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| | Solubility, Polymorphism, Crystallinity, and Crystal Habit of Acetaminophen and Ibuprofen by Initial Solvent Screening ... |
 | | The crystal habit of an API also has profound effects on the rate at which the API can be processed in filtering, washing, and drying, and the success of the API in powder flow, blending, direct compaction, roller compaction, wet granulation, and dissolution rate (16–19). |
 | | Because solubility, polymorphism, crystallinity, and crystal habit are all solvent dependent, solvent screening is of fundamental and foremost importance to many chemical process industries, especially the pharmaceutical industry (4, 20–22). |
 | | Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (+/-)-ibuprofen were determined by initial screening of 23 solvents for scale-up. |
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