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Topic: Cyclosporine

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	MedlinePlus Drug Information: Cyclosporine
		Cyclosporine and cyclosporine (modified) are used with other medications to prevent transplant rejection (attack of the transplanted organ by the transplant recipient's immune system) in people who have received kidney, liver, and heart transplants.
		Cyclosporine (modified) is also used alone or with methotrexate (Rheumatrex) to treat the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints) in patients whose symptoms were not relieved by methotrexate alone.
		Cyclosporine and cyclosporine (modified) are also sometimes used to treat Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) and to prevent rejection in patients who have received pancreas or cornea transplants.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601207.html (0 words)

	Patient Education - Cyclosporine
		Cyclosporine (Neoral, Sandimmune, Gengraf) is a potent immunosuppressant medication that is considered a disease modifying antirheumatic drug (DMARD) because it not only decreases the pain and swelling of arthritis but it may also prevent joint damage and reduce the risk of long term disability.
		Cyclosporine, used originally to prevent the rejection of transplanted kidneys, continues to be recommended for a variety of organ transplants.
		Cyclosporine inhibits a group of cells, known as T-lymphocytes, which are important in the immune system and contribute to the development of “autoimmune” diseases, such as rheumatoid arthritis and lupus.
	www.rheumatology.org /public/factsheets/cyclosporine.asp (0 words)

	CycloSPORINE
		Cyclosporine (non-modified): Erratic and incomplete; dependent on presence of food, bile acids, and GI motility; larger oral doses are needed in pediatrics due to shorter bowel length and limited intestinal absorption
		Cyclosporine dosage should be decreased by 25% to 50% in patients with no history of hypertension who develop sustained hypertension during therapy and, if hypertension persists, treatment with cyclosporine should be discontinued.
		Cyclosporine is widely used in the cardiovascular setting, particularly in patients with cardiac transplantation.
	www.umm.edu /altmed/drugs/cyclosporine-034500.htm (4802 words)

	RESTASIS® Professional: Targeted Delivery of LOW-DOSE Cyclosporine
		This emulsion technology provides effective drug delivery to ocular tissue and is effective with a low cyclosporine concentration (0.05%)
		Since the emulsion is designed to solubilize cyclosporine, it ensures penetration into surface tissue at low cyclosporine concentrations
		Other events reported in 1% to 5% of patients included conjunctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging, and visual disturbance (most often blurring).
	www.restasisprofessional.com /_clinical/clinical_targeted.htm (0 words)

	Cyclosporine
		Cyclosporine keeps donor bone marrow from reacting with your immune system and harming your blood vessels, liver, and gut after a bone marrow transplant.
		Cyclosporine may also be used to prevent rejection of solid organ transplants, such as kidney, liver, and heart transplants.
		Cyclosporine can decrease the ability of your body to fight infections, especially if you are taking other medicine for your cancer.
	www.hci.utah.edu /patientdocs/hci/drugs/cyclosporine.htm (689 words)

	Cyclosporine - VeterinaryPartner.com - a VIN company!
		Cyclosporine, sometimes referred to as cyclosporin A, is an immunosuppressive agent produced by the soil fungus Beauvaria nivea.
		Cyclosporine has since been found effective in numerous inflammatory conditions of the canine cornea with effects confined to the eye and minimal absorption into the body.
		In using cyclosporine for the treatment of atopic dermatitis, blood levels are generally not monitored because it is the concentration of drug in the patient's skin (not the blood) that is pertinent and there is no way to measure skin levels of cyclosporine.
	www.veterinarypartner.com /Content.plx?P=A&A=1619&S=0&EVetID=0 (957 words)

	National Psoriasis Foundation: Cyclosporine
		For example, in the case of pustular psoriasis, which can be life threatening, cyclosporine may be the treatment of choice during pregnancy, compared to the pregnancy risks associated with treatments such as methotrexate or Soriatane.
		Dovonex (also known by its generic name calcipotriene) used with low-dose cyclosporine has been shown to be safe and effective for the treatment of severe, chronic plaque psoriasis.
		Cyclosporine is taken daily by mouth and is available as either a capsule or a liquid.
	www.psoriasis.org /treatment/psoriasis/systemics/cyclosporine.php (860 words)

	Cyclosporine
		Cyclosporine, sometimes referred to as "cyclsporin A," is an immunosuppresive agent produced by the soil fungus Beauveria nivia.
		Cyclosporine has since been found effective in numerous inflammatory conditions of the canine cornea with effects confined to the eye and minimal absorption into the body.
		In using cyclosporine for the treatment of atopic dermatitis, blood levels are generally not monitored because it is the concentration of drug in the patient's skin (not the blood) which is pertinent and there is no way to measure skin levels of cyclosporine.
	www.marvistavet.com /html/body_cyclosporine.html (861 words)

	Cyclosporine for rheumatoid arthritis
		Cyclosporine is an immunosuppressive medication, which means that it decreases the action of your body's immune system.
		Cyclosporine is sometimes used for severe rheumatoid arthritis that has not responded to most other DMARD treatment.
		Cyclosporine is most often used to prevent the body from rejecting a newly transplanted organ.
	www.webmd.com /rheumatoid-arthritis/Cyclosporine-for-rheumatoid-arthritis (494 words)

	Cyclosporine - Drugs & Vitamins - Drug Library - DrugDigest
		CYCLOSPORINE (Sandimmune®, Neoral® Gengraf™) is a medication used to decrease the immune system's response to a transplanted organ, which the body would otherwise see as foreign.
		Cyclosporine is used to reduce immune responses and prevent rejection in patients who receive organ or bone marrow transplants.
		Cyclosporine is also used to treat severe rheumatoid arthritis, psoriasis, Crohn's disease or ulcerative colitis.
	www.drugdigest.org /DD/DVH/Uses/0,3915,179\|Cyclosporine,00.html (847 words)

	cyclosporine (Site not responding. Last check: )
		Cyclosporine is derived from a fungus (Beauveria nivea).
		Cyclosporine is used to prevent rejection of transplanted organs (for patients who have received a kidney or heart transplant, for example).
		Cyclosporine is approved for use in the treatment of rheumatoid arthritis and many patients (tens of thousands worldwide) have safely taken Cyclosporine and experienced significant improvement in their rheumatoid arthritis.
	www.midwestarthritis.com /html/cyclosporine.htm (771 words)

	Cyclosporine and Tacrolimus Toxicities
		Both cyclosporine and tacrolimus can reduce blood flow to the kidney which decreases the ability of the kidneys to function.
		In some instances, other medications may be required to treat the side effects from cyclosporine or tacrolimus.
		Grapefruit juice increases the levels of both tacrolimus and cyclosporine in the blood and therefore, it is best to avoid it altogether.
	www.kidneytransplant.org /article-cyclosporineandtacrolimustoxicities.html (429 words)

	Cyclosporine
		If you are taking cyclosporine and wish to use peppermint oil as well, notify your physician in advance, so that your blood levels of cyclosporine can be monitored and your dose adjusted if necessary.
		Acute intoxication of cyclosporin caused by coadministration of decoctions of the fruits of Citrus aurantium and the Pericarps of Citrus grandis.
		Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis.
	healthgate.partners.org /browsing/Content.asp?fileName=21718.xml&title=Cyclosporine (792 words)

	Cyclosporine Information on Healthline
		Cyclosporine is used to prevent your body from rejecting a kidney, liver, or heart transplant.
		Although not approved by the FDA for these purposes, cyclosporine has also been used in the treatment of pancreatic, corneal, bone marrow, and heart/lung transplants; alopecia areata; aplastic anemia; atopic dermatitis; Behcet's disease, biliary cirrhosis, Chron's disease; ulcerative colitis; diabetes; lichen planus; lupus nephritis; multiple sclerosis; myasthenia gravis; and other diseases.
		Cyclosporine is in the FDA pregnancy category C. This means that it is not known whether cyclosporine will harm an unborn baby.
	www.healthline.com /multumcontent/cyclosporine (740 words)

	Cyclosporine
		Cyclosporine is an immunosuppressive medication that prevents organ rejection by interfering with the bodyâs normal immune response.
		Cyclosporine may be taken with water on an empty or full stomach.
		Cyclosporine is generally taken twice a day; take the morning dose with breakfast.
	cms.clevelandclinic.org /transplant/body.cfm?id=152 (1204 words)

	1800PetMeds.com - Cyclosporine (Modified) 100 Mg Caps 30 Ct Btl
		Cyclosporine (Modified) capsule is a selective immunomodulator used for the treatment of atopic dermatitis in dogs.
		Cyclosporine Modified capsule is FDA approved for use in veterinary medicine for dogs at least 6 months of age and at least 4.5 lbs.
		Cyclosporine Modified is not FDA approved for use in veterinary medicine in cats.
	www.1800petmeds.com /pdetail.asp?SK=10466 (722 words)

	Cyclosporine Immunosuppressive Veterinary Medicine for Horses and Dogs
		Cyclosporine is non-cytotoxic, it inhibits T helper cell activity and shifts the regulation of the immune response towards immune tolerance.
		Cyclosporine does not penetrate well into the inner eye and it is therefore seldom used to treat anterior uveitis.
		Cyclosporine is an extremely stable molecule, however stability of the ophthalmic preparation is limited by solubility, oxidation of the vehicle, and sterility.
	www.wedgewoodpharmacy.com /monographs/cyclosporine.asp (1119 words)

	Cyclosporine: The Test
		The test for cyclosporine is ordered to measure the amount of drug in the blood to determine whether drug concentrations have reached therapeutic levels and are not in a toxic range.
		Cyclosporine is associated with several toxic side effects that can be avoided if blood levels are monitored and the dose adjusted if the level detected is too high.
		Cyclosporine is ordered frequently at the start of therapy, often on a daily basis when trying to establish a dosing regimen.
	www.labtestsonline.org /understanding/analytes/cyclosporine/test.html (861 words)

	ACS :: New Light on Cyclosporine
		Cyclosporine, a drug commonly used to help prevent rejection after organ transplantation, may cause cancer cells to become more aggressive, according to study released in the February 11, 1999, issue of Nature.
		Although doctors have known that cyclosporine can increase cancer growth in some patients, this side effect must be weighed against the obvious value of treating the patient?s other life-threatening conditions by organ transplantation.
		If patients are on cyclosporine, they need it, though they should be aware of the study, said Ralph Vogler, MD, scientific program director for the American Cancer Society.
	www.cancer.org /docroot/NWS/content/NWS_3_1x_New_Light_on_Cyclosporine.asp (559 words)

	Cyclosporine, Blood
		Cyclosporine is an immunosuppressive agent derived from Tolypocladium inflatum gams, a fungus originally isolated from a Norwegian soil sample.
		Monitoring blood levels is imperative because the pharmacokinetics of cyclosporine are not only complex, but vary over time in the same patient; thus, blood levels cannot be well predicted from dosing schedules.
		Because results will vary depending on the method and cyclosporine antibody employed (monospecific or polyspecific), it is best for a given patient's specimens to be analyzed at a single laboratory to eliminate as many assay-dependent variables as possible.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/td033700.htm (458 words)

	TopSearch10 - Search Results - cyclosporine side effects (Site not responding. Last check: )
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	cyclosporine-side-effects.tbl.sytes.net (96 words)

	Cyclosporine (Systemic) - MayoClinic.com (Site not responding. Last check: )
		Cyclosporine also is used to treat severe cases of psoriasis and rheumatoid arthritis.
		Cyclosporine lowers your body's resistance and there is a chance you might get the infection the immunization is meant to prevent.
		The dose of cyclosporine for patients with nephrotic syndrome is 3.5 to 5 mg per kg (1.6 to 2.3 mg per pound) of body weight a day.
	www.mayoclinic.com /health/drug-information/DR202176 (2528 words)

	Cyclosporine (Atopica®, Optimmune®) (Site not responding. Last check: )
		Cyclosporine affects calcium-ion uptake in a specific white blood cell (the lymphocyte), rendering that cell ineffective.
		Cyclosporine is prescribed to suppress the immune system in diseases such as immune mediated
		Because cyclosporine has a bitter taste, it may not be easy to administer without placing the medication in a gelcap (gelatin capsule).
	www.petplace.com /drug-library/cyclosporine-atopica-optimmune/page1.aspx (786 words)

	[No title]
		The calcineurin inhibitors tacrolimus and cyclosporine are both associated with an impaired glucose metabolism and with posttransplantation diabetes mellitus (PTDM) in 5 to 35% of all renal transplant recipients (1–9).
		Blood and plasma clearances of cyclosporine were calculated to be 0.36 and 0.47 L hr-1 Kg-1, respectively, and volume of distribution at steady state was calculated to be 1.21 L Kg-1, when cyclosporine was administered without a high fat meal.
		Blood and plasma clearances of cyclosporine were 0.44 and 0.70 L hr-1 Kg-1, respectively, when cyclosporine was administered along with a high fat meal.
	www.lycos.com /info/cyclosporine--studies.html (643 words)

	Cyclosporine(Ophthalmic) - [Medication] (Site not responding. Last check: )
		Cyclosporine ((SYE-kloe-spor-een)) belongs to a class of medicines known as immunosuppressants.
		Cyclosporine eye drops should only be given to pregnant women if needed.
		Hypersensitivity to cyclosporine or any ingredients in cyclosporine—This medicine should not be used if you have these conditions.
	www.luhs.org /health/kbase/htm/mdx-/drde/5004/53/mdx-drde500453.htm (1024 words)

	CHFpatients.com - Heart Transplant - Cyclosporine
		After you go home, your cyclosporine levels will be measured at each clinic visit, which is usually twice a week for the first 2 months, once a week for 2 more months, and once a month for the remainder of your first year.
		Cyclosporine is transformed in your body into about 15 metabolites.
		High cyclosporine levels cause acute poisoning symptoms such as nausea, headache, acute sensitivity of the skin, flushing, gum pain and bleeding, and a sensation of increased stomach size.
	www.chfpatients.com /tx/txcyclosporine.htm (1726 words)

	[No title]
		Gingival hypertrophy is a complication of cyclosporine therapy that affects one fourth to one third of patients receiving renal or cardiac transplants who receive traditional therapy [1].
		Cyclosporine is effective in the treatment of rheumatoid arthritis, but little is known about the prevalence of gingival hypertrophy and the treatment of this condition in patients with rheumatoid arthritis.
		Although higher doses of cyclosporine appear to cause more damage, duration of treatment appears to be the most important factor: the longer one remains on cyclosporine, the greater the damage.
	www.lycos.com /info/cyclosporine--treatment.html (385 words)

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