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Topic: Cytokeratin


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In the News (Sat 20 Jul 19)

  
  Cytokeratin - Wikipedia, the free encyclopedia
Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue.
Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin.
The intermediate filaments of the eukaryotic cytoskeleton, which the cytokeratins are one of its three components, have been probed to associate also with the ankyrin and spectrin complex protein network that underlies the cell membrane.
en.wikipedia.org /wiki/Cytokeratin   (629 words)

  
 Cytokeratin tumor markers and assays for their detection (US4775620)
The presence of this cytokeratin is diagnostic of neoplastic disease.
The extracellular cytokeratins have a molecular weight of approximately 40 to 46 kilodaltons and are related to approximately 42 to 48 kd proteins found on the cell surface of neoplastic epithelial cells.
The presence of cytokeratins in the tumor cells is diagnostic of the epithelial origin of the cells.
www.delphion.com /details?pn10=US04775620   (5974 words)

  
 Role of cytokeratin intermediate filaments in transhepatic transport and canalicular secretion.
Role of cytokeratin intermediate filaments in transhepatic transport and canalicular secretion.It is concluded that cytokeratin intermediate filaments play a critical role in the formation of the bile canaliculus, secretion of fluorescein diacetate and uptake of horseradish peroxidase.
The formation of cytokeratin- ubiquitin conjugates during aggregation suggests a role of ubiquitin in the control of cytokeratin organization in hepatocytes in the response to cell stress.
The role of cytokeratin filaments in the function of hepatocytes was investigated using a nickel-treated hepatocyte in vitro model.
www.ihop-net.org /UniPub/iHOP/gp/6533.html   (309 words)

  
 Recombinant Human Cytokeratin 8 - PRO-347
Nuclear localization of cytokeratin 8 and the O-linked N-acetylglucosamine-containing epitope H in epithelial cells of infiltrating ductal breast carcinomas: a combination of immunogold and EDTA regressive staining methods.
Cytokeratin 8/18 expression indicates a poor prognosis in squamous cell carcinomas of the oral cavity.
Cytokeratin 8 associates with the external leaflet of plasma membranes in tumour cells.
www.prospec.co.il /~prospec/cart/catalog/rHuCK8.html   (413 words)

  
 Identification with a recombinant antibody of an inner-ear cytokeratin, a marker for hair-cell differentiation -- Cyr ...
Identification with a recombinant antibody of an inner-ear cytokeratin, a marker for hair-cell differentiation -- Cyr et al.
cytokeratins 8, 9, and 19 and otokeratin, are known to occur in
Although the role of the cytokeratin in the inner ear is unclear, the reduced expression of this protein during hair-cell
www.pnas.org /cgi/content/full/97/9/4908   (3651 words)

  
 Mesothelial cell apoptosis is confirmed in vivo by morphological change in cytokeratin distribution -- Marchi et al. ...
cytokeratin as a means of identifying the apoptotic cells as mesothelial.
Cytokeratin distribution of rabbit pleural mesothelial cells grown in culture and exposed to crocidolite asbestos for 24 h.
Correlation of aggregated cytokeratin distribution with condensed nuclei characteristic of apoptosis in rabbit mesothelial cells exposed to crocidolite asbestos for 24 h in vitro.
ajplung.physiology.org /cgi/content/full/278/3/L528   (4921 words)

  
 Cytokeratin 4   (Site not responding. Last check: 2007-11-04)
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides.
Cytokeratin 1 has the highest molecular weight and the highest isoelectric pH, while cytokeratin 19 has the lowest molecular weight and a low isoelectric pH.
The cytokeratins are divided into the type I and type II subgroups, the type II family members comprising the basic to neutral cytokeratins 1-8, while the type I group comprises the acidic cytokeratins 9-20.
www.usbio.net /Product.aspx?ProdId=26141   (293 words)

  
 Limitations of cytokeratin 20 RT-PCR to detect disseminated tumour cells in blood and bone marrow of patients with ...
Limitations of cytokeratin 20 RT-PCR to detect disseminated tumour cells in blood and bone marrow of patients with colorectal cancer: expression in controls and downregulation in tumour tissue -- Vlems et al.
Expression of cytokeratin 20 in the blood of patients with disseminated carcinoma of the pancreas, colon, stomach, and lung.
Detection of cytokeratins 19/20 and guanylyl cyclase C in peripheral blood of colorectal cancer patients.
mp.bmjjournals.com /cgi/content/full/55/3/156   (5182 words)

  
 Identification of Cytokeratin 18 as a Bronchial Epithelial Autoantigen Associated with Nonallergic Asthma -- Nahm et ...
Antigens from bronchial epithelial cell lysate (lanes 1, 4, and 7), purified 49-kD autoantigen (lanes 2, 5, and 8), and purified bovine cytokeratin 18 (lanes 3, 6, and 9) were subjected to immunoblot analysis.
to cytokeratin 18 in the pathogenesis of nonallergic asthma.
Elevation of anti-cytokeratin 18 antibody and circulating cytokeratin 18: anti-cytokeratin 18 antibody immune complexes in sera of patients with idiopathic pulmonary fibrosis.
ajrccm.atsjournals.org /cgi/content/full/165/11/1536   (2514 words)

  
 Chemicon - Product #CBL195 - Anti-Cytokeratin 8, clone LP3K
The antibody reacts with cytokeratin 8 which is one of the first cytokeratins expressed in the embryo and persists into adult tissues (with cytokeratin 18) as the cytokeratin pair representing "minimal" epithelial cytokeratin expression.
Cytokeratins 8 and 18 are major components of all simple epithelial, although trace amounts may be detected in internal stratified epithelia and in certain smooth muscle tissues.
Development of serum assays since cytokeratin 8 is the protein responsible for the "tissue polypeptide antigen" (TPA) reported to be present at elevated levels in the serum of cancer patients
www.chemicon.com /browse/productdetail.asp?ProductID=CBL195   (327 words)

  
 Potential structural role of non-coding and coding RNAs in the organization of the cytoskeleton at the vegetal cortex ...
We hypothesized that the release of Vg1 RNA from the vegetal
The means of association of cytokeratin with germinal granules are unknown, but one possibility is that cytokeratin anchors germinal granules (pink spheres) indirectly, via an unknown binding protein(s) (yellow, 3).
During early cleavage, the cytokeratin network is present both in control and in antisense VegT or anti-pancytokeratin antibody-injected embryos, and the germ plasm islands segregate to the vegetal apex of vegetal blastomeres.
dev.biologists.org /cgi/content/full/132/15/3445   (6491 words)

  
 Cancer-associated Cleavage of Cytokeratin 8/18 Heterotypic Complexes Exposes a Neoepitope in Human Adenocarcinomas -- ...
A, PVDF membrane of SDS-PAGE-separated and purified cytokeratin stained with Coomassie Blue (a), with COU-1 (b), mouse anti-K8 antibody (c), and mouse anti-K18 antibody (d).
In addition, the reactivity of the different isolated cytokeratin fragments with the three antibodies is shown.
Shown is the secondary structure of the cytokeratin polypeptides, as predicted from the amino acid sequence, with a central rod domain flanked by a non-helical N-terminal head domain and a non-helical C-terminal tail domain.
www.jbc.org /cgi/content/full/277/24/21712   (6930 words)

  
 Cytokeratin 19 Fragment in Patients With Nonmalignant Respiratory Diseases -- Nakayama et al. 123 (6): 2001 -- Chest
Cytokeratin 19 was selectively expressed in regenerating or hyperplastic epithelial cells, which covered the surface of remodeling septal structures in the peripheral lungs.
Pujol, JL, Grenier, J, Daures, JP, et al Serum fragment of cytokeratin subunit 19 measured by CYFRA 21-1 immunoradiometric assay as a marker of lung cancer.
Dobashi, N, Fujita, J, Ohtsuki, Y, et al Elevated serum and BAL cytokeratin 19 fragment in pulmonary fibrosis and acute interstitial pneumonia.
www.chestjournal.org /cgi/content/full/123/6/2001   (2352 words)

  
 Group B Streptococci and Other Gram-Positive Cocci Bind to Cytokeratin 8 -- Tamura and Nittayajarn 68 (4): 2129 -- ...
Sixth, adherence of GBS to cytokeratins may not be a virulence factor but may in fact play a role in host defense.
Cell-surface cytokeratin 8 is the major plasminogen receptor on breast cancer cells and is required for the accelerated activation of cell-associated plasminogen by tissue-type plasminogen activator.
Cytokeratin 8 and 19 as antigens recognized by adenocarcinoma-reactive human monoclonal antibody AE6F4.
iai.asm.org /cgi/content/full/68/4/2129   (4895 words)

  
 Identification of cytokeratin 1 as a binding protein and presentation receptor for kininogens on endothelial cells -- ...
Identification of cytokeratin 1 as a binding protein and presentation receptor for kininogens on endothelial cells -- Hasan et al.
HUVEC in suspension, indicative of membrane expression of cytokeratin
Purified cytokeratin (1 µg/well) was coupled to microtiter plate wells in 0.1 M Na (pH 9.6) overnight at 4°C. After washing the wells with 0.01 M sodium phosphate and 0.15 M NaCl (pH 7.4), the indicated dilution of anti-RRY16 antiserum or its preimmune serum was added to the microtiter plate wells.
www.pnas.org /cgi/content/full/95/7/3615   (5447 words)

  
 Cytokeratin Touted As Superior Marker For Detecting Biliary Tract Carcinoma
According to a study from the United States, "The incidence of lymph node micrometastases in patients with biliary tract carcinoma is unknown.
The researchers concluded, "Cytokeratin immunostaining enables detection of micrometastases in histologically negative lymph nodes in patients with biliary tract carcinoma.
Natarajan and colleagues published the results of their research in the Journal of Surgical Research (Cytokeratin is a superior marker for detection of micrometastatic biliary tract carcinoma.
www.cancercompass.com /cancer-news/1,9308,00.htm   (395 words)

  
 Cytokeratin in anaplastic large cell lymphoma   (Site not responding. Last check: 2007-11-04)
Bands corresponding to cytokeratin 18 and cytokeratins 18 and 8 were seen on Western blot immunoanalysis using antibodies KS-B17.2 and CAM 5.2.
Although it is possible that the presence of cytokeratin in the cells of anaplastic large cell lymphoma represented phagocytosed filaments from the reticulum cells, it is more likely that the cytokeratins were synthesized by the malignant cells.
The finding of cytokeratin in anaplastic large cell lymphoma, although infrequent, adds to the confusion in the diagnosis of this pleomorphic neoplasm.
home.earthlink.net /~cfelten/cytokeratin_in_anaplastic_large_.htm   (148 words)

  
 Monoclonal Antibody CD133-2 (AC141) Against Hematopoietic Stem Cell Antigen CD133 Shows Crossreactivity with ...
Cytokeratin 18 is a member of the family of acidic cytokeratins
Haigh T, Chen C-P, Jones CJP, Aplin JD (1999) Studies of mesenchymal cells from 1st trimester human placenta: expression of cytokeratin outside the trophoblast lineage.
Moll R, Franke WW, Schiller DL (1982) The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.
www.jhc.org /cgi/content/full/50/8/1131   (1578 words)

  
 The Expression of p63 and Cytokeratin 5 in Mixed Tumors of the Canine Mammary Gland Provides New Insights into the ...
The Expression of p63 and Cytokeratin 5 in Mixed Tumors of the Canine Mammary Gland Provides New Insights into the Histogenesis of These Neoplasms -- Ramalho et al.
Cytokeratin 5 and p63 have been described as basal and myoepithelial
The co-expression of p63 and cytokeratin 5 in myoepithelial
www.vetpathology.org /cgi/content/abstract/43/4/424   (374 words)

  
 Cytokeratin 7 (clone ks 7.18) antibodies from Research Diagnostics Inc
Cytokeratin 7 (clone ks 7.18) antibodies from Research Diagnostics Inc
Lauerova,L., Kovarik, J., Bartek, J., Reithar, A. and Vojtesek, B.: novel monoclonal antibodies defining epitope of human cytokeratin 18 molecule.
Stosiek, P. and Kasper, M.: Neoexpression von Cytokeratin 7 bei der chronisch-atrophischen Gastritis mit perniziöser Anämie.
www.researchd.com /rdiabs/pro61025.htm   (430 words)

  
 Chemicon - Product #CBL272 - Anti-Cytokeratin 15, clone LHK15
This antibody reacts with the human cytokeratin identified as cytokeratin 15.
Cytokeratin 15 is a type 1 keratin expressed only in the basal cells of stratified epithelia.
Studies of cytokeratin 15 on frozen tissue sections.
www.chemicon.com /Product/ProductDataSheet.asp?ProductItem=CBL272   (287 words)

  
 Induction of rapid and reversible cytokeratin filament network remodeling by inhibition of tyrosine phosphatases -- ...
Induction of rapid and reversible cytokeratin filament network remodeling by inhibition of tyrosine phosphatases -- Strnad et al.
Induction of rapid and reversible cytokeratin filament network remodeling by inhibition of tyrosine phosphatases
The cytokeratin filament network is intrinsically dynamic, continuously exchanging
jcs.biologists.org /cgi/content/abstract/115/21/4133   (411 words)

  
 Corneal Epithelial-Specific Cytokeratin 3 is an Autoantigen in Wegener’s Granulomatosis-Associated Peripheral ...
Corneal Epithelial-Specific Cytokeratin 3 is an Autoantigen in Wegener’s Granulomatosis-Associated Peripheral Ulcerative Keratitis -- Reynolds et al.
Corneal Epithelial–Specific Cytokeratin 3 is an Autoantigen in Wegener’s Granulomatosis–Associated Peripheral Ulcerative Keratitis
The 550-bp insert in clone A10 was sequenced, and a DNA homology
www.iovs.org /cgi/content/full/40/9/2147   (2385 words)

  
 Cable-Piliated Burkholderia cepacia Binds to Cytokeratin 13 of Epithelial Cells -- Sajjan et al. 68 (4): 1787 -- ...
Cable-Piliated Burkholderia cepacia Binds to Cytokeratin 13 of Epithelial Cells -- Sajjan et al.
BEC cytokeratin fraction reversed the inhibitory effect of the
A cytokeratin mixture lacking CK13 was ineffective as
iai.asm.org /cgi/content/abstract/68/4/1787   (808 words)

  
 Cytokeratin Immunoreactivity in Lobular Intraepithelial Neoplasia -- Bratthauer et al. 51 (11): 1527 -- Journal of ...
Cytokeratin Immunoreactivity in Lobular Intraepithelial Neoplasia -- Bratthauer et al.
Figure 2 (A) Cytokeratin demonstration in classic LIN using 34ßE12.
Bratthauer GL, Moinfar F, Stamatakos MD, Mezzetti TP, Shekitka KM, Man YG, Tavassoli FA (2002) Combined E-cadherin and high molecular weight cytokeratin immunoprofile differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasias.
www.jhc.org /cgi/content/full/51/11/1527   (2252 words)

  
 Peripheral blood circulating cytokeratin-19 mRNA-positive cells after the completion of adjuvant chemotherapy in ...
Ruud P, Fodstad O, Hovig E. Identification of a novel cytokeratin 19 pseudogene that may interfere with reverse transcriptase–polymerase chain reaction assays used to detect micrometastatic tumor cells.
High percentage of false-positive results of cytokeratin 19 RT–PCR in blood: a model for the analysis of illegitimate gene expression.
Reverse transcriptase–polymerase chain reaction analysis of cytokeratin 19 expression in the peripheral blood mononuclear cells of normal female blood donors.
annonc.oxfordjournals.org /cgi/content/full/14/6/849   (4359 words)

  
 Ability of bivariate cytokeratin and deoxyribonucleic acid flow cytometry to determine the biologic aggressiveness of ...
Ability of bivariate cytokeratin and deoxyribonucleic acid flow cytometry to determine the biologic aggressiveness of resectable non-small cell lung cancer -- Otsuka et al.
Ability of bivariate cytokeratin and deoxyribonucleic acid flow cytometry to determine the biologic aggressiveness of resectable non–small cell lung cancer
Objective: The purpose of this study was to clarify the significance
jtcs.ctsnetjournals.org /cgi/content/abstract/124/2/293   (330 words)

  
 Clinical Equivalence of Two Cytokeratin Markers in Non-small Cell Lung Cancer: A Study of Tissue Polypeptide Antigen ...
Clinical Equivalence of Two Cytokeratin Markers in Non-small Cell Lung Cancer: A Study of Tissue Polypeptide Antigen and Cytokeratin 19 Fragments -- Buccheri et al.
Abbreviations: CK = cytokeratin; CYFRA 21–1 = cytokeratin
Pujol, JL, Grenier, J, Parrat, E, et al Cytokeratins as serum markers in lung cancer: a comparison of CYFRA 21–1 and TPS.
www.chestjournal.org /cgi/content/full/124/2/622   (3798 words)

  
 Expression of Ki-67 and cytokeratin 20 in hyperplastic polyps of the colorectum -- Davenport et al. 56 (3): 200 -- ...
Expression of Ki-67 and cytokeratin 20 in hyperplastic polyps of the colorectum -- Davenport et al.
Expression of Ki-67 and cytokeratin 20 in hyperplastic polyps of the colorectum
Aims: To study the expression of Ki-67 and cytokeratin 20 (CK20)
jcp.bmjjournals.com /cgi/content/full/56/3/200   (2249 words)

  
 cytokeratin - OneLook Dictionary Search
We found 4 dictionaries with English definitions that include the word cytokeratin:
Tip: Click on the first link on a line below to go directly to a page where "cytokeratin" is defined.
cytokeratin : The On-line Medical Dictionary [home, info]
www.onelook.com /?w=cytokeratin&ls=a   (94 words)

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