
	Where results make sense

Topic: Dantrolene

Related Topics

Spasticity

Cerebral palsy

Baclofen

Clonazepam

Dysarthria

Diazepam

	Dantrolene - Wikipedia, the free encyclopedia
		Dantrolene sodium is a muscle relaxant that is currently the only specific and effective treatment for malignant hyperthermia.
		Dantrolene can also be tried to treat malignant neuroleptic syndrome, because some patients have reacted favourably.
		Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor, and decreasing intracellular calcium concentration.
	en.wikipedia.org /wiki/Dantrolene (444 words)

	Facts about topic: (Malignant hyperthermia) (Site not responding. Last check: 2007-10-12)
		Dantrolene (additional info and facts about Dantrolene) is a muscle relaxant that works directly on the ryanodine receptor to prevent the release of calcium.
		Pretreatment with dantrolene has been advocated in the past to prevent MH, but this is probably unreliable, and the long half-life of the drug may leave patients weak for extended periods.
		After the widespread introduction of treatment with dantrolene (additional info and facts about dantrolene) the mortality of malignant hyperthermia fell from 80% in the 1960s to less than 10%.
	www.absoluteastronomy.com /encyclopedia/m/ma/malignant_hyperthermia.htm (736 words)

	National MS Society \| Dantrium (Dantrolene) (Site not responding. Last check: 2007-10-12)
		Dantrolene is a muscle relaxant for relief of cramping, spasms, and tightness of muscles caused by multiple sclerosis among other conditions.
		Dantrolene may be taken with or without food.
		Dantrolene has been shown to cause cancer and noncancerous tumors in animals that were given high doses over a long period of time.
	www.nationalmssociety.org /Meds-Dantrolene.asp (445 words)

	Data Sheet
		Studies have shown that in the presence of dantrolene sodium, the responses of the muscle to caffeine are decreased or delayed.
		Dantrolene sodium may prevent the increase in myoplasmic calcium and the acute catabolism within the muscle cell by interfering with the release of calcium from the sarcoplasmic reticulum to the myoplasm.
		It is recommended that the combination of intravenous dantrolene sodium and calcium channel blockers, such as verapamil, not be used during reversal of a malignant hyperthermia crisis until the relevance of these findings to humans is established.
	www.medsafe.govt.nz /Profs/Datasheet/d/DantriumIVinj.htm (1811 words)

	Dantrolene (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-10-12)
		Dantrolene does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.
		Dantrolene is also used to prevent or treat a medical problem called malignant hyperthermia that may occur in some people during or following surgery or anesthesia.
		Dantrolene has been shown to cause cancer and noncancerous tumors in some animals (but not in others) when given in large doses for a long time.
	www.mayoclinic.com /health/drug-information/DR202181 (1722 words)

	Dantrolene Sodium - The Specific Treatment for Malignant Hyperthermia
		Dantrolene may cause significant muscle weakness in patients with pre-existing muscle disease and should be used with extreme caution in those patients.
		Dantrolene should be available for the treatment of potential MH cases anywhere general anesthesia is administered, including hospitals and outpatient surgery centers.
		Although pre-treatment with dantrolene for known susceptibles is not usually necessary, in some situations, such as the patient who survived a crisis, some experts recommend pre-treatment with 2 mg/kg intravenously prior to induction of anesthesia.
	www.uam.es /departamentos/medicina/anesnet/gtoa/hipertermia/dantrolene.html (748 words)

	WE MOVE - Treatment of Pediatric Movement Disorders - Medication: Dantrolene
		Dantrolene (Dantrium®) is a direct muscle relaxant that blocks calcium from signaling muscles to contract.
		In some cases, dantrolene has been reported to be useful for hospitalized children who experience brief episodes of very severe dystonic spasms.
		Dantrolene is also used to treat malignant hyperthermia, a rare but dangerous side effect of anesthesia, and neuroleptic malignant syndrome, a rare but dangerous complication of neuroleptic medications.
	www.wemove.org /pediatric_treatment/medication_dantrolene.html (129 words)

	dantrolene Information on Healthline
		Dantrolene is used to treat muscle spasticity (stiffness and spasms) caused by conditions such as a spinal cord injury, stroke, cerebral palsy, or multiple sclerosis.
		Dantrolene is also used to prevent the development of malignant hyperthermia (a rapid rise in body temperature) and stiff muscles caused by anesthesia during or after surgery.
		Dantrolene is in the FDA pregnancy category C. This means that it is not known whether dantrolene will harm an unborn baby.
	www.healthline.com /drugs/dantrium/D00968A1.htm (1031 words)

	U.S. Pharmacist
		Dantrolene sodium is metabolized by the liver, and it is theoretically possible that its metabolism may be enhanced by drugs known to induce hepatic microsomal enzymes.
		Dantrolene sodium capsules, 4 to 8 mg/kg/day, in four divided doses should be administered for one to three days following an MH crisis to prevent recurrence of the manifestations of MH.
		Dantrolene prophylaxis, although demonstrated to be safe for the newborn, is generally not necessary.
	www.uspharmacist.com /index.asp?show=article&page=8_1041.htm (2522 words)

	FASEB Breakthroughs in Bioscience - Making Anesthesia Safer: Unraveling the Malignant Hyperthermia Puzzle (Site not responding. Last check: 2007-10-12)
		Dantrolene reverses the malignant hyperthermia induced muscle rigidity, high muscle temperatures and acid production in seven of the eight pigs treated with dantrolene.
		Sixty-five participating institutions stock 60 vials of dantrolene as the anesthesiologist-investigators educate their colleagues about recognizing malignant hyperthermia and treating it with the experimental dantrolene protocol.
		The study indicates that dantrolene, given early in the course of a malignant hyperthermia crisis, is both safe and effective.
	www.faseb.org /opar/mh (4674 words)

	ALS TDF
		Dantrolene downregulates the gene expression and activity of the ubiquitin-proteasome proteolytic pathway in septic skeletal muscle.
		BACKGROUND: In previous studies, dantrolene prevented sepsis-induced muscle proteolysis, but the influence of dantrolene on the expression and activity of the ubiquitin-proteasome proteolytic pathway is not known.
		In additional experiments, the effect of dantrolene on protein degradation was tested in L6 myotubes cultured in the absence or presence of dexamethasone.
	www.als.net /articles/articleDetail.asp?articleID=2276 (232 words)

	MedlinePlus Drug Information: Dantrolene (Systemic) (Site not responding. Last check: 2007-10-12)
		It is not known whether long-term use of dantrolene causes cancer or tumors in humans.
		Dantrolene may be taken with or without food or on a full or empty stomach.
		Serious side effects are very rare when dantrolene is taken for a short time (for example, when it is used for a few days before, during, or after surgery or anesthesia to prevent or treat malignant hyperthermia).
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202181.html (1710 words)

	Dantrolene - Talk Medical
		· Dantrolene is also used to prevent the development of malignant hyperthermia (a rapid rise in body temperature) and stiff muscles caused by anesthesia during or after surgery.
		Dantrolene may increase the sensitivity of your skin to sunlight.
		Continue to take Dantrolene and talk to your doctor if you experience ·drowsiness, dizziness, weakness or fatigue; ·diarrhea, constipation, upset stomach, or decreased appetite; ·difficulty swallowing (use caution to prevent choking); ·headache or insomnia; ·depression or confusion; ·blurred or abnormal vision; or ·increased urination.
	www.talkmedical.com /medications/1592/Dantrolene (739 words)

	Naloxone, Flumazenil and Dantrolene as Antidotes
		Identification and quantification of dantrolene sodium and its formulation 4.5.2.
		Dantrolene sodium is an orange, odorless powder with a melting point of 279-280 °C. It is slightly soluble in water, but it hydrolyses and precipitates the extremely insoluble (< 1 mg/l) free acid, dantrolene.
		Dantrolene sodium capsules and powder for injection should be kept at a temperature below 40 °C, preferably between 15 and 30 °C, and the capsules should be stored in well-closed containers.
	www.inchem.org /documents/antidote/antidote/ant01.htm (14737 words)

	ASA April 1997 Newsletter
		Dantrolene is a hydantoin derivative that is very safe when administered intravenously in the recommended dosages.
		Dantrolene contains a large amount of mannitol, a fact that should be considered when treating the patient with diuretics.
		Dantrolene formulations that dissolve more rapidly, cause fewer side effects or are less cumbersome to store and mix would be welcome improvements.
	www.asahq.org /Newsletters/1997/04_97/Prevention.html (1554 words)

	DANTRIUM Vials 20 mg
		In isolated muscle preparations, dantrolene sodium uncouples the excitation and contraction of skeletal musclep probably by interfering with the release of calcium from the sarcoplasmic reticulum.
		Dantrolene sodium may prevent the increase in myoplasmic calcium and the acute catabolism within the muscle cell by interfering with the release of calcium from the sarcoplasmic reticulum to the myoplasm Thus the physiologic, metabolic and biochemical changes associated with the crisis may be reversed or attenuated.
		Dantrium (dantrolene sodium) capsules should also be administered following a malignant hyperthermia crisis in doses of 4 to 8 mg per day in four divided doses, for a one to three day period to prevent recurrence of the manifestations of malignant hyperthermia.
	home.intekom.com /pharm/smith_kb/dantr-iv.html (1236 words)

	How to Manage the Risk of Malignant Hyperthermia - May 2002
		MH is of greater risk outside of hospitals because many ASCs don’t stock dantrolene (brand name Dantrium, manufactured by Proctor and Gamble Pharmaceuticals)—the only drug known to reverse MH—because of the rarity of the condition and the expense of the drug.
		It takes 36 vials of dantrolene (the drug comes in 20 mg vials) for a full dose to be mixed, although a full dose may not be required in all cases.
		The most crucial part of the rescue would be to administer dantrolene to the patient, as it is still the only drug known to be effective in treating MH.
	www.outpatientsurgery.net /2002/os05/f3.shtml (2099 words)

	Effects of Dantrolene on Steps of Excitation-Contraction Coupling in Mammalian Skeletal Muscle Fibers -- Szentesi et ...
		With these, the control transients (not shown for 5 and 25 µM dantrolene) would be equal in size in the figure to the traces presented in the first column.
		The effect of 50 µM dantrolene on the gating properties and pharmacology of the purified RYR.
		Francis, K.T. The effect of dantrolene sodium on the efflux of Ca from rat heavy sarcoplasmic reticulum.
	www.jgp.org /cgi/content/full/118/4/355 (9476 words)

	WE MOVE - Dantrolene sodium (Dantrium®)
		Dantrolene decreases muscle tone, clonus, and spasm and is less likely to cause problems with confusion or clouded thinking than are the benzodiazepines and baclofen taken by mouth.
		When used over a long period of time, dantrolene may cause a change in the type of muscle fiber so that the muscle fibers become more rapidly fatigued.
		Dantrolene is first-line therapy for the treatment of severe spasticity due to traumatic brain injury and may be very helpful in the treatment of spasticity due to cerebral palsy.
	www.wemove.org /spa/spa_dant.html (140 words)

	Warmed diluent speeds dantrolene reconstitution: [Le diluant rechauffe accelere la reconstitution du dantrolene] -- ...
		Maximal dantrolene concentrations in 0.1 M phosphate (pH 6.8 and 7.2) and 0.1 M THAM (pH 7.1–9.1) were determined spectrophotometrically.
		When dantrolene is reconstituted as recommended with 60 mL of water, the dantrolene concentration is about 1 mM.
		Dantrolene optical density at 385 nm increased linearly with
	www.cja-jca.org /cgi/content/full/50/2/127 (1806 words)

	Publication Abstracts- Aerospace Medical Association
		Several authors have shown that dantrolene may be effective in the treatment of heat stroke patients.
		The results suggest that dantrolene is effective as a prophylactic agent in sedentary animals only.
		It is hypothesized that the observed rapid cooling is associated with dantrolene's effect on muscle contraction, thus leading to attenuated heat production and peripheral vascular relaxation.
	www.asma.org /journal/abstracts/v70n10/v70n10p987.html (323 words)

	Effects of modulators of sarcoplasmic Ca2+ release on the development of skeletal muscle fatigue -- Germinario et al. ...
		Effects of 5 µM dantrolene (A), 20 µM dantrolene (B), and 5 mM caffeine (C) on contractile responses during fatiguing stimulation in EDL muscle.
		Dantrolene dose response in awake man: implications for management of malignant hyperthermia.
		Dantrolene inhibition of sarcoplasmic reticulum Ca release by direct and specific action at skeletal muscle ryanodine receptors.
	jap.physiology.org /cgi/content/full/96/2/645 (3102 words)

	The Skeletal Muscle Ryanodine Receptor Identified as a Molecular Target of [3H]Azidodantrolene by Photoaffinity Labeling
		Dantrolene is a skeletal muscle relaxant which acts by inhibiting intracellular Ca release from sarcoplasmic reticulum (SR).
		H]azidodantrolene, a photoactivatable analogue of dantrolene, has identified a 160 kDa SR protein with immunologic cross-reactivity to skeletal muscle ryanodine receptor (RyR) as a possible target [Palnitkar et al.
		-terminus of the RyR is a molecular target for dantrolene, and suggest a regulatory role for both n-calpain activity and ATP in the interaction of dantrolene with the RyR in vivo.
	pubs.acs.org /cgi-bin/abstract.cgi/bichaw/2001/40/i02/abs/bi001502s.html (352 words)

	Seizure-Induced Cell Death Produced by Repeated Tetanic Stimulation In Vitro: Possible Role of Endoplasmic Reticulum ...
		Dantrolene sodium (30 µM; Sigma) and thapsigargin (1 µM; Sigma) were dissolved in dimethyl sulfoxide (DMSO).
		Dantrolene and thapsigargin have no significant effect on normal synaptic transmission, the induction, or the maintenance of epileptiform discharges.
		Dantrolene was present for the duration of the experiment.
	jn.physiology.org /cgi/content/full/81/6/3054 (6697 words)

	Dantrium Capsules
		Dantrolene belongs to a group of medicines known as muscle relaxants.
		Dantrolene capsules are used to treat people with chronic muscle spasms caused by conditions such as cerebral palsy, multiple sclerosis, stroke, or spinal cord injury.
		Dantrolene capsules may also be used before surgery for people at risk of malignant hyperthermia and for follow-up treatment of this condition.
	www.medbroadcast.com /drug_info_details.asp?brand_name_id=1771&dowhat=accept_disclaimer (567 words)

	MedlinePlus Drug Information: Dantrolene Oral
		Dantrolene, a muscle relaxant, is used to treat spasticity or muscle spasms associated with spinal cord injuries, stroke, multiple sclerosis, cerebral palsy, or other conditions.
		Dantrolene comes as a capsule to take by mouth.
		Dantrolene may make your skin sensitive to sunlight.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682576.html (648 words)

	Dantrolene - Drugs & Vitamins - Drug Library - DrugDigest
		It helps to relax muscles, relieving spasms and stiffness of muscles in conditions such as multiple sclerosis, cerebral palsy, stroke, or injury to the spine.
		Dantrolene can also help prevent and treat a condition called malignant hyperthermia, which may occur after surgery or anesthesia.
		Dantrolene may make your skin sensitive to sunlight (UV).
	www.drugdigest.org /DD/DVH/Uses/0,3915,187\|Dantrolene,00.html (553 words)

	ASCO - Abstracts - PubMed Abstract View (Site not responding. Last check: 2007-10-12)
		REASONS FOR PERFORMING STUDY: Dantrolene sodium (Dantrium) has been used extensively for the treatment of myopathies in man and anecdotal evidence suggests it is of clinical benefit in the control of exercise-induced rhabdomyolysis (ER) in racehorses, although data to support this are currently lacking.
		For each horse, the difference in change between pre- and post exercise CK values between placebo and dantrolene treatments was calculated, with positive values indicating a greater rise with placebo than with dantrolene sodium treatment.
		CONCLUSIONS: The results confirmed that oral administration of dantrolene sodium, 1 h before exercise, had a statistically significant effect on reducing the difference between pre- and post exercise plasma CK levels compared with a placebo in the same animals, and preventing clinical ER in susceptible individuals.
	www.asco.org /ac/1,1003,_12-002867-00_18-0014649364,00.asp?SearchNames= (600 words)

	Hops induced Malignant Hyperthermia in Dogs
		The Dantrolene was administered and then over the course of the next 4 hours her temperature gradually returned to normal (I don't have exact times).
		Dantrolene sodium is the only known treatment for MH in humans.
		The use of Dantrolene was recommended by the NAPCC, but its effects on dogs were unknown prior to the use on Pascale.
	www.cse.ogi.edu /~ericwan/DOG/hops.html (877 words)

Try your search on: Qwika (all wikis)