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Topic: Creatine kinase

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Creatine Phosphokinase

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	Creatine - Wikipedia, the free encyclopedia
		Creatine was identified in 1832 when Michel Eugène Chevreul discovered it as a component of skeletal muscle which he later named creatine after the Greek word for flesh, Kreas.
		Creatine supplementation has been, and continues to be, investigated as a possible therapeutic approach for the treatment of muscular, neurological and neuromuscular diseases (arthritis, congestive heart failure, disuse atrophy, gyrate atrophy, McArdle's disease, Huntington's disease, miscellaneous neuromuscular diseases, mitochondrial diseases, muscular dystrophy, neuroprotection, etc.).
		Beal suspects that the neuroprotective effects of creatine in the mouse model of ALS are due either to an increased availability of energy to injured nerve cells or to a blocking of the chemical pathway that leads to cell death.
	en.wikipedia.org /wiki/Creatine (2061 words)

	Creatine kinase - Wikipedia, the free encyclopedia
		Creatine kinase (CK), also known as phosphocreatine kinase or creatine phosphokinase (CPK) is an enzyme (EC 2.7.3.2) expressed by various tissue types.
		Its function is the catalysis of the conversion of creatine to phosphocreatine, consuming adenosine triphosphate (ATP) and generating adenosine diphosphate (ADP) and the reverse reaction.
		In tissues that consume ATP rapidly, especially skeletal muscle, but also brain and smooth muscle, creatine phosphate serves as an energy reservoir for the rapid regeneration of ATP, the major source of energy in biochemical reactions.
	en.wikipedia.org /wiki/Creatine_kinase (398 words)

	Creatine
		Creatine is synthesized in the kidney, liver and pancreas from the amino acids L-arginine, glycine and L-methionine.
		Creatine is mainly synthesized in the kidney, liver and pancreas.
		There is some evidence of creatine synthesis in the retina, and supplementation with 1.5 grams of creatine daily for a year has been reported to bring improvement in genetic gyrate atrophy--not in the blindness that results from this condition but in the skeletal muscle abnormalities that also characterize it.
	www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/cre_0086.shtml (1948 words)

	Creatine News (Site not responding. Last check: 2007-11-01)
		Creatine kinase rapidly converts the initial stores of ATP to energy and is responsible for any high intensity, short duration activity such as sprinting, lifting, or the like.
		Creatine is naturally synthesized in the liver, pancreas, and kidneys from the precursor amino acids arginine, glycine, and methionone.
		Creatine is a naturally occurring amino acid found in a variety of foods, with the richest source being lean red meat.
	alsnetwork.com /creatine1.htm (5326 words)

	Multiple Funcitons of Creatine Kinase
		In animal models, creatine, as well as the creatine analog, b-GPA, was shown to remarkably protect the brain of mice from hypoxic damage and seizures in vivo [64,84] and significant neuroprotective effects of creatine and cyclocreatine have been described in an animal model of Huntington?s disease [44], as well as for Parkinsonism [66].
		Creatine kinase in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression.
		Rapid and irreversible inhibition of creatine kinase by peroxynitrite.
	www.synergen.ch /ai-mfck.htm (7135 words)

	BioMed Central \| Full text \| Elevated creatine kinase activity in primary hepatocellular carcinoma
		Creatine kinase (CK) isoenzymes catalyse the reversible transfer of the phosphate group of phosphocreatine (PCr) to ADP, to yield ATP and creatine (Cr).
		AdK, adenylate kinase; BB-CK, brain-type cytosolic CK isoenzyme; CK, creatine kinase; Cr, creatine; HCC, hepatocellular carcinoma; Mi-CK, mitochondrial CK; MM-CK, muscle-type cytosolic CK isoenzyme; PCr, phosphocreatine.
		Murthy VV: Adenylate kinase mimics creatine kinase-MM isoenzyme in a CK isoenzyme electrophoresis assay.
	www.biomedcentral.com /1471-230X/5/9 (3747 words)

	Protein Purity and Activity: Creatine Kinase as a Marker of Muscle Damage
		Creatine Kinase (CK), also known as phosphocreatine kinase (CPK), is a type of protein called an enzyme.
		Normally very little creatine kinase is found in the blood, so a rise in the amount of creatine kinase in the blood indicates that muscle damage has occurred, or is occurring.
		In this inquiry experience you will see how creatine kinase activity can be measured and used to purify creatine kinase from a complex mixture of cellular proteins so that its properties and functions may be studied.
	www.wv-hsta.org /cdc_chc/HSTABiomedCurriculum/ProteinPurity.htm (767 words)

	creatine in TutorGig Encyclopedia (Site not responding. Last check: 2007-11-01)
		Image Creatine Kinase.jpg thumb 200px Creatine Kinase Creatine kinase CK, also known as phosphocreatine kinase or creatine phosphokinase CPK is an enzyme EC number 2.7.3.2 expressed by various tissue..
		Creatine phosphate, or phosphocreatine, is made from ATP by the enzyme creatine kinase in a reversible reaction Creatine ATP math leftrightarrow math creatine phosphate ADP this reaction..
		Elevation of creatine kinase in blood is indicative of myositis.
	www.tutorgig.com /es/creatine (523 words)

	MDA / Quest Vol 7 No 1 / Simply Stated . . .The Creatine Kinase Test (Site not responding. Last check: 2007-11-01)
		Almost everyone with a neuromuscular disorder has had, or will have, a creatine kinase test.
		CK, also known as phosphocreatine kinase, or CPK, is a type of protein called an enzyme.
		The normal function of CK in our cells is to add a phosphate group to creatine, turning it into the high-energy molecule phosphocreatine.
	www.mdausa.org /publications/Quest/q71ss-cktest.html (593 words)

	UD Biological Sciences - Dr. George Molloy
		Willis, D., Zhang, Y., and Molloy, G.R. (2005) Transcription of brain creatine kinase in U87-MG glioblastoma is modulated by factor AP2.
		Wilson, C.D., Shen, W., Kuzhikandathil, E. and G.R. Molloy (1997) Expression of the brain creatine kinase gene in rat RT4 neurotumor cells and its modulation by cell confluence.
		Kuzikanithil, E., and Molloy, G.R. (1994) Transcription of the rat brain creatine kinase gene in glial cells is modulated by cAMP-dependent protein kinase.
	www.udel.edu /bio/people/faculty/gmolloy.html (897 words)

	creatine kinase (Site not responding. Last check: 2007-11-01)
		Creatine Kinase-MB Isoenzyme (CK-MB), influenza a, influenza b, monoclonal, monoclonals, monoclonal antibody, monoclonal antibodies...
		Creatine Kinase and Brain Energy Metabolism Function and Disease Volume 342 NATO Science Series: Life and Behavioural Sciences...
		the physiology of the Creatine Kinase catalyzed reaction in...
	www.musclegaintips.com /creatine/creatine-kinase.html (315 words)

	Creatine Monohydrate FAQ - ABSORB Creatine Monohydrate Company
		Creatine Monohydrate is a naturally occurring amino acid derivative that is stored as energy in muscle cells.
		Creatine Monohydrate is absorbed into the bloodstream quickly and rapidly increases energy and builds muscle strength.
		Creatine Kinase is the enzyme needed to reconvert creatine back into creatine phosphate.
	www.absorb-creatine.com /creatine_monohydrate_faq.asp (964 words)

	Pure Creatine Monohydrate (Site not responding. Last check: 2007-11-01)
		CREATINE is a protein found in the body, concentrated in the skeletal muscles, and critical to the production of energy in the ATP cycle.
		CREATINE kinase is the enzyme which triggers the breakdown of ATP to ADP causing the release of energy and the loss of a phosphorus molecule.
		CREATINE has a vital role in energy metabolism during the formation of ATP through the CREATINE kinase reaction, which would be advantageous for athletes that rely on this energy system.
	www.libertyzone.com /NScreatine.html (490 words)

	creatine kinase (Site not responding. Last check: 2007-11-01)
		Sci-Fit's: Creatine Monohydrate is a non-protein amino acid that may have an energy generating action during anaerobic exercise.
		Creatine, Creatine Kinase, and phosphocreatine make up an intricate cellular energy buffering and transport system connecting the sites of energy production with the sites of energy consumption.
		Creatine Monohydrate is a non-protein amino acid that may have an energy generating action during anaerobic exercise.
	www.healthfind.org /health/creatine+kinase (2355 words)

	Structural Changes of Creatine Kinase upon Substrate Binding -- Forstner et al. 75 (2): 1016 -- Biophysical Journal
		Radii of gyration derived from the Guinier representation of the scattering curves are plotted as function of creatine kinase concentration.
		Kinetics of assembly and dissociation of the mitochondrial creatine kinase octamer: a fluorescence study.
		Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis.
	www.biophysj.org /cgi/content/full/75/2/1016 (3955 words)

	Creatine Kinase
		VTI recombinant human Creatine Kinases include all three isoenzymes (MM, MB, and BB) found in muscle, cardiac and brain tissues.
		Researchers and manufacturers alike know VTI's recombinant Creatine Kinases for their quality and stability in enzymatic- and immuno-assays, liquid controls, and point-of-care rapid diagnostics.
		Past clients have utilized our Creatine Kinases in researching cardiac disease, mitochondrial disorders, inflammatory myopathies, myasthenia, polymyositis, McArdle's disease, NMJ disorders, muscular dystrophy, ALS, hypo- and hyperthyroid disorders, central core disease, acid maltase deficiency, myoglobinuria, rhabdomyolysis, motor neuron diseases, rheumatic diseases, and other disorders that create elevated or reduced levels of Creatine Kinase.
	www.viral-therapeutics.com /BioProducts/Creatine_Kinase/creatine_kinase.html (154 words)

	Worthington Creatine Kinase
		Creatine kinase (CK) is widely distributed and seems to be primarily concerned with ATP regeneration.
		One unit is defined as the conversion of one micromole of creatine to creatine phosphate per minute at 25°C and pH 8.9 under the specified conditions.
		Penny, A., and Jennings, A.: Reactivation of Creatine Kinase Activity by Preincubation with Buffered NAC Diluent, Ann Clin Biochem 25, 181, 1988
	www.worthington-biochem.com /CRK/default.html (4247 words)

	FRONTIERS IN BIOSCIENCE, VOLUME 1, 1996; VOLUME 2, 1997
		Mice deficient in ubiquitous mitochondrial creatine kinase are viable and fertile.
		The replacement vector 129-pRV8.3 was derived from a 9.0-kbp genomic BamHl fragment spanning exons 1-5 of the creatine kinase, muscle (CKM) gene, that originated from a....
		The FAK (focal adhesion kinase) gene was mutated by inserting the neomycin phosphotransferase gene (neo (r)) in the beginning of its kinase domain.
	www.bioscience.org /knockout/ck.htm (389 words)

	Faculty Members
		The brain type isozyme of creatine kinase (CKB) is a cytosolic enzyme which catalyzes the reversible transfer of a high energy phosphate group between phosphocreatine and ADP, and is thus involved in the regeneration of ATP and the buffering and transport of cellular energy.
		To understand the tissue specificity of mutual interactions between estrogen receptors, estrogens, SERMS (12,13) and phytoestrogens (14) we are proposing a model of mixed heterodimer formation, leading to receptor structures capable of binding different co-modulators to form regulatory complexes dependant on the cellular enviroment (13).
		Somjen, D., Vargas, A., Waisman, E., Wingender, W., Tegge, W. and Kaye, A.M. (1995) Stimulation of creatine kinase activity in rat skeletal tissue in vivo and in vitro by protease-resistant variants of parathyroid hormone fragments.
	www.weizmann.ac.il /molgen/members/kaye.html (910 words)

	Get FREE free high creatine kinase Information using Electrosurf Results for free high creatine kinase
		Adenylate Kinase, Phosphodiesterase, Creatine Kinase, Nucleoside Diphosphate Kinase.
		were then tested for levels of creatine kinase (a muscle waste produced during exercise) in...
		of strenuous training, blood concentrations of creatine kinase, a key enzyme which is often...
	www.electrosurf.co.uk /get.php?qry=free+high+creatine+kinase (890 words)

	Ref. HBE04 Creatine Kinase (Site not responding. Last check: 2007-11-01)
		Creatine kinase (CK) plays an important role in the energy-storing mechanism of tissue by catalysing the reversible reaction between creatine and ATP to form creatine phosphate and ADP.
		CK is distributed in various organs; the highest activities (in decreasing order) are skeletal muscle, heart and brain.
		Thus determination of CK is an aid in diagnosing muscular dystrophy and other diseases of the skeletal muscles, myocardial infarction, hypothyroidism, renal diseases and/ or dysfunction.
	www.diagnostics.be /products/clinical/biochemistry/hbe04.htm (233 words)

	search.com - creatine kinase
		The creatine kinase test measures the blood levels of certain muscle and brain…Creatine kinase (CK or CPK) is an enzyme (a type of protein) found in...
		Creatine kinase (CK), also known as phosphocreatine kinase or creatine phosphokinase (CPK)...
		Overview of Creatine Kinase blood test which diagnoses a heart attack and muscle damage.
	www.search.com /similar/creatine_kinase.html?tag=se.sr-1-118.related.c.10.3.top (411 words)

	Inactivation of phosphoglycerate mutase and creatine kinase isoenzymes in human serum -- Durany et al. 55 (4): 242 -- ...
		Figure 3 Inactivation of creatine kinase (CK) activity of human muscle extracts incubated at 37°C in 20mM Tris/HCl buffer, pH 7.5 (A,B), in whole serum (C,D), in dialysed serum (E,F), and in serum ultrafiltrate (G,H).
		Stability of commonly used thiols and of human creatine kinase isoenzymes during storage at various temperatures in various media.
		Wevers R, Landeghem A, Soons J. Postsynthetic modification in the creatine kinase M-chain and the disappearance of the enzyme from the circulation.
	mp.bmjjournals.com /cgi/content/full/55/4/242 (3519 words)

	Abbott Diagnostics - CK-MB Test
		AxSYM CK-MB is a Microparticle Enzyme Immunoassay (MEIA) for the quantitative measurement of the MB isoenzyme of creatine kinase (CK-MB) in human serum or plasma.
		CK-MB is an 84,000 molecular weight enzyme that represents a significant fraction of the creatine kinase present in myocardial tissue.
		Usefulness of a Rapid Initial Increase in Plasma Creatine Kinase Activity as a Marker of Reperfusion During Thrombolytic Therapy for Acute Myocardial Infarction.
	www.abbottdiagnostics.com /Reagents_Tests/testdetail.cfm?test=ck-mb (581 words)

	creatine kinase chemo (Site not responding. Last check: 2007-11-01)
		EC 3.1.3.1) from an amnion cell line; creatine kinase (CK, EC 2.7.3.2) from an embryo kidney cell...
		3.76 mg/dL; lactate, 3.7 mmol/L; creatine kinase, 420 U/L; amylase, 152 U/L; and magnesium, 1.6 mg/dL...
		of 2.5 mM creatine phosphate and 0.2 mg/ml creatine kinase.
	www.supplementsatwholesale.com /19/creatine-kinase-chemo.html (615 words)

	Medical Dictionary: Creatine kinase - WrongDiagnosis.com
		Creatine kinase: Encoded by human CKB Gene (ATP:Guanido Phosphotransferase Family), 381-aa 43-kDa cytoplasmic homodimer or heterodimer Creatine Kinase is a transferase involved in energy homeostasis that primarily catalyzes reversible formation of ATP and creatine from phosphocreatine.
		Three cytoplasmic isoenzymes have been identified in human tissues: MM from skeletal muscle, MB from myocardial tissue and BB from nervous tissue as well as a mitochondrial isoenzyme.
		Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
	www.wrongdiagnosis.com /medical/creatine_kinase.htm (207 words)

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