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Topic: Degranulation

In the News (Sun 29 Nov 09)

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	Fc{varepsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of ...
		of granules to the plasma membrane and degranulation.
		degranulation and the translocation of granules to the plasma
		The role of actin microfilaments in the down-regulation of the degranulation response in RBL-2H3 mast cells.
	www.jcb.org /cgi/content/full/170/1/115 (6312 words)

	Quantitative measurement of mast cell degranulation using a novel flow cytometric annexin-V binding assay.: Rigel ...
		Antigen-mediated crosslinking of their cell surface immunoglobulin E (IgE) receptors results in degranulation and the release of proinflammatory mediators, including histamine, tumor necrosis factor-a, and leukotrienes.
		Release of the enzyme b-hexosamidase was used for population-based measurements of degranulation.
		Two known inhibitors of degranulation, the phosphatidylinositol 3 kinase inhibitor wortmannin and overexpression of a mutant rab3d protein, were used as controls to validate the annexin-V binding assay.
	www.rigel.com /rigel/annexin_publ (261 words)

	Distinct Phosphoinositide 3-Kinases Mediate Mast Cell Degranulation in Response to G-protein-coupled Versus Fcepsilon ...
		R1-mediated degranulation in response to Fc RI ligation.
		Degranulation was expressed as annexin V-positive injected cells as a percentage of annexin V-positive non-injected cells on the same coverslip.
		carbachol in the presence of Alexa 488-annexin V for 45 min at 37 °C, and degranulation was determined as described in the legend to Fig.
	www.jbc.org /cgi/content/full/278/14/11874 (3544 words)

	Mast cells mediate the microvascular inflammatory response to systemic hypoxia -- Steiner et al. 94 (1): 325 -- Journal ...
		degranulated mast cells are indicated by the large arrowheads.
		Figure 4 illustrates the effects of hypoxia and compound 48/80 on mast cell degranulation as evidenced by ruthenium red uptake.
		Mast cell degranulation was estimated from ruthenium red intensity as determined by image analysis.
	jap.physiology.org /cgi/content/full/94/1/325 (5910 words)

	Neuro-psychodermatology
		In animals treated neonatally with capsaicin to deplete their sensory neurons of their neuropeptides, such as substance P (SP), mast cell degranulation due to immobilization stress was reduced to about 15%.
		Treatment of rats neonatally with capsaicin had no effect on either Evans blue extravasation or mast cell degranulation, indicating that the effect of exogenous CRH in the skin was not secondary to or dependent on the release of neuropeptides from sensory nerve endings.
		The effect of CRH on Evans blue extravasation and mast cell degranulation was inhibited by the mast cell stabilizer disodium cromoglycate (cromolyn), but not by the antisecretory molecule somatostatin.
	www.angelfire.com /journal2/sadhelp/neuropsy.htm (2230 words)

	Mechanism of Peptide-induced Mast Cell Degranulation . Translocation and Patch-Clamp Studies -- Lorenz et al. 112 (5): ...
		A typical time course for the degranulation of a mast cell dialyzed with 25 µM SP in low Ca buffering conditions is shown in Fig.
		The time course of mast cell degranulation after dialysis of SP through the patch pipette was measured as increase of membrane capacitance (top).
		The influence of intracellular calcium concentration on degranulation of dialysed mast cells from rat peritoneum.
	www.jgp.org /cgi/content/full/112/5/577 (7710 words)

	The degranulation two-step -- Tuma 170 (1): 9 -- The Journal of Cell Biology
		The degranulation two-step -- Tuma 170 (1): 9 -- The Journal of Cell Biology
		Mast cells are so full of granules that degranulation was thought
		RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane
	www.jcb.org /cgi/content/full/170/1/9-b (209 words)

	Anaplasma phagocytophilum Infection Induces Protracted Neutrophil Degranulation -- Choi et al. 72 (6): 3680 -- ...
		that prolonged degranulation, in the absence of intact phagocyte
		released to the cell membrane with degranulation (7).
		Neutrophils stimulated to degranulate with fMLP or infected with A.
	iai.asm.org /cgi/content/full/72/6/3680 (1534 words)

	Adenosine-Mediated Mast Cell Degranulation in Adenosine Deaminase-Deficient Mice -- Zhong et al. 298 (2): 433 -- ...
		Degranulation of mast cells in ADA-deficient mice occurs in an apparent adenosine-dependent and allergen-independent manner.
		in the degranulation of mast cells in lungs with elevated adenosine.
		Auchampach JA, Jin X, Wan TC, Caughey GH and Linden J (1997) Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor.
	jpet.aspetjournals.org /cgi/content/full/298/2/433 (5059 words)

	Degranulation enhances release of a stable contractile factor from rabbit polymorphonuclear leukocytes -- Hamilton et ...
		Degranulation enhances release of a stable contractile factor from rabbit polymorphonuclear leukocytes -- Hamilton et al.
		Degranulation enhances release of a stable contractile factor from rabbit polymorphonuclear leukocytes
		PMN degranulation was determined with an assay for myeloperoxidase (MPO) (38).
	ajpheart.physiology.org /cgi/content/full/274/5/H1545 (4030 words)

	Activation of RBL-2H3 Mast Cells Is Dependent on Tyrosine Phosphorylation of Phospholipase D2 by Fyn and Fgr -- Choi et ...
		Degranulation is expressed as a percentage of cellular ß-hexosaminidase that is released into the medium (A) or as a percentage of release observed in vector-expressing cells (C).
		H]myristate-labeled cells (A) and degranulation (B) after stimulation of cells with antigen for 3 min were determined as described for previous figures.
		The data are expressed as the percentage of PLD activity or degranulation that was observed in the absence of PP2.
	mcb.asm.org /cgi/content/full/24/16/6980 (7249 words)

	Defective Neutrophil Degranulation Induced by Interleukin-8 and Complement 5a and Down-Regulation of Associated ...
		Defective Neutrophil Degranulation Induced by Interleukin-8 and Complement 5a and Down-Regulation of Associated Receptors in Children Vertically Infected with Human Immunodeficiency Virus Type 1 -- Meddows-Taylor et al.
		PMN degranulation in response to C5a and IL-8 was measured by determination of the amount of
		PMN degranulation was evaluated in 15 HIV-1-uninfected children, 25 HIV-1-infected children with mild disease, and 23 HIV-1-infected
	cdli.asm.org /cgi/content/full/8/1/21 (4629 words)

	RedOrbit - Science - Responses of coelomocytes from Lumbricus terrestris to native and non-native eukaryotic parasites
		The degree of degranulation was monitored by measuring acid phosphatase levels, an enzyme released during degranulation.
		Following a 2 h co-incubation of extruded worm coelomocytes with Monocystis spores, there was a substantial release of acid phosphatase compared to spontaneous degranulation in control coelomocyte incubations (controls contained an equal number of coelomocytes from the same worm, incubated for the same time period but without the addition of a parasite).
		In summary, in vitro cultures showed that the L. terrestris' coelomocytes are capable of recognizing and vigorously responding to the spore stage of its ubiquitous parasites belonging to the genus Monocystis.
	www.redorbit.com /news/display?id=50813 (3087 words)

	Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposure -- ...
		Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposure -- Ahlstrom-Emanuelsson et al.
		Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposure
		The present study was supported by The Swedish Research Council, The Skåne County Council, The Crafoord Foundation, The Asthma and Allergy Foundation, The Swedish Medical Association, and The SwedishOtolaryngological Association.
	erj.ersjournals.com /cgi/content/abstract/24/5/750 (276 words)

	Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen -- Clark et al. 75 (6): 1001 ...
		Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen -- Clark et al.
		Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen
		Degranulation was most prominent in and primarily compartmentalized
	www.jleukbio.org /cgi/content/abstract/75/6/1001 (395 words)

	Impaired Interleukin-8-Induced Degranulation of Polymorphonuclear Neutrophils from Human Immunodeficiency Virus Type ...
		PMNL degranulation was measured in response to IL-8 by the release of
		The proportion of IL-8RA- and IL-8RB-expressing PMNLs (A), their relative fluorescence intensities (B), and the degranulation ability of the isolated PMNLs in response to 500 ng of IL-8 per ml (C) are shown as individual values (solid squares) and 10th and 90th percentiles (error bars).
		Impaired degranulation was detected not only in response to IL-8 but also in response to another agonist, fMLP.
	cdli.asm.org /cgi/content/full/6/3/345 (4342 words)

	TSRI - News and Publications
		The goal of our research is to determine the mechanisms by which actin microfilaments regulate the signaling pathways involved in degranulation in mast cells.
		Adhesion and spreading do not cause any degranulation on their own, but they do prime the cells, because antigen-stimulated spread cells degranulate to a much greater extent than do activated cells in suspension.
		We are investigating the role of the tyrosine kinases Lyn, Syk, and Btk in mediating this increased degranulation.
	www.scripps.edu /news/sr/sr98/memgen31.htm (400 words)

	Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A Possible ...
		Taylor AM, Galli SJ, Coleman JW 1995 Stem-cell factor, the kit ligand, induces direct degranulation of rat peritoneal mast cells in vitro and in vivo: dependence of the in vitro effect on period of culture and comparisons of stem-cell factor with other mast cell-activating agents.
		Turnbull AV, Rivier C 1996 Corticotropin-releasing factor, vasopressin and prostaglandins mediate and nitric oxide restrains the hypothalamic-pituitary-adrenal response to acute local inflammation in the rat.
		Degranulation of mast cells located in median eminence in response to compound 48/80 evokes adrenocortical secretion via histamine and CRF in dogs
	endo.endojournals.org /cgi/content/full/139/1/403 (5728 words)

	Human endothelial cells regulate polymorphonuclear leukocyte degranulation -- Topham et al. 12 (9): 733 -- The FASEB ...
		Degranulation by PMNs is a critical activation response (17).
		Degranulation of PMNs adherent to EC stimulated with IL-1 is time dependent.
		In two additional experiments, actinomycin D blocked release of the degranulating activity; in one of these, emetine and cycloheximide, which are inhibitors of protein synthesis, also blocked release.
	www.fasebj.org /cgi/content/full/12/9/733 (8539 words)

	SHIP Down-Regulates Fc{epsilon}R1-Induced Degranulation at Supraoptimal IgE or Antigen Levels -- Gimborn et al. 174 ...
		Subsequently, degranulation was assessed by measuring the release of
		Thapsigargin-induced degranulation of mast cells is dependent on transient activation of phosphatidylinositol-3 kinase.
		Protein kinase C- is a negative regulator of antigen-induced mast cell degranulation.
	www.jimmunol.org /cgi/content/full/174/1/507 (6096 words)

	Canine Mast Cell Adenosine Receptors: Cloning and Expression of the A3 Receptor and Evidence that Degranulation Is ...
		Canine Mast Cell Adenosine Receptors: Cloning and Expression of the A3 Receptor and Evidence that Degranulation Is Mediated by the A2B Receptor -- Auchampach et al.
		As an indicator of degranulation of BR cells, we measured the release of
		Characterization of the adenosine receptor that causes degranulation of canine mastocytoma cells.
	molpharm.aspetjournals.org /cgi/content/full/52/5/846 (5281 words)

	New Aspects of Degranulation and Fates of Airway Mucosal Eosinophils -- ERJEFÄLT and PERSSON 161 (6): 2074 -- ...
		of degranulation and fates of airway mucosal eosinophils (15)
		Eosinophils in allergy: role in disease, degranulation, and cytokines.
		Cytolysis and piecemeal degranulation as distinct modes of activation of airway mucosal eosinophils.
	ajrccm.atsjournals.org /cgi/content/full/161/6/2074 (6260 words)

	Respiratory Research \| Full text \| Effects of cigarette smoke on degranulation and NO production by mast cells and ...
		A rat basophilic leukemia cell line, RBL-2H3 representing mucosal type mast cells [19], which has been extensively applied in studies of mast cell biochemistry and signalling, was used as an in vitro model of mast cells for this study.
		Beta-hexosaminidase was used as a marker of mast cell activation and degranulation.
		To investigate whether free radicals in CSS contribute to the inhibition of degranulation, RBL-2H3 cells were incubated with free radical scavenger N-acetyl-L-cysteine (NAC, 1 mM) for 30 min prior to their incubation with CSS.
	respiratory-research.com /content/6/1/108 (5040 words)

	The Role of Actin Microfilaments in the Down-Regulation of the Degranulation Response in RBL-2H3 Mast Cells -- Frigeri ...
		IgE-sensitized cells in suspension were preincubated with increasing concentrations of either latrunculin (A) or cytochalasin D (B) for 15 min at 37°C. The cells were activated with either Ag or buffer for 45 min, and the percentage of ß-hexosaminidase released was monitored.
		Latrunculin increases the rate and extent of degranulation and intracellular Ca RBL cells were preincubated with 500 nM latrunculin for 15 min before activation with DNP-BSA.
		inhibition of actin polymerization and increased degranulation in
	www.jimmunol.org /cgi/content/full/162/4/2243 (6002 words)

	Investigating the FcERI Receptor Signaling Pathway and Mast Cell Degranulation using a Novel Label-free Cell-based ... (Site not responding. Last check: 2007-10-10)
		Degranulation is classically studied using enzymatic assays that are complicated and time consuming.
		Specifically, we have measured the EC value of FcERI stimulation and performed antagonist assays using cell-permeable inhibitors of kinases that are involved in the FcERI signaling cascade, including Lyn-, PI3-, and Syk-kinases.
		In addition, we show the activation of multiple endogenous receptors on mast cells demonstrating the use of CDS in identifying new receptor targets that may be of interest in mast cell research.
	www.sbsonline.org /sbscon/2005/posters/050629152359.php (214 words)

	Texas Medical Center NEWS
		Adachi’s VA lab is exploring the degranulation process in hopes of shutting it down.
		He believes degranulation is responsible for the bad effects of mast cells.
		The hospital’s laboratory is looking at the final step of degranulation, when the granule membrane fuses with the cell membrane and releases its contents.
	www.tmc.edu /tmcnews/11_15_02/page_18.html (569 words)

	In vitro activation of murine DRG neurons by CGRP-mediated mucosal mast cell degranulation -- De Jonge et al. 287 (1): ...
		In vitro activation of murine DRG neurons by CGRP-mediated mucosal mast cell degranulation -- De Jonge et al.
		B: the degranulation of MMC by CGRP and SP was expressed as a percentage of the MMC response to 10 µg/ml C48/80 (100%).
		Compound 48/80-induced degranulation of GnRH-like immunoreactive mast cells in the brain and mesentery of the gerbil.
	ajpgi.physiology.org /cgi/content/full/287/1/G178 (7320 words)

	MAST CELLSAND ORAL INFLAMMATION -- Walsh 14 (3): 188 -- Critical Reviews in Oral Biology & Medicine
		Mast cell degranulation upregulates alpha 6 integrins on epidermal Langerhans cells.
		Degranulation of human mast cells induces an endothelial central to leukocyte adhesion.
		Morphologically distinctive forms of cutaneous mast cell degranulation induced by cold and mechanical stimuli: an ultrastructural study.
	crobm.iadrjournals.org /cgi/content/full/14/3/188 (7627 words)

	Suppression of Adenosine A3 Receptor-Mediated Hypotension and Mast Cell Degranulation in the Rat by Dexamethasone -- ...
		Suppression of Adenosine A3 Receptor-Mediated Hypotension and Mast Cell Degranulation in the Rat by Dexamethasone -- Hannon et al.
		APNEA induced mast cell degranulation in thymus but not in skin or skeletal muscle.
		Fredholm BB, Arslan G, Halldner L, Kull B, Schulte G and Wasserman W (2000) Structure and function of adenosine receptors and their genes.
	jpet.aspetjournals.org /cgi/content/full/302/2/725 (3288 words)

	AEGiS-10CROI: Simultaneous Assessment of Degranulation and Cytokine Production in HIV- and CMV-specific CD8
		In some pts, responding T-cells were sorted and the clonality of degranulating and non-degranulating T-cells was compared.
		T-cells was concordant with degranulation in the same cells in all pts tested, although a significant proportion of responding T-cells degranulate without producing IFNand#947;.
		T-cells are not defective in their ability to degranulate and release cytotoxic granule contents upon recognition of cognate peptide.
	www.aegis.com /conferences/croi/2003/306.html (390 words)

	Regulatory Effects of Eotaxin, Eotaxin-2, and Eotaxin-3 on Eosinophil Degranulation and Superoxide Anion Generation -- ...
		The Eotaxins CCL11, CCL24, and CCL26 Induce EPO Degranulation from EOS.
		CCL24-, or CCL26-stimulated degranulation of EPO was inhibited
		Washed cells were dispensed to microcentrifuge tubes and were stimulated for 1 hr with the indicated concentrations of chemokines.
	www.ebmonline.org /cgi/content/full/227/8/645 (3848 words)

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