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Topic: Cyproheptadine

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	Cyproheptadine (Periactin®)
		Cyproheptadine is one type of antihistamine that inhibits the action of histamine, particularly its effect on H1 receptors.
		Cyproheptadine should not be used in animals with known hypersensitivity or allergy to the drug.
		Cyproheptadine should be used with caution in animals with glaucoma, prostate gland enlargement, heart failure or gastrointestinal obstructions.
	www.petplace.com /drug-library/cyproheptadine-periactin/page1.aspx (810 words)

	Data Sheet
		Cyproheptadine is not a hormone, but has effects on certain endocrine systems, in humans possibly as a result of its antiserotonin activity.
		The oral LD50 of cyproheptadine is 123 mg/kg, and 295 mg/kg in the mouse and rat, respectively.
		Cyproheptadine hydrochloride is a white to slightly yellowish crystalline solid, with a molecular weight of 350.89, which is soluble in water to the extent of about 4 mg per ml, freely soluble in methanol, sparingly soluble in ethanol, soluble in chloroform, and practically insoluble in ether.
	www.medsafe.govt.nz /profs/datasheet/p/periactintab.htm (2075 words)

	MedlinePlus Drug Information: Cyproheptadine
		Cyproheptadine, an antihistamine, relieves red, irritated, itchy, watery eyes; sneezing; and runny nose caused by allergies, hay fever, and the common cold.
		Cyproheptadine comes as tablets and a liquid to take by mouth.
		Cyproheptadine also is used to stimulate appetite and weight gain.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682541.html (623 words)

	Cyproheptadine - Wikipedia, the free encyclopedia
		Cyproheptadine is used in the treatment of allergies (specifically Hay fever) and is also used to stimulate appetite in underweight people (e.g.
		Cyproheptadine may also be used to combat SSRI-induced sexual dysfunction, but is used cautiously in this manner due to the fact that it may reverse the effects of the SSRI.
		Cyproheptadine is also used for the treatment of Cushing's Syndrome, the treatment of serotonin reactions secondary to meperidine, and may be used, though rarely, as a prophylactic drug for migraine headaches.
	en.wikipedia.org /wiki/Cyproheptadine (199 words)

	cyproheptadine - Drug Finder - MSN Health & Fitness (Site not responding. Last check: 2007-10-22)
		Cyproheptadine blocks the effects of the naturally occurring chemical histamine in your body.
		Cyproheptadine is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.
		Cyproheptadine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby.
	health.msn.com /drugfinder/articlepage.aspx?cp-documentid=100106547 (1170 words)

	Is there any evidence to support the use of Periactin (cyproheptadine hydrochloride) to stimulate appetite ? : NLH ...
		Cyproheptadine, with vitamins, increased weight gain compared to placebo, but produced hypersomnia in 60% of participants (as well as stomatitis).
		In this small study Subjects in the cyproheptadine (CH) group showed significant increases in weight (mean 3.45 kg vs. 1.1 kg in the placebo group).
		Cyproheptadine is an effective appetite stimulant in cystic fibrosis.
	www.clinicalanswers.nhs.uk /index.cfm?question=2801 (763 words)

	Cyproheptadine
		Hypersensitivity to cyproheptadine or any component of the formulation; narrow-angle glaucoma; bladder neck obstruction; acute asthmatic attack; stenosing peptic ulcer; GI tract obstruction; concurrent use of MAO inhibitors; avoid use in premature and term newborns due to potential association with SIDS
		Do not use in neonates, safety and efficacy have not been established in children <2 years of age; symptomatic prostate hypertrophy; antihistamines are more likely to cause dizziness, excessive sedation, syncope, toxic confusion states, and hypotension in the elderly.
		May stimulate appetite; in case reports, cyproheptadine has promoted weight gain in anorexic adults.
	www.umm.edu /altmed/ConsDrugs/Cyproheptadinecd.html (861 words)

	Definition of cyproheptadine - NCI Dictionary of Cancer Terms
		A drug that is used to treat asthma, allergies, and colds, and to relieve itching caused by certain skin disorders.
		It has also been used to stimulate appetite and weight gain, and is being studied in the treatment of weight loss caused by cancer and its treatment.
		Cyproheptadine belongs to the family of drugs called antihistamines.
	www.cancer.gov /Templates/db_alpha.aspx?print=1&cdrid=340927 (65 words)

	Cyproheptadine
		Cyproheptadine is an antihistamine that may be used to prevent an allergic reaction.
		Cyproheptadine is useful to relieve allergic symptoms; however, it will not cure the underlying disease.
		There may be other symptoms for which your veterinarian may prescribe cyproheptadine.
	www.cpvh.com /Pharmacy/ph16.html (354 words)

	Triprolidine Hydrochloride Drug Information, Professional (Site not responding. Last check: 2007-10-22)
		Transfusion reactions, urticarial (treatment)— Antihistamines are indicated for the symptomatic treatment of pruritus associated with allergic reactions and of mild, uncomplicated allergic skin manifestations of urticaria and angioedema, in dermatographism, and in urticaria associated with transfusions.
		Cyproheptadine has been used in the treatment of Cushing's disease because of its pronounced antiserotonin properties, which may decrease corticotropin release.
		Cyproheptadine may also provide antidiarrheal action against intestinal hypermotility associated with the excessive production of serotonin in patients with carcinoid tumors, and in some other conditions involving the release of serotonin.
	www.drugs.com /MMX/Triprolidine_Hydrochloride.html (8020 words)

	Pharmacological Characterization of an Adenylyl Cyclase-Coupled 5-HT Receptor in Aplysia: Comparison With Mammalian ... (Site not responding. Last check: 2007-10-22)
		Note that at the early time point, when perfusion with cyproheptadine first reduced excitability (2 to 4 min after the onset of the exposure), the excitability increase with the lower test current was almost completely eliminated, whereas the excitability increase with the higher test current was not significantly reduced.
		Note that the excitability increase with the lower test current was reversed almost immediately at the start of the cyproheptadine exposure, whereas the excitability increase with the higher test current was blocked gradually and was nearly complete after 4 min of cyproheptadine exposure.
		in the affinity of cyproheptadine for the 5-HT apAC
	jn.physiology.org /cgi/content/full/89/3/1440 (8967 words)

	PharmGKB: antihistamines
		Cyproheptadine may be particularly useful for cold urticaria, dermatitis including neurodermatitis and neurodermatitis circumscripta, eczema, eczematoid dermatitis, mild local allergic reactions to insect bites, angioneurotic edema, drug and serum reactions, anogenital pruritus and pruritus of chickenpox.
		Cyproheptadine is used as an appetite stimulant, in adults and children.
		Cyproheptadine is used for treatment of vascular headaches, such as migraine and histamine cephalalgia.
	www.pharmgkb.org /do/serve?objId=621&objCls=DrugProperties (2060 words)

	Cyproheptadine in cats
		Cyproheptadine is sometmes used in cats to stimulate their appetite.
		The objective of this study including 6 healthy cats was to determine disposition of cyproheptadine hydrochloride in cats after intravenous or oral administration of a single dose.
		On the basis of pharmacokinetic parameters determined in this study, the oral form of cyproheptadine appears to be suitable for use in clinical trials to treat anorexia in cats.
	www.vetcontact.com /en/art.php?a=1146&t= (436 words)

	Central Anticholinergic Syndrome on Therapeutic Doses of Cyproheptadine -- Watemberg et al. 103 (1): 158 -- Pediatrics (Site not responding. Last check: 2007-10-22)
		Cyproheptadine hydrochloride is a potent serotonin and histamine antagonist with anticholinergic and sedative effects.
		Cyproheptadine may cause adverse effects that are related to its different pharmacologic mechanisms of action.
		Cyproheptadine overdose has occasionally been reported as a cause of CAS in children.
	pediatrics.aappublications.org /cgi/content/full/103/1/158 (1857 words)

	Cyproheptadine - Patient UK
		Cyproheptadine is used to prevent and relieve allergic conditions such as hay fever and some allergic skin reactions.
		Cyproheptadine is also occasionally used to prevent migraines.
		Cyproheptadine may cause your skin to become more sensitive to sunlight than it is usually.
	www.patient.co.uk /showdoc/30002737 (739 words)

	Cyproheptadine - Buy Cyproheptadine Online - Fda approved Cyproheptadine without a Prescription at NPMeds.com
		Cyproheptadine is Dispatched from outside the United States.
		If Cyproheptadine will not be delivered to you within 20 days, we will repeat the sending or we will return your money.
		Common misspellings of Cyproheptadine: xyproheptadine, vyproheptadine, ctproheptadine, cuproheptadine, cyoroheptadine, cy[roheptadine, cypeoheptadine, cyptoheptadine, cypriheptadine, cyprpheptadine, cyprogeptadine, cyprojeptadine, cyprohiptadine, cyprohwptadine, cyproheotadine, cyprohe[tadine, cyprohepradine, cyprohepyadine, cyproheptodine, cyproheptsdine, cyproheptasine, cyproheptafine, cyproheptadene, cyproheptadune, cyproheptadibe, cyproheptadime, cyproheptadini, cyproheptadinw,
	www.npmeds.com /fda/online/Cyproheptadine.shtml (237 words)

	Periactin cyproheptadine at discount prices from Canadian Online Pharmacy
		Periactin (cyproheptadine) is an antihistamine used to treat or prevent symptoms of hay fever and other allergies.
		Periactin (cyproheptadine) may be recommended by your doctor or pharmacist as a source of calcium.
		Periactin (cyproheptadine) is only to be used by the patient for whom it is prescribed.
	www.candrugstore.com /SiteMap/Periactin_cyproheptadine.htm (786 words)

	AACAP: Cyproheptadine Might Be Helpful for Stimulant-Induced Weight Loss (Site not responding. Last check: 2007-10-22)
		MIAMI BEACH, FL -- October 21, 2003 -- Cyproheptadine, an antihistamine, might be a remedy for stimulant-induced weight loss in youths being treated for psychiatric disorders, according to preliminary research presented here on October 18th at the 50th Anniversary Meeting of the American Academy of Child and Adolescent Psychiatry.
		The investigators conducted a chart review of 28 child psychiatry outpatients who were prescribed cyproheptadine for insomnia or weight loss while on consistent or increasing doses of stimulants.
		The nightly cyproheptadine dose was 4-8 mg/day for a mean final dose of 4.9 mg/day.
	www.pslgroup.com /dg/23ca62.htm (434 words)

	Periactin Online, Description, Chemistry, Ingredients, Blackbox - Cyproheptadine - RxList Monographs
		Cyproheptadine HCl, is an antihistaminic and antiserotonergic agent.
		Cyproheptadine hydrochloride is a white to slightly yellowish crystalline solid, with a molecular weight of 350.89, which is soluble in water, freely soluble in methanol, sparingly soluble in ethanol, soluble in chloroform, and practically insoluble in ether.
		Cyproheptadine hydrochloride is available for oral administration in 4 mg tablets.
	www.rxlist.com /cgi/generic/cyprohept.htm (153 words)

	Cyproheptadine for Posttraumatic Nightmares -- RIJNDERS et al. 157 (9): 1524 -- Am J Psychiatry (Site not responding. Last check: 2007-10-22)
		A woke up in panic from her "usual nightmare." At that time no signs of sleep paralysis or EEG abnormalities were present on polysomnography.
		Cyproheptadine therapy was prescribed at up to 12 mg at 10:00 p.m.
		Her serum level of cyproheptadine 12 hours after intake of 12 mg was 6 µg/liter.
	ajp.psychiatryonline.org /cgi/content/full/157/9/1524-a (511 words)

	Healthopedia.com - Cyproheptadine Hydrochloride (Oral) - Drugs Information, Side Effects, & Interactions
		You should not use this medicine if you have ever had an allergic reaction to cyproheptadine or MAO inhibitors such as Marplan®, Nardil®, or Parnate®.
		You should not take cyproheptadine if you are breastfeeding, or have glaucoma, stomach ulcers, bladder or intestine problems, or an enlarged prostate.
		Cyproheptadine should not be taken if you are also taking a monoamine oxidase (MAO) inhibitor such as Nardil®, Marplan®, or Parnate®.
	www.healthopedia.com /drugs/quick/cyproheptadine-hydrochloride (515 words)

	NEJM -- Suppression of aldosterone by cyproheptadine in idiopathic aldosteronism (Site not responding. Last check: 2007-10-22)
		To study the role of serotonin in regulating the release of aldosterone, we gave single, oral doses of cyproheptadine, an antiserotoninergic agent, to five normal volunteers with high aldosterone levels secondary to sodium deprivation and to 14 patients with aldosteronism (six with idiopathic aldosteronism due to bilateral adrenal hyperplasia and eight with adrenal adenoma).
		A diet containing 150 mmol of sodium was given to the patients with spontaneous aldosteronism, and one containing 10 mmol of sodium was given to the normal subjects, for three days before treatment and throughout the study.
		Serum aldosterone was measured with the subject in the recumbent position before cyproheptadine administration and at 30-minute intervals for two hours afterward.
	content.nejm.org /cgi/content/abstract/305/4/181 (291 words)

	Doxylamine Succinate Drug Information, Professional
		-receptor) — Azatadine; Brompheniramine ; Cetirizine ; Chlorpheniramine ; Clemastine ; Cyproheptadine ; Desloratadine ; Dexchlorpheniramine ; Dimenhydrinate ; Diphenhydramine ; Doxylamine ;
		Well-controlled studies with azatadine, brompheniramine, chlorpheniramine, clemastine, cyproheptadine, dexchlorpheniramine, dimenhydrinate, and loratadine in humans have not been done.
		thickening of mucus — with cyproheptadine, dexchlorpheniramine and diphenhydramine
	www.drugs.com /MMX/Doxylamine_Succinate.html (8020 words)

	Cyproheptadine
		Cyproheptadine is used to treat hay fever and skin rashes and eye inflammation caused by
		Drinking alcoholic beverages while taking cyproheptadine may enhance side effects common to both, such as drowsiness and dizziness.
		For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb.
	www.gianteagle.com /healthnotes/Drug/Cyproheptadine.htm (309 words)

	Medical Dictionary: Cyproheptadine - WrongDiagnosis.com
		Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
		Cyproheptadine : serotonin antagonist and histamine H1 blocker used as an antipruritic, appetite stimulant, antiallergic, and to treat the post\-gastrectomy dumping syndrome.
		Because many drug names share similar spellings or sound almost identical when spoken, it is possible to mistake the name of a particular medication.
	www.wrongdiagnosis.com /medical/cyproheptadine.htm (281 words)

	Cyproheptadine
		Cyproheptadine is an antihistamine in many ways similar to other antihistamines with which we are more familiar.
		The histamine receptors we usually want to inactivate in combating allergic reactions are called “H1” receptors and this is the type inactivated by cyproheptadine.
		Cyproheptadine is best avoided in patients with glaucoma, recovering from urinary blockage, and heart failure patients.
	www.marvistavet.com /html/body_cyproheptadine.html (221 words)

	Periactin Pharmacology, Pharmacokinetics, Studies, Metabolism - Cyproheptadine - RxList Monographs
		Cyproheptadine is serotonin and histamine antagonist with anticholinergic and sedative effects.
		C-labeled cyproheptadine HCl in normal subjects, given as tablets or syrup, 2-20% of the radioactivity was excreted in the stools.
		No detectable amounts of unchanged drug were present in the urine of patients on chronic 12-20 mg daily doses of cyproheptadine syrup.
	www.rxlist.com /cgi/generic/cyprohept_cp.htm (202 words)

	Cyproheptadine - Drugs & Vitamins - Drug Library - DrugDigest
		It relieves symptoms of hay fever (seasonal rhinitis), hives (rash or itching), inflammation of the eyes (pink eye, allergic conjunctivitis), and other mild allergic conditions.
		Take cyproheptadine with food or milk if it upsets your stomach.
		Cyproheptadine may cause dry eyes and blurred vision.
	www.drugdigest.org /DD/DVH/Uses/0,3915,180\|Cyproheptadine,00.html (521 words)

	Cyproheptadine - The Merck Veterinary Manual
		Because of serotonin’s role in allergen-induced bronchoconstriction in cats, the serotonin antagonist cyproheptadine (2 mg, PO, sid-bid) may be used as an adjunct to glucocorticoids and bronchodilators to block bronchoconstriction in chronically asthmatic cats.
		Because of its long elimination half-life (12 hr), it requires several days to reach steady-state concentrations and may take 4-7 days to be clinically effective.
		Cyproheptadine’s serotonin antagonism in the appetite center stimulates appetite, so weight gain may be a problem.
	www.merckvetmanual.com /mvm/htm/bc/190907.htm (99 words)

	Acute Effects of Bromocriptine, Cyproheptadine, and Valproic Acid on Plasma Adrenocorticotropin Secretion in Nelson's ... (Site not responding. Last check: 2007-10-22)
		PMS of plasma ACTH (relative to the mean level at 0800–1000 h) in six patients with Nelson’s syndrome after single doses of bromocriptine (2.5 mg), cyproheptadine (8 mg), valproic acid (1 g), cyproheptadine plus valproic acid (Cypro + Valpro), or the combination of all three drugs.
		1978 Cyproheptadine treatment of Nelson’s syndrome: restoration of plasma ACTH circadian periodicity and reversal of response to TRF.
		1985 Concomitant suppression of plasma ACTH and beta-endorphin-like immunoreactivity by cyproheptadine, naloxone and somatostatin in the ectopic ACTH syndrome.
	jcem.endojournals.org /cgi/content/full/82/2/514 (2432 words)

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