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Cyclophosphamide - Wikipedia, the free encyclopedia Cyclophosphamide (the generic name for Cytoxan, Neosar) is a nitrogen mustard alkylating agent, used to treat various types of cancer and some autoimmune disorders. Cyclophosphamide is converted by mixed function oxidase enzymes in the liver to active metabolites. Cyclophosphamide is itself carcinogenic, potentially causing transitional cell carcinoma of the bladder as a long-term complication. en.wikipedia.org /wiki/Cyclophosphamide   (695 words)

Cytoxan (Cyclophosphamide) The dose of cyclophosphamide varies from patient to patient and is partially dependent upon the height and weight of the patient and the status of various blood tests (for example, whether your blood counts are high or low). Cyclophosphamide decreases the production of blood cells in the bone marrow and also inhibits their functioning once they are in the blood stream. Cyclophosphamide should not be taken by men or women capable of having children, unless adequate precautions are taken to prevent pregnancy. www.webspawner.com /users/cbreynolds/cytoxancyclopho.html   (937 words)

Johns Hopkins Vasculitis Center Discusses Cytoxan Treatment for Vasculitis Cyclophosphamide, also called Cytoxan, is classified as a “cytotoxic agent”, because it has a toxic effect on many types of cells (“good” cells as well as “bad”). Cyclophosphamide is one of a number of medications first developed as a chemotherapy drug (a medication used in the treatment of cancer). Leukemia/lymphoma — One of the long–term side–effects of cyclophosphamide use is a significant increase in the risk of bone marrow and lymph node cancers (known as leukemia and lymphoma, respectively). vasculitis.med.jhu.edu /treatments/cytoxan.html   (1880 words)

Cyclophosphamide for rheumatoid arthritis - SJMMC, Ann Arbor, Michigan MI Cyclophosphamide is an immunosuppressive medication, which means that it decreases the effects of your body's immune system. Cyclophosphamide is often used as chemotherapy in treatments for certain cancers, including non-Hodgkin's lymphoma and breast cancer. Cyclophosphamide has been found to be effective in reducing disease activity and joint inflammation in people with rheumatoid arthritis. www.sjmercyhealth.org /13307.cfm   (408 words)

Cyclophosphamide Drug Information It is used to treat cancer of the ovaries, breast, blood and lymph system, nerves (found primarily in children), retinoblastoma (a cancer of the eye found primarily in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). Cyclophosphamide interferes with the growth of cancer cells, which are eventually destroyed. Cyclophosphamide may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. www.drugs.com /cons/Cyclophosphamide.html   (2631 words)

Arthritis Research Campaign | Drugs for Arthritis: Cyclophosphamide   (Site not responding. Last check: 2007-10-23) Cyclophosphamide is used for several different types of rheumatic disease, including systemic lupus erythematosus (SLE), diseases which inflame the walls of blood vessels (e.g. Cyclophosphamide can also affect the blood count (one of the effects is that fewer blood cells are made). Because cyclophosphamide can make you more prone to infections, if you have not had chickenpox but come into contact with someone who has chickenpox or shingles, or if you develop chickenpox or shingles, you should stop cyclophosphamide and see your doctor immediately as you may need special treatment. www.arc.org.uk /about_arth/infosheets/6244/6244.htm   (1045 words)

Cyclophosphamide. DermNet NZ Cyclophosphamide is a potent drug that is primarily used in the treatment of cancer. Cyclophosphamide is found to be useful in the treatment of some skin diseases, particularly autoimmune skin diseases or those associated with some sort of immune disorder. Cyclophosphamide should only be used by a doctor experienced in its use, as the risk of toxicity is high and side effects potentially dangerous. dermnetnz.org /treatments/cyclophosphamide.html   (513 words)

Patient Education - Cyclophosphamide Cyclophosphamide (Cytoxan) belongs to a class of drugs known as alkylating agents, which were originally developed and are still used to treat some types of cancer. Cyclophosphamide is used in the treatment of lupus, systemic sclerosis (scleroderma), some forms of vasculitis,myopathies such as polymyositis and dermatomyositis, as well as some complications of rheumatoid arthritis. Some of the side effects of cyclophosphamide may be serious, so contact your doctor if you notice: blood in your urine, fevers and chills, easy bruising or bleeding, shortness of breath or swelling of the feet and ankles. www.rheumatology.org /public/factsheets/cyclophosphamide.asp?aud=pat   (862 words)

Cyclophosphamide pulses with oral prednisolone in the treatment of pemphigus: A pilot study Pulse intravenous cyclophosphamide therapy is established in the treatment of various autoimmune diseases such as autoimmune thrombocytopenic purpura, systemic lupus erythematosus, and lupus nephritis; this treatment is associated with improved outcome compared to other therapies including daily oral cyclophosphamide [9, 10]. Urologic toxicity is a major consideration with cyclophosphamide use, hemorrhagic cystitis and late bladder malignancies being the foremost [15, 16]. Amenorrhea due to cyclophosphamide therapy may be irreversible [19, 20], and is associated with large cumulative doses and prolonged lengths of treatment [21]. dermatology.cdlib.org /113/original/pemphigus-cytoxan/bhat.html   (3287 words)

cyclophosphamide (Cytoxan) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com PRESCRIBED FOR: Cyclophosphamide is used for the treatment of several types of cancers and often in combination with other drugs to treat breast cancer, leukemia and ovarian cancer. Cyclophosphamide increases the occurrence of heart failure that is caused by doxorubicin (Adriamycin), increases the action of blood thinners such as coumarin (Coumadin), and decreases the effects of quinolone antibiotics (Cipro). Cyclophosphamide causes kidney failure, and it also may affect the heart and lungs. www.medicinenet.com /cyclophosphamide/article.htm   (624 words)

MedlinePlus Drug Information: Cyclophosphamide Cyclophosphamide is in a class of drugs known as alkylating agents; it slows or stops the growth of cancer cells in your body. Cyclophosphamide is also used to treat bronchogenic carcinoma, small cell lung carcinoma, and other types of cancer. The most common side effect of cyclophosphamide is a decrease in the number of blood cells. www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682080.html   (604 words)

Cyclophosphamide - SJMMC, Ann Arbor, Michigan MI Cyclophosphamide is an alkylating agent and is related to mustard gas. Cyclophosphamide is available as an intravenous (IV) medicine and as tablets for oral use in 25 mg and 50 mg. Cyclophosphamide is often used before a bone marrow transplant or after another type of transplant, such as a kidney or liver transplant. www.sjmercyhealth.org /13306.cfm   (362 words)

Cyclophosphamide - Family factsheets - GOSH and ICH   (Site not responding. Last check: 2007-10-23) Cyclophosphamide is a chemotherapy drug used to treat certain types of cancer and leukaemia. If cyclophosphamide is used to treat conditions other than cancer, leukaemia and bone marrow transplants, it may be given by mouth in tablet form. Oral cyclophosphamide is best taken at the same time every day with plenty of water as directed by your doctor, nurse or pharmacist. www.gosh.nhs.uk /factsheets/families/F000243/index.html   (1009 words)

Cyclophosphamide : Cancerbackup Cyclophosphamide (pronounced sigh-clo-fos-fa-mide) is a chemotherapy drug that is given as a treatment for many types of cancer. It is most commonly used to treat lymphomas; cancers of the ovary, breast and bladder; and a type of leukaemia known as chronic lymphocytic leukaemia. With high-dose cyclophosphamide, fluids are given into the vein, along with a drug called mesna (Uromitexan®), which can help to prevent bladder irritation. www.cancerbackup.org.uk /Treatments/Chemotherapy/Individualdrugs/Cyclophosphamide   (1433 words)

Cytoxan - Cytoxan Side Effects - Cytoxan Information - Canada Pharmacy - Canada Drugs Cyclophosphamide is metabolized in the body initially by the mixed function oxidase enzymes of the liver microsomes; several toxic metabolites have been identified. Since cyclophosphamide has been reported to be more toxic in adrenalectomized dogs, adjustment of the dose of both replacement steroids and cyclophosphamide may be necessary for the adrenalectomized patient. Cyclophosphamide should be given cautiously to patients with any of the following conditions: leukopenia, thrombocytopenia, tumor cell infiltration of bone marrow, previous x-ray therapy, previous therapy with other cytotoxic agents, impaired hepatic or renal function. www.rxcarecanada.com /CYTOXAN.asp?currency=USD&page=/CYTOXAN.asp&q=prodid=CYTOXAN   (2701 words)

Cyclophosphamide (Cytoxan®, Neosar®) - PetPlace.com Due to its effect on rapidly growing cells, cyclophosphamide is used in the treatment of various types of cancers. Cyclophosphamide is also used in the treatment of specific immune system disorders. For cancer treatment, cyclophosphamide is dosed at 0.5 to 1 mg per pound (1 to 2 mg/kg) once daily. www.petplace.com /articles/artShow.asp?artID=1546   (666 words)

Cyclophosphamide Cyclophosphamide preparation should be performed in a Class II laminar flow biologic safety cabinet. Genitourinary: Severe, potentially fatal acute hemorrhagic cystitis or urinary fibrosis, believed to be a result of chemical irritation of the bladder by acrolein, a cyclophosphamide metabolite, occurs in 7% to 12% of patients and has been reported in up to 40% of patients in some series. Cyclophosphamide undergoes hepatic transformation in the liver to its 4-hydroxycyclophosphamide, which breaks down to its active form, phosphoramide mustard. www.musc.edu /pharmacyservices/Drugs/C/Cyclophosphamide.htm   (828 words)

ACS :: Cancer Drug Guide: cyclophosphamide Cyclophosphamide belongs to a general group of chemotherapy drugs known as alkylating agents. Cyclophosphamide can be given by mouth as a pill or liquid, or as a shot into a vein. Cyclophosphamide can lower your white blood cell count, especially 1 to 2 weeks after the drug is given. www.cancer.org /docroot/CDG/content/CDG_cyclophosphamide.asp   (959 words)

Cytoxan Online, Description, Chemistry, Ingredients, Blackbox - Cyclophosphamide - RxList Monographs (cyclophosphamide for injection, USP) is a sterile white lyophilized cake, or partially broken cake, containing 75 mg mannitol per 100 mg cyclophosphamide (anhydrous). Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Cyclophosphamide is a white crystalline powder with the molecular formula C www.rxlist.com /cgi/generic3/cyclophosphamide.htm   (151 words)

Cyclophosphamide   (Site not responding. Last check: 2007-10-23) Cyclophosphamide is taken by mouth or injected into the veins. Cyclophosphamide can decrease the number of white blood cells in your body, cells that usually help you fight infections. Cyclophosphamide may cause side effects that do not occur for months or years after you finish chemotherapy, including leukemia, bladder cancer, or decreased ability to have children. www.hci.utah.edu /patientdocs/hci/drugs/cyclophosphamide.htm   (471 words)

Cyclophosphamide (IARC Summary & Evaluation, Supplement7, 1987) Among 602 patients treated predominantly with cyclophosphamide for non-Hodgkin's lymphoma in Denmark, nine cases of acute nonlymphocytic leukaemia (ANLL) or preleukaemia were observed, compared to 0.12 expected on the basis of incidence rates in the general population [ref: 3]. Cyclophosphamide has been tested for carcinogenicity by oral administration and by intravenous and intraperitoneal injection in rats and by subcutaneous and intraperitoneal injection in mice. Increased incidences of chromosomal aberrations and sister chromatid exchanges were observed in peripheral blood lymphocytes and, in one study, in bone-marrow cells of patients treated with cyclophosphamide for a variety of malignant and nonmalignant diseases [ref: 9]. www.inchem.org /documents/iarc/suppl7/cyclophosphamide.html   (729 words)

Cyclophosphamide One uses cyclophosphamide to kill cells that are causing harm, usually cancer cells or inflammatory cells. Cyclophosphamide is toxic to the unborn fetus and should not be used in pregnancy. The majority of cyclophosphamide is excreted in urine and a dose is still detectable in urine some 72 hours after administration. www.marvistavet.com /html/body_cyclophosphamide_.html   (564 words)

Medical Dictionary: Cyclophosphamide - WrongDiagnosis.com Cyclophosphamide: A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. Cyclophosphamide : precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent; used in the treatment of lymphomas, leukemias and other cancers, and as an immunosupressive agent to prevent transplant rejection; its side effect, alopecia, has been used for defleecing sheep; may also cause sterility, birth defects, mutations, and cancer. www.wrongdiagnosis.com /medical/cyclophosphamide.htm   (260 words)

Clinical Trial Results Of Cyclophosphamide Treatments In Multiple Sclerosis Cyclophosphamide (CTX) is an Alkylating agent related to Nitrogen Mustards, whose AntiInflammatory and ImmunoSuppressive effects have been utilized to treat selected cases, of Multiple Sclerosis with a Progressive and worsening course. We report the case of a 48-year-old woman with Definite MS diagnosed in 1994 who has been in complete remission since a dose of 3800 mg of Cyclophosphamide was accidentally given intravenously in early 1997. Cyclophosphamide appears to be more efficient in early stage of Progressive Multiple Sclerosis independently of age, relapses or Neurological disability scale. members.tripod.com /~ThJuland/cytoxan2.html   (2773 words)

Cyclophosphamide Cyclophosphamide is a chemotherapy drug used primarily to treat various forms of cancer. Intravenous injections of the antioxidant, glutathione, may protect the bladder from damage caused by cyclophosphamide. A preliminary clinical study of cyclophosphamide with reduced glutathione as uroprotector. www.pccnaturalmarkets.com /health/Drug/Cyclophosphamide.htm   (2959 words)

News - Cyclophosphamide Cancer Therapy May Offer Lupus Patients New Hope Studies at other institutions are using a similar high-dose cyclophosphamide regimen, but also include a bone marrow or stem cell transplantation. Because high doses of cyclophosphamide are toxic to the bone marrow, some investigators collect and re-infuse a portion of the patient's bone marrow and/or stem cells following treatment to quickly repopulate the marrow destroyed by treatment. A larger, randomized trial of high-dose cyclophosphamide without stem cell transplantation versus standard therapy for organ-threatening active lupus is under way at the Johns Hopkins Lupus Center. www.docguide.com /news/content.nsf/news/8525697700573E1885256CAA0052EAEB   (736 words)

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