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Topic: DNA microarray

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In the News (Thu 20 Jun 19)

  Microarrays Factsheet
Microarrays are therefore useful when one wants to survey a large number of genes quickly or when the sample to be studied is small.
Microarrays may be used to assay gene expression within a single sample or to compare gene expression in two different cell types or tissue samples, such as in healthy and diseased tissue.
DNA Microarrays are small, solid supports onto which the sequences from thousands of different genes are immobilized, or attached, at fixed locations.
www.ncbi.nlm.nih.gov /About/primer/microarrays.html   (3611 words)

 ENS microarray platform: DNA microarray principle
DNA microarrays allow for rapid measurement and visualisation of differential expression between genes at the whole genome scale.
DNA fragments amplified by PCR technique are spotted on a microscopic glass slide coated with polylysine prior to spotting process.
Prior to hybridisation, DNA is denatured to obtained a single strand DNA on the microarray, this will allow the probe to bind to the complementary strand from the target.
www.transcriptome.ens.fr /sgdb/presentation/principle.php   (585 words)

 genome.gov | DNA Microarray Fact Sheet
One intense area of microarray research at the National Institutes of Health (NIH) is the study of cancer.
With the help of microarray technology, however, they will be able to further classify these types of cancers based on the patterns of gene activity in the tumor cells.
DNA microarrays are created by robotic machines that arrange minuscule amounts of hundreds or thousands of gene sequences on a single microscope slide.
www.genome.gov /10000533   (518 words)

 DNA microarray - Wikipedia, the free encyclopedia
A DNA microarray (also commonly known as gene or genome chip, DNA chip, or gene array) is a collection of microscopic DNA spots attached to a solid surface, such as glass, plastic or silicon chip forming an array for the purpose of expression profiling, monitoring expression levels for thousands of genes simultaneously.
Microarray technology evolved from Southern blotting, whereby fragmented DNA is attached to a substrate and then probed with a known gene or fragment.
Microarrays can be fabricated using a variety of technologies, including printing with fine-pointed pins onto glass slides, photolithography using pre-made masks, photolithography using dynamic micromirror devices, ink-jet printing [1], or electrochemistry on microelectrode arrays.
en.wikipedia.org /wiki/DNA_microarray   (1454 words)

 Microarray Technology
Microarray is one such technology which enables the researchers to investigate and address issues which were once thought to be non traceable.
Microarray technology has empowered the scientific community to understand the fundamental aspects underlining the growth and development of life as well as to explore the genetic causes of anomalies occurring in the functioning of the human body.
A typical microarray experiment involves the hybridization of an mRNA molecule to the the DNA template from which it is originated.
www.premierbiosoft.com /tech_notes/microarray.html   (972 words)

 Anatomy of a Comparative Gene Expression Study
DNA microarrays are perfectly suited for comparing gene expression in different populations of cells.
The reporters currently used in comparative hybridization to microarrays are fluorescent dyes (fluors), represented by the red and green circles attached to the cDNA's in the diagram [2].
Both types of DNA have been used before in array-like applications: cDNA libraries were used for comparative hybridization before the advent of fluorescent microarrays, while oligonucleotide arrays are available commercially today from Affymetrix Corporation for rapid resequencing of a few genes important to AIDS and some cancers.
www.cs.wustl.edu /~jbuhler/research/array   (2945 words)

 Stas Busygin's DNA Microarray Page
Microarrays for an Integrative Genomics (Computational Molecular Biology), provides a systematic introduction to the use of DNA microarrays as an investigative tool for functional genomics.
DNA Microarrays and Gene Expression : From Experiments to Data Analysis and Modeling, an interdisciplinary introduction to DNA arrays is essential reading for both biology and computer science researchers wanting to take advantage of this powerful new technology.
Exploration and Analysis of DNA Microarray and Protein Array Data, reviews basic molecular biology, with an introduction to microarrays and their preparation; discusses gene and sample clustering and methods for analysis of protein array data.
www.busygin.dp.ua /microarray.html   (941 words)

 dna array
Microarray technology is a simple but robust method to screen thousands of probes at once.
However, microarrays can be used for other purposes as well, such as protein interactions, SNP scoring or re-sequencing by hybridization.
The microarray unit of the Weizmann institute was founded in 1998 as part of the Genome Center, when microarrays were still at a very preliminary stage world-wide.
www.weizmann.ac.il /Biological_Services/dna_array/dna_array.html   (278 words)

 Affymetrix leads DNA microarray sector
In fact, this survey shows that the market for DNA microarrays is a fast-growing one, with 45 per cent of researchers expecting an increase in throughput over the next year.
The survey found that 81 per cent of researchers use commercial DNA microarrays, either exclusively or in addition to arrays printed in the lab or in a core facility.
The survey found that an emerging application for DNA microarrays would be their increasing presence in the clinical arena.
drugresearcher.com /news/news-ng.asp?n=62328-affymetrix-agilent-technologies-microarray...   (842 words)

 DNA Microarray Tutorial - Furber   (Site not responding. Last check: 2007-10-13)
DNA microarrays can achieve higher densities than nitrocellulose dot blots because very small quantities of DNA are bound to glass substrates, and they don't spread around as widely.
Diagnostic Microarrays: This same microarray technology also has the capability of examining thousands of different genes from a single small tissue sample to determine which are normal and which contain mutations.
In their vocabulary, the oligonucleotides on the chip are refered to as "probes," and the DNA rinsed over the chip is called the "target." Affymetrix has teamed up with Roche Molecular Systems, Inc. to produce clinical diagnostic kits using GeneChip probe arrays.
members.aol.com /johnfurber/array.html   (1303 words)

 BioMed Central | Full text | SIMAGE: simulation of DNA-microarray gene expression data
Differential incorporation of dyes in DNA occurs due to (i) the preference of reverse transcriptase for the physically smaller Cy3 label in case of direct labeling and (ii) differential hybridization because of the physically larger Cy5 label.
Parameters concerned with technical aspects of the DNA microarray spotter and scanner are, as expected, not significantly different, since the same equipment in one laboratory was used.
Any method for simulation of DNA microarray data can be questioned and criticized, mainly because there is neither established theory for the relation between expression (observed) and factors involved (some can be observed, others are hidden), nor for the statistical distribution of differential expression given by various causes across genes.
www.biomedcentral.com /1471-2105/7/205   (5387 words)

 Detection and Identification of Mycobacterium Species Isolates by DNA Microarray -- Fukushima et al. 41 (6): 2605 -- ...
The microarray was incubated in the presence of the fragmented
The fluorescent signal emitted by a target bound to the microarray was detected at a pixel resolution of 10 µm by using ScanArray Lite.
Microarray analysis was performed after amplification of DNAs from cultured clinical specimens with primers F99 and R184T7, immobilization of specific probes on a glass slide, and hybridization on the glass slide with Cy-5-labeled clinical specimens.
jcm.asm.org /cgi/content/full/41/6/2605   (4535 words)

 DNA microarray
NA Microarray technology is one of the most exciting new technologies in science and medicine.
Let's start by talking about what it is. Microarray testing is quite simply a way of testing a sample of cells and find out what genes are expressed and what genes are not expressed in that sample.
DNA microarray is new and exciting but it is not a routine part of lymphoma diagnosis or follow up.
www.nhlcyberfamily.org /tests/microarray.htm   (738 words)

 DNA Microarray Data for FAR1 and YBR293W
DNA microarrays can be used to measure the level of gene transcription.
Cluster from DNA Microarray 1: Expression at different alpha-factor concentrations.
This DNA microarray depicts genes with similar expression patterns when various concentrations of alpha-factor were present.
www.bio.davidson.edu /courses/genomics/2001/madden/assignment3.html   (513 words)

 Public Affairs Office: New Microarray Center Will Boost Lab's DNA and Protein Research
But knowing the sequence of an organism's DNA is only one step in understanding the role genes play in the organism's growth and development, and its susceptibility to disease and physical defects.
Microarrays, also known as biochips or gene chips, are a powerful new tool that researchers can use to quickly and efficiently determine which genes in a cell are active, or "expressed," under differing conditions, as well as their level of expression and how they interact with each other.
Microarrays are small glass, nylon or silicon slides on which tiny amounts of DNA are spotted or "printed" by robots in a regular pattern.
www.llnl.gov /PAO/news/news_releases/2004/NR-04-12-01.html   (701 words)

 DNA microarray | DNA microarray technology by febit biotech gmbh - the biotech company, DNA microarray, dna analysis, ...   (Site not responding. Last check: 2007-10-13)
DNA microarray technology by febit biotech gmbh - the biotech company, DNA microarray, dna analysis, microarray analysis, genotyping [Biotech, Technologiepark Heidelberg]
DNA microarray and DNA analysis technology by febit biotech gmbh
GENIOM is the fully integrated benchtop facility for your microarray lab.
www.dna-microarray.eu   (139 words)

 Bioinformatics.Org: POST-DOCTORAL POSITION - DNA MICROARRAY ANALYSIS, Uppsala, Sweden.   (Site not responding. Last check: 2007-10-13)
Technique platforms with state-of-the-art equipment in proteomics, DNA sequencing, SNP analysis and DNA microarrays are available to serve the research projects using different model organisms such as mouse, chicken, Arabidopsis and bacteria.
The applicant will be positioned at the DNA microarray unit at the Genetic Center at SLU but will also be affiliated to the Linneaus Center for Bioinformatics (LCB), a shared resource center for Bioinformatics between the SLU and the Uppsala University.
Part of the time can be used for developing bioinformatics tools linked to the DNA microarray analysis as well as integration of data from metabolomics, proteomics and analysis of gene families.
bioinformatics.org /forums/forum.php?forum_id=2374   (427 words)

 DNA Microarrrays (via CobWeb/3.1 planetlab2.tamu.edu)   (Site not responding. Last check: 2007-10-13)
A fiber-optic DNA biosensor microarray for the analysis of gene expression.
Shotgun DNA microarrays and stage-specific expression in plasmodium falciparum malaria.
DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale.
www.deathstarinc.com.cob-web.org:8888 /science/biology/chips.html   (2433 words)

 DNA Microarray Facility   (Site not responding. Last check: 2007-10-13)
The facility and its services: CBR’s DNA Microarray Facility is a fee-for-service laboratory operated by the Center for Agricultural Biotechnology.
Materials: With the exception of the DNA for printing and RNA for hybridization, the facility will provide all materials for printing and hybridization of the arrays.
When samples are not in a rectangular formation, two array runs are required to spot all the samples, which slows down processing of the project.
www.umbi.umd.edu /~cbr/dnamacore.htm   (2480 words)

 OVPR - Shared Resources - DNA Microarray Facility
The Fox Chase Cancer Center DNA microarray core facility was established in 1999.
The facility produces high quality human, mouse and yeast microarrays and provides researchers with technical expertise in array design, probe hybridization and data analysis.
The FCCC DNA Microarray Facility has been cited in several publications using the facility resource.
www.temple.edu /ovpr/OVPR/sharedres/microarray.html   (835 words)

 Research Facilities - Biotechnology - DNA Microarray Facility at Fox Chase Cancer Center   (Site not responding. Last check: 2007-10-13)
The DNA Microarray Facility was established for the purpose of producing DNA microarrays that contain available human, mouse and yeast cDNA clones and provides Fox Chase researchers with technical expertise in array design, probe hybridization and data analysis.
The basic service of the facility includes the establishment and maintenance of the DNA libraries, the preparation of DNA microarrays and labeled cDNA probes, the hybridization of DNA arrays and the operation of the confocal laser scanner.
The DNA Microarray Facility equipment includes a capillary-based DNA microarrayer with automated plate loaders (OmniGrid systems) from GeneMachines and a confocal laser scanner (GMS 428) from Affymetrix.
www.fccc.edu /research/facilities/DNAMicroarray.html   (284 words)

 MUSC Microarray Database   (Site not responding. Last check: 2007-10-13)
The database is a repository for DNA microarray data generated by MUSC investigators as well as researchers in the global research community.
Topography diagram of the MUSC DNA Microarray Database.
The MUSC DNA Microarray and Bioinformatics Facility is supported by grants from the National Cancer Institute (R24CA095841) and the National Heart Lung and Blood Institute (P20RR016434) as well as funds from the University Research Resource Foundation.
proteogenomics.musc.edu /projectManage.php?page=statSnapShot   (311 words)

 DNA Microarrays (Genome Chips) (by Leming Shi, PhD)
DNA Microarrays (Genome Chips) (by Leming Shi, PhD)
Base-pairing (i.e., A-T and G-C for DNA; A-U and G-C for RNA) or hybridization is the underlining principle of DNA microarray.
DNA microarray, or DNA chips are fabricated by high-speed robotics, generally on glass but sometimes on nylon substrates, for which probes* with known identity are used to determine complementary binding, thus allowing massively parallel gene expression and gene discovery studies.
www.gene-chips.com   (2281 words)

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