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Topic: Cyclin dependent kinase

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cyclin dependent kinase

cyclin dependent kinase complex

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	CDK6 - Cell division protein kinase 6
		Cyclin D1 expression was absent despite high levels of CDK4 and CDK6, and the CKI p27 was expressed in chondrocytes, osteoclasts, and at lower levels in osteoblasts.
		In contrast to p21 and p27 whose interaction with CDK subunits is dependent on or stimulated by the cyclin subunit, the interaction of p19 and p18 with CDK6 is hindered by the cyclin protein.
		Cyclins D1, D2 and D3 preferentially associate with two closely related members of the cyclin-dependent kinase family, Cdk4 and Cdk6 and the various complexes are each capable of phosphorylating the retinoblastoma gene product (pRb), at least in vitro.
	www.ihop-net.org /UniPub/iHOP/gg/87099.html (5142 words)

	cyclin dependent kinase inhibitors
		Aloisine A (RP107) is a cell-permeable compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25 with IC50 values of 150nM, 120 nM, 400 nM and 200 nM, respectively.
		Kenpaullone is a potent, cell-permeable inhibitor of glycogen synthase kinase-3b (GSK3b, IC50 = 230 nM), Lck (IC50 = 470 nM) and cyclin-dependent kinases (Cdks).
		Purvalanol A is a potent inhibitor of cyclin-dependent kinases with IC50 values of 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
	www.proteinkinase.de /html/cyclin_dependent_kinase_inhibi.html (1198 words)

	Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3 -- Li et al. ... (Site not responding. Last check: 2007-11-05)
		JNK3 kinase is phosphorylated on Thr131 by cdk5
		by an in vitro kinase assay with GST–cdk5–p35 (Figure 2B).
		Li,B.S., Ma,W., Zhang,L., Barker,J.L., Stenger,D.A. and Pant,H.C. (2001) Activation of phosphatidylinositol-3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural progenitor cells.
	embojournal.npgjournals.com /cgi/content/full/21/3/324 (5820 words)

	At2g27970 - cyclin-dependent kinase, putative / CDK, putative (Site not responding. Last check: 2007-11-05)
		At2g27970 is a homologue of Cks (Cyclin-dependent kinases regulatory subunit) from Drosophila melanogaster.
		At2g27970 is a homologue of CKS1B (Cyclin-dependent kinases regulatory subunit 1) from Homo sapiens.
		At2g27970 is a homologue of dom-6 (Cyclin-dependent kinases regulatory subunit) from Caenorhabditis elegans.
	www.ihop-net.org /UniPub/iHOP/gg/2720.html (88 words)

	Rediscovering Biology - Online Textbook: Unit 8 Cell Biology & Cancer
		Each cyclin-dependent kinase forms a complex with a particular cyclin, a protein that binds and activates the cyclin-dependent kinase.
		The kinase part of the complex is an enzyme that adds a phosphate to various proteins required for progression of a cell through the cycle.
		One important protein in the cell cycle is p53, a transcription factor (see Genetics of Development unit) that binds to DNA, activating transcription of a protein called p21.
	www.learner.org /channel/courses/biology/textbook/cancer/cancer_4.html (656 words)

	Activation of Cyclin-dependent Kinase 2 by Full Length and Low Molecular Weight Forms of Cyclin E in Breast Cancer ...
		kinase (CAK), a complex composed of cyclin H and CDK7 (10).
		Cyclin EL was mixed before and after immunodepleting tumor cell extracts of cyclin A overnight at 4 °C. Three rounds of immunodepletion were carried out for each mix using anti-cyclin A polyclonal antibodies.
		Cyclin EL was mixed before and after immunodepleting tumor cell extracts of cyclin E overnight at 4 °C. Three rounds of immunodepletion was carried out for each mix using anti cyclin E polyclonal antibodies.
	www.jbc.org /cgi/content/full/279/13/12695 (7206 words)

	Activating Phosphorylation of the Saccharomyces cerevisiae Cyclin-dependent Kinase, Cdc28p, Precedes Cyclin Binding -- ...
		H1 kinase activity was quantitated with the use of a phosphorimager, and the relative activity (rel.
		with cyclins and are subsequently phosphorylated by CAK.
		Blondel, M., and Mann, C. G2 cyclins are required for the degradation of G1 cyclins in yeast.
	www.molbiolcell.org /cgi/content/full/11/5/1597 (8089 words)

	Cyclin-dependent kinases as cellular targets for antiviral drugs -- Schang 50 (6): 779 -- Journal of Antimicrobial ...
		Advani, S. J., Brandimarti, R., Weichselbaum, R. and Roizman, B. The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes.
		Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis.
		Krucher, N. A., Meijer, L. and Roberts, M. The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker.
	jac.oupjournals.org /cgi/content/full/50/6/779 (7363 words)

	Activation of Cyclin-dependent Kinase 2 by Full Length and Low Molecular Weight Forms of Cyclin E in Breast Cancer ...
		Activation of Cyclin-dependent Kinase 2 by Full Length and Low Molecular Weight Forms of Cyclin E in Breast Cancer Cells -- Harwell et al.
		N-terminal deleted forms of cyclin E are able to activate CDK2.
		Cyclin A Is a c-Jun Target Gene and Is Necessary for c-Jun-induced Anchorage-independent Growth in RAT1a Cells
	www.jbc.org /cgi/content/abstract/279/13/12695 (552 words)

	Cyclin-dependent kinase -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-11-05)
		Cyclin-dependent kinase -- Facts, Info, and Encyclopedia article
		(Click link for more info and facts about Cyclin-dependent kinase) Cyclin-dependent kinase is a (Click link for more info and facts about protein kinase) protein kinase involved in regulation of the (Click link for more info and facts about cell cycle) cell cycle.
		A (Click link for more info and facts about cyclin-dependent kinase) cyclin-dependent kinase is activated by association with a (Click link for more info and facts about cyclin) cyclin forming a (Click link for more info and facts about cyclin-dependent kinase complex) cyclin-dependent kinase complex.
	www.absoluteastronomy.com /encyclopedia/c/cy/cyclin-dependent_kinase.htm (122 words)

	Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system -- Tsai et al. 119 ...
		Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells
		Amphiphysin 1 Binds the Cyclin-dependent Kinase (cdk) 5 Regulatory Subunit p35 and Is Phosphorylated by cdk5 and cdc2
		14-3-3 Is Phosphorylated by Casein Kinase I on Residue 233.
	dev.biologists.org /cgi/content/abstract/119/4/1029 (2614 words)

	Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis -- De Veylder et al. 13 (7): 1653 -- THE PLANT ...
		Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis -- De Veylder et al.
		Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis
		The CDK inhibitor NtKIS1a is involved in plant development, endoreduplication and restores normal development of cyclin D3; 1-overexpressing plants
	www.plantcell.org /cgi/content/abstract/13/7/1653 (1991 words)

	Molecular and Biochemical Characterization of the Involvement of Cyclin-Dependent Kinase A during the Early Development ...
		For each histone H1 kinase assay with the proteins of different tissue source, silver grain intensities were measured.
		CDK phosphorylation/dephosphorylation, lack or degradation of the corresponding mitotic cyclin, and inactivation by a CDK
		Wang H, Qungang Q, Schorr P, Cutler AJ, Crosby WL, Fowke LC (1998) ICK1, a cyclin-dependent protein kinase inhibitor from Arabidopsis thaliana interacts with both Cdc2a and CycD3, and its expression is induced by abscisic acid.
	www.plantphysiol.org /cgi/content/full/121/3/857 (7726 words)

	Pharmacological Cyclin-Dependent Kinase Inhibitors Inhibit Replication of Wild-Type and Drug-Resistant Strains of ...
		Pharmacological Cyclin-Dependent Kinase Inhibitors Inhibit Replication of Wild-Type and Drug-Resistant Strains of Herpes Simplex Virus and Human Immunodeficiency Virus Type 1 by Targeting Cellular, Not Viral, Proteins -- Schang et al.
		Pharmacological Cyclin-Dependent Kinase Inhibitors Inhibit Replication of Wild-Type and Drug-Resistant Strains of Herpes Simplex Virus and Human Immunodeficiency Virus Type 1 by Targeting Cellular, Not Viral, Proteins
		Banchio, C., Schang, L. M., Vance, D. Phosphorylation of Sp1 by Cyclin-dependent Kinase 2 Modulates the Role of Sp1 in CTP:Phosphocholine Cytidylyltransferase {alpha} Regulation during the S Phase of the Cell Cycle.
	jvi.asm.org /cgi/content/abstract/76/15/7874 (736 words)

	Analysis of gene expression in lymphoid cells can determine lymphoma cancer
		The researchers found that by taking a sample of blood and doing immunohistochemical analysis for the expression of CDK9 and CYCLIN T1, they were able to accurately pinpoint the type of lymphoma--Hodgkins or non-Hodgkins--as well as its stage of advancement.
		A member of a family of kinases, CDK9 was originally referred to as PITALRE, the name of the amino acid sequence that is similar in all members of this kinase family.
		Clinical work for the study was coordinated by Giordano and performed at the Department of Human Pathology and Oncology at the University of Siena in Italy in collaboration with professors Lorenzo Leoncini and Piero Tosi.
	www.medicalnewstoday.com /medicalnews.php?newsid=12787 (638 words)

	T05G5.3 (Site not responding. Last check: 2007-11-05)
		CDK5_BOVIN Cell division protein kinase 5 (Tau protein kinase II catalyticsubunit) (TPKII catalytic subunit) (Proline-directedprotein kinase 33 kDa subunit) (PDPK)gbAAA30606.1
		Cyclin-dependent kinase 5 [Homo sapiens]spQ00535CDK5_HUMAN Cell division protein kinase 5 (Tau protein kinase II catalyticsubunit) (TPKII catalytic subunit)(Serine/threonine-protein kinase PSSALRE)gbAAL15435.1
		Cyclin-dependent kinase 5 [Mus musculus]spP49615CDK5_MOUSE Cell division protein kinase 5 (Tau protein kinase II catalyticsubunit) (TPKII catalytic subunit)(Serine/threonine-protein kinase PSSALRE) (CRK6)pirA45091 protein kinase (EC 2.7.1.37) cdc2-related nclk - bovinepirI49592 protein kinase (EC 2.7.1.37) crk6 [similarity] - mouseembCAA57821.1
	sgce.cbse.uab.edu /cgi-bin/text_blast_server.py?PW=2-A8&DB=nr (2127 words)

	OUTPUT from blastx for A1B23TH (Site not responding. Last check: 2007-11-05)
		59 5e-08 pirS57928 protein kinase (EC 2.7.1.37) cdc2 homolog - cowpea 59 5e-08 pirJQ2243 protein kinase (EC 2.7.1.37) cdc2 homolog - mot...
		Human Cyclin-Dependent Kinase 2 pdb1BUHA Chain A, Crystal Structure Of The Human Cdk2 Kinase Complex With Cell Cycle-Regulatory Protein Ckshs1 pdb1CKPA Chain A, Human Cyclin Dependent Kinase 2 Complexed With The Inhibitor Purvalanol B pdb1AQ1
		Human Cyclin Dependent Kinase 2 Complexed With The Inhibitor Staurosporine gbAAA35667.1
	cbr-rbc.nrc-cnrc.gc.ca /reith/tetra/tetra4/A1B23TH.html (928 words)

	The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis -- Hakem et al. 189 (6): 957 -- The Journal of ...
		dependent kinase Cdk2 is activated in response to all specific
		Cyclin A-associated kinase activity is needed for paclitaxel sensitivity
		Caspase 3-mediated Cleavage of p21WAF1/CIP1 Associated with the Cyclin A-Cyclin-dependent Kinase 2 Complex Is a Prerequisite for Apoptosis in SK-HEP-1 Cells
	www.jem.org /cgi/content/abstract/189/6/957 (767 words)

	Activating Phosphorylation of the Saccharomyces cerevisiae Cyclin-dependent Kinase, Cdc28p, Precedes Cyclin Binding -- ...
		Activating Phosphorylation of the Saccharomyces cerevisiae Cyclin-dependent Kinase, Cdc28p, Precedes Cyclin Binding -- Ross et al.
		Eukaryotic cell cycle progression is controlled by a family of protein kinases known as cyclin-dependent kinases (Cdks).
		Cdc28p may be unable to bind tightly to cyclin.
	www.molbiolcell.org /cgi/content/abstract/11/5/1597 (472 words)

	Frequent Loss of Expression of the Cyclin-dependent Kinase Inhibitor p27 in Epithelial Ovarian Cancer -- Masciullo et ...
		kinase inhibitors and is a potential tumor suppressor gene.
		Cyclins, cdks, and CKIs are frequently altered in human cancer
		MacLachlan T. K., Sang N., Giordano A. Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer.
	cancerres.aacrjournals.org /cgi/content/full/59/15/3790 (4048 words)

	Proteinkinase.de provides reagents, chemicals and proteins for exploring cellular signaling networks
		We are specialised in kinase-related products especially protein kinase enzymes, inhibitors, substrates and protein kinase signaling activators as well as bioluminescent assays and anti protein kinase antibodies.
		Our range of services includes the performance of phosphorylation assays and assay development for medium to high throughput binding assays based on BIA technology, FP or Alpha screen.
		If you are looking for general information about protein kinases, protein phosphorylation and its impact for cellular growth and differentiation then visit proteinkinase.info (english and german).
	www.proteinkinase.de (326 words)

	Cyclin E in human cancers -- DONNELLAN and CHETTY 13 (8): 773 -- The FASEB Journal
		Cyclin E in human cancers -- DONNELLAN and CHETTY 13 (8): 773 -- The FASEB Journal
		Combined Evaluation of Expressions of Cyclin E and p53 Proteins as Prognostic Factors for Patients with Gastric Cancer
		Inverse correlation between high level expression of cyclin E and proliferation index in transitional cell carcinoma of the bladder
	www.fasebj.org /cgi/content/abstract/13/8/773 (766 words)

	Cyclin-dependent kinases as cellular targets for antiviral drugs -- Schang 50 (6): 779 -- Journal of Antimicrobial ...
		Cyclin-dependent kinases as cellular targets for antiviral drugs -- Schang 50 (6): 779 -- Journal of Antimicrobial Chemotherapy
		Cyclin-dependent kinases as cellular targets for antiviral drugs
		of the specific cdks that mediate the antiviral activities of
	jac.oupjournals.org /cgi/content/abstract/50/6/779 (422 words)

	The World's Healthiest Foods: Feeling Great
		Yet, with the growing demand for soy foods, tempeh is now becoming more and more available in supermarkets throughout the country.
		Depending upon the store, tempeh may either be kept in the refrigerated or freezer section.
		Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells.
	www.whfoods.com /genpage.php?tname=foodspice&dbid=126 (2207 words)

	Functional Analysis of the Transforming Growth Factor beta Responsive Elements in the WAF1/Cip1/p21 Promoter -- Datto ...
		cyclin-cyclin-dependent kinase complexes, primarily cyclin D-cyclin-dependent kinase 4 and cyclin E-cyclin-dependent kinase 2 complexes(5, 6).
		is mediated in part through several members of a recently described family of low molecular weight cyclin dependent kinase inhibitors.
		p21 was first cloned and characterized as an important effector that acts to block cyclin E-cyclin-dependent kinase 2 complex kinase activity in p53-mediated cell cycle arrest induced by DNA damage (14, 15, 16, 17, 18, 19, 20, 21).
	www.jbc.org /cgi/content/full/270/48/28623 (5543 words)

	Research
		Roberts, J.A., Bell, S.D. and White, M.F. Sulfolobus XPF is a structure specific, PCNA dependent endonuclease.
		Vernon, A. and Philpott, A. A single cdk inhibitor, p27Xic1, functions beyond the cell cycle to promote muscle differentiation in Xenopus.
		Vernon, A.E., Devine, C. and Philpott, A. The cdk inhibitor p27Xic1 is required for differentiation of primary neurons in Xenopus.
	www.hutchison-mrc.cam.ac.uk /research.html (3784 words)

	Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth -- ...
		Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth -- Ilyin et al.
		Articles by Ilyin, G. Articles by Guguen-Guillouzo, C. Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth
		expression pattern correlated with that of cyclin D1.
	ajpgi.physiology.org /cgi/content/abstract/285/1/G115 (385 words)

	Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar ...
		Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons
		The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic
		Integrin alpha 1beta 1-Mediated Activation of Cyclin-Dependent Kinase 5 Activity Is Involved in Neurite Outgrowth and Human Neurofilament Protein H Lys-Ser-Pro Tail Domain Phosphorylation
	jcs.biologists.org /cgi/content/abstract/110/2/257 (1229 words)

	Husted Publications (Site not responding. Last check: 2007-11-05)
		Microtubule dependent ligomerization of Tau: implications for physiological Tau function and Tauopathies.
		Calcium dependent open-closed conformations and interfacial energy maps of reconstituted individual hemichannels.
		, W.B., and Rothman, J.H. Essential embryonic roles of the CKI-1 Cip/Kip cyclin-dependent kinase inhibitor in cell-cycle exit, programmed cell death and organogenesis in C.
	www.nri.ucsb.edu /AR/07_pubs/07_Pubs_02_03.htm (2002 words)

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