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Topic: Cytoprotectant

In the News (Thu 31 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

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Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Assay system for anti-stress agents - Patent 6232060
		Cytoprotectant agents are shown to reverse the lactate dehydrogenase release in the presence of mitochondrial function interfering agents, as a model for the effects of hypoxia on cellular energetic function.
		Reduction in LDH release is indicative of cytoprotection.
		Cytoprotectant candidates may be added to the medium and their effect on the lactate release determined.
	www.freepatentsonline.com /6232060.html (2954 words)

	Clinical Practice (Site not responding. Last check: 2007-10-31)
		The normal cells most likely to be affected by cancer therapy are bone marrow and epithelial cells in the mouth, digestive tract, reproductive system, and hair follicles.
		The development of cytoprotective agents has lessened the side effects of certain therapies and improved the quality of life for people with cancer.
		The drug MESNA, (Mesnex), is one of the oldest cytoprotective agents and has been given for preventing hemorrhagic cystitis since the late 1970’s.
	www.ons.org /clinical/SymptomManagement/cytoprotection (170 words)

	Stress ulceration in critical care - what causes it?
		Ulceration is caused by ischemic injury to the gastric mucosa, loss of cytoprotectants and assault by gastric acid.
		The result is reduced production of cytoprotectant factors, such as prostaglandins, mucosal atrophy and increased permealility, loss of reparative capacity and loss of ability to neutralize acid (hydrogen ions).
		The mucosa is compromised by ischemia and attacked (mostly) by acid.
	www.ccmtutorials.com /support/ulcers/page_03.htm (173 words)

	Clinical Practice (Site not responding. Last check: 2007-10-31)
		Pilot trial of cytoprotection with amifostine given with high-dose chemotherapy and autologous peripheral blood stem cell transplantation.
		Amifostine as a Cytoprotectant for Patients Receiving Myeloablative Therapy for Allogeneic Hematopoietic Stem Cell Transplantation.
		Use of melphalan 280 mg/m2 plus amifostine cytoprotection and autologous stem cell transplantation in multiple myeloma patients.
	www.ons.org /clinical/SymptomManagement/cytoprotection/resources/stem.shtml (806 words)

	Bay Medical: News/PR
		The clinical trial, which involved the use of higher than normal radiation doses combined with the use of a cytoprotectant drug, Amifostine, included 24 patients with non-small cell lung cancer.
		Until recently, high radiation doses have not been considered feasible or safe for patients with advanced lung cancer.
		The drug Amifostine used in the trial is a cytoprotectant which concentrates in the healthy tissue, protecting this tissue from being damaged by radiation or chemotherapy.
	www.baymedical.org /general/news/2005072101.php (419 words)

	ONS Cytoprotection Resource Area (Site not responding. Last check: 2007-10-31)
		Pilot trial of cytoprotection with amifostine given with high-dose chemotherapy and autologous peripheral blood stem cell transplantation.
		Amifostine as a Cytoprotectant for Patients Receiving Myeloablative Therapy for Allogeneic Hematopoietic Stem Cell Transplantation.
		Use of melphalan 280 mg/m2 plus amifostine cytoprotection and autologous stem cell transplantation in multiple myeloma patients.
	onsopcontent.ons.org /toolkits/Cytoprotection/resources/stemcell.shtml (806 words)

	Milk thistle American Family Physician - Find Articles (Site not responding. Last check: 2007-10-31)
		Milk thistle has been used as a cytoprotectant for the treatment of liver disease, for the treatment and prevention of cancer, and as a supportive treatment of Amanita phalloides poisoning.
		Milk thistle (Silybum marianum) was used in classical Greece to treat liver and gallbladder diseases and to protect the liver against toxins.
		It recently has been investigated for use as a cytoprotectant, an anticarcinogen, and a supportive treatment for liver damage from Amanita phalloides poisoning.
	findarticles.com /p/articles/mi_m3225/is_7_72/ai_n15798324 (777 words)

	ONS Cytoprotection Resource Area (Site not responding. Last check: 2007-10-31)
		The normal cells most likely to be affected by cancer therapy are bone marrow and epithelial cells in the mouth, digestive tract, reproductive system, and hair follicles.
		The development of cytoprotective agents has lessened the side effects of certain therapies and improved the quality of life for people with cancer.
		The drug MESNA, (Mesnex), is one of the oldest cytoprotective agents and has been given for preventing hemorrhagic cystitis since the late 1970’s.
	onsopcontent.ons.org /toolkits/Cytoprotection (170 words)

	details
		Cinnamophilin as a novel antiperoxidative cytoprotectant and free radical scavenger.
		Furthermore, cinnamophilin exerted a divergent effect on the respiratory burst of human neutrophil by different stimulators.
		Our results show that cinnamophilin acts as a novel antioxidant and cytoprotectant against oxidative damage.
	cmbi.bjmu.edu.cn /ChinaPaper/details.asp?PubMedID=11342256 (237 words)

	Pretreatment with inducers of ER molecular chaperones protects epithelial cells subjected to ATP depletion -- Bush et ...
		We have investigated the potential cytoprotective role of endoplasmic reticulum (ER) molecular chaperones in a cultured cell
		A: Northern blot analysis of total RNA collected from MDCK cells grown in DMEM-5% FCS for 12-16 h in the absence (control, lane 1) or presence of 1 µM tunicamycin for 1 h (lane 2), 3 h (lane 3), 6 h (lane 4), and 14 h (lane 5), respectively.
		Transient ischemia or heat stress induces a cytoprotectant protein in the rat kidney.
	ajprenal.physiology.org /cgi/content/full/277/2/F211 (4917 words)

	IngentaConnect Microglial Integrity is Maintained by Erythropoietin Through Inte... (Site not responding. Last check: 2007-10-31)
		Recognized as a robust cytoprotectant for multiple tissues of the hematopoietic, vascular, cardiac, and nervous systems, erythropoietin (EPO) also is considered to be an attractive therapeutic candidate to modulate inflammatory cell function and survival during neurodegenerative disorders.
		To this end, microglia of the central nervous system serve a complex function not only to dispense of foreign organisms and injured cells of the brain, but also to foster tissue repair and reorganization during neuronal and vascular cell insults.
		Furthermore, expression and activation of Akt1 is vital to the cytoprotective capacity of EPO, since pharmacological inhibition of the PI 3-K pathway or gene silencing of Akt1 expression eliminates the ability of EPO to protect microglial cells.
	www.ingentaconnect.com /content/ben/cnr/2006/00000003/00000003/art00004 (292 words)

	Cytoprotection: Shelter from the Storm -- Klein and Muggia 4 (2): 112 -- The Oncologist
		Cytoprotection: Shelter from the Storm -- Klein and Muggia 4 (2): 112 -- The Oncologist
		the criteria for an ideal cytoprotectant as it improved the
		Capizzi R. Amifostine: the preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies.
	theoncologist.alphamedpress.org /cgi/content/full/4/2/112 (3456 words)

	Medi-Vet - Detail
		Action is to bind to ulcerated tissue in GI tract to aid healing of ulcers.
		There is some evidence that sucralfate may act as a cytoprotectant (by increasing prostaglandin synthesis).
		Clinical trails of efficacy in animals have not been conducted.
	www.medi-vet.com /detail.aspx~ID~2052 (113 words)

	JKMS vol 21 no. 5
		However, its cytoprotective effect against GM induced kidney injury has not yet been studied.
		In this study, we investigated the cytoprotective effect of HSP72 on GM-induced nephrotoxicity in vitro.
		Human Kidney tubular cell line, HK-2 cells were divided into four groups: control group, GM group (cells incubated with GM only), heat shock (HS) group (cells incubated at 43 degrees C for 30 min), and GM plus HS group, respectively.
	jkms.kams.or.kr /2006/abstract/904a.html (273 words)

	Phase III multicenter randomized trial of amifostine as cytoprotectant in first-line chemotherapy in ovarian cancer ...
		Phase III multicenter randomized trial of amifostine as cytoprotectant in first-line chemotherapy in ovarian cancer patients
		Influence of the cytoprotective agent Amifostine on pharmacokinetics of paclitaxel and taxotere.
		Concurrent administration of docetaxel and stealth liposomal doxorubicin with radiotherapy in non small cell lung cancer: excellent tolerance using subcutaneous amifostine for cytoprotectant.
	annonc.oxfordjournals.org /cgi/pmidlookup?view=long&pmid=12853351 (3985 words)

	amifostine - resources from the government and academia
		The potential of amifostine: from cytoprotectant to therapeutic...
		Entrez PubMed: Abstract, Amifostine stimulates the formation of hematopoietic bone marrow progenitors from B-cell chronic lymphocytic leukemia.
		The composition of claim 1, wherein the active compound is a cytoprotectant selected from the group consisting of amifostine, L-carbocisteine, leucovorin...
	www.cancer-help.org /medications/files/amifostine.html (2236 words)

	ALSTDF Forum
		kmaiese@med.wayne.edu Although usually identified as an essential cellular nutrient for cellular growth and maintenance, nicotinamide is under development as a novel cytoprotectant for acute and chronic neurodegenerative disorders.
		The downstream cellular and molecular cascades are considered vital for the cytoprotection offered by nicotinamide.
		These pathways encompass the modulation of Akt, the forkhead transcription factor FKHRL1, mitochondrial membrane potential, caspase activities and cellular energy metabolism, but remain independent of intracellular pH and mitogen-activated protein kinases.
	www.als.net /forum/post.asp?method=ReplyQuote&REPLY_ID=4015&TOPIC_ID=917&FORUM_ID=7 (1543 words)

	From the Cover: Biliverdin reductase: A major physiologic cytoprotectant -- Barañano et al. 99 (25): 16093 -- ...
		Bilirubin is a suprastoichiometric cytoprotectant against oxidative stress (a) and BVRA can redox cycle the tetrapyrrole in vitro (b–d).
		to be induced by oxidative stress and to be involved in cytoprotection.
		We propose that the cytoprotective role of the BVR cycle
	www.pnas.org /cgi/content/full/99/25/16093 (3926 words)

	A randomized trial of amifostine as a cytoprotectant for patients receiving myeloablative therapy for allogeneic ... (Site not responding. Last check: 2007-10-31)
		and studies suggest that the cytoprotection afforded to normal cells is due to the fact that normal cells have higher membrane alkaline phosphatase activity (required for the metabolism of the amifostine prodrug to the active thiol WR-1065) than tumor cells (Figure 1).
		While normal cells are somewhat protected from the effects of cytotoxic therapy, tumor cells that have deficient cell surface intestinal-type alkaline phosphatase are not.
		The narrow window of time for which amifostine is able to exert its cytoprotective effects would limit its efficacy.
	www.nature.com /bmt/journal/v34/n1/full/1704521a.html (3753 words)

	Bladder Cancer Treatments - chemotherapy for invasive tumors
		Selecting patients for chemotherapy, particularly for more aggressive regimens like CMV or M-VAC requires a great deal of clinical judgment, taking into account such aspects as kidney inefficiency and the overall health of the patient.
		Cytoprotectant drugs have been developed which can help protect against undesirable side effects.
		Surviving chemo Click here for information on anti nausea medications as well as cytoprotectant drugs.
	blcwebcafe.org /chemosused.asp (3536 words)

	Metallothionein Acts as a Cytoprotectant against Doxorubicin Toxicity -- Kimura et al. 292 (1): 299 -- Journal of ...
		indicate that basal and induced MT act as cytoprotectants against
		not clear that MT acts as cytoprotectant against Dox cardiotoxicity.
		Dox toxicity is observed in primary myocytes and hepatocytes and is mediated by free radicals.
	jpet.aspetjournals.org /cgi/content/full/292/1/299 (2874 words)

	Niacinamide....good for the brain Free discussion
		cytoprotection of nicotinamide is the modulation of an early and late phase of
		robust cytoprotective agents as nicotinamide in conjunction with the elucidation of
		Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain.
	gyxe.com /depression/16-294-niacinamide-good-for-the-brain-read.shtml (1844 words)

	[No title]
		They stimulate organization and antibody responses, seem to induce the bone marrow to proliferate the type of white blood cells needed for immediate resistance, and generate sophistication and fine tuning for an overall strategy of resistance.
		CYTOPROTECTANT A substance or reaction that acts against chemical or biological damage to cell membranes.
		The most common cytoprotectant actions are on the skin and the liver (hepatoprotectant), although there has been recent research involving lymphocyte T-cell cytoprotectants.
	www.swsbm.com /ManualsMM/MedHerbGloss2.txt (20331 words)

	Clinical Updates 12-06-99 (Site not responding. Last check: 2007-10-31)
		SAN ANTONIO-A cytoprotectant reduces salivary problems in head-and-neck cancer patients getting radiation therapy.
		In a controlled multicenter study of 303 patients with squamous-cell carcinoma, 51% of 153 patients given IV amifostine (Ethyol, Alza) about 15 minutes before each radiation treatment had grade 2 or higher xerostomia, vs. 78% of those who did not get the drug, says Duke radiation oncologist David Brizel.
		Overall survival at two years was 81% for the amifostine patients and 73% for the controls, Dr. Brizel told the American Society of Therapeutic Radiology and Oncology meeting here.
	www.physiciansweekly.com /archive/99/12_06_99/cu2.html (135 words)

	Erythropoietin Is a Novel Vascular Protectant Through Activation of Akt1 and Mitochondrial Modulation of Cysteine ...
		The potential for EPO to be an efficacious cytoprotectant in
		Cytoprotection by EPO in ECs is mediated in part by activation of Akt1.
		No enhanced or synergistic protection was observed during application of each caspase inhibitor combined with EPO compared with cultures exposed to EPO and anoxia alone.
	circ.ahajournals.org /cgi/content/full/106/23/2973 (3676 words)

	Different Faces of the Heme-Heme Oxygenase System in Inflammation -- Wagener et al. 55 (3): 551 -- Pharmacological ...
		to be cytoprotective in models of ischemic heart injury and
		HO-1 is up-regulated during the resolution of inflammation and controls the activity of the heme proteins COX and NOS both on the level of the prosthetic group heme, as well as by the generation of CO, which can bind to the heme group and alter the activity of the enzymes.
		Thus, HO seems to be cytoprotective by limiting the influx of
	pharmrev.aspetjournals.org /cgi/content/full/55/3/551 (6332 words)

	Wiley::Ashgate Handbook of Antineoplastic Agents
		This Handbook contains records for all the major drugs currently in use to treat cancer.
		Monographs are provided for 409 antineoplastic agents and, in addition, 23 cytoprotectant agents are described.
		For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) Number, and the Merck Index (12th Edition) Number are given.
	www.wiley.com /WileyCDA/WileyTitle/productCd-0566083825,descCd-description.html?print=true (180 words)

	StockProfit™ - Turning small investments into small fortunes
		Novelos Therapeutics, Inc., a biotechnology company, engages in the development and commercialization of oxidized glutathione-based compounds for the treatment of cancer and hepatitis, primarily in Russia.
		Its products include NOV-002, which is a cytoprotectant and an....
		Xtreme Companies, Inc. is engaged in manufacturing and marketing of mission-specific Fire-Rescue and Patrol boats used in emergency, surveillance and defense deployments.
	www.stockprofit.com (412 words)

	pansement gastro-intestinal - cytoprotectant (French to English translation glossary) IBS,Medical (general),Medical
		I found 'cytoprotective' agent, but I'm sure there is a more common term for these products that are used for ulcers, acidity, etc...
		You are right, I did confuse antacids with cytoprotectants.
		I found the same term so this is what I'll go with.
	www.proz.com /kudoz/662294?&print=1 (628 words)

	Mount Desert Island Biological Lab - Research Core (Site not responding. Last check: 2007-10-31)
		CHOROID PLEXUS: Renfro together with colleagues Miller, Villalobos and Gordon determined how thermal stress in the presence and absence of the endogenous cytoprotectant, trimethylamine oxide (TMAO), may alter transport of organic anions across the blood- cerebrospinal fluid (CSF) barrier in a non-mammalian model, the spiny dogfish shark, Squalus acanthias.
		Thus, the cytoprotectant, TMAO, may suppress the denaturation of protein, decreasing the major signal for increased HSP production.
		The findings suggest that if HSP is suppressed during thermal stress, that the transport of organic anions (or other compounds) out of the CSF may be reduced.
	www-apps.niehs.nih.gov /centers/public/res-core/ctr760-3089.htm (2786 words)

	Article
		Voltaren (Diclofenac): Voltaren (Diclofenac) is a NSAID (non-steroidal anti-inflammatory drug) that is excluded from the treatment of osteoarthritis when used alone.
		In Arthrotec, it is used along with a cytoprotectant called Misoprostol (protects the stomach and duodenum against ulceration), in which case it is an acceptable form of osteoarthritis treatment for those who are at high risk for gastrointestinal ulceration (GI).
		It is also important to note that Voltaren (Diclofenac), when compared to other NSAID's, has an increased risk of developing NSAID-induced hepatic injury.
	www.agenet.com /doc/3124 (434 words)

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