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Topic: Cyclin

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Maturation promoting factor

Dimer

	Cyclin - Wikipedia, the free encyclopedia
		Cyclins are a family of proteins involved in the progression of cells through the cell cycle.
		A cyclin forms a complex with the cyclin-dependent kinase (Cdk), which activates the latter's protein kinase function.
		Cyclins are so named because their concentration varies in a cyclical fashion during the cell cycle; they are produced or degraded as needed in order to drive the cell through the different stages of the cell cycle.
	en.wikipedia.org /wiki/Cyclin (368 words)

	Proteolytic Cleavage of Cyclin E Leads to Inactivation of Associated Kinase Activity and Amplification of Apoptosis in ...
		The full-length cyclin E, which is 50 kDa and is found predominantly in both normal and tumor cells, is the EL form (i.e., the 15-amino-acid elongated variant of cyclin E [46, 49]).
		Cdk2 interacts with most of the cyclin box and the C terminus of cyclin E (amino acid residues 131 to 395); the entire N terminus and partial cyclin box of cyclin E (amino acid residues 1 to 127) are responsible for p21 and p27 binding (5).
		Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.
	mcb.asm.org /cgi/content/full/22/7/2398 (7601 words)

	Variability of Placental Expression of Cyclin E Low Molecular Weight Variants -- Bukovsky et al. 67 (2): 568 -- Biology ...
		Variability of cyclin E (cE) expression in placental samples and a comparison with ovarian cancer (OvCa; papillary cystadenocarcinoma, female 56 yr of age) and normal ovary (nOv; female 26 yr).
		A comparison of cyclin E expression with expression of Thy-1 differentiation protein (Thy-1) in villous core and dilatation of blood sinusoids.
		Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex.
	www.biolreprod.org /cgi/content/full/67/2/568 (4842 words)

	Biomedicine Database, 17 (Site not responding. Last check: 2007-10-20)
		Cyclins and cyclin-dependent kinases are critically involved in control of cell cycle progression and presumably in proliferative events due to phlogistic challenge.
		Two types of cyclins, A and B, are known to be involved in the normal regulation of mitosis (M-phase cyclins).
		Cyclin B mRNA was overexpressed in the 2 biopsies with extracapillary proliferation, while cyclin D1 gene expression, highly dependent on PDGF, was detected at high amounts in 4 samples showing some degree of mesangial proliferation.
	www.xagena.it /biomedicine/biom0019.htm (287 words)

	Translational Regulation of Cyclin D1 by 15-Deoxy-{Delta}12,14-Prostaglandin J2 -- Campo et al. 13 (9): 409 -- Cell ...
		Cyclin D1 protein was immunoprecipitated at the indicated chase times and quantified by SDS gel electrophoresis and autoradiography.
		The half-life of cyclin D1 protein was calculated by regression analysis.
		Russell A., Thompson M. A., Hendley J., Trute L., Armes J., Germain D. Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer.
	cgd.aacrjournals.org /cgi/content/full/13/9/409 (6283 words)

	Pfam 19.0 : Cyclin_N (Site not responding. Last check: 2007-10-20)
		Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles PUBMED:12910258, and regulate cyclin dependent kinases (CDKs).
		G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase).
		Cyclins contain two domains of similar all-alpha fold, of which this entry is associated with the N-terminal domain.
	pfam.wustl.edu /cgi-bin/getdesc?acc=PF00134 (347 words)

	G1/S phase cyclin-dependent kinase overexpression perturbs early development and delays tissue-specific differentiation ...
		RNA encoding cyclin E alone or with cdk2, cyclin A2 alone or with cdk2, or cdk2 alone were injected into fertilised eggs and allowed to develop until stage 8.
		RNAs encoding cyclin E1 alone (A) or cyclin E1 with cdk2 (D), cyclin A2 alone (B) or cyclin A2 with cdk2 (E), cdk2 alone (C) or ß-gal as a control (F) were injected into one cell of a 2-cell embryo and allowed to develop to stage 8.5.
		Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation.
	dev.biologists.org /cgi/content/full/131/11/2577 (6737 words)

	The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation -- ...
		Although cyclin A or cyclin E bind only the amino terminus, two distinct cyclin-binding motifs [Cy1 and Cy2 (87)], which bind cyclin E/Cdk2 or cyclin A/Cdk2 complexes are indicated.
		Cyclin D1 can bind to the amino terminus, either alone or in the presence of Cdk4 and binds independently of the K region (87).
		The cyclin D1/Cdk4 holoenzyme is phosphorylated by a Cdk-activating kinase (475) (CAK), which consists of several subunits.
	edrv.endojournals.org /cgi/content/full/20/4/501 (8952 words)

	CYCLIN (Site not responding. Last check: 2007-10-20)
		It falls abruptly during mitosis due to the degradation of cyclin B. The complex of Cdk and cyclin B is called maturation promoting factor.
		Leland H. Hartwell, R. Timothy Hunt, and Paul M. Nurse won the 2001 Nobel Prize in Physiology or Medicine for their discovery of cyclin and cyclin-dependent kinase, central molecules in the regulation of the cell cycle.
		It is licensed under the GNU free documentation license.
	www.yotor.org /wiki/en/cy/Cyclin.htm (158 words)

	Novel splice variants of cyclin E with altered substrate specificity -- Porter and Keyomarsi 28 (23): e101 -- Nucleic ...
		For immunoprecipitation a polyclonal antibody to cyclin E (A. Koff) or to FLAG (Santa Cruz Biotechnology) was incubated with
		Cyclin E LMW forms bind to and immunoprecipitate with CDK2.
		General expression of novel splice variants of cyclin E in normal and tumor breast cells.
	nar.oxfordjournals.org /cgi/content/full/28/23/e101 (5283 words)

	Cyclin D2 Overexpression in Transgenic Mice Induces Thymic and Epidermal Hyperplasia whereas Cyclin D3 Expression ...
		C: Western blot analysis of cyclin D2 and cyclin D3 expression from protein lysates of thymus of K5D2 (2101 and 2102), K5D3 (2203 and 2201) and normal sibling mice (Wt) at 12 and 24 weeks of age.
		Russell A, Thompson M, Hendley J, True L, Armes J, Germain D: Cyclin d1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer.
		cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms.
	ajp.amjpathol.org /cgi/content/full/157/3/1039 (6143 words)

	Cyclin E in human cancers -- DONNELLAN and CHETTY 13 (8): 773 -- The FASEB Journal
		Cyclin E joins with cdk2 to regulate the transition from the G1 to the S phase.
		Cyclin E appears to be an important early factor in cervical squamous
		Scott, K. A., Walker, R. (1997) Lack of cyclin E immunoreactivity in non-malignant breast and association with proliferation in breast cancer.
	www.fasebj.org /cgi/content/full/13/8/773 (5272 words)

	p27kip1: A Multifunctional Cyclin-Dependent Kinase Inhibitor with Prognostic Significance in Human Cancers -- Lloyd et ...
		Dysregulation of CDKIs and cyclins leading to increased cell proliferation in adult endocrine tissues increases the likelihood of developing genetic alterations resulting in tumor development.
		cyclin dependent-kinase inhibitor bound to the cyclin A-cdk 2 complex.
		Brandeis M, Hunt T: The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase.
	ajp.amjpathol.org /cgi/content/full/154/2/313 (7224 words)

	The Role of the Cyclin-dependent Kinase Inhibitor p21 in Apoptosis -- Gartel and Tyner 1 (8): 639 -- Molecular Cancer ...
		B, apoptosis in human endothelial cells after growth factor deprivation, hypoxia-induced apoptosis in cardiomyocytes, and apoptosis induced by zinc depletion in human epithelial lines is mediated by caspase-3-dependent cleavage of p21 and up-regulation of cyclin A/Cdk2 activity.
		Apoptosis induced by butyrate in colorectal cancer cells is mediated by DEVD-caspase-dependent cleavage of p21.
		Cheng, M., Sexl, V., Sherr, C. J., and Roussel, M. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).
	mct.aacrjournals.org /cgi/content/full/1/8/639 (7804 words)

	NCBI CDD cd00043
		Protein binding domain functioning in cell-cycle and transcription control.
		Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs).
		Cyclins, TFIIB and RB contain 2 copies of the domain.
	www.ncbi.nlm.nih.gov /Structure/cdd/cddsrv.cgi?uid=cd00043 (104 words)

	Upstate - Product #05-373 - Anti-Cyclin B1 ( 05373 )
		Home : Research Products : Cyclin : Cyclin B :
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		human cyclin B1; does not cross-react with cyclin A or D
	www.upstate.com /browse/productdetail.q.ProductID.e.05-373 (135 words)

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