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| | Clinical Problem Solving: Long Spinal Pathways and Cranial Nerves |
 | | As the lesion enlarges, it may encroach upon 1) the anterior horn, damaging motor neurons and causing paralysis with muscle atrophy and/or on 2) the lateral corticospinal tract in the dorsolateral funiculus, causing weakness and paralysis of the distal limb. |
 | | The Babinski sign and weakness could result from damage to the corticospinal tract at any place along the pathway from motor cortex (precentral gyrus), posterior limb of the internal capsule, central 2/3 of the cerebral peduncle in the midbrain, ventral pons, medullary pyramid, pyramidal decussation, dorsolateral funiculus, and neck of the dorsal horn. |
 | | Thus, a single, relatively restricted lesion that could explain all of the observed signs would be located on the dorsolateral aspect of the spinal cord and would involve the dorsal root(s), corticospinal tract in the dorsolateral funiculus, and fasciculus cuneatus. |
| www2.umdnj.edu /~neuro/neuro03/schedule/sptrcta.htm (1715 words) |
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