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Topic: Crocin

In the News (Thu 16 Feb 12)

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	.:: GlaxoSmithKline - Consumer Healthcare ::.
		Crocin has been a trusted family name for over three decades and enjoys a strong medical heritage.
		Crocin paediatric range is a complete range - there is one for every age group, from infants to toddlers to older kids up to 12 years.
		Crocin Quik is a breakthrough paracetamol formulation, "that gets to work TWICE AS FAST as regular paracetamol tablets".
	www.gsk-ch.in /crocin.aspx (205 words)

	[No title]
		Crocin was found to significantly increase blood flow in the retina and facilitate retinal recovery.
		Increased blood flow due to vasodilation presumably improves oxygenation and nutrient supply of retinal structures and could be useful for treating ischemic retinopathy and age-related macular degeneration.
		In addition, recent behavioural and electrophysiological studies have demonstrated that saffron extract affects learning and memory in experimental animals; crocetin and crocin could be useful for treating neurodegenerative disorders.
	www.florahealth.com /flora/home/Canada/healthinformation/encyclopedias/Saffron.asp (633 words)

	Unbound MEDLINE \| Protection of crocin dyes on the acute hepatic damage induced by aflatoxin B1 and dimethylnitrosamine ...
		Feeding experiments demonstrated that crocin dyes at 0.1% in the diet could suppress partially the chronic hepatic damage induced by multiple dosages of AFB1 or DMN, but at a higher concentration of 1% crocin dye failed to do so because of their host toxicity.
		Crocin dyes are extracted from the fruits of Gardenia jasminoides and consist of carotenoids and geniposides as active principles.
		The protective mechanisms of crocin dyes may be attributed to their carotenoids which are converted metabolically to retinoids in rats.
	www.unboundmedicine.com /medline/ebm/record/2870820/full_citation/Protection_of_crocin_dyes_on_the_acute_hepatic_damage_induced_by_aflatoxin_B1_and_dimethylnitrosamine_in_rats (270 words)

	Crocin with new 3-D hologram pack
		Crocin, a popular household medicine, is manufactured by GlaxoSmithKline Asia Private Limited and marketed by GSKCH in India.
		Crocin will still be available in the familiar and well-recognised blue blister pack.
		In Crocin, we have used technology in which the hologram incorporates features like flip-flop, kinetic effect, 2D+3D effect and micro-text, which makes it very difficult for spurious manufacturers to duplicate,” he further added.
	www.chennaionline.com /cityfeature/newlaunches/crocin.asp (316 words)

	Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ...
		The macerated aqueous extract of saffron (with doses of 5, 20 and 80 mg/kg, i.p.) and crocin (with doses of 50, 200 and 400 mg/kg, i.p.) were administrated prior to induction of ischemia.
		Crocin and the saffron extract pretreatment resulted in a significant reduction in the free radical-mediated lipid peroxidation as indicated by a decrease in the MDA levels, at various dose levels (Figure 1, 2).
		Crocin and the saffron extract reversed the increase of MDA levels to a considerable extent, thereby confirming its antioxidant role in IRI.
	www.ualberta.ca /~csps/JPPS8(3)/H.Hosseinzadeh/crocin.htm (3585 words)

	BioMed Central \| Full text \| A new automated method for the determination of the Total Antioxidant Capacity (TAC) of ...
		Crocin was isolated from saffron by water/methanol extraction after repeated extraction with ethyl-ether, as described previously [18].
		After extraction, crocin was tested for purity (absorbance peak at 440 and a shoulder at 464), diluted in 30% methanol in water, diluted fivefold with phosphate buffer (10 mM, pH 7.4), and the concentration of crocin was adjusted to 20 μM with buffer, using the molecular absorbance coefficient of crocin ε
		The procedure was as follows: A concentration of crocin isolated from saffron as previously described [18], was adjusted at 25 μM with 10 mM phosphate buffer, pH 7.4 (A) and mixed with an inert filler at a final concentration of 7.5% (w/w).
	www.biomedcentral.com /1472-6890/2/3 (6675 words)

	Crocin at AllExperts
		Crocin is a natural carotenoid chemical compound that is found in the flowers crocus and gardenia.
		It has a deep red color and forms crystals with a melting point of 186 Â°C. When dissolved in water, it forms an orange solution.
		Crocin is the chemical ingredient primarily responsible for the color of saffron.
	en.allexperts.com /e/c/cr/crocin.htm (141 words)

	SaffronBloom.co.uk (Site not responding. Last check: )
		This means that the crocin underlying saffron's aroma is a digentiobiose ester of the carotenoid crocetin.
		Crocins themselves are a series of hydrophilic carotenoids that are either monoglycosyl or diglycosyl polyene esters of crocetin.
		The glycoside crocin is water-soluble, and so it does not as readily contribute its yellow colouring to oily substances.
	saffronbloom.co.uk /chemistry.html (0 words)

	YourArt.com >> Encyclopedia >> Crocin (Site not responding. Last check: )
		{{otheruses4a naturally occuring compoundthe Indian brand of painkillerparacetamol}} Crocin is a natural carotenoid chemical compound that is found in the flowers crocus and gardenia.
		It has a deep red color and forms crystals with a melting point of 186 Â°C. When dissolved in water, it forms an orange solution.
		Crocin is the chemical ingredient primarily responsible for the color of saffron.
	www.yourart.com /research/encyclopedia.cgi?subject=/Crocin (0 words)

	Protective Effect of Crocin against Blue Light- and White Light-Mediated Photoreceptor Cell Death in Bovine and Primate ...
		Crocin protected against blue light—mediated cell damage in a concentration-dependent manner with an EC of approximately 30 µM.) Recoverin and DAPI labeling were used to quantify the number of rods and cones using cell-based counting software.
		The number of photoreceptors in cell cultures posttreated with crocin was significantly greater than that in light-damaged culture.
		Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen.
	www.iovs.org /cgi/content/full/47/7/3156 (4704 words)

	ANTIDEPRESSANT EFFECT OF CROCUS SATIVUS L. STIGMA EXTRACTS AND THEIR CONSTITUENTS, CROCIN AND SAFRANAL, IN MICE
		The effects of aqueous and ethanolic extracts of Crocus sativus L. stigma and their constituents safranal and crocin were studied for the antidepressant activity using forced swimming test in mice.
		Safranal with a higher dose (0.5 mg/kg) and crocin at doses 50 and 600 increased climbing time.
		Crocin may act via the uptake inhibition of dopamine and norepinephrine, and safranal via serotonin.
	www.actahort.org /books/650/650_54.htm (171 words)

	Conditions We Treat \| NYU Pulmonary and Critical Care Medicine Division (Site not responding. Last check: )
		Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro.
		Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat.
		Study of the effect of crocin on rat experimental hyperlipemia and the underlying mechanisms [in Chinese].
	www.med.nyu.edu /medicine/pulmonary/patient/conditions/article.html?ChunkIID=111801 (0 words)

	.:: SAHARKHIZ SAFFRON ::.
		It was shown that crocin analogs isolated from saffron significantly increased the blood ow in the retina and choroid as well as facilitated retinal function recovery [18].
		Authors suggest that crocin analogs could be used to treat ischemic retinopathy and/or age-related macular degeneration.
		The selective action of crocin in female rats as compared with male rats suggests that the effects of crocin in animals might be partially depend ent on hormonal factors.
	www.saharkhizsaffron.com /En/saffronen_04.htm (1533 words)

	R2IClub
		But it seems that the effect of Tylenol is different from that of Indian paracetamols like crocin, dolo etc. When I take a crocine, it tastes bitter (may be because it is missing the glaced coating of tylenol), and I sweat.
		The differences are due to dosages/ Crocin comes in 500 MG tablets and tylenol typically in 375 mg dosage.
		Crocin makes me sweat and shiver when the fever is reducing, may the correct feeling of a medicine, but not really comfy.
	groups.msn.com /R2IClub/general.msnw?action=get_message&mview=0&ID_Message=13643&LastModified=4675452064605888178 (0 words)

	Gardenia: Key Herb for Dispelling Dampness and Heat Via the Triple Burner
		Crocin extract is the trade term for the yellow, water-soluble food colorant obtained from Gardenia jasminoides (commonly called "cape jasmine") and from Crocus sativus (saffron).
		Crocin is the gentiobiose form of the carotenoid crocetin.
		The aroma of saffron arises from a volatile aldehyde, safranal, which is produced during processing from picrocrocin; the latter is responsible for the bitter taste of saffron.
	www.itmonline.org /arts/gardenia.htm (1403 words)

	RIKECOLOR YG
		It is a water soluble yellow color with Crocin, which is the same ingredient as Saffron yellow, as its principal-ingredient.
		Today, Crocin is widely used as a food color in Chinese noodles, pastry, desserts, and confections.
		Crocin yellow color may turn green if it is used in fermented food and food made of flour.
	www.rike-vita.co.jp /int/color/color_yg.html (236 words)

	Trevithick-Sutton, Mol Vis 2006; 12:1127-1135.
		Based on an unrepresentative carotenoid, crocin, it has been assumed that carotenoids do not directly scavenge free radicals [5], except for the destruction of singlet oxygen [6] and peroxyl radicals, which is reported to only occur at low oxygen tensions [7].
		Crocin has no allylic H atoms to abstract and superoxide addition to one end of the conjugated system can produce at most seven resonance contributors.
		Since crocin is not similar in structure to the carotenoids of the eye, lutein and zeaxanthin, it is imperative that the general assumption that carotenoids cannot scavenge superoxide [5] be set aside.
	www.molvis.org /molvis/v12/a127 (0 words)

	Climate (English)
		The saffron stigma, which is what basically forms commercial saffron, has a distinct and unique color, flavor and aroma and some of the groups of chemical compounds responsible for each of these properties have now been identified.
		Saffron’s coloring power is mainly produced by crocin (chemical composition: C44 H64 O24), which is one of the few naturally occurring carotenoids easily soluble in water.
		The coloring agent crocin is readily soluble in water and it is this water solubility that makes it preferred to other carotenoids as a colorant for food and medicine.
	www.farhangsara.com /safferon.htm (1134 words)

	Spartanburg SC \| GoUpstate.com \| Spartanburg Herald-Journal (Site not responding. Last check: )
		Crocins themselves are a series of hydrophilic carotenoids that are either monoglycosyl or diglycosyl polyene esters of crocetin.
		The "Aquila" saffron (zafferano dell'Aquila) — defined by high safranal and crocin content, shape, unusually pungent aroma, and intense colour — is grown exclusively on eight hectares in the Navelli Valley of Italy's Abruzzo region, near L'Aquila.
		Saffron samples are then assigned to one of these grades by gauging the spice's crocin content, which is revealed by measurements of crocin-specific spectroscopic absorbance.
	www.goupstate.com /apps/pbcs.dll/section?category=NEWS&template=wiki&text=saffron (3292 words)

	Cancer Decisions - Free Newsletter - January 7, 2002
		It also contains antioxidants such as crocin, a flavonoid that is a major source of the characteristic yellowish-red pigment.
		Long-term treatment with crocin of female rats with colon cancer enhanced their survival without major toxic effects.
		Cancer cells treated with crocin had empty areas, reduced cytoplasm, and a destruction of their DNAÉ all potentially good things for patients.
	www.cancerdecisions.com /010702.html (1164 words)

	Welcome to The Best Persian Saffron Site
		This means that the crocin underlying saffron's aroma is a digentiobiose ester of the carotenoid crocetin.
		The glycoside crocin is water-soluble, and so it does not as readily contribute its yellow colouring to oily substances.
		Thus, at concentrations of 500 and 1000 ppm crocin studies showed neutralisation of 50% and 65% of radicals, respectively.
	www.saffron.biz /saffron.php (4707 words)

	Iranian Journal of Pharmaceutical Research (2004): Supplement 1The effect of crocin (a derivative of Crocus sativus L.) ...
		The effect of crocin (a derivative of Crocus sativus L.) on neural development and regeneration of rat: in vivo and in vitro study
		Crocin is a glycosyl ester of the polyene dicarboxylic acid crocetin and is one of the few families of carotenoids found in nature, which are freely soluble in water.
		Presence of crocin made a 2.4-fold increase (P<0.03) in DRG outgrowth within 48 hrs and caused a 2.1-fold increase (P<0.03) in the stimulatory effect of fetal calf serum (FCS) on DRG outgrowth, over an 18-hour period.
	www.ijpr-online.com /Docs/2004S1/125.htm (334 words)

	Saffron - Aroma from Carotenoids
		It was proposed by Pfander and Schurtenberger (1982) that the biogenesis of the color principles and odor active compounds is derived by bio-oxidative cleavage of Zeaxanthin at the points indicated.
		Himeno, H.; Sano, K. Synthesis of crocin, picrocrocin and safranal by saffron stigma-like structures proliferated in vitro.
		Sujata, V.; Ravishankar, G. A.; Venkataraman, L. Methods for the analysis of the saffron metabolites crocin, crocetins, picrocrocin and safranal for the determination of the quality of the spice using thin-layer chromatography, high-performance liquid chromatography and gas chromatography., J. Chromatogr.
	www.leffingwell.com /saffron.htm (1046 words)

	myLot - crocin-flu
		The new CROCIN - FLU -boon to people
		the new tablet crocin flu which is introduced for releif from headache, cold and throat pain is a fantastic medicine as i hav experienced all d three and the releif is got n having 2 doses of...
		Started by pree_6 (14) in crocin • 1 week ago • 0 responses
	www.mylot.com /w/keywords/crocin-flu.aspx (98 words)

	[No title]
		Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture.
		The present study was performed to investigate the effect of crocin on blue light- and white light-induced rod and cone death in primary retinal cell cultures.
		Crocin protected the photoreceptors against blue light- or white light-mediated damage in a concentration-dependent manner with an EC50 of approximately 30 microM.
	www.galenicom.com /medline/article/16799063/au:Kubota+R (327 words)

	Institute of Medicinal Plants (Site not responding. Last check: )
		As in traditional medicine, saffron is used as exhilarating agent and also our previous study showed the antidepressant effect of saffron extracts, in this study, the effects of aqueous and ethanolic extracts of Crocus sativus stigma and its constituents safranal and crocin were studied for the antidepressant activity using the forced swimming test in mice.
		Crocin increased stereotypic activity and safranal decreased the total activity.
		On the basis of these results, the antidepressant effect of Crocus sativus stigma extracts may be mediated via safranal and crocin.
	www.imp.ac.ir /Publications/Journal/Journal11/Issue3.asp (225 words)

	Complete Saffron information from Drugs.com
		Upon drying, a hypothetical protocrocin of the fresh plant is decomposed into one molecule of crocin (a colored glycoside) and two molecules of picrocrocin (a colorless bitter glycoside).
		5 Crocin is a mixture of glycosides: crocetin, a dicarboxylic terpene lipid, and alpha-crocin, a digentiobiose ester of crocetin.
		Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat.
	www.drugs.com /npp/saffron.html (1883 words)

	SAFETY OF CROCIN 1000 - Editorial
		Until recently, the maximum strength of a paracetamol formulation used to be 500 mg including that of Crocin.
		Crocin 1000 is being promoted as a pain reliever for chronic conditions like osteoarthritis, rheumatic arthritis, headache, toothache, period pain and muscle pain on the label of the bottle.
		At the same time the label assures that Crocin 1000 does not irritate the stomach and the maximum daily dose can go upto 4000 mg.
	www.pharmabiz.com /article/detnews.asp?articleid=12355§ionid=47 (551 words)

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