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Topic: Cyclooxygenase 1

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Cyclooxygenase 2

Prostaglandin

Aspirin

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Cyclooxygenase

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	Cyclooxygenase - Wikipedia, the free encyclopedia
		Cyclooxygenase (COX) is an enzyme (EC 1.14.99.1) that is responsible for formation of important biological mediators called prostanoids (including prostaglandins, prostacyclin and thromboxane).
		Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain; this is the method of action of well-known drugs such as aspirin and ibuprofen.
		, and a cyclooxygenase site, where arachidonic acid is converted into the hydroperoxy endoperoxide prostaglandin G
	en.wikipedia.org /wiki/Cyclooxygenase (781 words)

	eMedicine - Cyclooxygenase Deficiency : Article by John R Witherow
		Synonyms and related keywords: cyclooxygenase deficiency, COX deficiency, prostaglandin-endoperoxide synthase deficiency, PTGS deficiency, fatty acid cyclooxygenase deficiency, prostaglandin H synthase deficiency, PGH synthase deficiency, EC 1.14.99.1 deficiency, eicosanoid, seminal fluid, COX inhibition, COX-1, PTGS-1,COX-2, PTGS-2
		Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS), fatty acid COX, PGH synthase, and EC 1.14.99.1, is a key regulatory enzyme in the synthetic pathway of eicosanoid production.
		Platelets have 3 distinct roles in coagulation: (1) initial adhesion, (2) phospholipid externalization, and (3) platelet aggregation.
	www.emedicine.com /med/topic3096.htm (3337 words)

	COX1 / Cyclooxygenase 1 antibody (ab2338) datasheet (Site not responding. Last check: 2007-10-21)
		If COX1 / Cyclooxygenase 1 antibody (ab2338) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund.
		Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2.
		Immunizing Peptide for COX1 / Cyclooxygenase 1 antibody
	www.abcam.com /?datasheet=2338 (666 words)

	Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition -- Simmons et al. 56 (3): 387 -- ...
		Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition -- Simmons et al.
		Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
		The fate of arachidonic acid in cells as it is metabolized by lipoxygenases to HETEs and hydroperoxyeicosatetraenoic acids (HPETEs) or by cyclooxygenases to prostaglandin H
	pharmrev.aspetjournals.org /cgi/content/full/56/3/387 (7689 words)

	Spatiotemporal Expression of Cyclooxygenase 1 and Cyclooxygenase 2 during Delayed Implantation and the Periimplantation ...
		Spatiotemporal Expression of Cyclooxygenase 1 and Cyclooxygenase 2 during Delayed Implantation and the Periimplantation Period in the Western Spotted Skunk -- Das et al.
		Spatiotemporal Expression of Cyclooxygenase 1 and Cyclooxygenase 2 during Delayed Implantation and the Periimplantation Period in the Western Spotted Skunk
		Cyclooxygenases and prostaglandin E synthases in the endometrium of the rhesus monkey during the menstrual cycle
	www.biolreprod.org /cgi/content/abstract/60/4/893 (509 words)

	Inhibitors of Cyclooxygenase-2, but Not Cyclooxygenase-1 Provide Structural and Functional Protection against ...
		administered 1 mg of flurbiprofen in 1% carboxymethylcellulose
		The ED estimates of drug potency were derived using nonlinear regression fitting of a sigmoidal dose-response curve to the data, with the minimum constrained to the value obtained for the mean performance of the lesioned side from the vehicle-treated group, or 0 for lesion size.
		Luo J, Lang JA, and Miller MW (1998) Transforming growth factor beta1 regulates the expression of cyclooxygenase in cultured cortical astrocytes and neurons.
	jpet.aspetjournals.org /cgi/content/full/306/1/218 (5270 words)

	AKS Use Case - Digging out specific COX inhibitors (Site not responding. Last check: 2007-10-21)
		Cyclooxygenases are a family of well-known enzymes that regulates the conversion of arachidonic acid to prostaglandin.
		Although both cyclooxygenases share a common biological function, we can see that they have different cooccurrences with diseases and chemicals probably due to their diferent roles in the organism.
		Thanks to AKS we were able to see relevant documents regarding cyclooxygenases, find the different association to diseases and drugs of the two main isozymes, establish a time-line research and look for the main authors with whom we might want to collaborate in our possible future research on cyclooxygenases.
	aks.bioalma.com /UseCases/COX.htm (2386 words)

	HDL-Induced Prostacyclin Release in Smooth Muscle Cells Is Dependent on Cyclooxygenase-2 (Cox-2) -- Viñals et ...
		Cyclooxygenase (Cox; prostaglandin G/H synthase, E.C. is the rate-limiting enzyme in the conversion of arachidonic
		RNA from rabbit lung was run in an agarose/formaldehyde gel (10 and 5 µg, lanes 1 and 2, respectively) transferred to a Hybond membrane, and hybridized to the radiolabeled pRCox-1 insert.
		Expression of a mitogen-inducible cyclooxygenase in brain neurons:regulation by synaptic activity and glucocorticoids.
	atvb.ahajournals.org /cgi/content/full/17/12/3481 (4580 words)

	Endothelin-1 Induces Cyclooxygenase-2 Expression Via Nuclear Factor of Activated T-Cell Transcription Factor in ...
		Cell extracts of COS cells transfected with an empty vector (pcDNA3, lane 1) or expression vectors of NFAT2 (lane 2), NFAT1 (lane 3), or NFAT4 (lane 4) or extracts of rat mesangial cells (lane 5) were subjected to immunoblot analysis.
		Extracts in lanes 1 through 5 were incubated with the monoclonal antibody to NFAT2 (7A6).
		COS cells were seeded on 10-cm-diameter dishes and transfected with 5 µg of the NFAT2 expression vector (lanes 3 and 4) or a control vector (pcDNA3, lanes 1 and 2).
	jasn.asnjournals.org /cgi/content/full/12/7/1359 (6457 words)

	Formulation dependent pharmacokinetics, bioavailability and renal toxicity of a selective cyclooxygenase-1 inhibitor ...
		On the morning of study, SC-560 was weighed and dissolved in PEG 600 or suspended in 1% methylcellulose (MC) (~0.5 mL).
		L) was collected pre-dose through the catheter and at 2, 10 min, and 0.5, 1, 2, 4, 8, 12, and 24 h after iv dosing and at 0.25, 0.5, 1, 2, 4, 8, 12, and 24 h after oral dosing.
		Table 1: Pharmacokinetics data of SC-560 after iv and oral administration in rats (mean ± SD, n=5).
	www.ualberta.ca /~csps/JPPS6(2)/N.Davies/sc-560.htm (2940 words)

	240_COX-1
		Both forms of PGHS are heme proteins composed of two 70,000 Dalton subunits, and possess both cyclooxygenase and peroxidase activity.
		Inhibition of the cyclooxygenase activity of PGHS is responsible for the anti-inflammatory activity of aspirin, indomethacin, ibuprofen, piroxicam, and other non-steroidal anti-inflammatory drugs (NSAIDs).
		The committed step in the biosynthesis of the prostaglandins, thromboxanes, and prostacyclin is carried out by the membrane-bound enzyme prostaglandin G/H synthase (PGHS), which exhibits both cyclooxygenase and peroxidase activities.
	www.oxfordbiomed.com /1cox240.html (236 words)

	Cyclooxygenase-1 and -2 Are Required for Production of Infectious Pseudorabies Virus -- Ray et al. 78 (23): 12964 -- ...
		REF cells were infected with PRV (MOI = 1) in the presence of increasing concentrations of indomethacin (A), NS398 (C), or FR122047 (E).
		Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).
		The prophylactic use of cyclooxygenase inhibitors in recurrent herpes simplex infections.
	jvi.asm.org /cgi/content/full/78/23/12964 (6890 words)

	Immunohistochemical Localization of Cyclooxygenase-1 and Cyclooxygenase-2 in the Human Fetal and Adult Male ...
		thought to be derived from the prostate gland (1, 2).
		1995 Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin- induced gastric ulceration.
		1998 Cloning, developemental expression and immunohistochemistry of cyclooxygenase 2 in the endometrium during embryo implantation and gestation in mink (Mustela vison).
	jcem.endojournals.org /cgi/content/full/85/9/3436 (3348 words)

	Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase - Patent 5409944
		The second form of cyclooxygenase, cyclooxygenase-2, is rapidly and readily inducible by a number of agents including mitogens, endotoxin, hormones, cytokines and growth factors.
		As prostaglandins have physiological and pathological roles, we have concluded that the constitutive enzyme, cyclooxygenase-1, is responsible, in large part, for endogenous basal release of prostaglandins and hence is important in their physiological functions such as the maintenance of gastrointestinal integrity and renal blood flow.
		For the treatment of any of these cyclooxygenase mediated diseases compounds of Formula I may be administered orally, topically, parenterally, by inhalation spray or rectally in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles.
	www.freepatentsonline.com /5409944.html (4506 words)

	Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal ...
		Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux -- Jang et al.
		border of the duodenum, 1 cm distal to the pylorus.
		Cyclooxygenase 2 expression in Barrett’s esophagus and adenocarcinoma: ex vivo induction by bile salts and acid exposure.
	gut.bmjjournals.com /cgi/content/full/53/1/27 (3790 words)

	Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2 -- ...
		in 1× TBS-0.05% Tween 20, hybridization with the secondary antibody
		Expression of mRNA transcripts for cyclooxygenase (COX)-1, COX-2, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in colonic myofibroblasts.
		RNA was isolated from a confluent monolayer of cells and reverse transcribed, and relevant transcripts were amplified by polymerase chain reaction using specific primers.
	ajpgi.physiology.org /cgi/content/full/273/6/G1341 (3931 words)

	Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate ...
		Carreira-Barbosa, F., Concha, M.L., Takeuchi, M., Ueno, N., Wilson, S.W., and Tada, M. Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish.
		Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.
		Smith, W.L., DeWitt, D.L., and Garavito, R.M. Cyclooxygenases: Structural, cellular, and molecular biology.
	www.genesdev.org /cgi/content/full/20/1/77 (4607 words)

	Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer ...
		Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans -- Tatsuguchi et al.
		Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans
		Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice
	gut.bmjjournals.com /cgi/content/abstract/46/6/782 (937 words)

	Regulation of Macrophage Cytokine Production by Prostaglandin E2. DISTINCT ROLES OF CYCLOOXYGENASE-1 AND -2 -- Williams ...
		Prostaglandins are important mediators of a wide variety of physiological processes (reviewed in Ref. 1).
		The abbreviations used are: Cox, cyclooxygenase; IL, interleukin; TNF, tumor necrosis factor; pAlb, polymerized albumin; LPS,
		Sertoli Cell Expression of Steroidogenic Acute Regulatory Protein-Related Lipid Transfer 1 and 5 Domain-Containing Proteins and Sterol Regulatory Element Binding Protein-1 Are Interleukin-1{beta} Regulated by Activation of c-Jun N-Terminal Kinase and Cyclooxygenase-2 and Cytokine Induction
	www.jbc.org /cgi/content/full/272/41/25693 (5122 words)

	Cyclooxygenase-1 Is a Potential Target for Prevention and Treatment of Ovarian Epithelial Cancer -- Daikoku et al. 65 ...
		Integr Cancer Ther, June 1, 2006; 5(2): 150 - 171.
		Cancer, December 1, 2005; 12(4): 761 - 772.
		Ther., November 1, 2005; 315(2): 668 - 677.
	cancerres.aacrjournals.org /cgi/content/abstract/65/9/3735 (378 words)

	Cyclooxygenase-1 and -2 Expression in Urothelial Carcinomas of the Urinary Bladder in Cows -- Borzacchiello et al. 40 ...
		Cyclooxygenase (COX) is a rate-limiting enzyme for prostaglandin
		temperature at a dilution of 1 : 10.
		Smith WL, Garavito MR, DeWitt DL: Prostaglandin endoperoxide H synthases (cyclooxygenases) -1 and -2.
	www.vetpathology.org /cgi/content/full/40/4/455 (1824 words)

	Transforming Growth Factor-beta 1 Enhances Ha-ras-induced Expression of Cyclooxygenase-2 in Intestinal Epithelial Cells ...
		Transforming Growth Factor-beta 1 Enhances Ha-ras-induced Expression of Cyclooxygenase-2 in Intestinal Epithelial Cells via Stabilization of mRNA -- Sheng et al.
		1 and is necessary for the synergistic stabilization
		Metab., January 1, 2002; 87(1): 358 - 363.
	www.jbc.org /cgi/content/abstract/275/9/6628 (1506 words)

	Ontogeny of cyclooxygenase-1 and cyclooxygenase-2 gene expression in ovine lung -- Brannon et al. 274 (1): 66 -- AJP - ...
		J Appl Physiol, April 1, 2005; 98(4): 1526 - 1533.
		J Appl Physiol, March 1, 2005; 98(3): 1111 - 1118.
		J Appl Physiol, June 1, 2001; 90(6): 2094 - 2100.
	ajplung.physiology.org /cgi/content/abstract/274/1/L66 (588 words)

	Expression of Cyclooxygenase-1 and -2 in the Baboon Endometrium during the Menstrual Cycle and Pregnancy -- Kim et al. ...
		Cyclooxygenase (COX) is the rate-limiting enzyme in the biosynthesis
		COX-1 (A) and COX-2 (B) are shown for normal cycling day 10 PO endometrium (lane 1) and for an antiprogestin-treated animal (lane 2), with the corresponding densitometric analysis expressed as the mean of two replicate determinations.
		Bany BM, Kennedy TG 1997 Regulation of cyclooxygenase gene expression in rat endometrial stromal cells: the role of epidermal growth factor.
	endo.endojournals.org /cgi/content/full/140/6/2672 (4243 words)

	Roles of Cyclooxygenase (COX)-1 and COX-2 in Prostanoid Production by Human Endothelial Cells: Selective Up-Regulation ...
		Metab., January 1, 2005; 90(1): 372 - 378.
		Ethics, April 1, 2004; 30(2): 182 - 184.
		Biol., June 1, 2003; 23(6): 1111 - 1115.
	www.jimmunol.org /cgi/content/abstract/167/5/2831 (672 words)

	The Molecular Perspective: Cyclooxygenase-2 -- Goodsell 5 (2): 169 -- The Oncologist
		In the illustration, the membrane is shown with blue shading.
		The cyclooxygenase active site, which performs the first reaction in prostaglandin synthesis, is found deep within a pocket that opens into the membrane, allowing easy access to insoluble arachidonic acid.
		In the illustration at right, the nonsteroidal anti-inflammatory drug molecule indomethacin is shown in green bound inside the pocket.
	theoncologist.alphamedpress.org /cgi/content/full/5/2/169 (675 words)

	Full Text: Pros and Cons of Selective Inhibition of Cyclooxygenase-2 versus Dual Lipoxygenase/Cyclooxygenase ...
		Unfortunately, in spite of positive experimental and clinical data, recent findings suggest that it may be unwise to separate so sharply the functions of the prostaglandins produced by the two cyclooxygenases (Table 1).
		It is therefore conceivable that dual inhibition of both cyclooxygenase and 5-lipoxygenase should counteract inflammatory vascular changes as well as leukocyte induced damage, resulting in a more profound antiinflammatory action than the mere blockade of cyclooxygenase.
		Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
	www.jrheum.com /subscribers/01/11/2375.html (5249 words)

	All Prostaglandins (Site not responding. Last check: 2007-10-21)
		COX3, Cyclooxygenase 1, PCOX 1, PCOX1, PGG/HS, PGH synthase 1, PGHS 1, PGHS1, PH...
		ELISA, WB COX3, Cyclooxygenase 1, PCOX 1, PCOX1, PGG/HS, PGH synthase 1, PGHS 1, PGHS1, PH...
		IHC-Fr COX3, Cyclooxygenase 1, PCOX 1, PCOX1, PGG/HS, PGH synthase 1, PGHS 1, PGHS1, PH...
	www.abcam.com /?c=861 (528 words)

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