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Topic: Cynomolgus monkey


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In the News (Thu 8 Jan 09)

  
  Monkey - Wikipedia, the free encyclopedia
Monkeys range in size from the Pygmy Marmoset, at 14-16 cm (5-6 inch) long (plus tail) and 120-140 g (4-5 oz) in weight, to the male Mandrill, almost 1 metre (3 ft) long and weighing 35 kg (75 lb).
While baby monkeys are usually as easy to keep clean as a human infant (by diapering), monkeys that have reached puberty usually remove their diapers and cannot be toilet trained.
The Monkey is the ninth in the 12-year cycle of animals which appear in the Chinese zodiac related to the Chinese calendar.
en.wikipedia.org /wiki/Monkey   (1310 words)

  
 Monkeys in space - Wikipedia, the free encyclopedia
Monkeys from several species were used, including rhesus, cynomolgus, squirrel, and Philippine monkeys as well as pigtailed macaques.
The first monkey astronaut was Albert, a rhesus monkey, who on June 11, 1948 rode to over 63 km (39 miles) on a V2 rocket.
Monkeys Krosh and Ivasha flew on Bion 10 from December 29, 1992 to January 7, 1993.
en.wikipedia.org /wiki/Monkeys_in_space   (804 words)

  
 [No title]
Prevalence and ultrastructure of Sarcocystis in rhesus monkeys.
Pathology of hepatitis A infection in the owl monkey (Aotus trivirgatus).
Pneumocystis infection in macaque monkeys: Macaca fuscata fuscata and Macaca fascicularis.
www.afip.org /CLDavis/syllabi/primates.txt   (12465 words)

  
 European Society of Clinical Microbiology and Infectious Diseases
In the presence of rat, cynomolgus monkey and human liver microsomes, less than 10% of BAL4815 is metabolized during a 120 min period.
BAL4815 is bound to plasma proteins with a free fraction of 3.5%, 3.6% and 2.2% in rat, cynomolgus monkey and human, respectively.
BAL4815 is slowly eliminated with half-lives of 5 h in rat and 10 h in cynomolgus monkey.
www.blackwellpublishing.com /eccmid15/abstract.asp?id=36969   (410 words)

  
 Reproductive Biology and Endocrinology | Full text | Comparative maturation of cynomolgus monkey oocytes in vivoand in ...
Young, adult cynomolgus monkeys were given recombinant human (rh) gonadotropins to stimulate the development of multiple follicles, and oocytes were aspirated 0, 12, 24, or 36 h after injection of an ovulatory dose of rhCG.
Adult female cynomolgus monkeys (Macaca fascicularis) aged 8.5 ± 0.3 years were studied under the approval of the Institutional Animal Care and Use Committee at the Eastern Virginia Medical School and in accordance with the NIH Guide for the Care and Use of Laboratory Animals.
Normally, MII monkey oocytes have a bipolar, barrel-shaped spindle with chromosomes aligned uniformly at the equator plate (Figure 1A, a).
www.rbej.com /content/4/1/14   (5063 words)

  
 Comparison of Human and Monkey Peptide Transporters: PEPT1 and PEPT2   (Site not responding. Last check: 2007-10-24)
Monkey PEPT1 (2127 bp and 708 amino acids) was found to be >94 and >92% identical to human PEPT1 at the cDNA and amino acid level, respectively.
To verify that monkey PEPT1 is a proton-dependent cotransporter and to compare its transport function with that of human PEPT1, the uptake of the hydrolysis-resistant Gly-Sar dipeptide was assessed in mock-transfected cells with an empty vector and cells transfected with vectors containing PEPT1.
Sequence analysis confirmed that this shorter transcript was indeed monkey PEPT2-specific and 411 bp in length, whereas the longer transcript was 600 bp in length and was identical to the wild-type transcript except for an 189 bp insertion.
pubs.acs.org /cgi-bin/sample.cgi/mpohbp/2004/1/i03/html/mp0499712.html   (5995 words)

  
 Studies on the Mechanism of Fibrate-Inhibited Expression of Plasminogen Activator Inhibitor-1 in Cultured Hepatocytes ...
Cynomolgus monkey hepatocytes were incubated for two consecutive periods of 24 hours with different concentrations of gemfibrozil, clofibric acid, clofibrate, and bezafibrate, and the conditioned media were analyzed for PAI-1 antigen as described in the "Methods" section.
Cynomolgus monkey hepatocytes were incubated for 48 hours in the absence (control) or presence of 0.6 mmol/L gemfibrozil.
Cynomolgus monkey hepatocytes were incubated for 5 hours in incubation medium with (+) or without (-) 10 µmol/L of the PKC inhibitor Ro 31-8220.
atvb.ahajournals.org /cgi/content/full/17/1/26   (5164 words)

  
 Molecular Evidence for Distinct Genotypes of Monkey B Virus (Herpesvirus Simiae) Which Are Related to the Macaque Host ...
Cercopithecine herpesvirus 1 (herpesvirus simiae, or monkey B virus [BV]) is an alphaherpesvirus indigenous to macaque monkeys
Monkey kidney cells (Vero) were used to propagate viruses and for all experimental procedures.
In a standard ELISA (A) sera from cynomolgus monkeys (352-84, 267-76, and 410-94), pigtail macaques (91099, 92209, and 90153), and rhesus monkeys (MM339-95, MM336-95, and MM329-95) were tested at a 1:4,000 dilution with antigens prepared from rhesus (E2490), cynomolgus (E90-136), pigtail (Kumquat), and Japanese (7709609) macaques.
jvi.asm.org /cgi/content/full/72/11/9224   (4387 words)

  
 Choriocarcinoma and Teratoma in the Ovary of a Cynomolgus Monkey -- Toyosawa et al. 37 (2): 186 -- Veterinary Pathology
Choriocarcinoma and Teratoma in the Ovary of a Cynomolgus Monkey
teratoma in the contralateral ovary of a cynomolgus monkey (Macaca
Lindsey JR, Wharton LR, Jr Woodruff JD, Baker HJ: Intrauterine choriocarcinoma in a rhesus monkey.
www.vetpathology.org /cgi/content/full/37/2/186   (881 words)

  
 Comparative in vitro metabolism of indinavir in primates--a unique stereoselective hydroxylation in monkey.
The in vitro metabolism of indinavir (CRIXIVAN, MK-0639, L-735,524), an HIV protease inhibitor, was evaluated using liver microsomes from cynomolgus monkey, rhesus monkey, chimpanzee and human.
The cis-(indan)hydroxylated metabolite of indinavir was formed only in cynomolgus and rhesus monkey livers, whereas trans-(indan)hydroxylation and N-dealkylation were observed as the major metabolites in all primates tested.
The present study has demonstrated that monkeys were unique in their abilities to form the stereoselective metabolite and were not appropriate surrogates for the qualitative prediction of indinavir metabolism in human.
www.aegis.com /aidsline/2000/jun/A0061324.html   (450 words)

  
 Bartonella quintana in Cynomolgus Monkey | CDC EID
A young adult female cynomolgus monkey (Macaca fascicularis), born October 1, 1998, in a breeding facility in Vietnam, was shipped on February 28, 2001, to Covance Inc. (Alice, TX, USA), where she was quarantined and acclimated by the vendor.
Confinement practices used for monkey 1505 should have eliminated or substantially restricted possible exposure to insect vectors, such as the human body louse (Pediculus humanis).
Persistent infection was suspected but was not documented in this monkey because of the delay in bacterial identification.
www.cdc.gov /ncidod/eid/vol11no12/03-0045.htm   (1856 words)

  
 BioMed Central | Full text | Analysis of 10,000 ESTs from lymphocytes of the cynomolgus monkey to improve our ...
Because the cynomolgus monkey serves as an ideal animal model for in vivo HIV and other simian virus infections [1-5], HIV vaccine trials [6], organ transplantations [7,8], tuberculosis [9], and stress-related mood disorders in females [10], such knowledge could be critical to basic genetic and clinical studies.
By comparing the novel transcripts in cynomolgus monkeys with the human genome and mapping these transcripts to human and chimpanzee chromosomes, we could isolate new genes that may not be present in current gene annotation reservoirs of both species.
The cynomolgus monkey is one of the most widely used surrogate animal models for an increasing number of human diseases and vaccines, such as HIV and heart transplantation.
www.biomedcentral.com /1471-2164/7/82   (6138 words)

  
 Bioavailability and Pharmacokinetics of Dehydroepiandrosterone in the Cynomolgus Monkey -- Leblanc et al. 88 (9): 4293 ...
Bioavailability and Pharmacokinetics of Dehydroepiandrosterone in the Cynomolgus Monkey -- Leblanc et al.
Bioavailability and Pharmacokinetics of Dehydroepiandrosterone in the Cynomolgus Monkey
4-androstenedione, dehydroepiandrosterone and oestradiol-17ß in the crab-eating monkey (Macaca fascicularis) from birth to adulthood.
jcem.endojournals.org /cgi/content/full/88/9/4293   (5084 words)

  
 A Single Amino Acid Difference between Human and Monkey Interleukin (IL)-1beta Dictates Effective Binding to Soluble ...
To determine sIL1R-II binding by monkey IL-1 in in vitro assays, the cDNAs for cynomolgus monkey (Macaca fascicularis) and
cloned from cynomolgus monkey, and the cDNA corresponding to the
Cynomolgus and rhesus IL1R-II were found to be identical (not shown).
www.jbc.org /cgi/content/full/277/49/47619   (4626 words)

  
 Histochemical detection and quantification of macrophages in rhesus and cynomolgus monkey atherosclerotic lesions -- ...
Histochemical detection and quantification of macrophages in rhesus and cynomolgus monkey atherosclerotic lesions -- Davis et al.
experimental atherogenesis in rhesus and cynomolgus monkeys was performed.
cholesterol levels were higher in the cynomolgus monkeys than in the rhesus
www.jhc.org /cgi/content/abstract/32/12/1319   (229 words)

  
 Molecular characterization and organ distribution of type A and B cholecystokinin receptors in cynomolgus monkey -- ...
Molecular characterization and organ distribution of type A and B cholecystokinin receptors in cynomolgus monkey -- Holicky et al.
The cynomolgus type B CCK receptor was also closely related to the human receptor (96% conserved).
Cynomolgus receptors are most closely related to human receptors.
ajpgi.physiology.org /cgi/content/full/281/2/G507   (3595 words)

  
 Hepatic Alveolar Echinococcosis in Cynomolgus Monkeys (Macaca fascicularis) -- Bacciarini et al. 41 (3): 229 -- ...
Hepatic Alveolar Echinococcosis in Cynomolgus Monkeys (Macaca fascicularis) -- Bacciarini et al.
Hepatic Alveolar Echinococcosis in Cynomolgus Monkeys (Macaca fascicularis)
Sex, age, microscopic features in the liver and results of serology, and PCR assays in 12 cynomolgus monkeys with alveolar echinococcosis.
www.vetpathology.org /cgi/content/full/41/3/229   (2144 words)

  
 Directory of open access journals
Cynomolgus monkey testicular cDNAs for discovery of novel human genes in the human genome sequence
In order to contribute to the establishment of a complete map of transcribed regions of the human genome, we constructed a testicular cDNA library for the cynomolgus monkey, and attempted to find novel transcripts for identification of their human homologues.
In this report, we determined 302 full-insert sequences of cynomolgus monkey cDNAs with enough length of open reading frames to discover novel transcripts as human homologues.
www.doaj.org /abstract?id=81732&toc=y   (301 words)

  
 Effect of Vasectomy on Gene Expression in the Epididymis of Cynomolgus Monkey -- Doiron et al. 68 (3): 781 -- Biology ...
The histology of monkey epididymis was not affected at 3 and
Sections of monkey proximal (lanes 1, 7) and distal (lanes 2, 8) caput, proximal (lanes 3, 9) and distal (lanes 4, 10) corpus, and proximal (lanes 5, 11) and distal (lanes 6, 12) cauda were probed with a P31m, HE1-l, HE2-l, or HE5-l cDNA.
Cryosections of monkey proximal (A, B) and distal (C, D) caput, proximal (E, F) and distal (G, H) corpus, and proximal (I, J) and distal (K, L) cauda segments of the epididymis were probed with DIG-labeled antisense or sense (negative control; F*) HE2-l cRNA.
www.biolreprod.org /cgi/content/full/68/3/781   (4203 words)

  
 Regeneration through nerve allografts in the cynomolgus monkey (Macaca fascicularis) -- Tajima et al. 73 (2): 172 -- ...
Regeneration through nerve allografts in the cynomolgus monkey (Macaca fascicularis) -- Tajima et al.
With the use of ulnar nerves of cynomolgus monkeys, the present study
monkey, at a level that corresponded to that from which the graft was
www.ejbjs.org /cgi/content/abstract/73/2/172   (449 words)

  
 A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease -- ...
A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease -- Pennathur et al.
Concentrations of (a) ortho-tyrosine, (b) meta-tyrosine, (c) o,o’-dityrosine, and (d) 3-nitrotyrosine in aortic proteins of cynomolgus monkeys as a function of glycated hemoglobin.
Litwak, K.N., Cefalu, W.T., and Wagner, J.D. Chronic hyperglycemia increases arterial low-density lipoprotein metabolism and atherosclerosis in cynomolgus monkeys.
www.jci.org /cgi/content/full/107/7/853   (5066 words)

  
 STAT3 Is Dispensable for Maintenance of Self-Renewal in Nonhuman Primate Embryonic Stem Cells -- Sumi et al. 22 (5): ...
Cynomolgus monkey ES cells were transiently transfected with
Differentiation of cynomolgus monkey embryonic stem cells in a feeder cell–free culture.
Suemori H, Nakatsuji N. Growth and differentiation of cynomolgus monkey ES cells.
stemcells.alphamedpress.org /cgi/content/full/22/5/861   (5182 words)

  
 Effects of Various Extenders and Permeating Cryoprotectants on Cryopreservation of Cynomolgus Monkey (Macaca ...
Cranfield MR, Kempske SE, Schaffer N. The use of in vitro fertilization and embryo transfer techniques for the enhancement of genetic diversity in the captive population of the lion-tailed macaque.
Holt WV, Wilton LJ, Marshall VS. Cryopreservation of spermatozoa from the marmoset monkey (Callithrix jacchus).
Cryopreservation of vervet monkey semen and recovery of progressively motile spermatozoa.
www.andrologyjournal.org /cgi/content/full/26/3/387   (4195 words)

  
 Distribution of Uridine Diphosphate-Glucuronosyltransferase (UGT) Expression and Activity in Cynomolgus Monkey Tissues: ...
Distribution of Uridine Diphosphate-Glucuronosyltransferase (UGT) Expression and Activity in Cynomolgus Monkey Tissues: Evidence for Differential Expression of Steroid-Conjugating UGT Enzymes in Steroid Target Tissues -- Albert et al.
A, The expression of UGT transcripts was assessed in total RNA from monkey tissues by RT-PCR analysis, using oligonucleotides specific for UGT1A or UGT2B.
The level of activity in the tissues in A is higher than that in the tissues in B, as indicated by the scales of the vertical axes.
endo.endojournals.org /cgi/content/full/141/7/2472   (5199 words)

  
 CD4/GP120mac251 interaction induces phospholipase A2 (PLA2) activation in cynomolgus monkey lymphocytes.
CD4/GP120mac251 interaction induces phospholipase A2 (PLA2) activation in cynomolgus monkey lymphocytes.
Cynomolgus monkey are susceptible to infection with select simian immunodeficiency virus (SIV).
We investigated the early interactions between SIV envelope glycoproteins (gp120mac251) and macaque lymphocytes.
www.aegis.com /aidsline/1999/may/A9950300.html   (357 words)

  
 Plasma Lipoprotein Profile in the Male Cynomolgus Monkey under Normal, Hypogonadal, and Combined Androgen Blockade ...
In summary, in the cynomolgus monkey, GDX and CAB induced opposite
various peripheral tissues of the cynomolgus monkey (34).
Gupta SV, Khosla P 2001 Palmitic and stearic acids similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid.
jcem.endojournals.org /cgi/content/full/89/4/1849   (4527 words)

  
 Cloning, expression, and functional characterization of cynomolgus monkey (Macaca fascicularis) CC chemokine receptor 1 ...
Cloning, expression, and functional characterization of cynomolgus monkey (Macaca fascicularis) CC chemokine receptor 1 -- Gupta et al.
Cloning, expression, and functional characterization of cynomolgus monkey (Macaca fascicularis) CC chemokine receptor 1
we cloned the cynomolgus monkey CCR1 (cCCR1) gene, and the sequence
www.jleukbio.org /cgi/content/abstract/78/5/1175   (305 words)

  
 Definition of monkey - Merriam-Webster Online Dictionary
2 a : a person resembling a monkey b : a ludicrous figure :
4 : a desperate desire for or addiction to drugs -- often used in the phrase monkey on one's back; broadly : a persistent or annoying encumbrance or problem
For More Information on "monkey" go to Britannica.com
www.merriam-webster.com /dictionary/monkey   (157 words)

  
 Apolipoprotein A-I metabolism in cynomolgus monkey. Identification and characterization of beta-migrating pools -- ...
antibody to cynomolgus monkey apolipoprotein (apo) A-I. Two bands were
precipitated by antibody to cynomolgus monkey apo B. The apo A-I(50 kD)
monkey, which must be taken into consideration in any comprehensive model
atvb.ahajournals.org /cgi/content/abstract/9/4/470   (505 words)

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