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Topic: Cytarabine

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	MedlinePlus Drug Information: Cytarabine
		Cytarabine can cause a decrease in the number of blood cells in your bone marrow.
		Cytarabine belongs to a group of drugs known as antimetabolites.
		Cytarabine is also used to treat non-Hodgkin's lymphoma.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682222.html (476 words)

	Cytarabine -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-11-03)
		Cytarabine is rapidly deaminated in the body into the inactive (A nitrogen-containing base found in RNA (but not in DNA) and derived from pyrimidine; pairs with adenine) uracil derivative form and therefore, it is often given by continuous intravenous infusion.
		Cytarabine possessess also an (Any drug that destroys viruses) antiviral activity, and it has been used for the treatment of generalised (Any of the animal viruses that cause painful blisters on the skin) herpes infection.
		However, cytarabine is not very selective and causes (additional info and facts about bone marrow suppression) bone marrow suppression and other severe side effects, so it is used merely for the chemotherapy of cancer.
	www.absoluteastronomy.com /encyclopedia/c/cy/cytarabine.htm (355 words)

	Cytarabine - chemotherapy for leukemia and lymphoma - Non-Hodgkin's lymphoma
		Cytarabine is an injectable chemotherapy drug that is commonly used to treat acute myeloid leukemia.
		Cytarabine, which is marketed under the brand name "Cytosar-U," works by interfering with the growth and function of cancer cells.
		Because cytarabine's effects are not limited to cancerous cells, patients experience the results of damage to other, normally dividing cells in their bodies.
	www.leukemialymphomatreatmentfyi.com /cytarabine.html (503 words)

	Drug Dictionary
		Cytarabine may be administered intravenously (into a vein), subcutaneously (injection under the skin), intramuscularly (injection into a muscle), or intrathecally (into the spinal fluid).
		Cytarabine also comes in a long-acting form (DepoCyt™) that may be placed under the skin in a reservoir, with a catheter leading to the brain.
		The route, dose and scheduling in which cytarabine is administered is dependent upon many factors, including the condition being treated, the particular treatment regimen being utilized, the patient’s height and weight, overall health, and the patient’s tolerance of therapy.
	patient.cancerconsultants.com /drug_dictionary.aspx?id=641 (1318 words)

	CYTARABINE
		This medication belongs to a class of medicines called by antimetabolites.
		The cancer cells in the body are destroyed by cytarabine.
		This medicine is available in the form of injection and given it into a vein.
	www.combat-cancer.com /drugs/CYTARABINE.htm (168 words)

	cytarabine of Augusta, Georgia
		Cytarabine interferes with the growth of cancer cells and slows their growth and spread in the body.
		Cytarabine is used to treat blood cancers (acute non-lymphocytic leukemia, acute lymphocytic leukemia and chronic myelocytic leukemia).
		Cytarabine is in the FDA pregnancy category D. This means that cytarabine is known to cause birth defects in an unborn baby.
	www.universityhealth.org /16138.cfm (1081 words)

	Cytosar Online, Description, Chemistry, Ingredients - Cytarabine (Injectable) - RxList Monographs
		The main toxic effect of cytarabine is bone marrow suppression with leukopenia, thrombocytopenia, and anemia.
		Cytarabine is an odorless, white to off-white, crystalline powder which is freely soluble in water and slightly soluble in alcohol and in chloroform.
		Cytarabine is a synthetic nucleoside which differs from the normal nucleosides cytidine and deoxycytidine in that the sugar moiety is arabinose rather than ribose on deoxyribose.
	www.rxlist.com /cgi/generic3/cytarabine.htm (276 words)

	Cytarabine detail at IndyaPharma (Site not responding. Last check: 2007-11-03)
		Cytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture.
		Cytarabine caused the transformation of hamster embryo cells and rat H43 cells in vitro.
		Cytarabine was clastogenic to meiotic cells; a dose-dependent increase in sperm-head abnormalities and chromosomal aberrations occurred in mice given i.p.
	www.indyapharma.com /Cytarabine-detail.htm (2976 words)

	DepoCyt - Cytarabine Liposomal - Liposomal Ara-C - Chemotherapy Drugs - Chemo (Site not responding. Last check: 2007-11-03)
		Liposomal cytarabine is used to treat lymphomatous meningitis (lymphoma found in the lining of the brain and spinal cord).
		Liposomal cytarabine is given is by intraventricular or intrathecal infusion.
		The amount of liposomal cytarabine that you receive depends on many factors, including the type of cancer you have, your height and weight, your general health, any other health problems you may have.
	www.chemocare.com /bio/bio.sps?iBiographyID=9143 (1391 words)

	Cytarabine injection: BC Cancer Agency
		Cytarabine (sye-TARE-a-been) is a drug which is used to treat leukemia and other kinds of cancer.
		Cytarabine may cause sterility in men and menopause in women which may be permanent.
		Cytarabine may damage sperm and may be harmful to the baby if used during pregnancy.
	www.bccancer.bc.ca /HPI/DrugDatabase/DrugIndexPt/Cytarabineinjection.htm (957 words)

	Depocyt Online, Description, Chemistry, Ingredients - Cytarabine Liposome - RxList Monographs
		DepoCyt is a sterile, injectable suspension of the antimetabolite cytarabine, encapsulated into multivesicular lipid-based particles.
		DepoCyt is formulated as a sterile, non-pyrogenic, white to off-white suspension of cytarabine in Sodium Chloride 0.9% w/v in Water for Injection.
		Cytarabine, the active ingredient, is present at a concentration of 10 mg/mL, and is encapsulated in the particles.
	www.rxlist.com /cgi/generic/depocyt.htm (258 words)

	Cytarabine : CancerBACUP (Site not responding. Last check: 2007-11-03)
		Cytarabine (pronounced sigh tare a been) is chemotherapy that is given as a treatment for some types of cancer.
		It is sometimes called Ara C. Cytarabine is most commonly used to treat a type of leukaemia known as acute myeloid leukaemia.
		Cytarabine is a clear fluid after being dissolved from powder.
	www.cancerbacup.org.uk /info/cytarabine.htm (1318 words)

	Cytarabine: BC Cancer Agency
		Cytarabine is metabolized intracellularly into its active triphosphate form (cytosine arabinoside triphosphate).
		High-dose cytarabine and total body irradiation with or without cyclophosphamide as a preparative regimen for marrow transplantation for acute leukemia.
		High-dose cytarabine dose modification reduces the incidence of neurotoxicity in patients with renal insufficiency.
	www.bccancer.bc.ca /HPI/DrugDatabase/DrugIndexPro/Cytarabine.htm (1717 words)

	Cytosar-U - Drugs & Vitamins - Drug Library - DrugDigest
		Cytarabine is for injection or infusion into a vein, or injection under the skin or into the spinal fluid.
		Cytarabine may cause different side effects depending upon the dose, type of infusion, and other chemotherapy agents given.
		Cytarabine injection will be given to you in a hospital or clinic setting.
	www.drugdigest.org /DD/DVH/Uses/0,3915,181\|Cytosar-U,00.html (873 words)

	cytarabine liposomal - [Medication] (Site not responding. Last check: 2007-11-03)
		Cytarabine liposomal should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.
		Cytarabine liposomal is in the FDA pregnancy category D. This means that cytarabine liposomal is known to cause birth defects in an unborn baby.
		Cytarabine liposomal will be administered by injection into the fluid surrounding the brain and spinal cord.
	www.bcbswny.com /kbase/multum/d04834a1.htm (993 words)

	Cytarabine (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-11-03)
		This medicine may cause birth defects (such as defects of the arms, legs, or ears, which occurred in two babies) if either the male or female is taking it at the time of conception or if it is taken during pregnancy.
		Because cytarabine may cause serious side effects, breast-feeding is generally not recommended while you are receiving it.
		Although there is no specific information comparing use of cytarabine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
	www.mayoclinic.com /health/drug-information/DR202177 (1785 words)

	Cure Rate Soars In Some AML Patients Receiving High-Dose Cytarabine (Site not responding. Last check: 2007-11-03)
		The study revealed that 78 percent of patients with core binding factor AML who received the drug cytarabine at high dose were in complete remission five years after treatment (and therefore potentially cured) compared to only 16 percent who received the standard dose.
		During the second phase of their treatment, a phase known as intensification therapy, the patients were randomly assigned to receive cytarabine at either standard dose (100 milligrams per square meter of body surface), intermediate dose (400 mg/m2), or high-dose (3,000 mg/m2, equivalent to three grams of drug/m2).
		Last, of the 88 patients in the other abnormalities group, 21 percent of those receiving the high drug dose were in complete remission, compared to 13 percent receiving the intermediate dose and 13 percent receiving the standard dose.
	www.pslgroup.com /dg/ba2da.htm (781 words)

	Cytarabine
		Cytarabine is injected into the veins, under the skin, into the muscle, or near the spinal cord (called intrathecal administration).
		Cytarabine can decrease the number of white blood cells in your body, cells that usually help you fight infections.
		Cytarabine can cause swelling of the brain or spinal cord, also called "chemical arachnoiditis syndrome," when it is injected near the spinal cord.
	www.hci.utah.edu /patientdocs/hci/drugs/cytarabine.htm (386 words)

	IngentaConnect Clinical Pharmacokinetics of Cytarabine Formulations (Site not responding. Last check: 2007-11-03)
		Cytarabine (cytosine arabinoside, Ara-C) is an effective chemotherapeutic agent for the treatment of acute myelogenous leukaemia and lymphocytic leukaemias.
		As cytarabine is an S-phase-specific drug, prolonged exposure of cells to cytotoxic concentrations is critical to achieve maximum cytotoxic activity.
		However, the activity of cytarabine is decreased by its rapid deamination to the biologically inactive metabolite uracil arabinoside.
	www.ingentaconnect.com /content/adis/cpk/2002/00000041/00000010/art00002 (265 words)

	Emerging Trends in Management of Acute Myeloid Leukemia
		compared a standard regimen of cytarabine and daunorubicin with a similar regimen in which daunorubicin was replaced by mitoxantrone.
		the superiority of cytarabine plus idarubicin to cytarabine plus daunorubicin in improved outcome was evident among patients <60 years of age but not among older patients.
		Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated patients with acute myeloid leukemia.
	www.meds.com /leukemia/trends/mon_pt1.html (2592 words)

	Cytarabine
		This fact sheet explains what cytarabine is, how it is given and some of the possible side effects.
		Cytarabine is a drug used to treat certain types of cancer and leukaemia.
		If your child is receiving lower doses of cytarabine as an outpatient the side effects are likely to be less.
	www.gosh.nhs.uk /factsheets/families/F040246 (668 words)

	High-dose cytarabine and mitoxantrone as salvage therapy for refractory non-Hodgkin's lymphoma -- Wang et al. 27 (3): ...
		High-dose cytarabine and mitoxantrone as salvage therapy for refractory non-Hodgkin's lymphoma -- Wang et al.
		High-dose cytarabine alone or in combination with mitoxantrone has been shown to be active against refractory non-Hodgkin's lymphoma in therapeutic trials.
		Mitoxantrone and high-dose cytarabine as salvage therapy for refractory non-Hodgkin's lymphoma.
	jjco.oxfordjournals.org /cgi/content/full/27/3/154 (2454 words)

	Cytarabine Liposome (Site not responding. Last check: 2007-11-03)
		Liposomal cytarabine is injected near the spinal cord (called intrathecal administration).
		Liposomal cytarabine can cause swelling of the brain or spinal cord, also called "chemical arachnoiditis syndrome." You may be given other medicines to reduce the severity of this reaction.
		Liposomal cytarabine can decrease the number of white blood cells in your body, cells that usually help you fight infections.
	www.hci.utah.edu /patientdocs/hci/drugs/cytarabine_liposome.htm (238 words)

	Cytarabine Liposomal - Talk Medical
		Cytarabine Liposomal interferes with the growth of cancer cells and slows their growth and spread in the body.
		· Cytarabine Liposomal is in the FDA pregnancy category D. This means that Cytarabine Liposomal is known to cause birth defects in an unborn baby.
		Do not take Cytarabine Liposomal without first talking to your doctor if you are pregnant or could become pregnant during treatment.
	www.talkmd.com /medications/print-1563 (645 words)

	Cytarabine news articles (Site not responding. Last check: 2007-11-03)
		The commitment for DepoCyt (liposomal cytarabine) in neoplastic and lymphomatous meningitis is considered delayed; the study was initially stalled by...
		Induction chemotherapy was two cycles of DHAP (dexamethasone, high-dose cytarabine and cisplatin) followed by stem cell mobilization with methotrexate...
		Induction chemotherapy was two cyles of DHAP (dexamethasone, high-dose cytarabine and cisplatin) followed by stem cell mobilization with methotrexate...
	www.mongabay.com /drugs/drugs/Cytarabine.html (792 words)

	cytarabine liposomal Information and Resources Online at The Drug Database - Find Useful Articles and Websites on ... (Site not responding. Last check: 2007-11-03)
		Liposomal cytarabine interferes with the growth of cancer cells, which are eventually...
		Liposomal cytarabine interferes with the growth of cancer cells, which are eventually destroyed...
		and Cytarabine Versus Daunorubicin Liposomal and Cytarabine Versus Cyclophosphamide, Cytarabine, and...
	www.thedrugdatabase.com /directory/C/cytarabine_liposomal (322 words)

	Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of ...
		Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase -- Gardembas et al.
		cytarabine was not able to prevent expansion of mutated cells.
		Preferential inhibition by cytarabine of CFU-GM from patients with chronic granulocytic leukemia.
	www.bloodjournal.org /cgi/content/full/102/13/4298 (5091 words)

	Cytarabine
		Cytarabine preparation should be performed in a Class II laminar flow biologic safety cabinet.
		If cytarabine contacts the skin, wash and flush thoroughly with water.
		Dosage adjustment in hepatic impairment: Dose may need to be adjusted since cytarabine is partially detoxified in the liver.
	www.musc.edu /pharmacyservices/Drugs/C/Cytarabine.htm (471 words)

	CYTARABINE Side Effects, CYTARABINE Drug Information, CYTARABINE Dosage
		CYTARABINE will be given where you can be closely monitored by your doctor because serious, even fatal, blood disorders (e.g., anemia, bone marrow suppression) have been caused by CYTARABINE.
		Cytarabine is one of a large group of drugs known as "antineoplastics"; these drugs are also known as cancer drugs, chemotherapy, or "chemo".
		Cytarabine is not recommended for use during pregnancy.
	www.pharmacyhealth.net /d/cytarabine-9052.htm (561 words)

	Healthopedia.com Drugs Information - Cytarabine, Liposomal : Before Using (DepoCyt)
		Pregnancy—Liposomal cytarabine has not been studied in humans, but has been found to cause birth defects or other problems in rats and mice.
		However, liposomal cytarabine is not recommended during breast-feeding because it may cause unwanted effects in nursing babies.
		There is no specific information comparing use of liposomal cytarabine in the elderly with use in other age groups.
	healthopedia.com /drugs/detailed/cytarabine-liposomal/before-using.html (548 words)

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