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Topic: Dapoxetine

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	J&J's dapoxetine effective for premature ejaculation
		The data on dapoxetine, first reported in May 2005, show that the drug was able to triple the duration of intercourse in men who had been with the same partner for at least six months and persistently suffered from premature ejaculation.
		Dapoxetine is a selective serotonin reuptake inhibitor, in the same class as many of the antidepressants used to treat premature ejaculation at the moment, but is the only one to have been studied this extensively in clinical trials.
		Dapoxetine is the first on-demand agent for premature ejaculation, Jon Pryor, M.D., of the University of Minnesota here, and colleagues, reported in the Sept. 9 issue of The Lancet.
	www.natap.org /2006/newsUpdates/091206_04.htm (2700 words)

	Dapoxetine Hydrochloride Significantly Improves Premature Ejaculation (Site not responding. Last check: 2007-10-09)
		The primary efficacy endpoint was IELT adjusted for baseline as measured by a stopwatch held by the female partner.
		In the group treated with 30 mg of dapoxetine, 2.5% rated their control over ejaculation as "fair to very good" before treatment; after treatment, this increased to 51.8%.
		The percentage of men who rated their sexual satisfaction as "good to very good" nearly doubled after treatment with both doses of dapoxetine (20.2% to 38.7% for the 30 mg dose and 22.3% to 46.5% for the 60 mg dose) compared with placebo treatment (21.6% to 24.6%).
	www.pslgroup.com /dg/24d83a.htm (611 words)

	Channelnewsasia.com
		The drug, which is goes under the lab name of dapoxetine hydrochloride, will be the first pharmaceutical treatment specifically intended for premature ejaculation if the US Food and Drug Administration (FDA) and other licensors give their approval.
		Men who took the placebo extended their time to ejaculation to 1.75 minutes; for those on the 30mg dose of dapoxetine, it was 2.78 minutes; and for those on 60mg, it was 3.32 minutes.
		Dapoxetine is made by ALZA Corp. of Mountain View, California, a wholly-owned subsidiary of Johnson & Johnson.
	www.channelnewsasia.com /stories/health/view/229229/1/.html (796 words)

	Dapoxetine treating premature ejaculation
		The little blue pill Viagra that made erectile dysfunction a household word may soon be eclipsed by Dapoxetine, the first-ever pill to treating premature ejaculation.
		Dapoxetine is expected to receive approval from the U.S. Food and Drug Administration early 2006 year.
		Dapoxetine has the same active ingredients of some anti-depressants, like Zoloft, which have been used in low doses for treating the ailment.
	www.dapoxetine-online.biz /_comments.php (288 words)

	Boston.com / Business / Old drugs, new life
		Known as dapoxetine, the drug is in the third stage of clinical trials,...
		Known as dapoxetine, the drug is in the third stage of clinical trials, and if approved by regulators in coming years it would be the first prescription approved to treat the condition, most prevalent in young men.
		Dapoxetine is also in that class, but according to Dynogen's Thor it was set aside as a depression therapy partly because it has a short duration of action, meaning patients must take the pills several times a day for a lasting effect.
	www.boston.com /business/globe/articles/2003/12/31/old_drugs_new_life (1088 words)

	That other male sex problem
		Dapoxetine, developed by Johnson & Johnson Pharmaceutical Services, acts in much the same way as those antidepressants that increase the availability of the chemical serotonin in the brain.
		Pryor called dapoxetine a "very safe" drug, which comes with a very low risk of side effects such as headache and nausea and does not appear to suppress sexual desire or carry risks such as suicidal ideation -- concerns that in recent months have prompted the FDA to issue warnings associated with some antidepressants.
		Whether or not dapoxetine works for a man, premature ejaculation can roil a relationship or be borne of pre-existing relationship problems.
	www.azcentral.com /health/men/articles/0601mensex-ON.html (924 words)

	Premature Ejaculation Treatment - Health and Medical Information produced by doctors - MedicineNet.com
		Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) but is slightly different from the SSRIs (such as Zoloft, Paxil, and Prozac) widely prescribed for depression and other psychiatric disorders.
		Hopes that Dapoxetine would become the first drug approved for premature ejaculation dimmed last October, when the FDA sent a "not approvable" letter to the manufacturer.
		In the manufacturer-funded study, Pryor and colleagues compared 30-milligram and 60-milligram doses of Dapoxetine to a placebo in roughly 2,600 men with moderate to severe premature ejaculation.
	www.medicinenet.com /script/main/art.asp?articlekey=63987 (745 words)

	On-Demand SSRI Called Effective for Premature Ejaculation - CME Teaching Brief® - MedPage Today
		The drug is dapoxetine, a short-acting selective serotonin reuptake inhibitor that has been in regulatory limbo since the FDA issued a "not-approvable" letter last Oct. 26.
		Of 2,614 men (mean age 40.5, range 18 to 77) with moderate-to-severe premature ejaculation, 870 were given a placebo, 874 took 30 mg of dapoxetine, and 870 took 60 mg of dapoxetine as needed, one to three hours before anticipated sexual activity.
		Dapoxetine improved patients' perception of control over ejaculation and overall satisfaction with sexual intercourse, a benefit shred by their partners, Dr. Pryor said.
	www.medpagetoday.com /Surgery/Urology/tb/4066 (870 words)

	Premature ejaculation treatment drug dapoxetine from Johnson & Johnson improves control, satisfaction, time
		Dapoxetine data demonstrates that men taking dapoxetine hydrochloride for the treatment of premature ejaculation experienced significant improvements in sexual function, including ejaculatory control, satisfaction with sexual intercourse for men and their partners, and increases in intravaginal ejaculatory latency time (IELT)*.
		IELT increased significantly with the first dose of dapoxetine, and increases in IELT were maintained over the 12-week study period.
		The study also found that dapoxetine was generally well tolerated, with most side effects of mild-to-moderate severity.
	www.dancewithshadows.com /business/premature-ejaculation-drug.asp (989 words)

	Dapoxetine for premature ejaculation :: OnThePharm
		Dapoxetine, an SSRI patented by ALZA pharmaceuticals is showing some real promise combatting premature ejaculation.
		Dapoxetine, of course, has been around for a little while, though it’s not available yet by prescription.
		Patients were randomly assigned to receive placebo (870), 30 mg dapoxetine (874), or 60 mg dapoxetine (870) and were instructed to take a dose 1-3 hours before sexual intercourse.
	onthepharm.net /2006/09/dapoxetine-for-premature-ejaculation.html (523 words)

	PPD Acquires Lilly's Patents for Dapoxetine; Adjusts Earnings Guidance for 2003
		As previously disclosed, PPD in-licensed dapoxetine from Lilly in 1998, developed the compound through Phase II proof-of-concept, and then out-licensed it to ALZA Corporation, a wholly-owned subsidiary of Johnson & Johnson, in January 2001.
		Dapoxetine is currently in Phase III development for premature ejaculation, which is thought to affect 30 percent of males worldwide.
		If approved, dapoxetine would be the first prescription drug with a labeled claim for this indication.
	www.ppdi.com /corporate/news/detail.htm?ID=124895 (547 words)

	How does dapoxetine work for premature ejaculation? : NLH Question Answering Service
		Dapoxetine has a rapid onset of action of approximately 1.5 hours and a short half-life and the company anticipate a dose of 30 or 60mg 1-3 hours before intercourse not to be taken more frequently than once every 24 hours.
		Dapoxetine is a short acting SSRI developed specifically for the treatment of premature ejaculation.
		Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials.
	www.clinicalanswers.nhs.uk /index.cfm?question=4001 (554 words)

	Dapoxetine Blog (Site not responding. Last check: 2007-10-09)
		Dapoxetine, submitted to the FDA in the form of dapoxetine hydrochloride, was developed by ALZA Corporationand its parent company, Johnson & Johnson.
		"Dapoxetine is the International Nonproprietary Name of a drug currently being considered for approval by the FDA for the treatment of premature ejaculation in men, which would make it the first drug approved for such treatment.
		Dapoxetine did not appear to affect the pharmacokinetics of tadalafil or sildenafil.
	www.ambers-website.info /dapoxetine/index.shtml (844 words)

	What Is Dapoxetine
		Dapoxetine is based on a treatment originally intended for use in relieving symptoms of depression.
		Dapoxetine's odds of approval look good, and PPD's cut from U.S. sales is expected to be in the mid-single to low-double digits.
		Given that dapoxetine would be the first drug for treating premature ejaculation, many are predicting it will be a blockbuster, which bodes well for PPD.
	www.whatisdapoxetine.com (1532 words)

	Dapoxetine hydrochloride premature ejaculation online treatment sexual drug
		Dapoxetine hydrochloride was originally an antidepressant and one of the side effects of several antidepressants is retarded ejaculation (an inability to reach orgasm), inability to sustain an erection and/or impotence.
		It was pharmacologist Thor Karl who spotted the repositioning potential of Dapoxetine hydrochloride and suggested its indication for premature ejaculation treatment.
		Dapoxetine hydrochloride data clearly indicates that men taking dapoxetine for the treatment of PE experienced significant improvements in sexual function, as well as in ejaculatory control, satisfaction with sexual intercourse for men and their partners, and increases in IELT (intravaginal ejaculatory latency time).
	www.dapoxetine-online.biz (431 words)

	Dapoxetine: LY 210448.
		Dapoxetine is the D-enantiomer of LY 243917 and is 3.5 times more potent as a serotonin reuptake inhibitor than the L-enantiomer.Dapoxetine was in phase I clinical trials in the US with […]
		Dapoxetine is the D-enantiomer of LY 243917 and is 3.5 times more potent as a serotonin reuptake inhibitor than the L-enantiomer.Dapoxetine was in phase I clinical trials in the US with Eli Lilly as an antidepressant, but no recent development has been reported for this indication.
		Both Lilly and PPD had an option to re-license dapoxetine upon completion of phase II trials, but neither company exercised its option, and the rights remained with PPD GenuPro.In December 2003, PPD Inc. acquired from Eli Lilly and Co. the patents for dapoxetine for development in the field of genitourinary disorders.
	counsellingresource.com /medications-research/2005/09/02/dapoxetine-ly-210448 (416 words)

	The Rest of the Story
		The dapoxetine story is different, though, in the way that science, marketing, and reimbursement will converge once the product is on the market.
		That latter point may be diminished somewhat in the case of dapoxetine, since people are more willing to pay out of pocket for something that improves their sex life, as compared to, say, something that treats cancer.
		If Forbes is correct, and dapoxetine results in $500 million in sales in the first year, that potentially means that the insurance industry will have to come up with an extra $500 million dollars next year, that they did not have to pay this year.
	trots.blogspot.com /2005_05_22_trots_archive.html (2549 words)

	ALZA Corporation Licenses Dapoxetine from PPD GenuPro
		Under the terms of the agreement, ALZA will receive worldwide rights to develop and commercialize dapoxetine and be responsible for manufacturing, clinical, regulatory, sales and marketing costs resulting from the license.
		Dapoxetine was licensed by PPD GenuPro in August 1998 from Eli Lilly and Company.
		Except for historical information, all of the statements, expectations and assumptions, including expectations and assumptions about the value of this agreement and the successful development of dapoxetine going forward, contained in the foregoing are forward-looking statements that involve a number of risks and uncertainties.
	www.ppdi.com /corporate/news/detail.htm?ID=74315 (676 words)

	Dapoxetine Safe And Effective In Treating Premature Ejaculation
		Dapoxetine, a new antidepressant, has been found to be safe and effective for the treatment of premature ejaculation, according to two major clinical trials.
		After three months, the men taking a 30-milligram dose of dapoxetine took an average 2.78 minutes to ejaculate after penetration, those on a 60-milligram dose took 3.32 minutes.
		Dapoxetine was rejected by the FDA last year.
	www.medicalnewstoday.com /healthnews.php?newsid=51474 (450 words)

	BBC NEWS \| Health \| Drug treats premature ejaculation (Site not responding. Last check: 2007-10-09)
		The US drug approval agency the Food and Drug Administration is reviewing an application for dapoxetine, which was developed by Ortho-McNeil Pharmaceutical, an affiliate of Johnson and Johnson.
		Dapoxetine is chemically similar to a family of antidepressants called SSRIs (selective serotonin reuptake inhibitors).
		Trials of dapoxetine have included 2,614 men aged 18-77 with premature ejaculation, who maintained monogamous sexual relationships for more than six months.
	news.bbc.co.uk /1/hi/health/4575015.stm (417 words)

	U of M Researchers Show Drug Treatment for Premature Ejaculation is Effective - Academic Health Center, University of ...
		The drug, dapoxetine, is a selective serotonin reuptake inhibitor (SSRI) that was developed specifically to treat premature ejaculation.
		Dapoxetine, however, is a short-acting drug that has an effect within about one hour.
		“Dapoxetine also improved patients’ perceptions of control over ejaculation, satisfaction with sexual intercourse, and overall impression of the change in their condition,” Pryor said.
	www.ahc.umn.edu /news/releases/premature090806/home.html (506 words)

	New drug may help alleviate male sexual dysfunction - Minnesota Daily
		The men in the study were given 30 or 60 milligrams of the drug dapoxetine, a short-acting antidepressant that is said to work if taken one to three hours before intercourse.
		Pryor said dapoxetine is different than other antidepressants because it has peak blood levels within an hour and 95 percent of the drug leaves the bloodstream within 24 hours.
		Whether or not dapoxetine is approved by the FDA, Pryor said he is confident a solution is in the near future.
	www.mndaily.com /articles/2006/09/12/68915 (663 words)

	Dapoxetinenews - What is Dapoxetine?
		Under the agreement ALZA acquired the right to develop and commercialize dapoxetine for urogenital indications, including premature ejaculation, on a worldwide basis.
		ALZA and Johnson and Johnson Pharmaceutical Research and Development, are developing dapoxetine and will seek approval from regulatory authorities around the world.
		Following successful regulatory approval, dapoxetine will be marketed by Ortho-McNeil Pharmaceutical, Inc. in the USA, Janssen-Ortho Inc. in Canada and by Janssen-Cilag companies around the world.
	www.dapoxetinenews.com /what_is_dapoxetine.html (335 words)

	New drug for the treatment of premature ejaculation has great results
		Premature ejaculation may be the most common male sexual disorder according to the American Urological Association, they estimate that PE may affect 27% to 34% of men across all age ranges, in contrast to erectile dysfunction, which is estimated to affect 10% to 12% of all men, who are usually older in age.
		Jon L. Pryor, M.D., chairman and program director of the Department of Urologic Surgery at the University of Minnesota and lead investigator of the dapoxetine phase III clinical trials, says PE can be a lifelong condition experienced from the beginning of sexual activity or can develop after years of satisfactory sexual activity.
		The results showed that the men taking dapoxetine 30 mg and 60 mg experienced more than a three-to- four fold increase in mean IELT compared with placebo, and IELT increased significantly with the first dose of dapoxetine, and increases in IELT were maintained over the 12-week study period.
	www.news-medical.net /?id=10349 (853 words)

	Dapoxetine developed to treat premature ejaculation (Site not responding. Last check: 2007-10-09)
		A Phase III clinical trial demonstrated that men taking Dapoxetine for the treatment of premature ejaculation (PE) experienced significant improvements in sexual function, including ejaculatory control, satisfaction with sexual intercourse for men and their partners, and increases in intravaginal ejaculatory latency time (IELT).
		Premature ejaculation was defined as persistent or recurrent ejaculation sooner than desired either before or shortly after penetration, typically reflecting an IELT of two minutes or less, over which the sufferer has minimal or no control.
		An observational study published in 2005 in The Journal of Sexual Medicine found that patient-reported outcome measures (PROs), such as control over ejaculation, satisfaction with sexual intercourse and distress are important factors in assessing the benefit of treatments for premature ejaculation in clinical studies.
	www.xagena.it /news/medicinenews_net_news/085ebbec4e5bc8d8f79481dbf896267a.html (542 words)

	HON - News : New Drug Treats Premature Ejaculation (Site not responding. Last check: 2007-10-09)
		However, after 12 weeks, men taking dapoxetine increased their time to ejaculation to 2.78 minutes for those receiving a 30-milligram dose, and to 3.32 minutes for those receiving a 60-milligram dose, the researchers found.
		One expert familiar with dapoxetine thinks the drug has promise but will not be available in the United States.
		"The problem is that dapoxetine was presented to the U.S. Food and Drug Administration last year, and they rejected it out-of-hand as a treatment for premature ejaculation," said Dr. James Barada, director of the Center for Sexual Health in Albany, N.Y. The drug can produce side effects such as nausea, headache, upset stomach and weakness.
	www.hon.ch /News/HSN/534824.html (791 words)

	Dapoxetine for Premature Ejaculation
		Dapoxetine hydrochloride, was originally an antidepressant drug but researchers discovered it had an interesting side-effect.
		Dapoxetine (3D structure of dapoxetine shown left) was originally an antidepressant and one of the side effects of several antidepressants is retarded ejaculation (an inability to reach orgasm), inability to sustain an erection and/or impotence.
		Since this article was written regulatory approval for dapoxetine hydrochloride has been refused, so read on to discover how to cure premature ejaculation, permanently (visit (http://scibase.epremature.hop.clickbank.net)).
	www.sciencebase.com /dapoxetine_for_premature_ejaculation.html (389 words)

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