Cyclin-dependent kinase complex

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	Cyclin-dependent kinase complex - Wikipedia, the free encyclopedia
		A cyclin-dependent kinase complex (abbreviated cdkc, also called cyclin-CDK) is a protein complex formed by the association of cyclin with cyclin-dependent kinase.
		These complexes are able to phosphorise other compounds under consumption of ATP, and are hereby involved in the regulation of the cell cycle.
		There are three classes of cdkc depending on the phase of the cell cycle.
	en.wikipedia.org /wiki/Cyclin-dependent_kinase_complex (93 words)

	Cyclin-dependent kinase - Wikipedia, the free encyclopedia
		A cyclin-dependent kinase is activated by association with a cyclin forming a cyclin-dependent kinase complex.
		Cyclin-dependent kinase is a protein kinase involved in regulation of the cell cycle.
		Timothy Hunt, and Paul M. Nurse won the 2001 Nobel Prize in Physiology or Medicine for their discovery of cyclin and cyclin-dependent kinase, central molecules in the regulation of the cell cycle.
	en.wikipedia.org /wiki/Cyclin_dependent_kinase (86 words)

	Complex Regulation of the Cyclin-Dependent Kinase Inhibitor p27kip1 in Thyroid Cancer Cells by the PI3K/AKT Pathway: Regulation of p27kip1 Expression and Localization -- Motti et al. 166 (3): 737 -- American Journal of Pathology
		Complex Regulation of the Cyclin-Dependent Kinase Inhibitor p27kip1 in Thyroid Cancer Cells by the PI3K/AKT Pathway: Regulation of p27kip1 Expression and Localization -- Motti et al.
		Complex Regulation of the Cyclin-Dependent Kinase Inhibitor p27
	ajp.amjpathol.org /cgi/content/abstract/166/3/737 (210 words)

	A Genetic Study of Signaling Processes for Repression of PHO5 Transcription in Saccharomyces cerevisiae -- Lau et al. 150 (4): 1349 -- Genetics
		, A., I., and E., 1994 Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85.
		cyclin-CDK complex is inhibited by the CDK inhibitor (CKI) Pho81p
		complex with NR as the sensor and NR as the effector (
	www.genetics.org /cgi/content/full/150/4/1349 (5879 words)

	Control of Mitotic Events by Nap1 and the Gin4 Kinase -- Altman and Kellogg 138 (1): 119 -- The Journal of Cell Biology
		The Gin4 kinase is activated and phosphorylated during mitosis in a Nap1-dependent manner.
		for the redundant cyclins CLB1, CLB3, and CLB4.
		The kinase activity of Gin4 is activated by phosphorylation.
	www.jcb.org /cgi/content/full/138/1/119 (8691 words)

	Mechanisms Governing Maintenance of Cdk1/Cyclin B1 Kinase Activity in Cells Infected with Human Cytomegalovirus -- Sanchez et al. 77 (24): 13214 -- The Journal of Virology
		Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics.
		cyclin B1 and its associated kinase activity in human fibroblasts
		is ubiquitinated and degraded by the anaphase-promoting complex
	jvi.asm.org /cgi/content/full/77/24/13214 (7479 words)

	Pledger - Cancer Biology Ph.D Program
		In particular, the regulation of cyclin dependent kinase activities are studied, including the expression of cyclins, cyclin dependent kinases, cyclin dependent kinase inhibitors (p27kip1 and p21cip1), and cyclin/cyclin dependent kinase complex formation-activation.
		Wharton, W., Savell, J., Cress, W.D., Seto, E., Pledger, W. Inhibition of mitogenesis in Babl/c-3T3 cells by trichostatin A: Multiple alterations in the induction and activation of cyclin/cdk complexes.
		Bagui, T., Jackson, R., Agrawal, D., and Pledger, W.J. Analysis of Cyclin d3-cdk4 Complexes in Fibroblasts Expressing and Lacking p27kip1 and p21cip1.
	www.med.usf.edu /com/iop/cancer/pledger.html (261 words)

	Inhibition of Cyclin E-Cyclin-Dependent Kinase 2 Complex Formation and Activity Is Associated with Cell Cycle Arrest and Withdrawal in Oligodendrocyte Progenitor Cells -- Ghiani and Gallo 21 (4): 1274 -- Journal of Neuroscience
		Inhibition of Cyclin E-Cyclin-Dependent Kinase 2 Complex Formation and Activity Is Associated with Cell Cycle Arrest and Withdrawal in Oligodendrocyte Progenitor Cells -- Ghiani and Gallo 21 (4): 1274 -- Journal of Neuroscience
		Inhibition of Cyclin E-Cyclin-Dependent Kinase 2 Complex Formation and Activity Is Associated with Cell Cycle Arrest and Withdrawal in Oligodendrocyte Progenitor Cells
		but the kinase activities of both cyclin D-cdk4/6 and cyclin E-cdk2
	www.jneurosci.org /cgi/content/abstract/21/4/1274 (510 words)

	A distinct cyclin-dependent kinase-activating kinase of Arabidopsis thaliana -- Umeda et al. 95 (9): 5021 -- Proceedings of the National Academy of Sciences
		A distinct cyclin-dependent kinase-activating kinase of Arabidopsis thaliana
		The Plant-Specific Kinase CDKF;1 Is Involved in Activating Phosphorylation of Cyclin-Dependent Kinase-Activating Kinases in Arabidopsis
		forms a tight complex with Cdc2-related protein kinases in plants (40, 47, 48).
	www.pnas.org /cgi/content/full/95/9/5021 (4663 words)

	YGM 2002 Abstract #167
		The Pho80p-Pho85p cyclin-cyclin dependent kinase (CDK) complex acts as a negative regulator to block PHO5 expression when phosphate levels are high.
		Results suggest that phosphorylation of particular residues within Pho81p is crucial for its activity as a cyclin-dependent kinase inhibitor.
		The PHO81 gene encodes an inhibitor of the Pho80p-PHO85p CDK complex.
	www.yeastgenome.org /community/meetings/yeast02/abshtml/167.html (270 words)

	Pneumocystis carinii Uses a Functional Cdc13 B-Type Cyclin Complex during Its Life Cycle -- Kottom et al. 22 (6): 722 -- American Journal of Respiratory Cell and Molecular Biology
		A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and dissembles nuclei of clam oocytes in vitro.
		aimed at manipulating the activity of the cyclin- cyclin-dependent
		In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.
	ajrcmb.atsjournals.org /cgi/content/full/22/6/722 (5662 words)

	SKP1/SKP2/CDK2/cyclin A complex
		Human SKP1 and SKP2 were identified as components of a stable SKP1/SKP2/CDK2/cyclin A/Cks (cyclin-dependent kinase subunit) complex that was present in elevated levels in human transformed cell lines compared to their non-transformed counterparts [7].
		An initial goal is to characterise the interaction between SKP2 and CDK2/cyclin A. Certain CDK substrates and cyclin-dependent kinase inhibitors (CKIs) of the Cip/Kip1 class stably associate with CDK2/cyclin A through a cyclin-binding RXL motif (single-letter amino acid code) [5].
		This complex includes the SKP2 sequence N-terminal to the F-box (residues 112-153) that is required for association with CDK2/cyclin A. A complex of CDK2 phosphorylated on Thr160 with cyclin A3 (a construct that encodes residues 173-432) (pCDK2/cyclin A3) suitable for crystallisation trials is purified from E.
	biop.ox.ac.uk /www/lj2000/endicott/endicott_02.html (367 words)

	YGM 2000 Abstract #389
		It is a tripartite cyclin-dependent kinase complex that, in addition of a kinase subunit (Ctk1) and a C-type cyclin subunit (Ctk2), contains a third factor of unknown function, (Ctk3), that displays no homology with known proteins.
		The cyclin-dependent kinase Ctk1 requires its association with two unstable subunits for its CTD kinase activity.
		Altogether, our results suggest that, in contrast to other cyclin-dependent kinases, Ctk1 is not solely activated by its cyclin, but by the Ctk2/Ctk3 heterodimer.
	www.yeastgenome.org /community/meetings/yeast00/abshtml/389.html (206 words)

	BUR1 and BUR2 Encode a Divergent Cyclin-Dependent Kinase-Cyclin Complex Important for Transcription In Vivo -- Yao et al. 20 (19): 7080 -- Molecular and Cellular Biology
		The Kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae.
		Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo.
		Although cyclins are not closely related at the primary amino acid level, their structures are highly conserved.
	mcb.asm.org /cgi/content/full/20/19/7080 (5092 words)

	Cancer, the cell cycle and tyrosine kinase receptors
		Thus, growth factor dependent synthesis of the G1 cyclin will promote progression through the G1 checkpoint, and commit to mitosis.
		MAP kinases may, amongst other things, promote expression of cyclins.
		Cyclin B rises in concentration during the cell cycle as it is synthesized
	yakko.bme.virginia.edu /biom304/notes/cancer.htm (795 words)

	Interaction of the S phase regulator Cdc18 with cyclin-dependent kinase in fission yeast -- Brown et al. 94 (12): 6142 -- Proceedings of the National Academy of Sciences
		of a protein kinase catalytic subunit complexed with a regulatory
		for the assay of Cdc18-associated kinase from cdc2-L7 and cdc2-33
		Concomitantly, Cdc18 is dissociated from the preinitiation complex
	www.pnas.org /cgi/content/full/94/12/6142 (5276 words)

	A New C-Type Cyclin-Dependent Kinase from Tomato Expressed in Dividing Tissues Does Not Interact with Mitotic and G1 Cyclins -- Joubès et al. 126 (4): 1403 -- PLANT PHYSIOLOGY
		The complexity of the plant cell cycle is reflected by the existence of several types of cyclins and CDKs.
		could be associated with a putative CTD kinase activity responsible
		In the pericarp, mRNAs corresponding to CDKC and CDKA
	www.plantphysiol.org /cgi/content/full/126/4/1403 (6055 words)

	The CDK-activating kinase CAK1 can dosage suppress sporulation defects of smk1 MAP kinase mutants and is required for spore wall morphogenesis in Saccharomyces cerevisiae -- Wagner et al. 16 (6): 1305 -- The EMBO Journal
		Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae
		The CDK-activating kinase CAK1 can dosage suppress sporulation defects of smk1 MAP kinase mutants and is required for spore wall morphogenesis in Saccharomyces cerevisiae -- Wagner et al.
		Mitogen-activated protein (MAP) kinase pathways are evolutionarily conserved kinase cascades that are required for the response
	embojournal.npgjournals.com /cgi/content/abstract/16/6/1305 (848 words)

	HUA ENHANCER3 reveals a role for a cyclin-dependent protein kinase in the specification of floral organ identity in Arabidopsis -- Wang and Chen 131 (13): 3147 -- Development
		Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.
		Only the protein kinase domains from these proteins were used in the analysis.
		The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
	dev.biologists.org /cgi/content/full/131/13/3147 (6173 words)

	Cyclin D1 Overexpression in Mouse Epidermis Increases Cyclin-dependent Kinase Activity and Cell Proliferation in Vivo but Does Not Affect Skin Tumor Development -- Rodriguez-Puebla et al. 10 (7): 467 -- Cell Growth & Differentiation
		Cyclin D1 Overexpression in Mouse Epidermis Increases Cyclin-dependent Kinase Activity and Cell Proliferation in Vivo but Does Not Affect Skin Tumor Development -- Rodriguez-Puebla et al.
		Cyclin D1 Overexpression in Mouse Epidermis Increases Cyclin-dependent Kinase Activity and Cell Proliferation in Vivo but Does Not Affect Skin Tumor Development
		and was correlated with elevated CDK4 and CDK6 kinase activities.
	cgd.aacrjournals.org /cgi/content/abstract/10/7/467 (754 words)

	Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1 -- Casaccia-Bonnefil et al. 11 (18): 2335 -- Genes and Development
		Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
		Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1 -- Casaccia-Bonnefil et al.
		Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27
	www.genesdev.org /cgi/content/full/11/18/2335 (5949 words)

	RNA Polymerase II Holoenzymes and Subcomplexes -- Myer and Young 273 (43): 27757 -- Journal of Biological Chemistry
		The abbreviations used are: TBP, TATA-binding protein; GTF, general transcription factor; CDK, cyclin-dependent kinase; Pol, polymerase; CTD, C-terminal domain; PIC, preinitiation complex.
		Promoter-dependent Roles for the Srb10 Cyclin-dependent Kinase and the Hda1 Deacetylase in Tup1-mediated Repression in Saccharomyces cerevisiae
		Proteomic and genomic characterization of chromatin complexes at a boundary
	www.jbc.org /cgi/content/full/273/43/27757 (4195 words)

	The Role of the Cyclin-dependent Kinase Inhibitor p21 in Apoptosis -- Gartel and Tyner 1 (8): 639 -- Molecular Cancer Therapeutics
		Adimoolam, S., Lin, C. X., and Ford, J. The p53-regulated cyclin-dependent kinase inhibitor, p21 (cip1, waf1, sdi1), is not required for global genomic and transcription-coupled nucleotide excision repair of UV-induced DNA photoproducts.
		Cheng, M., Sexl, V., Sherr, C. J., and Roussel, M. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).
		A, p21 may block apoptosis by interacting with proapoptotic molecules such as procaspase-3, caspase-8, and the kinase apoptosis signal-regulating kinase 1 (ASK1) or by inducing cell cycle arrest after binding to cyclin E/Cdk2 complexes or by binding to cyclin A/Cdk2 complexes.
	mct.aacrjournals.org /cgi/content/full/1/8/639 (7833 words)

	Regulation of the Yeast Transcriptional Factor PHO2 Activity by Phosphorylation -- Liu et al. 275 (41): 31972 -- Journal of Biological Chemistry
		kinase PHO85 and cyclin PHO80 phosphorylates and presumably inactivates
		The results of the two-hybrid assay (16) argued that DNA binding by PHO4 is dependent on the phosphate-sensitive interaction
		Protein Kinase CDC28 Can Interact with PHO2 in the Two-hybrid System-- Because the potential phosphorylation site of PHO2 resembles the consensus motif of sites phosphorylated by cdc2/CDC28-type
	www.jbc.org /cgi/content/full/275/41/31972 (4729 words)

	Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis -- De Veylder et al. 13 (7): 1653 -- THE PLANT CELL
		Phosphorylation of Retinoblastoma-Related Protein by the Cyclin D/Cyclin-Dependent Kinase Complex Is Activated at the G1/S-Phase Transition in Tobacco
		Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis -- De Veylder et al.
		Misexpression of the Cyclin-Dependent Kinase Inhibitor ICK1/KRP1 in Single-Celled Arabidopsis Trichomes Reduces Endoreduplication and Cell Size and Induces Cell Death
	www.plantcell.org /cgi/content/abstract/13/7/1653 (2069 words)

	Molecules To Go (Formerly known as Molecules R Us)
		HEADER COMPLEX (TRANSFERASE/CYCLIN) 14-JUL-96 1FIN TITLE CYCLIN A - CYCLIN-DEPENDENT KINASE 2 COMPLEX COMPND MOL_ID: 1; COMPND 2 MOLECULE: CYCLIN-DEPENDENT KINASE 2; COMPND 3 CHAIN: A, C;
		First 100 lines from the PDB structure record...
	molbio.info.nih.gov /cgi-bin/moldraw?1FIN (96 words)

	Sue Golding Graduate Division @ AECOM - Prelich, Gregory
		Yao, S. and Prelich, G. (2002) Activation of the Bur1-Bur2 cyclin-dependent kinase complex by Cak1. Mol.
		and Prelich, G. and BUR2 encode a divergent cyclin-CDK complex important for transcription in vivo. Mol.
		Prelich, G. (2002) RNA Polymerase II carboxy-terminal domain kinases: emerging clues to their function. Eukaryotic Cell 1: 153-162.
	www.aecom.yu.edu /phd/faculty/Prelich.htm (158 words)

	Rediscovering Biology - Online Textbook: Unit 8 Cell Biology & Cancer
		Each cyclin-dependent kinase forms a complex with a particular cyclin, a protein that binds and activates the cyclin-dependent kinase.
		There are specific cyclin-dependent kinase/cyclin complexes at the entry points into the G1, S, and M phases of the cell cycle, as well as additional factors that help prepare the cell to enter S phase and M phase.
		The kinase part of the complex is an enzyme that adds a phosphate to various proteins required for progression of a cell through the cycle.
	www.learner.org /channel/courses/biology/textbook/cancer/cancer_4.html (656 words)

	Cyclin-dependent kinase -- Facts, Info, and Encyclopedia article
		A (Click link for more info and facts about cyclin-dependent kinase) cyclin-dependent kinase is activated by association with a (Click link for more info and facts about cyclin) cyclin forming a (Click link for more info and facts about cyclin-dependent kinase complex) cyclin-dependent kinase complex.
		(Click link for more info and facts about Cyclin-dependent kinase) Cyclin-dependent kinase is a (Click link for more info and facts about protein kinase) protein kinase involved in regulation of the (Click link for more info and facts about cell cycle) cell cycle.
		Cyclin-dependent kinase -- Facts, Info, and Encyclopedia article
	www.absoluteastronomy.com /encyclopedia/c/cy/cyclin-dependent_kinase.htm (122 words)

	OUTPUT from blastx for A1B23TH
		Human Cyclin-Dependent Kinase 2 pdb1BUHA Chain A, Crystal Structure Of The Human Cdk2 Kinase Complex With Cell Cycle-Regulatory Protein Ckshs1 pdb1CKPA Chain A, Human Cyclin Dependent Kinase 2 Complexed With The Inhibitor Purvalanol B pdb1AQ1
		Human Cyclin Dependent Kinase 2 Complexed With The Inhibitor Staurosporine gbAAA35667.1
		58 6e-08 pdb1E1VA Chain A, Human Cyclin Dependent Kinase 2 Complex...
	cbr-rbc.nrc-cnrc.gc.ca /reith/tetra/tetra4/A1B23TH.html (928 words)

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In the News (Sat 26 Dec 09)