), the squamous epithelium of the external nares was also affected. www.gasdetection.com /TECH/hcl.html   (13351 words)

MedlinePlus Medical Encyclopedia: Florescent eye test The light causes the dye to glow green. Abnormalities in the corneal epithelium will cause the dye to stain that region. The information provided should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. www.nlm.nih.gov /medlineplus/ency/imagepages/9330.htm   (203 words)

Regional variation in distribution of EGF receptor in developing and adult corneal epithelium -- Zieske and Wasson 106 ... Regional variation in distribution of EGF receptor in developing and adult corneal epithelium factor receptor was greatly reduced in central corneal epithelium and Orientation and directed migration of cultured corneal epithelial cells in small electric fields are serum dependent jcs.biologists.org /cgi/content/abstract/106/1/145   (742 words)

NDRI - Human Tissue and Organs for Research - National Disease Research Interchange - Researcher Bibliography   (Site not responding. Last check: 2007-10-20) Graham, M.A., Rawe, I., Darrt, D.A., Joyce, N.C. Protein Kinase C Regulation of Corneal Cell Proliferation and Cell Cycle. Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. Takemoto, L. Increased deamidation of asparagine-101 from alpha-A crystallin in the high molecular weight aggregate of the normal human lens. www.ndriresource.org /html/bib_eye.htm   (1793 words)

Human Corneal Epithelium   (Site not responding. Last check: 2007-10-20) Click on the image to get a larger view. Confocal microscope image of human corneal epithelium, triple-labelled to localise F-actin (TRITC-phalloidin; red), the tight junction protein ZO1 (indirect immunostaining; green) and nuclei (DAPI; blue). Image obtained using a Leica TCS NT confocal imaging system. www.bch.bris.ac.uk /mrccif/Image26.html   (44 words)

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