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Topic: Cystine


In the News (Wed 8 Oct 08)

  
  Cystine definition - Medical Dictionary definitions of popular medical terms
Cystine: An amino acid that is particularly notable because it is the least soluble of all of the naturally occurring amino acids and because it precipitates out of solution in the genetic disease cystinuria to form stones in the urinary tract.
Cystine is the chief sulfur-containing compound in protein.
Cystine is generated by the union of two cysteine molecules and so is sometimes called dicysteine.
www.medterms.com /script/main/art.asp?articlekey=7733   (129 words)

  
  Cystine - Wikipedia, the free encyclopedia
Cystine was discovered in 1810 but was not recognized as a component of proteins until it was isolated from the horn of a cow in 1899.
Cystine is an oxidized dimeric form of cysteine.
Cystine is the preferred form of cysteine for the synthesis of glutathione in cells involved in the immune function including macrophages and astrocytes.
en.wikipedia.org /wiki/Cystine   (666 words)

  
 Cystine
Cystine is a nonessential, sulfur-containing amino acid that is formed from the oxidation of the amino acid cysteine.
Cystine also aids in the formation of carotene which is an agent of hair growth and health.
A deficiency of cystine is very unlikely, however, certain chronic diseases inhibit the formation of cysteine from methionine and may result in a cystine deficiency.
www.supplementnews.org /cystine/index.htm   (644 words)

  
 Cystinosis - Wikipedia, the free encyclopedia
It is caused by abnormal transport of the amino acid cystine from lysosomes of all tissues, resulting in a massive intra-lysosomal cystine accumulation.
Via an as yet unknown mechanism, lysosomal cystine appears to amplify apoptosis such that cells die inappropriately, leading to loss of renal epithelial cells, accounting for the renal Fanconi syndrome, and similar loss in other tissues can account for the short stature, retinopathy, and other features of the disease.
The cause of cystinosis is due to a mutation in the gene CTNS which codes for cystinosin, the lysosomal cystine transporter.
en.wikipedia.org /wiki/Cystinosis   (649 words)

  
 Cystinuria
In addition to excess levels of the amino acid cystine, high amounts of the amino acids lysine, arginine, and ornithine are found in the urine.
When excess cystine crystals clump together to form a stone, the stone can block portions of the interior of the kidney or the tube (the ureter) that connects the kidney to the urinary bladder.
These cystine stones can be painful, and depending upon where the stone becomes trapped, the pain can be felt in the lower back or the abdomen.
www.healthatoz.com /healthatoz/Atoz/ency/cystinuria.jsp   (1081 words)

  
 Urolithiasis-Cystine in Dogs
Cystine urolithiasis is most common in male dogs with an average age of onset of three to five years.
Cystinuria (presence of cystine in the urine) is a predisposing factor.
Cystinuria is an inborn error of metabolism characterized by defective transport of cystine by the tubular cells of the kidneys.
www.petplace.com /dogs/urolithiasis-cystine-in-dogs/page1.aspx   (823 words)

  
 Home | aHealthyme.com
In addition to excess levels of the amino acid cystine, high amounts of the amino acids lysine, arginine, and ornithine are found in the urine.
When excess cystine crystals clump together to form a stone, the stone can block portions of the interior of the kidney or the tube (the ureter) that connects the kidney to the urinary bladder.
These cystine stones can be painful, and depending upon where the stone becomes trapped, the pain can be felt in the lower back or the abdomen.
www.ahealthyme.com /article/gale/100084427   (1105 words)

  
 eMedicine - Cystinuria : Article by Chandra Shekhar Biyani, MBBS, MS, DUrol, FRCS (Urol), FEBU
Cystine is absorbed in the small intestine in a manner similar to that of the kidneys.
Cystine is one of the sulfur-containing amino acids; therefore, the urine may have the characteristic odor of rotten eggs.
Pak CY, Fuller CJ: Assessment of cystine solubility in urine and of heterogeneous nucleation.
www.emedicine.com /med/topic498.htm   (8881 words)

  
 AllRefer Health - Cystinuria (Cystine Stones, Stones - Cystine)
The disorder is usually diagnosed after an episode of stones, where analysis of the composition of the stones indicates cystine.
Less than 3% of known urinary tract stones are cystine stones.
Cystine stones are most common in young adults under age 40.
health.allrefer.com /health/cystinuria-info.html   (473 words)

  
 THE MERCK MANUAL, Sec. 19, Ch. 261, Congenital Anomalies
An inherited defect of the renal tubules in which resorption of the amino acid cystine is impaired, urinary excretion is increased, and cystine stones often form in the urinary tract.
The primary defect is diminished renal tubular resorption of cystine, which increases cystine concentration in the urine.
Cystine is poorly soluble in acidic urine; when its urinary concentration exceeds its solubility, precipitation results, both as crystals and stones.
www.merck.com /pubs/mmanual/section19/chapter261/261k.htm   (1351 words)

  
 Smart Basics - Smart Basics Glossaries--Citruline: Smart Basics   (Site not responding. Last check: 2007-10-22)
Both cystine and cysteine are rich in sulphur and can be readily synthesized by the body.
Cystine is found abundantly in hair keratin, insulin and certain digestive enzymes.
Cystine or cysteine is needed by the body for proper utilization of vitamin B6.
www.ehot.com /smartbasics/cystine_glos.html   (305 words)

  
 *Cystinuria Clearinghouse*
Cystinuria (also called cystine stone disease) is a rare, internal disorder of the function of the necessary amino acids cystine, methionine, arginine, orthinine, and lysine, that results in chronic and erratic cystine kidney stone production.With the exception of methionine, the others have been anagrammed COLA for an easy remembrance.
Cystine stones are the hardest of all kidney stones in composition, so this means they are the hardest to dissolve and break up.
Cystine is the building block for hair, skin, and nails, and you may notice harder nails at certain times or changes in hair or skin.
cystinuriaclearinghouse.com /index.html   (18459 words)

  
 Stimulation of cystine uptake by nitric oxide: regulation of endothelial cell glutathione levels -- Li et al. 276 (4): ...
for induced cystine uptake in the elevation in GSH.
Cystine uptake was determined in presence or absence of glutamate (5 mM) in uptake assay buffer.
Cystine uptake was determined in presence or absence of acivicin (5 mM) added to uptake assay buffer.
ajpcell.physiology.org /cgi/content/full/276/4/C803   (5288 words)

  
 Biochemical Characterization of Cystine Lyase from Broccoli (Brassica oleracea Var. italica)   (Site not responding. Last check: 2007-10-22)
Biochemical Characterization of Cystine Lyase from Broccoli (Brassica oleracea Var.
Cystine lyase is the enzyme responsible for off-aroma deterioration in fresh unblanched broccoli.
The molecular weight of cystine lyase was determined to be 100 kDa by three methods, with two subunits of 48 kDa each and a carbohydrate content of 3%.
pubs.acs.org /cgi-bin/abstract.cgi/jafcau/1999/47/i06/abs/jf981153x.html   (193 words)

  
 Cystine   (Site not responding. Last check: 2007-10-22)
A little cystine occurs free in blood, but the rest is utilized in protein formation, helping to hold proteins together as they travel around the body.
Cystine has detoxification properties that have proven to protect the body from the absorption of excess copper and against damage from alcohol and smoking.
Cystine also plays an important role in the activity of the white blood cells, which fight disease.
www.innvista.com /HEALTH/nutrition/amino/cystine.htm   (197 words)

  
 eMedicine - Cystinuria : Article Excerpt by: Chandra Shekhar Biyani, MBBS, MS, DUrol, FRCS (Urol), FEBU
Background: Cystinuria is an autosomal recessive defect in reabsorptive transport of cystine and the dibasic amino acids ornithine, arginine, and lysine from the luminal fluid of the renal proximal tubule and small intestine.
Transport of L-cystine in the brush-border membrane vesicle is sodium-independent and electrogenic.
In persons with cystinuria, the movement of cystine or cysteine from the tubular cells into the blood is not affected.
www.emedicine.com /med/byname/cystinuria.htm   (669 words)

  
 N-Acetyl Cysteine Crystals, Vitamin Nac, Cystine Stones
Cysteine is considered a non-essential amino acid because it is formed from methionine in the body.
Cysteine is very unstable and is readily oxidized to the amino acid cystine.
Since Cysteine is more soluble than cystine, it is used more readily in the body and is usually best for treating most illnesses.
www.wellfx.com /InfoBase/vitamin_cysteine_.htm   (1348 words)

  
 Cystine in White Blood Cells - Biochemical Analysis   (Site not responding. Last check: 2007-10-22)
This protocol allows for the determination of the cystine levels in white blood cell extracts.
The measurement of white blood cell cystine is useful in the diagnosis and management of these individuals.
The concentration of the cystine is determined by amino acid analysis using the ninhydrin reaction.
www.bcm.edu /geneticlabs/tests/biochem/cystineinwbc.html   (119 words)

  
 Herbal Descriptions - Cystine   (Site not responding. Last check: 2007-10-22)
Cystine is a non-essential amino acid (can be manufactured by the body with proper nutrition).
Cystine functions as an antioxidant and is a powerful aid to the body in protecting against radiation and pollution.
It is necessary for the formation of the skin, which aids in the recovery from burns and surgical operations.
www.viable-herbal.com /herbdesc1/1cystine.htm   (349 words)

  
 Kidney International - Abstract of article: Urinary cystine excretion and capacity in patients with cystinuria
We used a solid-phase assay of urinary cystine capacity in a large sample of patients with cystinuria.
A general linear model in which 24 h cystine excretion was the dependent variable showed that creatinine, urea nitrogen, and sodium excretions were associated with cystine excretion (P<0.02, all three).
This assay of cystine capacity was reliable in the presence of CBTD.
www.nature.com /ki/journal/v69/n6/abs/5000104a.html   (395 words)

  
 MoonDragon's Health & Wellness: Nutrition - Amino Acids: Cysteine & Cystine
Cystine or the N-acetyl form of cysteine (N-acetylcysteine) may be used in place of L-cysteine.
Cystine is the product of an oxidation between the thiol side chains of two cysteine amino acids.
As such, cystine is not considered one of the 20 amino acids.
www.moondragon.org /health/nutritionbasics/aminoacids/cystine.html   (1477 words)

  
 Cystine amino acid information page. All about cystine and the role it plays in your diet.
Cystine is a crystalline, sulfur-containing amino acid, formed from two molecules of the amino acid cysteine.
It can be converted to cysteine by reduction and was discovered in 1810 but was not recognized as a component of proteins until 1899, when it was isolated from animal horn — it is particularly abundant in skeletal and connective tissues, hair and digestive enzymes.
The steps followed in the formation of cystine and cysteine, is from methionine to cystathionine and then to cysteine to cystine.
www.anyvitamins.com /cystine-info.htm   (420 words)

  
 Comparison of Cystine Determination in Mixed Leukocytes vs Polymorphonuclear Leukocytes for Diagnosis of Cystinosis and ...
Comparison of Cystine Determination in Mixed Leukocytes vs Polymorphonuclear Leukocytes for Diagnosis of Cystinosis and Monitoring of Cysteamine Therapy -- Levtchenko et al.
Cystine was measured by HPLC as described previously (3).
Cystine (nmol/mg of protein) in ML preparations and PMN cells.
www.clinchem.org /cgi/content/full/50/9/1686   (1440 words)

  
 cystine and its relationship to chemotherapy, radiation, tuberculosis, emphysema.
cystine and its relationship to chemotherapy, radiation, tuberculosis, emphysema.
In the field of nutrition, well-being and health, cystine has an important part to play.
Not only is it required for optimum general health, but also have specific functions in the body in which it assists.
www.anyvitamins.com /healthlist/cystine.htm   (287 words)

  
 Characterization of multiple cysteine and cystine transporters in rat alveolar type II cells -- Knickelbein et al. 273 ...
was secondary to reduction of cystine to cysteine.
Inhibition of glutamate and cystine uptake by aspartate or glutamate.
Buthionine sulfoximine inhibition of cystine uptake and glutathione biosynthesis in human lung carcinoma cells.
ajplung.physiology.org /cgi/content/full/273/6/L1147   (4710 words)

  
 Cystine   (Site not responding. Last check: 2007-10-22)
Cystine crystals are flat colorless plates and have a characteristic hexagonal shape with equal or unequal sides.
Cystine crystalluria or urolithiasis is an indication of cystinuria, which is an inborn error of metabolism involving defective renal tubular reabsorption of certain amino acids including cystine.
Renal function otherwise appears to be normal and, aside from a tendency to form uroliths, the defect is without serious consequence.
www.diaglab.vet.cornell.edu /clinpath/modules/ua-sed/cystine.htm   (86 words)

  
 Metallothionein, glutathione, and cystine transport in pulmonary artery endothelial cells and NIH/3T3 cells -- Susanto ...
Metallothionein, glutathione, and cystine transport in pulmonary artery endothelial cells and NIH/3T3 cells -- Susanto et al.
increase cystine transport and GSH in BPAEC (13).
Cystine uptake and glutathione level in fetal brain cells in primary culture and in suspension.
ajplung.physiology.org /cgi/content/full/274/2/L296   (3029 words)

  
 Intralysosomal Cystine Accumulation in Mice Lacking Cystinosin, the Protein Defective in Cystinosis -- Cherqui et al. ...
Cystine crystals, consisting of fine white, needle-shaped points, can be observed in the cornea.
Cystine transport is defective in isolated leukocyte lysosomes from patients with cystinosis.
The utilization of a cystine binding protein from Escherichia coli for the determination of acid-soluble cystine in small physiological samples.
mcb.asm.org /cgi/content/full/22/21/7622   (5665 words)

  
 Amazon.com: Cystine   (Site not responding. Last check: 2007-10-22)
Cystine nephrolithiasis in an endangered canid, Chrysocyon brachyurus (Carnivora: Canidae).: An article from: Revista de Biología Tropical by Norma B. Mussart and José A. Coppo (Sep 1, 1999)
The selenium analog of cystine and the diselenides of the lower fatty acids, by John Charles Gordon (Unknown Binding - Jan 1, 1935)
Cystine - Low Cost Bulk -- If you are in the market for pallet quantities of Cystine, give V. Clark a call.
www.amazon.com /s?ie=UTF8&keywords=Cystine&tag=dragoncon&index=blended&link_code=qs&page=1   (473 words)

  
 Cystinosis
Impaired efflux of cystine across lysosomal membranes results in intralysosomal accumulation of free cystine.
Cystine accumulation results in cystine crystals in the cornea, conjunctiva, bone marrow, lymph nodes, leukocytes, and internal organs.
The free thiol cysteamine slows progression of renal dysfunction, improves growth, and dissolves corneal cystine crystals.
www.lysosomallearning.com /healthcare/about/lsd_hc_abt_cystinosis.asp   (326 words)

  
 Effect of cystine on the methionine requirement of healthy Indian men determined by using the 24-h indicator amino acid ...
Effect of cystine on the methionine requirement of healthy Indian men determined by using the 24-h indicator amino acid balance approach -- Kurpad et al.
Effect of cystine on the methionine requirement of healthy Indian men determined by using the 24-h indicator amino acid balance approach
with cystine intakes of 5 and 12 mg · kg
www.ajcn.org /cgi/content/abstract/80/6/1526?ck=nck   (515 words)

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