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	demyelination - multiple sclerosis encyclopaedia
		Demyelination is the major underlying factor responsible for the symptoms of multiple sclerosis (MS).
		Demyelination is the destructive removal of myelin, an insulating and protective fatty protein which sheaths nerve cells (neurons).
		The cause and precise mechanism of demyelination is not clearly understood but there is good evidence that the body's own immune system is at least partially responsible.
	www.mult-sclerosis.org /demyelination.html (341 words)

	Myelin - Wikipedia, the free encyclopedia
		Demyelination is the act of demyelinating, or the loss of the myelin sheath insulating the nerves, and is the hallmark of some neurodegenerative autoimmune diseases.
		Demyelination is a loss of myelin and is the root cause of symptoms experienced by patients with diseases such as multiple sclerosis and transverse myelitis.
		The immune system may play a role in demyelination associated with such diseases.
	en.wikipedia.org /wiki/Demyelination (577 words)

	World of MS - MS - The Disease - Demyelination (Site not responding. Last check: 2007-10-30)
		Demyelination is the term used for a loss of myelin, a substance in the white matter that insulates nerve endings.
		Demyelination is the root cause of the symptoms that people with MS experience.
		Even when the patches of scarring caused by demyelination have healed and re-myelination has occurred, the response time of the nerve endings tends to remain slower.
	www.msif.org /en/ms_the_disease/demyelination.html (136 words)

	ALD Foundation - Adrenoleukodystrophy (ALD)
		The presentation of symptoms occurs between the ages of 4 and 10, and affects the brain with demyelination.
		Demyelination is the stripping away of the fatty coating that keeps nerve pulses confined and maintains the integrity of nerve signals.
		Demyelination is an inflammatory response and nerve cells throughout the brain are destroyed.
	www.aldfoundation.org /ald_info.html (145 words)

	Cognetix (Site not responding. Last check: 2007-10-30)
		Demyelination occurs when a myelinated axon loses its myelin sheath.
		MS is a demyelinating disease of the CNS marked by destruction of myelin sheaths accompanied by inflammation.
		Demyelination typically results in a decrease of loss of the ability of the neuron to conduct action potentials, in part due to exposure of potassium channels formerly masked by the myelin sheath.
	www.cognetix.com /indi_myelin.asp (211 words)

	[No title] (Site not responding. Last check: 2007-10-30)
		Demyelination with relative preservation of axons has been considered to be the pathologic hallmark of multiple sclerosis (MS) since the description of this disorder by Charcot in 1868 [1].
		The concept of primary axonal injury with secondary demyelination as the basis of MS is contrary to a century of thinking regarding the pathogenesis of this disorder.
		Demyelinated axons rarely remyelinate and the cause of this is unknown.
	www.mult-sclerosis.org /news/Apr2003/FullTextAxonalInjuryinMS.html (5064 words)

	CD4 T-Cell-Mediated Demyelination Is Increased in the Absence of Gamma Interferon in Mice Infected with Mouse Hepatitis ...
		The role of IL-10 in mouse hepatitis virus-induced demyelinating encephalomyelitis.
		Demyelination induced by murine hepatitis virus JHM strain (MHV-4) is immunologically mediated.
		Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase.
	jvi.asm.org /cgi/content/full/76/14/7329 (2400 words)

	Remicade Side Effects: Demyelination (Site not responding. Last check: 2007-10-30)
		Demyelination is the degeneration of a protective substance that insulates nerve axons (fibers) called myelin.
		When nerve axons become demyelinated, this process is drastically impaired and neurological impulses slow to a rate ten times less than normal.
		During relapses of multiple sclerosis (a well known type of a demyelinating disease) patches of demyelinated and inflamed neurons appear in the central nervous system (brain and spinal cord.) These patches are known as lesions.
	www.remicade-infliximab.com /pages/demyelination..html (420 words)

	Macrophage Infiltration, but Not Apoptosis, Is Correlated with Immune-Mediated Demyelination following Murine Infection ...
		An increase in macrophages temporally correlates with demyelination.
		Patterns of oligodendrocyte pathology in coronavirus-induced subacute demyelinating encephalomyelitis in the Lewis rat.
		Murine coronavirus infection: a paradigm for virus-induced demyelinating disease.
	jvi.asm.org /cgi/content/full/73/10/8771 (6111 words)

	Demyelination of the Brain Is Associated with Methionine Adenosyltransferase I/III Deficiency -- Chamberlin et al. 98 ...
		Demyelination of the Brain Is Associated with Methionine Adenosyltransferase I/III Deficiency -- Chamberlin et al.
		Demyelination of the Brain Is Associated with Methionine Adenosyltransferase I/III Deficiency
		Austin (1991) Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway.
	www.jci.org /cgi/content/full/98/4/1021 (3965 words)

	NERVE TISSUE DAMAGE RELATED TO MULTIPLE SCLEROSIS CAN BE REPAIRED, UC IRVINE SCIENTISTS FIND
		Demyelination is a central feature of multiple sclerosis, a chronic central nervous system disease that can cause blurred vision, poor coordination, slurred speech, numbness, acute fatigue and, in its most extreme form, blindness and paralysis.
		Lane and his colleagues used a mouse model of multiple sclerosis that is triggered by infecting the animals with a mouse hepatitis virus.
		After the mice began to show the effects of demyelination, including partial hind limb weakness and paralysis, they were injected with antibodies designed to block the activity of the CXCL-9 and CXCL-10 molecules in the central nervous system.
	www.ucihealth.com /News/Releases/100801NerveTissueMS.htm (627 words)

	Bystander CD8 T Cell-Mediated Demyelination After Viral Infection of the Central Nervous System -- Haring et al. 169 ...
		Demyelination was most extensive in MHV-infected mice in which transgenic cells were activated with CFA:peptide gp33 (column 4) or CFA:peptide N52 (column 7) or by infection with LCMV (column 5).
		inflammatory response or demyelination in mice infected with
		The mechanism of bystander demyelination remains to be determined.
	www.jimmunol.org /cgi/content/full/169/3/1550 (4411 words)

	Expression of the Human Histocompatibility Leukocyte Antigen DR3 Transgene Reduces the Severity of Demyelination in a ...
		and demyelination in transgenic mice and nontransgenic littermate
		Clatch, R.J., R.W. Melvold, S.D. Miller, and H.L. Lipton (1985) Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease is influenced by the H-2D region: correlation with TMEV-specific delayed-type hypersensitivity.
		Rodriguez (1989) Characterization of the inflammatory response in the CNS of mice susceptible or resistant to demyelination by Theiler's virus.
	www.jci.org /cgi/content/full/101/8/1765 (5612 words)

	UPOJ Volume 13 Spring 2000 Pages 29-34 (Site not responding. Last check: 2007-10-30)
		In progressive entrapment neuropathies, demyelination precedes axonal degeneration; in fact, nerves are relatively resistant to axonal degeneration [1].
		NCS are used to detect demyelination and axonal degeneration in a nerve, to localize the site of the lesion, and to quantify the degree of injury.
		The electrical features of demyelination are slowing of the conduction velocity, especially when it is diffuse along the length of a nerve.
	www.uphs.upenn.edu /ortho/oj/2000/html/oj13sp00p29.html (4148 words)

	Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute ...
		The extent of inflammation, demyelination and axonal injury were assessed in spinal cord cross-sections from CD59a-deficient and control mice, and all these parameters were enhanced in the absence of CD59a.
		Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis.
		Attenuation of experimental autoimmune demyelination in complement-deficient mice.
	www.nature.com /labinvest/journal/v84/n1/full/3700015a.html (4793 words)

	Cytomegalovirus. Induced demyelination associated with acquired immune deficiency syndrome.
		The second patient had a discrete focus of demyelination in the hypothalamic region associated with well-preserved axons and intact neurons.
		The third patient had subacute encephalomyelitis principally encephalomyelitis principally characterized by microglial nodule formation in the brain and spinal cord, in addition to necrotizing lesions in the thoracic cord and segmental demyelination in the anterior spinal nerve roots.
		It is possible that these patients had virus-induced demyelination in the face of altered immunoregulation.
	www.aegis.com /aidsline/1985/jan/M8510009.html (381 words)

	Demyelination, Eastern Carolina
		Demyelination is a process in which the insulating coating (myelin sheath) around the nerves is destroyed, slowing or halting the passage of nerve impulses.
		The myelin sheath allows nerve impulses to be sent between the brain, the spinal cord, and the nerves in the rest of the body smoothly and quickly.
		Demyelination occurs in diseases such as multiple sclerosis (MS), Guillain-Barré syndrome, and chronic inflammatory demyelinating polyneuropathy (CIDP).
	www.uhseast.com /171389.cfm (148 words)

	Distribution patterns of demyelination correlate with clinical profiles in chronic inflammatory demyelinating ...
		for demyelination, the presence of a demyelinative lesion was
		Patterns of sensory nerve conduction abnormalities in demyelinating and axonal peripheral nerve disorders.
		Inflammatory infiltrates in sural nerve biopsies in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy.
	jnnp.bmjjournals.com /cgi/content/full/72/1/37 (3210 words)

	The Membrane Attack Complex of Complement Causes Severe Demyelination Associated with Acute Axonal Injury -- Mead et ...
		Demyelination index (+SD) on day 14 of disease induction for each group of rats is shown in a, as determined by quantitative image analysis on LFB/CV-stained cervical spinal cord sections.
		Demyelination index measures the area of spinal cord white matter that does not stain for myelin.
		Demyelination was quantified in representative sections for each rat and is shown as a dot plot of demyelinated area in square millimeters (a).
	www.jimmunol.org /cgi/content/full/168/1/458 (5772 words)

	Demyelination definition - Medical Dictionary definitions of popular medical terms
		Demyelination: A degenerative process that erodes away the myelin sheath that normally protects nerve fibers.
		Demyelination exposes these fibers and appears to cause problems in nerve impulse conduction that may affect many physical systems.
		Demyelinization is seen in a number of diseases, particularly multiple sclerosis.
	www.medicinenet.com /script/main/art.asp?ArticleKey=11143 (139 words)

	Multiple Sclerosis Society Website - Welcome to the MS Society - Demyelination
		In contrast, the progressive forms of the disease were characterised by more demyelination and axonal damage compared to the other types of MS.
		Higher levels of demyelinated areas and inflammation throughout the brain were found in secondary progressive disease compared to primary progressive.
		The level of widespead damage within the brain was found to be independent of the number of lesions seen.
	www.mssociety.org.uk /news_events/news/research/demyelination.html (380 words)

	Researcher Profile: Rodriguez, Moses , M.D. (Site not responding. Last check: 2007-10-30)
		Our laboratory is focused on determining the mechanisms of demyelination and remyelination in diseases such as human multiple sclerosis.
		Using a series of knockout mice, we have demonstrated that the MHC class I immune response is critical for the development of neurological deficits.
		In collaboration with Dr. Pease, we are dissecting the role of D versus K region mouse MHC molecules in resistance versus susceptibility to neurologic deficits.
	mayoresearch.mayo.edu /mayo/research/staff/rodriguez_m.cfm (644 words)

	BrainTF24-PML - Progressive multifocal leukoencephalopathy _Text
		Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of a latent papovavirus (the JC virus) infection.
		PML is characterized pathologically by focal or confluent areas of demyelination, mainly distributed throughout the cerebral white matter.
		The foci of demyelination can have a resemblance to those of multiple sclerosis, but occasionally they are large and confluent, mimicking foci of ischemic necrosis or cystic degeneration.
	www.mribhatia.com /braintf24/braintf24text.html (1269 words)

	CPSP Resource Article - Recognizing and treating acquired demyelination of the central nervous system in children (Site not responding. Last check: 2007-10-30)
		Multiple sclerosis (MS) is a neurological disease defined by recurrent attacks of immune cells on the white matter of the brain and spinal cord, leading to temporary or permanent disability.
		The cause of MS is believed to involve stimulation of immune cells by one or more environmental agents (i.e., viruses) and misdirection of these cells to attack white-matter proteins (a process called demyelination).
		Treatment of acute demyelination of the CNS should be considered when symptoms are of a severity as to interfere with daily function.
	www.cps.ca /english/cpsp/Resources/CentralNervousSystem.htm (619 words)

	CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination.
		A chronic demyelinating disease results from murine infection with the neurotropic strain JHM of mouse hepatitis virus (MHV-JHM).
		In this study, the individual roles of CD4 and CD8 T cells in MHV-induced demyelination were investigated using recombination-activating gene 1-/- (RAG1-/-) mice infected with an attenuated strain of MHV-JHM.
		Adoptive transfer of CD4 T cell-enriched donors resulted in more severe clinical disease accompanied by less demyelination than was detected in the recipients of undepleted cells.
	www.aegis.com /aidsline/2000/nov/A00B0542.html (517 words)

	Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic ...
		Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis -- Akassoglou et al.
		demyelinating lesions in the spinal cord (27, 28).
		induction of the inflammatory response and demyelination in
	www.pnas.org /cgi/content/full/101/17/6698 (3449 words)

	Glial Growth Factor/Neuregulin Inhibits Schwann Cell Myelination and Induces Demyelination -- Zanazzi et al. 152 (6): ...
		and demyelination in Schwann cell-DRG neuron cocultures, myelinated
		Demyelination appeared to be a direct, nontoxic effect of GGF
		dedifferentiation, and demyelination in the distal stump, the
	www.jcb.org /cgi/content/full/152/6/1289 (6763 words)

	Neuron - Wikipedia, the free encyclopedia
		Multiple sclerosis is a neurological disorder that results from abnormal demyelination of peripheral nerves.
		Neurons with demyelinated axons do not conduct electrical signals properly.
		Some neurons do not generate action potentials, but instead generate a graded electrical signal, which in turn causes graded neurotransmitter release.
	en.wikipedia.org /wiki/Neuron (1942 words)

	Osmotic Demyelination Syndrome in End-Stage Renal Disease After Recent Hemodialysis: MRI of the Brain -- Tarhan et al. ...
		Osmotic Demyelination Syndrome in End-Stage Renal Disease After Recent Hemodialysis: MRI of the Brain -- Tarhan et al.
		entity characterized by edema and demyelination in the pons
		This one-sided persistent lesion was interpreted as infarct, not extrapontine osmotic demyelination syndrome.
	www.ajronline.org /cgi/content/full/182/3/809 (3541 words)

	demyelination
		Yes there are other things that can cause demyelination but usually not in a relapsing remitting pattern.
		We often see cervical spinal cord demyelination in MS, in fact we have a clinical trial looking at percentage of cervical demyelination and MS upon initial diagnosis.
		The demyelination caused by MS lesions vs. Tranverse Myelitis lesions appear distinctly differently on an MRI.
	www.medhelp.org /forums/neuro/messages/30646a.html (660 words)

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