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Topic: DNA helicase

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UNIX System Labs

Disinfection

Nereis

GCJ

Bey of the Ottoman Empire

	ms+biblio (Site not responding. Last check: 2007-10-20)
		Detailed understanding of the mechanism of helicase action is of inherent interest because the chemistry that underlies the conversion of energy derived from NTP hydrolysis into directional motion is in general poorly understood.
		, the factor primarily responsible for the unwinding of the DNA duplex at replication forks in chromosomal DNA synthesis (LeBowitz and McMacken, 1986).
		and Kornberg, A. Assembly of the primosome of DNA replication in Escherichia coli.
	www.cnb.uam.es /~bioinfo/paper/carmen/carmen.html (5094 words)

	Werner Syndrome Protein. I. DNA HELICASE AND DNA EXONUCLEASE RESIDE ON THE SAME POLYPEPTIDE -- Shen et al. 273 (51): ...
		DNA Helicase and Exonuclease Activities Are Encoded by Distinct Domains of the WRN Gene-- An N-terminal domain in WRN was recently shown to encode a DNA sequence motif that is conserved in several exonucleases (28-30).
		Glycerol gradient centrifugation of WRN DNA helicase and exonuclease.
		DNA helicase, WRN protein was incubated for 1 h at 4 °C with the indicated amounts of preimmune serum (A) or anti-WRN antiserum (B).
	www.jbc.org /cgi/content/full/273/51/34139 (5174 words)

	DNA Helicase WRN
		Along with the helicase-C (carboxy-terminal helicase) domain, this region of the protein is thought to be the essential to the helicase activity of the protein (Sanger Institute- Ensembl Protein Report, 2003).
		The conserved helicase domain in the protein is shown shaded in fl, and the degree of relatedness between the proteins is shown on the right.
		Bloom Syndrome is caused by mutations of the WRN homolog BLM.
	www.bio.davidson.edu /Courses/Molbio/MolStudents/spring2003/McCord/wrn.htm (1946 words)

	X-Ray Crystallography Reveals Helicase that Unwinds DNA
		Helicases have become a competitive field of inquiry because defects in human forms underlie several diseases, including the cancer-prone Bloom's syndrome and a disease of premature aging called Werner syndrome.
		The large helicase donut sits atop a smaller one that is the primase, another enzyme of the replication fork.
		Richardson¹s lab prepared a helicase fragment of the helicaseprimase that was amenable to X-ray crystallography.
	www.hms.harvard.edu /news/releases/1099helicase.html (1035 words)

	A Dominant-negative Mutant of Human DNA Helicase B Blocks the Onset of Chromosomal DNA Replication -- Taneja et al. 277 ...
		D, helicase activity was measured as a function of the concentration of wt HDHB (filled circles), mutant A (unfilled triangles), and mutant B (unfilled circles) in standard helicase reactions, except that KCl was omitted from the buffer, and the reaction volume was 20 µl.
		The polarity of HDHB helicase activity was determined by using the DNA substrates diagrammed in Fig.
		DNA polymerase I Klenow fragment to yield a population of helicase
	www.jbc.org /cgi/content/full/277/43/40853 (6163 words)

	Biochemical Characterization of the Werner Syndrome DNA Helicase—Exonuclease (Site not responding. Last check: 2007-10-20)
		Being a member of the RecQ family of DNA helicases, WRN possesses a 3’g5’ helicase activity that resides in a 7-motif domain at the center of the 1432 amino acid polypeptide.
		The penchant of both the helicase and exonuclease for alternative DNA structures might reflect their roles in resolving aberrant DNA formations that form during the metabolism of cellular DNA.
		Conceivably, therefore, a better understanding of the modes of operation and in vivo roles of the WRN protein are to be gained by studying the properties of its helicase and exonuclease in reconstituted multiprotein complexes.
	www.eurekah.com /abstract.php?chapid=1118&bookid=82&catid=75 (383 words)

	Interactions of DNA Helicases with Damaged DNA: Possible Biological Consequences -- Villani and Tanguy Le Gac 275 (43): ...
		DNA helicases are a class of enzymes able to unwind the two complementary DNA strands in a reaction dependent on energy derived
		To overcome the deleterious effects of DNA lesions, a variety of DNA repair systems is present in all living organisms (5).
		as the replicative helicase at the fork (48).
	www.jbc.org /cgi/content/full/275/43/33185 (4001 words)

	DNA2 - DNA replication helicase DNA2
		Mutations in the gene for the conserved, essential nuclease-helicase Dna2 from the yeast Saccharomyces cerevisiae were found to interact genetically with POL1 and CTF4, which encode a DNA Polymerase alpha subunit and an associated protein, suggesting that Dna2 acts in a process that involves Pol alpha.
		Downstream DNA primers, RNA primers, and small 5'-flaps were efficiently matured by Pol delta and FEN1, and Dna2 did not stimulate maturation.
		The temperature-dependent lethality of dna2 (ts) mutants was suppressed by overexpression of genes encoding subunits of polymerase delta (cdc1(+) and cdc27(+)), DNA ligase I (cdc17(+)), and Fen-1 (rad2(+)).
	www.pdg.cnb.uam.es /UniPub/iHOP/gg/36556.html (1064 words)

	Identification and Characterization of Escherichia coli DNA Helicase II Mutants That Exhibit Increased Unwinding ...
		DNA helicase II is a single-stranded DNA-dependent ATPase that unwinds double-stranded DNA with a 3'-to-5' polarity with respect
		Plasmid DNA was isolated according to the alkaline lysis method (38) for mini-scale preparations.
		DNA helicase II is known to be required in the methyl-directed DNA mismatch repair pathway (29).
	jb.asm.org /cgi/content/full/180/2/377?view=full&pmid=9440527 (6381 words)

	Premature aging and predisposition to cancers caused by mutations in RecQ family helicases. (Site not responding. Last check: 2007-10-20)
		DNA helicases, because they unwind duplex DNA, have important roles in cellular DNA events such as replication, recombination, repair, and transcription.
		Multiple DNA helicase families with seven consensus motifs have been found, and members within each helicase family also share sequence homologies between motifs.
		In this paper, on the basis of five years of work, I overview the updated molecular biology of five human RecQ helicases; genetic diseases such as Werner's, Bloom's, and Rothmund-Thomson's syndromes caused by helicase mutations; the associated premature aging phenotype; and an increased risk of neoplasms.
	www.arclab.org /medlineupdates/abstract_11795503.html (193 words)

	DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. (Site not responding. Last check: 2007-10-20)
		DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
		Deficiency in a helicase of the RecQ family is found in at least three human genetic disorders associated with cancer predisposition and/or premature ageing.
		The RecQ helicases encoded by the BLM, WRN and RECQ4 genes are defective in Bloom's, Werner's and Rothmund-Thomson syndromes, respectively.
	www.arclab.org /medlineupdates/abstract_11257107.html (151 words)

	Directory of open access journals
		Bloom syndrome cells expressing the deletion alleles lacking the ribosomal DNA and telomere association domains have altered cell cycle populations with increased S or G2/M cells relative to normal.
		These results identify telomere and ribosomal DNA repeated sequence elements as chromosomal targets for the BLM DNA helicase during the S/G2 phase of the cell cycle.
		The BLM DNA helicase participates in genomic stability at ribosomal DNA repeats and telomeres.
	www.doaj.org /abstract?id=82845&toc=y (239 words)

	Directory of open access journals
		BLM, the protein altered in BS, is a member of the RecQ DNA helicase family, whose members share an average of 40% identity in the helicase domain and have divergent N-terminal and C-terminal flanking regions of variable lengths.
		The BLM DNA helicase has been shown to localize to the ND10 (nuclear domain 10) or PML (promyelocytic leukemia) nuclear bodies, where it associates with TOPIIIα, and to the nucleolus.
		The helicase activity and the C-terminal domain of BLM are critical for maintaining genomic stability as measured by the sister chromatid exchange assay.
	www.doaj.org /abstract?id=80274&toc=y (245 words)

	Biochemical Analysis of the Intrinsic Mcm4-Mcm6-Mcm7 DNA Helicase Activity -- You et al. 19 (12): 8003 -- Molecular and ...
		The DNA helicase (A), ATPase (B), and single-stranded DNA binding (C) activities of the mutant Mcm4,6,7 complex where DE in motif B of the Mcm6 protein was converted to AA (Mcm4,6DE-AA,7) were measured and compared with those of the wild-type Mcm4,6,7 complex (wild).
		Ishimi, Y. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
		Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein.
	mcb.asm.org /cgi/content/full/19/12/8003 (8532 words)

	Helicase-catalyzed DNA unwinding -- Lohman 268 (4): 2269 -- Journal of Biological Chemistry
		DNA helicases are ubiquitous and multiple helicases have been identified in
		The prime consequence of an oligomeric helicase is that it
		A Kinetic Analysis of the Oligonucleotide-modulated ATPase Activity of the Helicase Domain of the NS3 Protein from Hepatitis C Virus.
	www.jbc.org /cgi/content/abstract/268/4/2269 (1371 words)

	Anand Gandhi's Page for Part 3 of the Genetics Web Assignment (Site not responding. Last check: 2007-10-20)
		The molecule that I used for this exercise is DNA Helicase.
		I chose DNA Helicase because I was interested in its role in the DNA replication process.
		DNA Helicase is an unwinding protein that denatures the strands of the double helix at the origin of synthesis.
	www.creighton.edu /~agandhi/agpart03.html (221 words)

	The yeast Ku protein is a DNA helicase Heidi M. Feldmann Institut für Biochemie der Universität München, ... (Site not responding. Last check: 2007-10-20)
		The yeast Ku protein is a DNA helicase Heidi M. Feldmann Institut für Biochemie der Universität München, Feodor-Lynen-Str.
		Recently, we have shown that yKu is involved in DNA repair and recombination.
		To characterize the in vivo function of yKu helicase activity we are generating mutants of the ATP-binding motif of the p70 subunit.
	www.yeastgenome.org /yeast98/abshtml/040.html (320 words)

	Requirement for Three Novel Protein Complexes in the Absence of the Sgs1 DNA Helicase in Saccharomyces cerevisiae -- ...
		Requirement for Three Novel Protein Complexes in the Absence of the Sgs1 DNA Helicase in Saccharomyces cerevisiae -- Mullen et al.
		Arrowheads indicate cells with DNA trapped in the neck between mother and daughter.
		, L. and H., 1993 Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae.
	www.genetics.org /cgi/content/full/157/1/103 (6520 words)

	Browse Helicase DB content
		Superfamily I DNA and RNA helicase, UvrD [Wolbachia endosymbiont strain TRS of Brugia malayi]
		DNA helicase II [Yersinia pestis biovar Medievalis str.
		DNA helicase IV [Yersinia pestis biovar Medievalis str.
	www.pasteur.fr /formation/infobio/web/2005/helicases/browse_helicases_output.html (1212 words)

	Interactions study of yeast and human mitochondrial DNA polymerases reveal a new yeast mitochondrial DNA helicase ... (Site not responding. Last check: 2007-10-20)
		Interactions study of yeast and human mitochondrial DNA polymerases reveal a new yeast mitochondrial DNA helicase involved in replication.
		A faithful replication of mitochondrial DNA (mtDNA) is of major importance since many mutations in this genome cause a variety of diseases.
		One of the potential MIP1 interactor is an helicase, the primary localization of which is however the nucleus.
	www.yeastgenome.org /yeast98/abshtml/336.html (324 words)

	[No title] (Site not responding. Last check: 2007-10-20)
		123 1e-26 PIR:AG0918 DNA helicase II [imported] - Salmonella enterica subs...
		102 2e-20 PIR:AI0467 DNA helicase II (EC 3.6.1.-) [imported] - Yersinia pe...
		45 0.003 PIR:G97026 superfamily I DNA helicase [imported] - Clostridium a...
	pedant.gsf.de /cgi-bin/wwwdbp.pl?Db=Saccharomyces_cerevisiae&Name=blast&String=5643&Cmd=Fetch (2387 words)

	helicase CATEGORY QUERY
		DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease, chi sequence recognition (recB)
		DNA helicase, resolution of Holliday junctions, branch migration (recG)
		DNA helicase involved in mitochondrial DNA repair and telomere length
	magpie.genome.wisc.edu /magpie-cgi-bin/magpie_cat?helicase (465 words)

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