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Topic: Cytostatic


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In the News (Sat 11 Oct 08)

  
 Patent 4797282: Drug depot containing cytostatics
Large numbers of cytostatics are known and, in principle, all can be used according to the invention, as long as they are compatible with the other constituents of the depot and are not decomposed by the heat being produced during the polymerization of the material.
The admixture of the amino acid to the base material is carried out analogously to that of the cytostatic, it also being possible to mix the amino acid and cytostatic previous to incorporation of the cytostatic in said base material, or to incorporate the amino acid in the prepolymer.
This cytostatic can be admixed as a finely divided powder to the other constituents, that is to say the prepolymer and the monomer, and thus be homogeneously distributed in the resulting polymer.
www.freepatentsonline.com /4797282.html

  
 Patent 5242909: Method of using 4-(2-(P-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) propenyl)phenoxy)ethyl)morpholine with cytostatics
Therapy with cytostatic agents is frequently associated with undesirable effects which have their origin in the toxicity of the cytostatic agent.
The dosing in an individual case must be fitted to the requirements of the patient and to the other cytostatic or BRM used in parallel, which lies in the purview of the specialist knowledge.
The invention is also concerned with a commercial pack containing as the pharmaceutically active substance 4-[2-[p-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl ]phenoxy]ethyl]morpholine together with instructions for its use in combination with a cytostatic agent for the simultaneous, separate or sequential use in cancer prophylaxis or therapy particularly for cancers which are sensitive to such a combination.
www.freepatentsonline.com /5242909.html

  
 Combination of selenium-containing compounds with cytostatics - US Patent 6656509
The cytostatic used together with selenium or a selenium compound may also be a cytostatic inhibiting nucleic acid synthesis, for example methotrexate and fluorouracil, which belong to the group of antimetabolites, or the topisomerase inhibitor topotecan, mRNA synthesis inhibitors such as doxorubicin, or alkylating agents such as cyclophosphamide and chlorambucil.
The cytostatic that is used together with selenium or a selenium compound may be a mitosis-inhibiting cytostatic.
Furthermore, a selenium oxide is preferred as the selenium compound for enhancing the effect of a cytostatic or a mixture of cytostatics.
www.patentstorm.us /patents/6656509.html

  
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Cytostatics and anastomotic healing in the intestine: an experimental study on the effect of parenteral nutrition.
A negative effect of cytostatics on anastomotic bursting strength was found in the ileum 7 days after operation.
The effects of parenteral nutrition on the healing of experimental ileal and colonic anastomoses constructed on the 3rd day of a 5-day cytostatics course were investigated.
darwinpharmacy.com /ref-weight-loss-006/weight-loss-006-research-abs3.289.html

  
 Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture.
Seventh Cain Memorial Award lecture.The development of the oxazaphosphorine cytostatics cyclophosphamide, ifosfamide, and trofosfamide was based on the idea of applying the transport form/active form principle to the highly reactive nitrogen mustard group.
With mesna protection, these cytostatics can be given in higher doses with increased safety, and their therapeutic efficacy can be enhanced.
The aim of considerably increasing the therapeutic index of alkylating agents has been achieved by the oxazaphosphorine cytostatics.
www.pdg.cnb.uam.es /UniPub/iHOP/gp/6153113.html

  
 Disruption of the Murine Major Vault Protein (MVP/LRP) Gene Does Not Induce Hypersensitivity to Cytostatics -- Mossink et al. 62 (24): 7298 -- Cancer Research
of cytostatics, was examined in a MTT assay.
ES cells in response to increasing concentrations of cytostatic
Presented are the drug concentrations at which proliferation is reduced to 50% as compared to untreated cells.
cancerres.aacrjournals.org /cgi/content/full/62/24/7298

  
 Effect of cytostatics on prostaglandin F2 alpha prostacyclin, and thromboxane in patients with gynecologic malignancies -- Ylikorkala et al. 58 (4): 483 -- Obstetrics & Gynecology
Effect of cytostatics on prostaglandin F2 alpha prostacyclin, and thromboxane in patients with gynecologic malignancies -- Ylikorkala et al.
Effect of cytostatics on prostaglandin F2 alpha prostacyclin, and thromboxane in patients with gynecologic malignancies
Thus, malignancies may be accompanied by increased production of prostacyclin and thromboxane A2, which can be lowered by cytostatics.
www.greenjournal.org /cgi/content/abstract/58/4/483

  
 BioMed Central Full text Clinical studies with cytostatics in children
Most of the findings on the activity of new cytostatics in paediatric cancers are based on scientific data generated by drug sensitivity testing panels of labs within the GPOH and from other international paediatric research groups.
Most of the cytostatic drugs required for treatment have not been approved for paediatric use, which could present problems.
Childhood is in itself a risk factor for the development of drug toxicities due to growth, development of drug metabolism and clearance as well as functional organ development.
www.biomedcentral.com /abstracts/AGAH/3/op013

  
 Inhibitory effect of various cytostatics and cycloheximide on acute experimental pancreatitis in rats -- Korbova et al. 18 (11): 913 -- Gut
Inhibitory effect of various cytostatics and cycloheximide on acute experimental pancreatitis in rats -- Korbova et al.
Inhibitory effect of various cytostatics and cycloheximide on acute experimental pancreatitis in rats
gut.bmjjournals.com /cgi/content/abstract/18/11/913

  
 Effect of Hyaluronidase on Pharmacodynamics and Pharmakokinetics of Cytostatics
Although pharmacokinetic data are essential for selecting optimal conditions for an effective combination of the enzyme with cytostatic drugs, studies on pharmacokinetics and tissue distribution of hyaluronidase are very limited.
Investigations on the resorption and penetration of cytostatics into tumors in combination with hyaluronidase are also scarce.
Our pharmacological studies are focussed on the treatment of malignant melanoma and brain tumours.
www.uni-regensburg.de /Fakultaeten/nat_Fak_IV/Pharmazie/buschauer/research/hyasepharmacodyn.htm

  
 Cytostatics
Cytostatic drugs have the ability to prevent the growth and proliferation of cells.
They are often used to prevent growth and development of malignant cells and neoplasms and in this case named antineoplastic drugs.
we.vub.ac.be /%7Ecege/ENG/compounds/cytostatics.htm

  
 A Combined Effect of Pseudorabies Virus Growth Factor (PGRF) and Various Cytostatics on Tumour
These cytostatics suppressed the ability of PRGF to change the transformed phenotype of Hep-2 cells, and on the other hand, PRGF diminished the effect of these cytostatics on growth and metabolism (DNA and protein content, glucose consumption, lactate and ammonia production) compared to non-treated control cells.
One of activities of pseudorabies virus /PRV/ growth factor /PRGF/ is its ability to change the transformed phenotype of cultured tumour cells toward the normal one.This activity of PRGF was studied in combination with antiproliferative activity of various cytostatics.
An undesirable outcome was observed, when PRGF was combined with 11 out of 12 cytostatics.
www.vfu.cz /acta-vet/vol66/159-97.htm

  
 Toremifene combined with cytostatics: effects on growth and histamine concentration of human mammary cancer in mouse subrenal capsule assay (SRCA)
Suonio E, Tuomisto L, Kangas L. Toremifene combined with cytostatics: effects on growth and histamine concentration of human mammary cancer in mouse subrenal capsule assay (SRCA).
Toremifene combined with cytostatics: effects on growth and histamine concentration of human mammary cancer in mouse subrenal capsule assay (SRCA)
www.uku.fi /wwwdata/julkaisutoiminta/julkaisut/1993/9300784.html

  
 IITD PAN - Wroc³aw
Summarized data revealed that CBM-4A possessed similar properties as other oxazaphosphorine cytostatics.
Acute and cumulative toxicity, behavioral screening tests and effects of subchronic and chronic treatment (influence on body weight, mortality, blood morphology, proteins level, urea and creatinine concentration, enzymes activity) were taken into account.
www.iitd.pan.wroc.pl /cgi/journal.exe?en+aite+1994_42+5-6+04_Cytostatics+405

  
 Cytostatics
cytostatics is a valid word in this word list, but no definition for it has been loaded yet.
Words within cytostatics not shown as it has more than seven letters.
The word "cytostatics" uses 11 letters: A C C I O S S T T T Y.
www.morewords.com /word/cytostatics

  
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The suppression of hemopoiesis was much less manifested, if cytostatics were used together with diuretics (diacarbe or furocemid).
[Hematopoietic indices in rats with sarcoma 45 in the process of treatment with cytostatics and diuretic agents]
The results support the notion that the bulk of Cl- influx in rat parotid acinar cells is via a loop diuretic-sensitive Na+/K+/Cl- co-transport mechanism as may occur in other secretory epithelia.
darwinpharmacy.com /ref-furosemide/furosemide-research-abs3.33.html

  
 Chemie.DE News-Center: Iron Complex with a Killer Instinct
Nucleoside analogs, such as the nucleoside antibiotics Carbovir and Tubercidine, are established drugs for fighting viruses, bacteria, and fungi, as well as being cytostatics.
03/24/2004 - German researchers have successfully developed a new class of cytostatics that drive cancer cells to programmed suicide (apoptosis): iron-containing nucleoside analogs.
Analogs of natural metabolites are under consideration as drugs because they so closely resemble their "models" in structure that they compete with them, inhibiting or misdirecting physiological processes.
www.chemie.de /news/e/36244

  
 Fermentative preparation process for and crystal forms of cytostatics - US Patent 6380227
Fermentative preparation process for and crystal forms of cytostatics The invention relates to a new biotechnological preparation process that can be used on an industrial scale for the production of epothilones, especially a process for concentrating these compounds in the culture medium, as well as a new strain for the fermentative preparation of these compounds.
Fermentative preparation process for and crystal forms of cytostatics
Method of treating a warm-blooded animal suffering from a proliferative disease, comprising administering a dosage of a crystal form of epothilone B as claimed in claim 1 or claim 5 which is effective for treating said disease to a warm-blooded animal requiring such treatment.
www.patentstorm.us /patents/6380227.html

  
 NextPharma: Cytostatics
This site located just south of Brussels - and within short distance of Brussels international airport - has a separate warehouse and production area for cytostatics.
www.pencef.de /9+M52087573ab0.0.html

  
 U.S. Pregrant 20040176605 - New pyridyl alkane acid amides as cytostatics and immunosuppressives
New pyridyl alkane acid amides as cytostatics and immunosuppressives
U.S. Pregrant 20040176605 - New pyridyl alkane acid amides as cytostatics and immunosuppressives
The invention relates to new pyridyl alkane acid amides according to general formula (I) as well as methods for their production, medicaments containing these compounds as well as their medical use, especially in the treatment of tumors or for immunosuppression.
cxp.paterra.com /uspregrant20040176605.html

  
 Magic Bullets Will Revolutionise Cancer Market
As a direct result of the success of its subsidiary Genentech's two MAb products, Roche was the number two corporation in the L1X, or "All Other Cytostatics", ATC class in World Review 2000, with 29% of the market, after Bristol-Myers Squibb (BMS) with 51%.
In addition, Roche was one of just three of the top ten companies in ATC L (which covers cancer treatments) to increase its share of the market in 1999.
The potential for geographic growth for the products is clear, particularly given the August 2000 approval of Herceptin in the EU.
www.ims-global.com /insight/news_story/0011/news_story_001103.htm

  
 Pharmaceutical Technology - Haupt Pharma - Drug Development, Clinical Supply And Contract Manufacturing
Special emphasis is put on the manufacturing and packaging of sexual and thyroid hormones, narcotics and cytostatics, for which HAUPT has special dedicated areas.
All of HAUPT Pharma's production plants package the manufactured pharmaceuticals in a number of different forms: blisters, cans, tubes, bottles, sachets.
www.pharmaceutical-technology.com /contractors/contract/haupt

  
 L.a.n.c.e. C hemosensitivitytesting at the highest level· Laboratory for Applied Neoplasia Research and Cytostatics Evaluation
C hemosensitivitytesting at the highest level· Laboratory for Applied Neoplasia Research and Cytostatics Evaluation
Laboratory for Applied Neoplasia Research and Cytostatics Evaluation Inc.
Download On this side you find our current flyer "chemosensitivity testing on the highest level" as.pdf File as well as the forms prepared particularly for testing as.pdf File for download.
www.lance.de /lance/gb_content/lance_download_gb.html

  
 Roche fights back into the top 10
The leading therapy class for the combined entity would be L1X 'All other Cytostatics'.
Merging with Novartis and its product Glivec (imatinib) would strengthen Roche's current leading position in this area with products MabThera (rituximab) and Herceptin (trastuzumab).
www.ims-global.com /insight/news_story/0302/news_story_030227.htm

  
 IngentaConnect Enhanced sensitivity of periphera...c effects of various cytostatics
Enhanced sensitivity of peripheral blood lymphocytes from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics
IngentaConnect Enhanced sensitivity of periphera...c effects of various cytostatics
You may be required to register and activate access/purchase before you can obtain the full text.
www.ingentaconnect.com /content/els/13835742/2003/00000544/00000002/art00091

  
 Browse words starting with cytostatics - More Words
No longer words starting with cytostatics found in this word list.
Browse words starting with cytostatics - More Words
www.morewords.com /browse/cytostatics

  
 ASCO - Browse by Meeting - Immune Implications of Cytostatics Loaded in Drug Carriers of Second Generation (Nanoparticles).
Immune Implications of Cytostatics Loaded in Drug Carriers of Second Generation (Nanoparticles).
ASCO - Browse by Meeting - Immune Implications of Cytostatics Loaded in Drug Carriers of Second Generation (Nanoparticles).
Home > Publications > Abstracts > Browse by Meeting >
www.asco.org /ac/1,1003,_12-002627-00_18-002-00_19-00100221,00.asp

  
 AN EXPERIMENTAL SYSTEM FOR THE SIMULTANEOUS ESTIMATION OF MITOSTATIC AND LYMPHOTOXIC EFFECTS OF IMMUNOSUPPRESSANTS AND CYTOSTATICS -- Petrov et al. 133 (3): 640 -- The Journal of Experimental Medicine
AN EXPERIMENTAL SYSTEM FOR THE SIMULTANEOUS ESTIMATION OF MITOSTATIC AND LYMPHOTOXIC EFFECTS OF IMMUNOSUPPRESSANTS AND CYTOSTATICS -- Petrov et al.
Articles by Petrov, R. Articles by Seslavina, L. The Journal of Experimental Medicine, Vol 133, 640-648, Copyright © 1971 by The Rockefeller University Press
Hydrocortisone acetate had a more narrow range of selective
www.jem.org /cgi/content/abstract/133/3/640

  
 EFIT 98 - Apoptosis is Differentially Regulated in Leukemia, CD4 and CD5 Lymphocytes and can be Selectively Induced by Cortisone, Cytostatics or Thymic Peptides
EFIT 98 - Apoptosis is Differentially Regulated in Leukemia, CD4 and CD5 Lymphocytes and can be Selectively Induced by Cortisone, Cytostatics or Thymic Peptides
www.highlights-forschung.de /kongresse/EFIT/texte/englisch/nebe1.html

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