
	Where results make sense

Topic: DNA repair

Related Topics

DNA damage

Tumor supressor gene

P53 gene

Gene therapy

DNA

DNA replication

Apoptosis

Cancer

Oncogene

Mutation

Metastasis

Carcinogen

DNA motif

Werner syndrome

Inflammation

In the News (Wed 25 Nov 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	DNA repair - Wikipedia, the free encyclopedia
		DNA repair is a process constantly operating in cells; it is essential to survival because it protects the genome from damage and harmful mutations.
		The DNA repair ability of a cell is vital to the integrity of its genome and thus to its normal functioning and that of the organism.
		DNA damage has now been shown to be a causative factor in diseases from atherosclerosis to Alzheimer's, where patients have a lesser capacity for DNA repair in their brain cells.
	en.wikipedia.org /wiki/DNA_repair (2933 words)

	Recombinational DNA Repair (RR)
		DNA double-strand breaks (DSB) are potentially harmful damages that can arise either spontaneously or from exposure to DNA-damaging agents such as ionizing radiation.
		The possibility that mammalian cells also possess this pathway was suggested as early as 1985 by the finding that cultured cells perform recombination in gene targeting experiments and more recently by the fact that homologs of the yeast HRR genes could be readily identified in human and rodent cells.
		In humans, the predominant mechanism of recombinational repair is non-homologous (illegitimate) DNA end-joining, where the entire reaction involves the following steps: recognition, recruitment and physical alignment, processing of the termini, gap filling and ligation.
	greengenes.llnl.gov /repair/html/rr.html (1032 words)

	DNA Repair Creme - Synergy4Life
		DNA Repair Creme is part of the next generation (GEN IV) of technology to use enzymes and biotechnology to enhance your skin's recovery capabilities and to delay aging.
		These special enzymes that exist in nature, as well as in your body, are designed to repair damage to cellular DNA caused by exposure to solar radiation.
		To protect your cells from Apoptosis, the DNA repair enzymes in your body attach directly to the DNA molecules and repair damage.
	www.synergy4life.com /pro3132.html (292 words)

	[7G] DNA Repair Mechanisms
		There are three major DNA repairing mechanisms: base excision, nucleotide excision and mismatch repair.
		DNA's bases may be modified by deamination or alkylation.
		The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications - Carcinogenesis, 2003.
	www.web-books.com /MoBio/free/Ch7G.htm (555 words)

	Active Motif » DNA Repair Protein ELISAs
		DNA repair proteins act to maintain genome integrity by recognizing, binding to and repairing damaged DNA.
		Understanding and quantifying DNA repair proteins can help elucidate the molecular mechanisms of DNA damage and repair pathways, and understand the damage specificity of a repair protein.
		Current techniques used to study DNA damage and repair include EMSAs and Western blots, which are time consuming, do not allow for high-throughput and provide only semi-quantitative results.
	www.activemotif.com /catalog/assay_kits/dna_repair (208 words)

	ORMUS, DNA Repair and Health
		The conclusion of Barton et al is that DNA double helix has the ability to do chemistry at distance: "A DNA molecule with a chemical group artificially tethered to one end appears to mediate a chemical change far down the helix, causing a patch of damaged DNA to be mended.
		Regardless of the physical damage cellular DNA may sustain, such as by ionizing radiation, phage-induced mutations, etc., the subtle template is always there, and though it may be depleted of vitality, it is not susceptible to these sorts of structural damage.
		To their surprise, they found characteristic and reproducible patterns of photon scattering both while DNA molecules remained in the path of the laser beam and after the DNA molecules were removed from the laser pathway.
	www.subtleenergies.com /ormus/tw/dna.htm (6723 words)

	DNA Repair (Site not responding. Last check: 2007-10-19)
		"DNA damage is caused by UV and ionizing radiation, oxidation, deamination (removal of DNA amino groups) and spontaneous cell damage.
		As a result, DNA may be modified, and DNA strands may be broken or misplaced.
		The medical implications are that people deficient in the repair activity might be at a higher risk for cancer than the average population.
	clemsonews.clemson.edu /WWW_releases/2004/September/DNA_Repair.html (504 words)

	Important DNA repair mechanism linked to premature aging yields its secrets
		In humans, failure of transcription-coupled repair is the cause of Cockayne Syndrome, an extreme form of accelerated aging that is inevitably fatal early in life.
		DNA is constantly under attack from sources inside and outside the body, including sunlight, ionizing radiation, other environmental carcinogens, and free radicals from the cellular metabolism.
		DNA damage ranges from one or a few altered nucleotides in a single strand of the double helix, to breaks in one or both strands and crosslinks between the two strands.
	www.medicalnewstoday.com /medicalnews.php?newsid=33385&nfid=rssfeeds (1707 words)

	DNA Repair
		DNA in the living cell is subject to many chemical alterations (a fact often forgotten in the excitement of being able to do DNA sequencing on dried and/or frozen specimens [Link]).
		Excision Repair, in which the damaged base or bases are removed and then replaced with the correct ones in a localized burst of DNA synthesis.
		If the sequence used as a template for repairing a gene by homologous recombination differs slightly from the gene needing repair; that is, is an allele, the repaired gene will acquire the donor sequence.
	users.rcn.com /jkimball.ma.ultranet/BiologyPages/D/DNArepair.html (1889 words)

	Eukaryotic DNA Repair
		In some cases, when the damage can't be repaired, the cell is allowed to go through division anyway, in the hope that repairs might be made in subsequent cell cycles.
		The repair mechanisms use different mechanisms of the expanding DNA polymerase family, some of which have prokaryotic homologues, as do many other factors in these systems.
		Many DNA repair systems use AP endonuclease (APE) to excise the damaged region and can "pass off" the repair to the next repair subunit and so can be protected from further problems (recombination) or damage.
	bricker.tcnj.edu /Amb/amble7.html (1658 words)

	Berti Lab: Enzymatic Transition States and Enzyme Inhibitors
		Our DNA is constantly being damaged - one of the major problems is oxidative damage.
		When OG-containing DNA is replicated, adenine (A) is incorporated with a 200-fold preference over the correct base, C. If the cell divides again, A will pair with T, creating an overall G->T mutation.
		DNA containing an OG:A mismatch, with the A residue flipped-out, ready to be hydrolyzed by MutY.
	www.chemistry.mcmaster.ca /berti/research/dna_repair.html (279 words)

	Cancer and DNA repair research (Site not responding. Last check: 2007-10-19)
		Using yeast, we recently demonstrated that the ATM PI 3-kinase pathway (defective in A-T cells) is required to release a silencing/DSB repair complex (composed of Sir2, Sir3 and Sir4) from telomeres in response to DNA damage (Mills et al., 1999 Cell [pdf]).
		We are currently investigating this novel mechanism and the role of chromatin in DNA repair.
		Because fundamental aspects of cell cycle control and DNA repair are conserved in eukaryotic organisms, studies in model systems such as the budding yeast Saccharomyces cerevisiae are valuable tools for understanding carcinogenesis in humans.
	www.hms.harvard.edu /pathol/sinclair/Pages/cancerndnarepair.html (1133 words)

	DNA repair sub-group (Site not responding. Last check: 2007-10-19)
		Besides the fascinating questions of chemical recognition and catalysis preformed by these enzymes, the study of DNA repair mechanisms in humans is of interest because of the role of DNA damage to disease and aging.
		DNA glycosylases protect the integrity of the genome by catalyzing the first step in the base excision—repair of lesions in DNA.
		The enzymatic addition of methyl groups to DNA is an essential element of genomic function in organisms ranging from bacteria to mammals.
	glviris.harvard.edu /research.d/DNArepair (970 words)

	Human DNA Repair Genes -- Wood et al. 291 (5507): 1284 -- Science (Site not responding. Last check: 2007-10-19)
		(BER), nucleotide excision repair (NER), and mismatch repair (MMR).
		Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma.
		DNA repair in higher plants; photoreactivation is the major DNA repair pathway in non-proliferating cells while excision repair (nucleotide excision repair and base excision repair) is active in proliferating cells.
	www.sciencemag.org /cgi/content/full/291/5507/1284 (4305 words)

	NADH com:pg160 NADH DNA repair system used in CFS treatments
		Damaged DNA is the basis for a number of chronic and neuro degenerative diseases.
		DNA is nucleic acid that carries the genetic information in the cell and is capable of self-replication and synthesis of RNA.
		If the DNA is altered by outside physical or chemical agents, the newly developing children cells may be different from their parent cells and may not function correctly.
	www.nadh.com /fatigue/Cfs160.htm (808 words)

	Elsevier.com - DNA Repair
		DNA Repair provides a forum for the comprehensive coverage of cellular responses to DNA damage in living cells.
		The journal publishes original observations on genetic, cellular, biochemical and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses to cells exposed to genomic insult, as well as their relationship to human diseases.
		DNA Repair also welcomes Correspondence from the scientific community, especially as they relate to papers previously published in the journal.
	www.elsevier.com /locate/dnarepair (381 words)

	Research Core - DNA Repair & Mutagenesis
		DNA repair and mutagenesis includes research relating to the induction of DNA damage, cellular responses to DNA damage, and biological outcomes resulting from the combination of damage and cellular response.
		DNA is damaged continuously as a result of endogenous biochemical processes that modify DNA structure, or generate free radicals and reactive electrophiles, which can chemically modify DNA.
		It is becoming clear the cellular response to DNA damage is part of a complex web of regulatory activities that must be understood to appreciate the mechanisms maintaining cellular homeostasis or result in pathology or cell death.
	www.niehs.utmb.edu /reasearchcore/dna.htm (1809 words)

	DNA Repair
		- mutants (phr-) don't photoreactivate and are partly deficient in excision repair of dimers
		In E. coli, if damaged (dimerized) DNA is not repaired before the replication fork proceeds into the damaged site, the polymerase holoenzyme stops, dissociates, and reinitiates synthesis about 1000 bp downstream leaving a "gap" with the damaged bases.
		UV damage is repaired in the presence of light.
	it.stlawu.edu /~tbudd/repair.html (1720 words)

	New DNA repair enzyme makes mistakes to save lives of cells (Site not responding. Last check: 2007-10-19)
		DNA is a double-stranded molecule that contains genes necessary for the production of proteins, which in turn determine all aspects of a cell's structure, function and movement.
		There are many causes of DNA damage - the sun's ultraviolet rays, environmental toxins, radiation from X-rays or agents in chemotherapy - and the source determines which enzyme is involved and its technique for repair.
		POL-Q also repairs bases that are damaged or chemically altered due to abuse or stress placed on the cell, such as from radiation or oxidants, free radicals that are byproducts of oxygen consumption.
	www.brightsurf.com /news/oct_04/EDU_news_102204.php (1210 words)

	MOLECULAR MECHANISMS OF DNA REPAIR IN EUKARYOTES
		DNA repair is a cellular mechanism to correct damage to DNA before it becomes fixed as a mutation or chromosomal aberration, which may lead to deleterious results such as cell death or tumorigenesis.
		Therefore, understanding the molecular mechanism of DNA repair is important for reducing the risk of cancer as well as developing more effective cancer therapies.
		To understand the functions of p21 in DNA repair, we examined the effects of p21 on base excision repair in vitro and in vivo.
	www.fccc.edu /research/reports/current/matsumoto.html (938 words)

	Secrets of a Salty Survivor
		This happens because DNA molecules are accustomed to being surrounded by a dense swarm of water molecules, and the DNA actually depends on the influence of these water molecules to keep its double-helix structure intact and to avoid damage.
		When dissolved back into water, the cells spring to life again, repair all the damage to their DNA caused by the partial desiccation, and go right on living.
		Learning how all these repair mechanisms work could teach scientists a lot about how DNA repair occurs in humans, and perhaps point to ways to enhance people's natural ability to cope with damage to their DNA--a possible boon to astronauts.
	science.nasa.gov /headlines/y2004/10sep_radmicrobe.htm (1496 words)

	Repair your DNA (Site not responding. Last check: 2007-10-19)
		Our DNA is constantly monitored for mutations, and if found, they are repaired.
		Insects are the most effective producers of gene repairing substances known to man.
		In essence, they have no offense (immune system), but an amazing defense (gene repairing capability) As soon as a problematic gene appears (like cancer) it is immediately either repaired, sealed, or destroyed.
	www.cancer-therapy.net /cell_repair.htm (509 words)

	Functional Characterization of Polymorphisms in DNA Repair Genes Using Cytogenetic Challenge Assays (Site not responding. Last check: 2007-10-19)
		A major barrier to understanding the role of polymorphic DNA repair genes for environmental cancer is that the functions of variant genotypes are largely unknown.
		The BER pathway is involved in the repair of DNA damage caused by a variety of internal and external factors including ionizing radiation, alkylating agents, and oxidation.
		On the other hand, the presence of DNA adducts is used as a biomarker of exposure, and the extent of DNA repair in modifying the adduct levels is not yet clear.
	www.ehponline.org /txg/members/2003/6632/6632.html (5458 words)

	DRIG - What is DNA repair?
		As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans.
		DNA repair is involved in processes that minimize cell killling, mutations, replication errors, persistence of DNA damage and genomic instability.
		repair pathways for the bulk genome (inactive genomic regions) and for
	www.nih.gov /sigs/dna-rep/whatis.html (833 words)

Try your search on: Qwika (all wikis)