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Topic: Cryoprecipitate

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	Blood Component Therapy \| Cryoprecipitate (CRYO) (Site not responding. Last check: 2007-09-10)
		Cryoprecipitate is indicated for bleeding or immediately prior to an invasive procedure in patients with significant hypofibrinogenemia (<100 mg/dL).
		Cryoprecipitate should not be used for patients with von Willebrand disease or Hemophilia A (Factor VIII deficiency) unless they do not (or are not known to) respond to DDAVP and recombinant and/or virally inactivated preparations are not available.
		Fibrin glue: Although single units of cryoprecipitate are available for use in the preparation of fibrin glue to be applied locally for surgery, commercially available, virally inactivated concentrates have a higher fibrinogen concentration and are preferred for this purpose (Tisseel®).
	www.psbc.org /therapy/cryo.htm (337 words)

	March1995 - Cryoprecipitate Component Characteristics
		Cryoprecipitate is a human blood component obtained from fresh frozen plasma (FFP) prepared from a unit of whole blood (WB).
		One unit of cryoprecipitate derived from a unit of whole blood contains a volume of 10-20 mL, 80-100 units of factor VIII which consists of both the procoagulant activity and the von Willebrand factor, 150-250 mg of fibrinogen, 50-100 units of factor XIII, and 50-60 mg of fibronectin.
		In the past, cryoprecipitate rich in factor VIII and von Willebrand factor, was considered the treatment of choice for factor VIII replacement in Hemophilia A and von Willebrand disease.
	www.itxm.org /TMU1995/tmu3-95.htm (814 words)

	OHC : UKHCDO Guidelines on therapeutic products : Part 2 (Site not responding. Last check: 2007-09-10)
		Cryoprecipitate is prepared from porcine plasma and the factor VIII purified by affinity chromatography using polyelectrolyte resin.
		Cryoprecipitate supernatant is adsorbed to an ion-exchange gel, washed with a low salt buffer, and FIX eluted with a buffer containing a higher concentration of sodium chloride.
		This component is manufactured from cryoprecipitate and is subjected to solvent/detergent treatment and a terminal, dry heat treatment at 80°C for 72 h.
	www.medicine.ox.ac.uk /ohc/guide2.htm (2032 words)

	Lindsey Tribunal
		The reason this was done was because cryoprecipitate was made from a single donor as opposed to large donor populations, and he believed that this would reduce the risk of viral infection.
		Tedder said he couldn’t answer this directly but that it would depend on the amount of cryoprecipitate that was used, the length of time over which it was used, and the number of infected donors in the donor pool.
		Nevertheless, cryoprecipitate was not completely safe since it was still derived from blood donations and the instance of NANB Hepatitis was high in the population.
	www.haemophilia-society.ie /lindsay/days146-173.htm (19626 words)

	Abstract
		Cryoprecipitate is the traditional source of fibrinogen and factor VIII.
		The yield of the proteins in cryoprecipitate is typically 40% of the amount present in plasma.
		Assays were performed on the cryoprecipitate for fibrinogen yield (control: 26.4% ± 5.9%, treated; 97.0 ± 2.1%), fVIII yield (control; 35.4 ± 12.6%, treated; 97.2 ± 2.5%), and the weight of each cryoprecipitate pellet was measured (control: 0.6 ± 0.2 g, treated: 15.0 ± 3.5 g).
	www.blackwellpublishing.com /isth2003/abstract.asp?id=9816 (314 words)

	NWO Regional Cancer Centre (Site not responding. Last check: 2007-09-10)
		Once the Lab is notified they have to obtain the cryoprecipitate, thaw it and combine the number of units required into one container.
		If there is a physician's order, the Lab can also send the cryoprecipitate in a syringe to be given through a butterfly needle or in a blood administration bag.
		After cryoprecipitate is administered flush tubing with saline or in the case of the syringe method, replace it with a 10 ml syringe filled with sterile saline and flush.
	www.nworcc.on.ca /procedures/tb12001.htm (301 words)

	eMJA: Appropriateness of platelet, fresh frozen plasma and cryoprecipitate transfusion in New South Wales public ... (Site not responding. Last check: 2007-09-10)
		33% (136/414) of platelet, 37% (248/669) of FFP and 62% (37/60) of cryoprecipitate transfusions were assessed as inappropriate.
		Cryoprecipitate was used almost exclusively at tertiary referral hospitals.
		Sixty-eight per cent of these patients were transfused once with cryoprecipitate (mean, 4.6 units), 27% were transfused twice (mean, 3.8 units), and 5% were transfused three times (mean, 2.7 units).
	www.mja.com.au /public/issues/178_03_030203/sch10318_fm.html (3049 words)

	Untitled Document (Site not responding. Last check: 2007-09-10)
		Cryoprecipitate was prepared from serial DDAVP-stimulated plasma exchange donation using peripheral venous access, ACD-A anti- coagulant, and autologous cryoprecipitate-depleted plasma as replacement fluid.
		Ninety-four percent of the cryoprecipitate was transfused after one year of storage, with a mean collection to transfusion interval of 2.7 years.
		Cryoprecipitate tested after 13 to 77 months of storage showed 48 to 124 percent of the original FVIII activity; decreased activity was noted with increasing length of storage.
	www.cc.nih.gov /about/ar_archives/ar99/Z01CL-02101-01.htm (424 words)

	Clotting factor replacement for hemophilia
		Cryoprecipitate is not likely to transmit a disease because it is from only one donor.
		Cryoprecipitate must be frozen, so it is not easily kept at home.
		Cryoprecipitate is less expensive than donated and recombinant factor concentrates.
	www.webmd.com /hw/blood_disorders/hw190139.asp?printing=true (893 words)

	Coagulation Disorders: Encyclopedia of Children's Health
		In severe cases, bleeding may only stop if the clotting factor that is missing is replaced through infusion of human blood components containing concentrated amounts of specific clotting factors.
		These may be prepared in the form of fresh frozen plasma or cryoprecipitate.
		Cryoprecipitate was invented in 1965 to replace the need for whole plasma transfusions, which introduced more volume than needed and carried the threat of exposure to hepatitis or AIDs.
	health.enotes.com /childrens-health-encyclopedia/coagulation-disorders (3112 words)

	Cryoprecipitate \| OSU College of Veterinary Medicine (Site not responding. Last check: 2007-09-10)
		Cryoprecipitate is rich in factor VIII and von Willebrand's factor, so it is used for the treatment of hemophilia A and von Willebrand's disease; it can also be used as a topical hemostatic in surgery.
		Cryoprecipitate should be thawed in a 37°C water bath in a waterproof plastic bag for 30 minutes.
		Cryoprecipitate must be administered with a standard in-line blood filter.
	www.vet.ohio-state.edu /docs/497.htm (178 words)

	CBBS: Rinsing bags of cryoprecipitate with saline before pooling
		The inquiring colleague has always thought that it was considered 'good practice' to pool cryoprecipitate with a rinse, since he believes it is logical that rinsing would ensure residual fibrinogen, AHF, etc would not be left behind adherent to the walls of product containers.
		A colleague in the Pacific Northwest reports that she is aware of two traditional manufacturing 'formats' for single donor cryoprecipitate and a novel prepooled format which is available in her area.
		She is fearful that other blood banks may be using inappropriate saline solutions for preparation of pooled cryoprecipitate, such as the saline used by respiratory therapists or for blood bank serologic testing.
	www.cbbsweb.org /enf/2004/cryo_rinse.html (1001 words)

	American Red Cross Blood Services, New England Region, Maine, Massachusetts, New Hampshire, Vermont
		Cryoprecipitate should not be used in the treatment of Hemophilia B (Factor IX deficiency, Christmas disease).
		Cryoprecipitate has also been used in the production of "fibrin glue" with the addition of thrombin to form an insoluble clot for application to surgical margins and other surgical applications.
		Therefore, DDAVP may be used instead of cryoprecipitate or factor concentrates in these patients.
	www.newenglandblood.org /professional/cryoguide.htm (415 words)

	2005 MLS Project - Renee Ann Rath (Site not responding. Last check: 2007-09-10)
		Cryoprecipitate is a blood component that is frequently misused
		cryoprecipitate at the UAH and RAH from January 5 to February 13, 2004 and
		cryoprecipitate ordering patterns, they are continuing to decrease.
	www.ualberta.ca /~medlabsc/2005-abstracts/rath.html (223 words)

	Cryo Precipitate bath - Blood Banking Equipment
		Cryoprecipitate bath Model CB-704 is used for quick thawing of plasma at + 4º C and improves yields over conventional air thawing methods.
		Cryoprecipitate bath is fabricated out of sheet steel with a stainless steel inner chamber.
		Note Use of Remi make or any good quality 3KVA servo controlled voltage stabilizer is a must for CB-704, guarantee invalid in case of non use of voltage stabilizer.
	www.remilabworld.com /bloodbank/cryo.html (110 words)

	Cryoprecipitate AHF - NoBlood
		Cryoprecipitate AHF /, Fresh frozen plasma (FFP) is separated from a unit of whole blood.
		When FFP is thawed in the cold, a cryoprecipitate forms that is rich in fibrinogen, factor VIII, von Willebrand factor, factor XIII, and fibronectin.
		Cryoprecipitate AHF contains coagulation factors Factor VIII, Factor XIII, fibrinogen, von Willebrand factor, and fibronectin.
	www.noblood.org /glossary-terms/2450-cryoprecipitate-ahf.html (289 words)

	Lymphadenopathy-associated virus antibodies and T cells in hemophiliacs treated with cryoprecipitate or concentrate.
		Lymphadenopathy-associated virus antibodies and T cells in hemophiliacs treated with cryoprecipitate or concentrate.
		Evidence for exposure to lymphadenopathy-associated virus (LAV) was investigated in 48 patients with hemophilia, 15 of whom had been treated exclusively with single-donor cryoprecipitate.
		The prevalence of antibodies to LAV in all patients was 53% in 1983 and 63% in 1984, while in patients treated only with cryoprecipitate, the prevalence was 31% in 1983 and 40% in 1984.
	www.aegis.com /aidsline/1985/dec/M85C0116.html (418 words)

	BLOOD MATTERS 12 (Site not responding. Last check: 2007-09-10)
		The demand for Cryoprecipitate is nationally relatively small, although there are locally higher variations in requests.
		This proved a very unsatisfactory procedure as the loss of Cryoprecipitate was significant due to the ‘stickiness’ of the Cryoprecipitate and the very small volumes involved.
		The future of Cryoprecipitate has been very much a concern recently, particularly around the possibility of provision of a pathogen inactivated component.
	www.blood.co.uk /hospitals/library/pages/bm/issue12/bm1208.htm (534 words)

	Update on Plasma and Cryoprecipitate Transfusion
		Plasma and cryoprecipitate are employed in treating patients with coagulopathies due to deficiency of one or more coagulation factors.
		When FFP is thawed slowly at 4º C, a white precipitate forms at the bottom of the bag, which can then be separated from the supernatant plasma.
		This “Cryoprecipitated Anti-Hemophilic Factor” is 15-20 ml in volume and contains: 150-250 ml of fibrinogen, 80-100 units of Factor VIII, von Willebrand’s Factor, Factor XIII, and fibronectin.
	www.itxm.org /tmu2004/issue2004-1.htm (947 words)

	ARCBS > PG > Appropriate Use of Fresh Frozen Plasma and Cryoprecipitate
		The guidelines were produced in cooperation with the Commonwealth Department of Health and Aged Care, the Royal Australasian College of Surgeons, the Australian and New Zealand College of Anaesthetists, and other relevant groups.
		May be appropriate in the presence of bleeding and abnormal coagulation.
		At fibrinogen levels lower than 1.0g/L and where there is clinical bleeding, use of cryoprecipitate to keep fibrinogen levels above 1.0g/L may be indicated.
	www.transfusion.com.au /TRANSFUSIONPOCKETGUIDES/Pocket_NHMRC_FFPCry.asp (981 words)

	South Texas Blood & Tissue Center Products - Plasma
		A, AB Cryoprecipitate may be given without regard to ABO type in adults
		Plasma and cryoprecipitate may be transfused without regard to Rh type
		Multiple units of cryoprecipitate may be mixed together (pooled)
	www.stbtc.org /products_plasma.htm (78 words)

	AccessMedicine - Harrison's Internal Medicine: Blood Components
		Topics Discussed: anemia; anti-human leukocyte antigen antibody; blood component removal; blood component transfusion; blood platelets; cryoprecipitate; cryoprecipitate transfusion; cytotoxic antibody test; exchange transfusion, whole blood; fresh-frozen plasma; fresh-frozen plasma transfusion; hemorrhage; human leukocyte antigens; packed blood cell transfusion; packed red blood cell transfusion; plasma; plasma proteins; platelet transfusion; thrombocytopenia; whole blood.
		The platelet-rich plasma is then centrifuged at high speed to yield one unit of random donor (RD) platelets and one unit of FFP.
		Cryoprecipitate is produced by thawing FFP to precipitate the plasma proteins, then separated by centrifugation.
	www.accessmedicine.com /content.aspx?aID=66209 (330 words)

	GB Virus C Infection in Patients with Type II Mixed Cryoglobulinemia -- Misiani et al. 127 (10): 891 -- Annals of ...
		not concentrate in cryoprecipitate in patients co-infected with
		the isolated and washed cryoprecipitate was resuspended in a
		cryoprecipitate than in supernatant in 4 of the 5 patients studied
	www.annals.org /cgi/content/full/127/10/891 (2012 words)

	von Willebrand's disease (Site not responding. Last check: 2007-09-10)
		it is best to give the cryoprecipitate close to the time of surgery.
		cryoprecipitate on hand to use prior to surgery as a preventative measure
		But we keep cryoprecipitate in our freezer to use if an emergency
	www.vetinfo.com /dvonwillebrands.html (1646 words)

	Blood and Tissue Resources Program at Wadsworth Center, New York State Department of Health
		Antibodies induced by bovine thrombin have also been reported to cause thrombosis.
		Note: Cryoprecipitate contains factor VIII, von Willebrand factor, fibrinogen, and factor XIII.
		As with platelets and fresh frozen plasma, each unit of cryoprecipitate derives from one unit of donor blood; a patient who receives 10 units of cryoprecipitate receives 10 donor exposures.
	www.wadsworth.org /labcert/blood_tissue/cryo.htm (512 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Energy Citations Database (ECD) Document #5416411 - Effect of storage time on the opsonic activity of fibronectin in plasma cryoprecipitate
		Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
		Effect of storage time on the opsonic activity of fibronectin in plasma cryoprecipitate
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=5416411 (161 words)

	AIDS in a patient with hemophilia receiving mainly cryoprecipitate.
		AIDS in a patient with hemophilia receiving mainly cryoprecipitate.
		Gerstein HC; Fanning MM; Read SE; Shepherd FA; Glynn MF
		A 25-year-old man with hemophilia who had been treated primarily with cryoprecipitate presented with epigastric pain and loose, melenic stools.
	www.aegis.com /aidsline/1984/oct/M84A0064.html (337 words)

	Blood and Lymph Disorders in Dogs (Site not responding. Last check: 2007-09-10)
		or cryoprecipitate also be typed and cross-matched prior to administering?
		So it is best to go ahead and do the minor crossmatch when giving a patient
		plasma or cryoprecipitate but it is probably not absolutely necessary to do
	www.vetinfo.com /dblood.html (6894 words)

	Cryoprecipitate made available at affordable rate
		CHENNAI, April 17: Jeevan, a voluntary blood bank in the city, has made available Cryoprecipitate, a blood component which is essential to haemophiliacs throughout their lives.
		Haemophiliacs now depend on imported `Factor-8', containing the precipitate, which costs Rs 3,000 per 250 units.
		Copyright © 1998 Indian Express Newspapers (Bombay) Ltd.
	www.expressindia.com /ie/daily/19980421/11151834.html (75 words)

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