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Congenital Lactic Acidosis (CLA) and Dichloroacetate (DCA) |
 | | DCA is an investigational drug that we believe may help children with CLA, both in terms of reducing the acidity of their blood and preventing or decreasing neuromuscular damage. |
 | | DCA is the most powerful stimulator of PDH ever administered to humans, and exerts its effects in virtually all tissues, including the brain, heart, muscles, and liver. |
 | | The second aspect regarding DCA's usefulness is that most reports to date have been "open-label" studies, that is, families, patients, and caregivers knew exactly when DCA was being given, so their interpretations of its relative safety and efficacy, compared to standard treatment, may not have been entirely objective. |
| cla-dca.gcrc.ufl.edu /familyinfo.html (1269 words) |
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