| | UpToDate Diagnosis and treatment of delayed puberty |
 | | Delayed puberty is defined clinically by the absence or incomplete development of secondary sexual characteristics by an age at which 95 percent of children of that sex and culture have initiated sexual maturation. |
 | | Staging of puberty is usually performed by the criteria of Tanner and, according to the National Center for Health Statistics, the upper 95th percentile in the United States for age for boys is 14 (testicular development being the first sign) and for girls is 12 (breast development being the first sign) (show table 1). |
 | | Delayed puberty usually results from inadequate gonadal steroid secretion, which is most often caused by a defective secretion of GnRH that results in low gonadotropins, the key functional defect in patients with constitutional delay; it can, however, also be caused by a variety of hypothalamic, pituitary, and gonadal disorders. |
| patients.uptodate.com /topic.asp?file=pediendo/16184 (589 words) |