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Topic: Cytopathy

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	Neurological mitochondrial cytopathies. Mehndiratta MM, Agarwal P, Tatke M, Krishnamurthy M Neurol India (Site not responding. Last check: 2007-08-19)
		The mitochondrial cytopathies are genetically and phenotypically heterogeneous group of disorders caused by structural and functional abnormalities in mitochondria.
		The mitochondrial cytopathies are genetically and phenotypically heterogeneous group of disorders caused by structural and functional abnormalities in mitochondria leading to involvement of nervous system (mitochondrial encephalomyopathies) and other organ systems (mitochondrial cytopathies).
		Neurological manifestations of mitochondrial cytopathies comprise of multineuraxial involvement with raised serum lactic acid and positive muscle biopsy for mitochondrial abnormalities confirmed by genetic analysis for mitochondrial DNA/nuclear DNA mutation.
	www.neurologyindia.com /article.asp?issn=0028-3886;year=2002;volume=50;issue=2;spage=162;epage=7;aulast=Mehndiratta (2466 words)

	BBC - Health - Conditions - Mitochondrial cytopathy
		Someone with mitochondrial cytopathy may have such mild symptoms that they're not troubled by the condition at all.
		It's not possible to prevent the mitochondrial cytopathies and it's not possible to cure the condition either so treatment is targeted at relieving symptoms and delaying the progression of the disease.
		Just as each person with mitochondrial cytopathy is unique, with a unique group of symptoms, treatment needs to be precisely tailored for the individual patient.
	www.bbc.co.uk /health/conditions/mitochondrialcytopathy2.shtml (588 words)

	Mitochondrial Cytopathies
		Mitochondrial cytopathies are inherited or acquired disorders, although rarely they can be the result of a spontaneous mutation in early development of the embryo.
		Once a patient is diagnosed with a specific mitochondrial cytopathy, treatment can be initiated to relieve symptoms and delay the progression of the disease.
		It is difficult to predict the course of mitochondrial cytopathies.
	www.clevelandclinic.org /health/health-info/docs/2600/2603.asp?index=9493&src=news (777 words)

	S7C12P9-Vesicular-misc
		Centrally, the superficial unit shows a plate-like zone of necrosis with increased cytoplasmic acidophilia and with lysis of the nuclei of dead keratinocytes.
		In a sense, this is a form of cytopathy.
		Patterns of this type correlate with the form of cytopathy characterized as ballooning degeneration.
	www.mcl.tulane.edu /classware/pathology/medical_pathology/InflamDermato/S7C3aHydroa/S7C12P9VesicularMisc/s7c12p9vesicularmisc.html (497 words)

	United Mitochondrial Disease Foundation - Medical Article List by Subject
		Bader-Meunier ; B ; 846* ; Refractory anaemia and mitochondrial cytopathy in childhood.
		Cursiefen ; C ; 5798 ; Bilateral zonular cataract associated with the mitochondrial cytopathy of Pearson syndrome.
		Fayon ; M ; 853 ; Fatal neonatal liver failure and mitochondrial cytopathy: an observation with antenatal ascites.
	biochemgen.ucsd.edu /UMDF/mito-cytop.htm (1369 words)

	BioMed Central \| Full text \| Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode ...
		This case illustrates that, in the neonatal period, hyperammonemia and ventricular tachycardia may be the presenting features of a lethal carnitine-acylcarnitine translocase deficiency or of a mitochondrial cytopathy, associated with a milder clinical course.
		It has been reported before that an increased excretion of orotate in sick children may not be uncommon and that a positive allopurinol load test may indicate unrecognized mitochondrial disease, making orotic acid as a potential marker of mitochondrial dysfunction [35].
		Mitochondrial cytopathies are a group of disorders that are clinically heterogeneous with variable forms of presentation.
	www.biomedcentral.com /1471-2431/2/12 (3978 words)

	Bioline International Official Site (site up-dated regularly)
		Fourteen cases of neurological mitochondrial cytopathies presenting with different types of clinical features are being reported.
		Initially mitochondrial cytopathies were regarded as rare clinical entities, but in the last few years due to heightened awareness and research, mitochondrial abnormalities have been attributed in many neurological disorders.
		Muscle biopsy was positive for mitochondrial cytopathy (SDH and GMT staining) in two patients (Table II).
	www.bioline.org.br /request?ni02046 (2453 words)

	podejrzenie cytopatii mitochondrialnej - suspicion of mitochondrial cytopathy (Polish to English translation glossary) ...
		If suspicion of mitochondrial cytopathy is high, blood may be collected any time to examine the DNA for mitochondrial point mutations and deletions.
		Antiretroviral therapy-induced acute pancreatitis with suspicion of mitochondrial cytopathy in a HIV-.
		to discuss in some cases a surgery for full-thickness intestinal biopsies, and/or a neuromuscular biopsy in case of mitochondrial cytopathy suspicion.
	www.proz.com /kudoz/1658726 (234 words)

	Patent 6,500,646
		Examples of the factor involved in immune response reactions include complement regulatory proteins such as MCP and a decay-accelerating factor (DAF) which are factors that suppress a complement activating reaction, UTI which inhibits immunocyte-derived proteases and the second region of UTI, as well as modified versions, variants and derivatives of these factors.
		Examples of the factor suppressing the cytopathy due to active oxygen and/or the factor inhibiting the activity of proteases include UTI, the second region of UTI, elafin, a secretory leukoprotease inhibitor (SLPI) and so forth, as well as modified versions, variants and derivatives of these factors.
		Examples of the factor suppressing the cytopathy due to active oxygen and/or the factor inhibiting the activity of proteases include UTI, the second region of UTI, SLPI and so forth, as well as modified versions, variants and derivatives of these factors.
	www.pharmcast.com /Patents/Yr2002/December2002/123102/6500646_CellMembrane123102.htm (4382 words)

	NEJM -- Mitochondrial inheritance in a mitochondrially mediated disease
		Mendelian inheritance involves the transmission to successive generations of DNA contained in genes in the nucleus, but DNA is also contained in mitochondria, where it is believed to be responsible for the encoding of certain mitochondrial enzymes.
		Since nearly all mitochondrial DNA is maternally transmitted, one might expect a nonmendelian pattern of inheritance in mitochondrial cytopathy, a syndrome in which there are abnormalities in mitochondrial structure and deficiencies in a variety of mitochondrial enzymes.
		These results are consistent with mitochondrial transmission of mitochondrial cytopathy; the inheritance and enzyme defects of mitochondrial cytopathy can be considered in the light of recent evidence that subunits of respiratory-enzyme complexes are encoded solely by mitochondrial DNA.
	content.nejm.org /cgi/content/short/309/3/142 (280 words)

	Mitochondrial Cytopathy (generic Term)
		Mitochondrial cytopathy (generic term) Mitochondrial diseases of nuclear origin.
		Mitochondrial cytopathy (generic term) Mitochondrial diseases, clinically undefinite Mitochondrial diseases (generic term) Mitochondrial...
		cytopathy (generic term) Mitochondrial diseases of nuclear origin Mitochondrial diseases, clinically undefinite Mitochondrial Diseases...
	www.medicality.org.uk /diseases/mitochondrial-cytopathy-(generic-term).php (230 words)

	mitochondrial myopathy - Neurology and Neurosurgery Forum
		We usually see an increase in lactic acid, or an abnormal urine organic acid (often 2-glutaric acid increases) and/or abnormal serum amino acid levels (alanine to lysine ratio in usually increased).
		What we usually see in mitochondrial cytopathy driven GI problems is pseudo-obstruction, diarrhea, or constipation.
		We usually diagnosis a mitochondrial cytopathy by serum lactate, pyruvate, amino acids, carnitine and acyl carnitine; and urine organic acids, amino acids, carnitine and acyl carnitine.
	www.medhelp.org /forums/neuro/messages/30742a.html (269 words)

	details
		Severe muscle weakness in Fanconi's syndrome is rarely the result of mitochondrial cytopathy.
		Mitochondrial cytopathy cannot be excluded in Fanconi's syndrome with late onset of muscular impairment.
		Long-term follow-up of his clinical course is suggested to understand the natural history of this unusual case.
	cmbi.bjmu.edu.cn /ChinaPaper/details.asp?PubMedID=10913735 (109 words)

	A Case of Mitochondrial Cytopathy with a Typical Point Mutation for MELAS, Presenting with Severe Focal-Segmental ...
		Though her only neurological disorder was mild hearing loss, her short stature and elevated lactate and pyruvate values in cerebrospinal fluid suggested mitochondrial cytopathy.
		Mitochondrial cytopathies are often associated with hypertrophic cardiomyopathy but rarely with renal disease.
		The present case of atypical mitochondrial cytopathy was characterized by a unique clinical course and rare complications with focal-segmental glomerulosclerosis.
	content.karger.com /ProdukteDB/produkte.asp?Aktion=ShowFulltext&ArtikelNr=13406&Ausgabe=225200&ProduktNr=223979 (302 words)

	Court Reserves Decision - Health - RedOrbit
		A HIGH Court judge reserved his decision yesterday on whether doctors can withdraw treatment from a woman dying from a disease that has already killed her brother.
		Eileen Doran, 31, is being treated at Walton Neurological Centre in Liverpool for the incurable brain disease mitochondria cytopathy.
		The case was referred to the High Court in London to review an earlier decision allowing them not to resuscitate the woman if she stops breathing.
	www.redorbit.com /news/health/294095/court_reserves_decision/index.html (287 words)

	Revista de Neurología - Visualización del resumen (Site not responding. Last check: 2007-08-19)
		Greater knowledge of the different pathologies and the development of new diagnostic techniques have allowed the list of symptomatic forms to be extended and congenital disorders of the metabolism account for a significant percentage as an aetiopathogenic factor.
		Yet, although it is known that mitochondrial cytopathies can trigger the development of West’s syndrome, few reports exist concerning their association.
		As part of the process of diagnosing West’s syndrome, we recommend tests be carried out to determine the levels of lactic and pyruvic acid, carnitine and amino acids in plasma, and possibly in the cerebrospinal fluid, as well as those of amino acids and organic acids in urine.
	www.revneurol.com /VeureResum.asp?i=i&aof=58703475580786663819&Par1=DeAutor.asp&Par2=39&Par3=07 (238 words)

	Recognizing mitochondrial disease : Epilepsy.com
		Mitochondrial disease or cytopathy (from cyto-, cell, and -pathy, disease) is not uncommon.
		In three large population studies, approximately 1 person in 9,000 had either a disease-causing mitochondrial DNA mutation or another mitochondrial defect.
		In the simplest terms, mitochondrial disease or cytopathy can ultimately be thought of as a deficiency of energy production.
	www.epilepsy.com /epilepsy/recognizing_mitochondrial_disease.html (1224 words)

	T4-CELL-AIDS HYPOTHESIS Debunked Pt 3 (Site not responding. Last check: 2007-08-19)
		Halford John Mackinder Abstract The data generally accepted as proving the HIV theory of AIDS, HIV cytopathy, destruction of T4 lymphocytes, and the relationsip between T4 cells, HIV and the acquired immune deficiency clinical syndrome are critically evaluated.
		It is concluded these data do not prove that HIV preferentially destroys T4 cells or has any cytopathic effects, neither do they demonstrate that T4 cells are preferentially destroyed in AIDS patients, or that T4 cell destruction and HIV are either necessary or sufficient prerequisites for the development of the clinical syndrome.
		In 1985, Gallo and his colleagues (Gallo et al., 1985) showed that in mitogenically stimulated lymphocyte cultures from AIDS patients or in cultures from healthy donors "infected" with HIV, there is a decrease in the total number of viable cells.
	www.talkabouthealthnetwork.com /group/misc.health.aids/messages/95593.html (2041 words)

	Congenital Mitochondrial Cytopathy and External Opthalmoplegia
		Mitochondrial cytopathy was suspected and enzyme studies revealed a deficit on the first unit of mitochondrial respiratory chain.
		Mitochondrial cytopathies, clinical manifestations of CPEO and its differential diagnosis are discussed.
		This case is unusual due to the immediate improvement of both the blepharoptosis and exotropia with the introduction of a ketogenic diet and coenzyme Q. Search this Site
	www.orthopticsnwest.org.uk /abstract-15 (144 words)

	Book Information- AIDS; Virus or Drug Induced?- Duesberg on AIDS
		Abstract: The data generally accepted as proving the HIV theory of AIDS, HIV cytopathy, destruction of T4 lymphocytes, and the relationsip between T4 cells, HIV and the acquired immune deficiency clinical syndrome are critically evaluated.
		It is concluded these data do not prove that HIV preferentially destroys T4 cells or has any cytopathic effects, neither do they demonstrate that T4 cells are preferentially destroyed in AIDS patients, or that T4 cell destruction and HIV are either necessary or sufficient prerequisites for the development of the clinical syndrome.
		In 1985, Gallo and his colleagues (Gallo et al., 1985) showed that in mitogenically stimulated lymphocyte cultures from AIDS patients or in cultures from healthy donors "infected" with HIV, there is a decrease in the total number of viable cells.
	www.duesberg.com /articles/ept4cells.html (12566 words)

	IBNS - Abstracts Submitted For 2005 (Site not responding. Last check: 2007-08-19)
		The neuropsychological functioning of patients with mitochondrial cytopathies, disorders of the energy-producing organelles of the cells, has been largely unexamined in the literature.
		There are currently over 40 known types of mitochondrial cytopathies, which vary greatly in their physiological and behavioral manifestations.
		In the following project we had the opportunity to compare the neuropsychological profiles of a family (a 39 year old mother, her 17 year-old-son and 13 year-old-daughter) afflicted by the same mitochondrial cytopathy caused by the same genetic defect.
	www.ibnshomepage.org /FullAbstract.asp?ID=5 (319 words)

	ab_hardman_humanexcep_7\|Exceptionality and the Family\|Debate Forums\|Real Lives - Real Concerns
		The family's former health plan denied vital services and constantly threatened to reduce others for Kristen, the Kocoureks' 9-year-old daughter who is adopted.
		Kristen has congenital central hypoventilation syndrome, which causes breathing problems, and mitochondrial cytopathy, an inherited metabolic disorder in which the body cannot generate enough cellular energy.
		Her sister, Annalies, 13, also has mitochondrial cytopathy.
	wps.ablongman.com /ab_hardman_humanexcep_7/0,6725,8284-,00.html (344 words)

	MedFriendly.com: Cytopathy
		Cytopathy is any disease or disorder of a cell, or of the structures contained within a cell.
		Cytopathy comes from the Greek word "kytos" meaning "a hollow cell," and the Greek word "pathos" meaning "suffering." Put the two words together and you have "suffering (of) a hollow cell."
		You may not reprint or redisplay this material for commercial use without the express written consent of MedFriendly.com.
	medfriendly.com /cytopathy.html (131 words)

	S5C7P1LE
		This reaction serves as a model for changes encountered in a variety of cell-poor lichenoid reactions.
		It is cell-mediated disease expressed in patterns of cytopathy and, here, affecting cells of the basal unit of squamous epithelium.
		Only slight modifications are required to adapt this model in squamous epithelium to changes in a variety of epithelia in various organ system; all the epithelial adaptations would be in the same basic category as a cell-poor “lichenoid” reactions (and embrace the concept of apoptosis).
	www.som.tulane.edu /classware/pathology/medical_pathology/InflamDermato/S5C2LE/S5C7P1LE/s5c7p1le.html (494 words)

	Epilepsy and mitochondrial disease : Epilepsy.com
		The most frequent EEG finding in a patient with a mitochondrial cytopathy is an independent spike SpikeAn EEG pattern strongly correlated with seizures; “benign” spikes are not associated with seizures.
		Closeseen in multiple brain regions over the left and right hemisphere, combined with a generalized slowing SlowingA term used to describe a group of brain waves on the EEG that have a lower frequency than expected for the subject’s age and level of alertness and the area of the brain recorded.
		The two most common epilepsy syndromes associated with mitochondrial disease are West syndrome (infantile spasms) and Progressive Myoclonic Epilepsy.
	www.epilepsy.com /epilepsy/epilespy_mitochondrial_disease.html (2095 words)

	Lipomatosis simetrica multiple con polineuropatia de presentacion familiar. (Site not responding. Last check: 2007-08-19)
		RESULTS: LSM was associated with axonal PNP and hyperlipidemia in the seven members of the three families, with an apparent pattern of autosomal recessive inheritance.
		No conclusive data of mitochondrial cytopathy, in the form of significant morphological changes, biochemistry of the mitochondrial respiratory chain or micochondrial DNA were found.
		CONCLUSION: Although mitochondrial cytopathy has been described as part of the syndromes in which LSM occurs, there may be other undefined aspects, such as disorders of lipid metabolism which form part of the pathogenesis.
	www.infodoctor.org /cgi-bin/abstracts.pl?uid=11562837 (247 words)

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