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Topic: Dementia with Lewy bodies


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  Lewy body - Wikipedia, the free encyclopedia
A classical Lewy body is an eosinophilic cytoplasmic inclusion that consists of a dense core surrounded by a halo of 10-nm wide radiating fibrils, the primary structural component of which is alpha-synuclein.
A Lewy body is composed of the protein alpha-synuclein associated with other proteins such as ubiquitin, neurofilament protein, and alpha B crystallin.
Lewy bodies are also present in neurons in dementia with Lewy bodies and the Lewy body variant of Alzheimer's disease, as well as Hallervorden-Spatz syndrome.
en.wikipedia.org /wiki/Lewy_body   (282 words)

  
 Dementia with Lewy bodies - Wikipedia, the free encyclopedia
Dementia with Lewy Bodies (DLB) exhibits clinical overlap between Alzheimer's disease and Parkinson's disease.
That is, when Lewy Body inclusions are found in the cortex, they often co-occur with Alzheimer's disease pathology found primarily in the hippocampus, including: neurofibrillary tangles (abnormally phosphorylated tau protein), senile plaques (deposited beta-amyloid protein), and granulovacuolar degeneration.
Dementia with Lewy Bodies is not a DSM-IV recognized diagnosis.
en.wikipedia.org /wiki/Dementia_with_Lewy_bodies   (668 words)

  
 Dementia with Lewy Bodies
Lewy bodies appear in deteriorating nerve cells and are often found in damaged regions deep within the brains of people with Parkinson’s disease.
However, when Lewy bodies are found in other areas of the brain, such as in the outer layer (cortex), a dementia occurs with symptoms similar to those of Alzheimer’s disease.
Individuals with DLB are often abnormally sensitive to medications that physicians use to treat delusions, agitation or hallucinations that a person may exhibit during the course of a dementing illness.
www.alz.org /grtrcinc/aaRelLewyBodies.htm   (735 words)

  
 [No title]   (Site not responding. Last check: 2007-10-22)
Dementia with Lewy bodies (DLB) may be responsible for about a fifth of the total cases of dementia in the UK, making it the second most common cause of dementia, affecting about 130,000 people in the UK.
DLB is a dementia which is caused by degeneration and death of nerve cells in the higher parts of the brain.
Lewy bodies are found in ordinary Parkinson's disease as well but the extent and pattern of distribution in the brain is quite different.
www.parkinsons.org.uk /shared_asp_files/uploadedfiles/{056862DC-90E7-409C-B5BA-4758FDABB0C1}_Lewybody3303_04.txt   (1442 words)

  
 Lewy Body Dementia
Lewy bodies are round collections of brain proteins which are the pathological hallmark of Parkinson's disease in the substantia nigra.
Synuclein Missense Mutations in Lewy Bodies and Familial Parkinsons: Alpha-Synuclein is a presynaptic protein that is implicated in the pathogenesis of various neurodegenerative diseases.
Dementia with Neurofilament Inclusions: This may be a different type of dementia characterized clinically by early-onset with frontal lobe signs, focal atrophy of the frontal and temporal lobes, and microscopically by the presence in many brain regions of intraneuronal, cytoplasmic, neurofilament inclusions.
www.modern-psychiatry.com /new_page_35.htm   (1103 words)

  
 Dementia With Lewy Bodies
Dementia is a progressive (gradually worsening) decline of mental abilities that disturbs "cognitive" functions such as memory, thought processes, and speech as well as behavior, and movements.
Dementia with Lewy bodies (DLB) is the name for a group of disorders in which dementia is caused by the presence of Lewy bodies in the brain.
Lewy bodies are small round clumps of normal proteins that for unknown reasons become abnormally clumped together inside neurons (brain cells).
www.emedicinehealth.com /dementia_with_lewy_bodies/article_em.htm   (455 words)

  
 Role of Cholinesterase Inhibitors in Parkinson's Disease and dementia with Lewy Bodies -- Aarsland et al. 17 (3): 164 ...
Basal fore-brain neurons in the dementia of Parkinson disease.
Pathology and neurotransmitter abnormalities of dementia with lewy bodies.
Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s disease.
jgp.sagepub.com /cgi/content/refs/17/3/164   (1674 words)

  
 Dementia with Lewy bodies
Lewy bodies are classically associated with PD. They are rarely seen in the cerebral cortex in PD but are in several areas of the cortex (temporal, frontal, parietal) in DLB.
Dementia with Lewy bodies is a common cause of dementia.
Quantifying fluctuation in dementia with Lewy bodies, Alzheimer’s disease, and vascular dementia.
www.cfpc.ca /cfp/2003/Oct/vol49-oct-cme-2.asp   (4641 words)

  
 Lewy Body Disease: Symptoms and Treatment
Lewy Body disease, also known as dementia with Lewy Bodies (DLB), is a fatal dementia that is caused by abnormal structures in the brain which impair its ability to function properly.
The progression of Lewy Body disease is slow and the cause is unknown.
For people with Lewy Body disease, it may be preferable to find ways of dealing with a persons' distress that does not involve medication, or to use atypical antipsychotic medications to try to treat the symptoms.
www.helpguide.org /elder/lewy_body_disease.htm   (729 words)

  
 Postgraduate Medicine: Defining diffuse Lewy body disease
Lewy bodies are the neuronal inclusion bodies seen in the midbrain in Parkinson's disease; however, they are much harder to visualize in cortical neurons than in midbrain neurons (3) (figures 1 and 2).
Diffuse Lewy body disease is found at autopsy in 15% to 20% of patients with dementia (1).
The dementia seen in diffuse Lewy body disease is similar to that of Alzheimer's disease (4) and includes prominent memory loss, aphasia, and apraxia initially and executive deficits (eg, disinhibition, loss of initiative, incontinence) later.
www.postgradmed.com /issues/2003/05_03/stewart2.htm   (2084 words)

  
 FCA Print: Dementia with Lewy Bodies
Dementia with Lewy Bodies (DLB) is a progressive degenerative disease or syndrome of the brain.
Lewy bodies are often present in the nuclei (nerve cells) of brains afflicted with a variety of disorders.
Because Lewy bodies are also often found in the brains of those diagnosed with Alzheimer’s, Parkinson’s, Down syndrome and other disorders, researchers agreed in 1995 to use the term “Dementia with Lewy Bodies” to describe both a single disease (sometimes called “pure DLB”) and a spectrum of disorders with similar or related pathology.
www.caregiver.org /caregiver/jsp/print_friendly.jsp?nodeid=570   (2598 words)

  
 CMRIS
Because these structures and many of the symptoms of dementia with Lewy bodies are associated with Parkinson's and Alzheimer's diseases, researchers do not yet understand whether dementia with Lewy bodies is a distinct clinical entity or perhaps a variant of Alzheimer's or Parkinson's disease.
In 1996 scientists published guidelines for the diagnosis of dementia with Lewy bodies (McKeith IG, et al, Neurology, vol 47, pp 1113-1114, Nov 1996).
Research efforts also include basic investigations of Lewy bodies, in an effort to understand the biological consequences of Lewy body formation and the mechanisms of disease progression.
psychiatry.mc.duke.edu /CMRIS/ED/LewyBody.htm   (381 words)

  
 LEWYNET from Nottingham Med School
Dementia with Lewy bodies is a preferred term which describes several common disorders causing dementia.
When the brain from a patient with Lewy body dementia is examined at autopsy loss of nerve cells is seen from the midbrain region where the substantia nigra is located.
Neuroleptic sensitivity in dementia with Lewy bodies and Alzheimer's disease.
www.nottingham.ac.uk /pathology/lewy/lewyinfo.html   (1979 words)

  
 eMedicine - Dementia With Lewy Bodies : Article by Howard A Crystal, MD   (Site not responding. Last check: 2007-10-22)
Postmortem examination in both PD and DLB demonstrate LBs in the substantia nigra and possibly in the locus ceruleus, dorsal raphe, substantia innominata, and dorsal motor nucleus of the vagus.
Depression is frequent in DLB and may result from damage in the dorsal raphe and locus ceruleus and/or as a psychological response to impaired function.
Fernandez HH, Wu CK, Ott BR: Pharmacotherapy of dementia with Lewy bodies.
www.emedicine.com /neuro/topic91.htm   (3935 words)

  
 Dementia with Lewy bodies -- McKEITH 180 (2): 144 -- The British Journal of Psychiatry
Lewy bodies are neuronal inclusions composed of abnormally phosphorylated,
Fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease is qualitatively distinct
Dementia With Lewy Bodies and the Neurobehavioral Decline of Mervyn Peake
bjp.rcpsych.org /cgi/content/full/180/2/144   (1972 words)

  
 Memory and Aging Center: Dementia with Lewy Bodies
Dementia with Lewy-Bodies sometimes occurs alone as the presenting illness and sometimes it occurs simultaneously with Alzheimer’s or Parkinson’s disease.
Dementia with Lewy-Body is the second most frequent cause of dementia in elderly adults.
Dementia with Lewy-Bodies is difficult to diagnose because it resembles and overlaps with other dementias like Alzheimer’s disease and Vascular dementia and Parkinson’s disease.
memory.ucsf.edu /Education/Disease/dlb.html   (549 words)

  
 Lewy Body Dementia   (Site not responding. Last check: 2007-10-22)
The hallmark feature is the presence of widespread Lewy bodies throughout the neo and archi cortex with the presence of Lewy body and cell loss in the subcortical nucleii
Quantification and Characterisation of Fluctuating Cognition in Dementia with Lewy Bodies and Alzheimer's Disease - Dementia and Geriatric Cognitive Disorders
Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese population -- Psychiatry and Clinical Neurosciences
www.psychejam.com /lewy_body_dementia.htm   (334 words)

  
 Dementia With Lewy Body from Alzheimer's Outreach
Degeneration of the cortical areas of the brain with formation of abnormal structures inside nerve cells called cortical Lewy bodies which can be detected by immunochemical staining for the protein ubiquitin.
An important feature which helps to distinguish DLB from Alzheimer's disease is the presence of striking fluctuations in cognitive performance during the early stages of the disease.
Patients with DLB are often abnormally sensitive to neuroleptic therapy, developing parkinsonism even if they have not shown such signs before drug administration.
www.zarcrom.com /users/alzheimers/odem/lewy7.html   (1876 words)

  
 NINDS Dementia With Lewy Bodies Information Page   (Site not responding. Last check: 2007-10-22)
Dementia with Lewy bodies, the second most frequent cause of dementia in elderly adults, is a neurodegenerative disorder associated with abnormal structures (Lewy bodies) found in certain areas of the brain.
Dementia with Lewy bodies is a slowly progressive condition for which there is no cure.
NINDS conducts and supports research on dementing disorders, including dementia with Lewy bodies, to learn more about diagnosis, treatment, and prevention.
users3.ev1.net /~drtony/lewybody.htm   (495 words)

  
 Not all dementia is Alzheimer: Dementia with Lewy bodies -- Knopman and Jankowiak 65 (12): E26 -- Neurology
Not all dementia is Alzheimer: Dementia with Lewy bodies -- Knopman and Jankowiak 65 (12): E26 -- Neurology
Lewy bodies are seen in brain tissue viewed under the microscope.
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop.
www.neurology.org /cgi/content/short/65/12/E26?rss=1   (1189 words)

  
 Diagnostic Criteria for Dementia With Lewy Bodies Reconsidered -- Serby and Samuels 9 (3): 212 -- American Journal of ...
DLB patients with VHs in their study were on dopaminergic drugs.
Litvan I, MacIntyre A, Goetz CG, et al: Accuracy of the clinical diagnosis of Lewy body disease, Parkinson's disease, and dementia with Lewy bodies.
Perry RH, Irving D, Tomlinson BE: Lewy body prevalence in the aging brain: relationship to neuropsychiatric disorders, Alzheimer-type pathology, and catecholaminergic nuclei.
ajgponline.org /cgi/content/full/9/3/212   (2322 words)

  
 Amazon.com: Dementia with Lewy Bodies : Clinical, Pathological, and Treatment Issues: Books: Jeffrey L. Cummings,Robert ...   (Site not responding. Last check: 2007-10-22)
Dementia with Lewy bodies (DLB) is among the most common causes of degenerative dementia.
The aims of this volume are to establish clinical diagnostic criteria and pathological protocols for DLB, and to explore evidence indicating that DLB patients may be responsive to symptomatic therapy.
Dementia associated with Lewy bodies (here termed Lewy body dementia) is potentially recognizable in life.
www.amazon.com /exec/obidos/tg/detail/-/0521561884?v=glance   (673 words)

  
 EEG findings in dementia with Lewy bodies and Alzheimer's disease -- Briel et al. 66 (3): 401 -- Journal of Neurology, ...
Consensus guidelines for the clinical and pathological diagnosis of dementia with Lewy bodies (DLB).
Dementia and Parkinson's disease associated with diffuse cortical Lewy bodies.
Senile dementia of Lewy body type: a clinically and neuropathologically distinct form of Lewy body dementia in the elderly.
jnnp.bmjjournals.com /cgi/content/full/66/3/401   (1958 words)

  
 Dementia With Lewy Bodies Information Page: National Institute of Neurological Disorders and Stroke (NINDS)
Dementia with Lewy bodies, the second most frequent cause of degenerative dementia in elderly adults, is a neurodegenerative disorder associated with abnormal structures (Lewy bodies) found in certain areas of the brain.
Recent research has revealed that Lewy bodies contain deposits of a protein called alpha-synuclein that is also linked to Parkinson's disease and multiple system atrophy.
NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency.
www.ninds.nih.gov /disorders/dementiawithlewybodies/dementiawithlewybodies.htm   (559 words)

  
 White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular ...
Alzheimer's disease and vascular dementia are associated with an increase in changes in white matter on MRI.
Alzheimer's disease and vascular dementia, an increased prevalence
This is the first study to examine the presence of changes in white matter on MRI in dementia with Lewy bodies.
jnnp.bmjjournals.com /cgi/content/full/67/1/66   (4779 words)

  
 Cholinesterase inhibitors for dementia with Lewy bodies (Cochrane Review)   (Site not responding. Last check: 2007-10-22)
Background: Dementia with Lewy bodies (DLB) was first described in 1983, and clinical diagnostic criteria were published in the early to mid 1990s.
Characteristic symptoms are dementia, marked fluctuation of cognitive ability, early and persistent visual hallucinations and spontaneous motor features of Parkinsonism.
Authors' conclusions: Patients with dementia with Lewy bodies who suffer from behavioural disturbance or psychiatric problems may benefit from rivastigmine if they tolerate it, but the evidence is weak.
www.cochrane.org /cochrane/revabstr/AB003672.htm   (647 words)

  
 Alzheimers Australia
Dementia with Lewy bodies is a common form of dementia, sharing many similarities with
Dementia with Lewy bodies is caused by the
Any person with dementia or a carer for a person with dementia should seek professional advice about a specific situation.
www.alzheimers.org.au /content.cfm?infopageid=912   (420 words)

  
 Dementia with Lewy Bodies: Molecular Pathogenesis and Implications for Classification -- Cummings 17 (3): 112 -- ...   (Site not responding. Last check: 2007-10-22)
Dementia with Lewy Bodies: Molecular Pathogenesis and Implications for Classification -- Cummings 17 (3): 112 -- Journal of Geriatric Psychiatry and Neurology
of dementia correlates with the abundance of Lewy bodies in
Dementia with Lewy bodies is one of many
jgp.sagepub.com /cgi/content/abstract/17/3/112   (243 words)

  
 Lewy Body Dementia Association Home Page
The Lewy body dementias (LBD) are a spectrum of diseases involving degenerative dementia with a wide variance of symptoms, medicine management and progression in each individual.
When Parkinsonian symptoms preceed dementia by at least one year, scientists refer to the disease as Parkinson's disease with dementia (PDD).
Common names for the Lewy body dementias are listed below.
www.lewybodydementia.org   (152 words)

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