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Topic: Delavirdine

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	Aidsmap \| Delavirdine - overview
		Delavirdine is licensed for the treatment of HIV infection in combination with NRTIs in the United States.
		Delavirdine is an inhibitor of the cytochrome P450 CYP3A4 system, a metabolic pathway in the liver which controls the elimination of drugs from the body.
		Delavirdine levels are reduced by saquinavir (Invirase / Fortovase) and by nelfinavir (Viracept), but delavirdine has been shown to boost blood levels of saquinavir fivefold and to double blood levels of indinavir when either of the drugs are combined with it.
	www.aidsmap.com /en/docs/D9E519F3-B09E-4C89-AB4D-F60E7D34971A.asp (1870 words)

	Rescriptor (delavirdine, DLV). Buy Rescriptor & all your HIV/AIDS drugs here.
		Delavirdine is a non-nucleoside reverse transcriptase inhibitor (a "non-nuke" or NNRTI).
		Delavirdine was approved in 1997 as an antiviral drug for people with HIV infection.
		Delavirdine is broken down by the liver and can interact with other drugs that also use the liver.
	www.hiv-aids-help-desk.com /rescriptor.html (551 words)

	[No title]
		Delavirdine mesylate is a bis(heteroaryl)piperazine (BHAP) derivative nonnucleoside reverse transcriptase inhibitor (NNRTI).
		Delavirdine mesylate was approved by the FDA on April 4, 1997, for use in combination with at least two other antiretroviral agents for the treatment of adults with HIV-1 infection.
		The aqueous solubility of delavirdine free base at 23 C is 2942 mcg/ml at pH 1.0, 295 mcg/ml at pH 2.0, and 0.81 mcg/ml at pH 7.4.
	www.aidsinfo.nih.gov /drugs/htmldrug_tech.asp?int_id=0166 (1805 words)

	AIDS Committee of Windsor: HIV Treatment Information > Combination Therapy
		Delavirdine (Rescriptor) received accelerated approval from the FDA (Food and Drug Administration) for use in combination with other antiretroviral therapies for the treatment of HIV when therapy is warranted.
		Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
		Delavirdine should NOT BE USED with alprazolam (Xanax), astemizole (Hismanal), cisapride (Propulsid), midazolam (Versed), Rifampin (Rifadin, Rifater), terfenadine (Seldane) and triazolam (Halcion) as their use in combination with delavirdine may lead to serious and/or life-threatening side effects.
	www.mnsi.net /~aidscw/rescriptor.htm (716 words)

	[No title]
		Delavirdine was approved by the FDA on April 4, 1997, for use with other antiretroviral medications in the treatment of HIV infection in adults.
		Delavirdine does not cure or prevent HIV infection or AIDS and does not reduce the risk of passing the virus to other people.
		Delavirdine may also cause serious kidney problems with symptoms including agitation; coma; confusion; dark urine; decreased urine output; depression; dizziness; headache; hostility; irritability; lack of energy; loss of appetite; muscle twitching; nausea; rapid weight gain; seizures (convulsions); swelling of face, ankles, or hands; and unusual tiredness or weakness.
	www.aidsinfo.nih.gov /drugs/htmldrug_nt.asp?int_id=0166 (527 words)

	DELAVIRDINE Faq
		Delavirdine is an antiretroviral medication that slows down the replication of the human immunodeficiency virus (HIV) and may therefore slow the progression of the HIV disease.
		Delavirdine is meant to be taken in combination with nucleoside analogues and/or protease inhibitors.
		Delavirdine should not be given in combination with non-sedating antihistamines, such as terfenadine (Seldane) and astemizole (Hismanal).
	www.tthhivclinic.com /delav.htm (690 words)

	Howstuffworks "Delavirdine: A Profile of a HIV Drug"
		Delavirdine works by inhibiting the reproduction, or growth, of the virus, which slows the progression of AIDS.
		Delavirdine does not cure HIV infection or AIDS, but it may delay onset of other infections and diseases caused by AIDS.
		The effects of delavirdine may be reduced by carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, cimetidine, famotidine, nizatidine, or ranitidine.
	health.howstuffworks.com /define-delavirdine.htm (713 words)

	Delavirdine - Drugs & Vitamins - Drug Library - DrugDigest
		Delavirdine may reduce the amount of HIV in the blood and increase the number of CD4 cells (T-cells) in the blood.
		Delavirdine is used in combination with other drugs to treat the HIV virus.
		Delavirdine requires acid in the stomach to be absorbed into the body.
	www.drugdigest.org /DD/DVH/Uses/0,3915,191\|Delavirdine,00.html (1046 words)

	Metabolism of the human immunodeficiency virus type 1 reverse transcriptase inhibitor delavirdine in rats.
		Delavirdine mesylate (U-90152T) is a highly specific nonnucleoside reverse transcriptase inhibitor currently under development for the treatment of AIDS.
		The excretion, disposition, and metabolism of delavirdine were investigated in Sprague-Dawley rats after oral administration of [14C]delavirdine mesylate at single doses ranging from 10 to 250 mg/kg and multiple doses ranging from 20 to 250 mg/kg/day.
		The metabolism of delavirdine in the rat was extensive.
	www.aegis.com /aidsline/1997/jul/M9771469.html (393 words)

	The Body: TAGline/Volume 4 Issue 1
		Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), similar to Boehringer-Ingelheim's nevirapine, which was approved by the FDA in June, 1996.
		According to Pharmacia and Upjohn (makers of delavirdine), the Data Safety and Monitoring Board (DSMB) recommended terminating the study because the protocol goals of showing a clinical outcome difference between the two regimens was unlikely to be achieved.
		In these studies, co-administration of delavirdine and saquinavir raised saquinavir levels by five times, producing blood levels of saquinavir that were comparable to those achieved in the Stanford high-dose saquinavir study.
	www.thebody.com /tag/jan97.html (2576 words)

	delavirdine - HIV: health and medical information about HIV and AIDS
		Delavirdine is in a class of drugs called reverse transcriptase inhibitors which also includes zalcitabine (Hivid), zidovudine (Retrovir), didanosine (Videx), and lamivudine (Epivir).
		Delavirdine does not kill existing HIV virus, and it is not a cure for HIV.
		Delavirdine increases the blood concentration of indinavir (Crixivan), saquinavir (Invirase), warfarin (Coumadin), quinidine (Cardioquin, Quinaglute), clarithromycin (Biaxin), benzodiazepines (e.g., Valium, Ativan), nifedipine (Adalat, Procardia) and ergotamine (Ergostat).
	www.medicinenet.com /delavirdine/article.htm (530 words)

	Herpesviruses 2000: Delavirdina (Site not responding. Last check: 2007-11-03)
		Delavirdine is an anti-AIDS drug approved for use in the United States in 1997.
		Delavirdine is taken orally and is meant to be used in conjunction with other anti-AIDS therapies to improve their effectiveness.
		Delavirdine is a non-nucleoside reverse transcriptase inhibitor that works to prevent reverse transcriptase from replicating the HIV genome.
	www.stanford.edu /group/virus/herpes/2000/herpes2000drug1.html (444 words)

	MedlinePlus Drug Information: Delavirdine
		Delavirdine should always be used with another antiviral medication to avoid resistance to the HIV virus.
		Delavirdine is used to treat human immunodeficiency virus (HIV) infection in patients with or without acquired immunodeficiency syndrome (AIDS).
		Delavirdine is not a cure and may not decrease the number of HIV-related illnesses.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a600034.html (718 words)

	Delavirdine treatment increases ritonavir concentrations (Site not responding. Last check: 2007-11-03)
		Delavirdine is known to inhibit CYP3A4, the authors explain, an enzyme that both metabolizes ritonavir and is potently inhibited by ritonavir.
		Addition of delavirdine to the antiretroviral regimen was associated with a mean 51% increase in systemic exposure to ritonavir (as measured by AUC(0-12), the authors report.
		In contrast, delavirdine pharmacokinetics did not appear to be changed by its coadministration with ritonavir-containing antiretroviral regimens, the researchers note.
	www.aidsmeds.com /news/20030613clin023.html (434 words)

	AEGiS-RITA!: NRTI: DELAVIRDINE (Rescriptor) - March 2000 (Site not responding. Last check: 2007-11-03)
		Delavirdine should be stored at a controlled room temperature of 68° to 77°F in a tightly closed container and protected from high humidity.
		Delavirdine should not be taken with the following: alprazolam (Xanax), midazolam (Versed), triazolam (Halcion), carbamazipine (Carbatrol, Tegretol, Tegretol XR), phenobarbital, phenytoin (Dilantin), cisapride (Propulsid), cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), ranitidine (Zantac), rifampin (Rifadin, Rimactane) or rifabutin (Mycobutin).
		Delavirdine was approved on the basis of 3 studies: Pharmacia & Upjohn Study 0021, Study 0017 and ACTG 261.
	www.aegis.com /pubs/rita/2000/RI000312.html (739 words)

	[No title]
		Delavirdine is an antiretroviral (anti-HIV) agent belonging to the class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs).
		Since Delavirdine may interact with many other medications, it is best to check with the pharmacist at the clinic before starting any new medication.
		Delavirdine needs to be taken at least 1 hour before taking any antacids or ddI (Videx).
	www.crha-health.ab.ca /clin/sac/delavird.htm (474 words)

	NATAP: Upjohn letter re delavirdine-protease inhibitor interactions - National AIDS Treatment Advocacy Project/ HIV / ... (Site not responding. Last check: 2007-11-03)
		When seven healthy volunteers received delavirdine 400 mg tid with and without saquinavir 600 mg tid, coadministration of the two drugs resulted in a slight reduction in the mean steady-state trough plasma delavirdine concentrations from 17 +/- 5 EM to 13 + 3 EM.
		Although a pharmacokinetic interaction between delavirdine and ritonavir at their recommended doses Is theoretically possible, no evidence of an interaction was observed at doses of delavirdine 400 mg bid and ritonavir 300 mg bid.
		Administration of delavirdine 400 mg tid with a 400 mg single-dose of indinavir resulted in a mean value of the indinavir AUC which was slightly less than the value from an 800 mg single-dose of indinavir alone.
	www.natap.org /1998/drug/delav3.html (526 words)

	Hopkins HIV Report July 1997 - Product Information (Site not responding. Last check: 2007-11-03)
		A potential advantage of delavirdine is that it increases blood levels of saquinavir, indinavir, and nelfinavir.
		Delavirdine inhibits P450 CYP 3A indicating inhibition of its own metabolism as well as that of indinavir, nelfinavir and saquinavir.
		Delavirdine increases levels of indinavir (reduce dose of indinavir to 600 mg tid) and nelfinavir (recommendations not published, but consider reducing dose to 500 mg tid).
	www.hopkins-aids.edu /publications/report/jul97_6.html (1045 words)

	Delavirdine
		This occurs rapidly in subjects receiving delavirdine therapy in the absence of maximal virologic suppression.
		Although the addition of the Y181C mutation in a zidovudine resistance background was shown to restore zidovudine susceptibility in vitro, the clinical correlation of this observation remains uncertain.
		Delavirdine mesylate, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor.
	www.hivresistanceweb.com /protected/drug/delavirdine.shtml (481 words)

	Rescriptor Online, Description, Chemistry, Ingredients, Blackbox - Delavirdine Mesylate - RxList Monographs
		RESCRIPTOR Tablets contain delavirdine mesylate, a synthetic non-nucleoside reverse transcriptase inhibitor of the human immunodeficiency virus type 1 (HIV-1).
		Delavirdine binds directly to reverse transcriptase (RT) and blocks RNA-dependent and DNA-dependent DNA polymerase activities.
		In Vitro HIV-1 Susceptibility: In vitro anti—HIV-1 activity of delavirdine was assessed by infecting cell lines of lymphoblastic and monocytic origin and peripheral blood lymphocytes with laboratory and clinical isolates of HIV-1.
	www.rxlist.com /cgi/generic/rescriptor.htm (480 words)

	MedlinePlus Drug Information: Delavirdine (Systemic) (Site not responding. Last check: 2007-11-03)
		Delavirdine (de-la-VIR-deen) is used, in combination with other medicines, in the treatment of the infection caused by the human immunodeficiency virus (HIV).
		Delavirdine will not cure or prevent HIV infection or AIDS; however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system.
		Antacids—Use of this medicine with delavirdine may decrease the amount of delavirdine in the body.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/203521.html (1464 words)

	1996 December 6, ATN 260 - FDA Advisory Committee Deadlocks on Delavirdine (Site not responding. Last check: 2007-11-03)
		Indeed, in the one study that evaluated delavirdine's effect on rates of opportunistic diseases or death, delavirdine plus ddI was no better than ddI alone.
		The study that assessed the effects of delavirdine on disease progression compared the standard dose of ddI plus 400 mg of delavirdine three times daily against ddI plus placebo in almost 1200 people with an average CD4 count of 135.
		The interaction between delavirdine and saquinavir seems enticing because low blood levels are a major problem with the current formulation of saquinavir.
	www.hsph.harvard.edu /Organizations/healthnet/HIV/docs/atn/atn260c.html (1514 words)

	Rescriptor (delavirdine) Treatment Increases Norvir (ritonavir) Concentrations (Site not responding. Last check: 2007-11-03)
		Delavirdine treatment results in increased systemic exposure to ritonavir, presumably by inhibiting its metabolism, according to a report in the May issue of Antimicrobial Agents and Chemotherapy.
		In contrast, most nonnucleoside reverse transcriptase inhibitors besides delavirdine are known to be enzyme inducers.
		Gene D. Morse from University of Buffalo, New York and associates evaluated the pharmacokinetics of ritonavir and delavirdine in 12 HIV-infected patients who had delavirdine mesylate (400 mg every 8 hours) added to their existing antiretroviral regimens that already included ritonavir.
	www.hivandhepatitis.com /recent/nnrtis/061603i.html (306 words)

	DELAVIRDINE a Commonly Used Medication
		concomitant use of: rifabutin (reduces delavirdine levels by >90%), rifampin, non-sedating antihistamines, sedative hypnotics, antiarhythmics, calcium channel blockers, ergot alkaloid preparations, amphetamines, cisapride, astemizole, terfenadine.
		Phenytoin, phenobarbital, and carbamazapine may cause substantial reduction in plasma delavirdine.
		Indinavir dose reduction is recommended when co-administered with delavirdine, to 600 mg tid.
	www.hivdent.org /drugs/DELAVIRDINE.htm (154 words)

	Aidsmap \| Amprenavir levels boosted tenfold by delavirdine in children
		Combining the non-nucleoside reverse transcriptase inhibitor (NNRTI) delavirdine as both an active drug and a booster for the protease inhibitor (PI), amprenavir, in children on salvage therapy appears to be well tolerated and effective after 18 months, according to a small German study published in the July 2nd issue of the journal AIDS.
		Previous pharmacokinetic studies in healthy adults have shown that delavirdine is a potent inhibitor of the cytochrome P450 enzyme and increases plasma concentrations of PIs.
		Although delavirdine is not an approved NNRTI in the EU, is it available on expanded access, and may be a useful alternative to combining PIs with the other NNRTIs, efavirenz and nevirapine, both of which are potent PI inducers.
	www.aidsmap.com /news/newsdisplay2.asp?newsId=2775 (757 words)

	DELAVIRDINE (Rescriptor)
		Delavirdine was approved in 1997 as an antiretroviral drug (ARV) for people with HIV infection.
		Delavirdine is inconvenient because it is taken three times a day.
		If you take delavirdine with other ARVs, you can reduce your viral load to extremely low levels, and increase your CD4 cell counts.
	www.aids.org /factSheets/433-Delavirdine-Rescriptor.html (602 words)

	HIV Medicine 2006 \| Delavirdin
		Delavirdine is rarely used, due to impractical dosing and drug interactions.
		Comments/Warnings: delavirdine is contraindicated for concurrent treatment with rifabutin, rifampin, carbamazepine, phenytoin, alprazolam, astemizole, phenobarbital, cisapride, midazolam, terfenadine and triazolam.
		Delavirdine interacts with numerous drugs via reduction of CYP3A-activity.
	www.hivmedicine.com /textbook/drugs/delavi.htm (171 words)

	Healthopedia.com - Delavirdine (Oral) (Rescriptor) - Drugs Information, Side Effects, & Interactions
		Delavirdine does not cure HIV or AIDS, but combinations of drugs that treat HIV infection may slow the disease progress and may prolong your life.
		Combining delavirdine with these medicines may increase the risk of unwanted side effects from these drugs or from delavirdine.
		Delavirdine will not keep you from giving HIV to your partner during sex.
	www.healthopedia.com /drugs/quick/delavirdine (842 words)

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