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Topic: Dendritic cell


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In the News (Wed 30 Dec 09)

  
 Dendritic cell - Wikipedia, the free encyclopedia
The lifespan of activated dendritic cells, while somewhat varying according to type and origin, is of a similar order of magnitude, but immature dendritic cells seem to be able to exist in an unactivated state for much longer.
However, the exact genesis and development of the different types and subsets of dendritic cells and their interrelationship is only marginally understood at the moment, as dendritic cells are so rare and difficult to isolate that only in recent years they have become subject of focused research.
When the dendritic cell takes up HIV and then travels to the lymph node, the virus is able to move to helper T-cells, and this infection of helper T-cells is the major cause of disease.
en.wikipedia.org /wiki/Dendritic_cell   (1188 words)

  
 Welcome
Dendritic Cell (DC) therapy represents a new and promising immunotherapeutic approach for treatment of advance cancer as well as for secondary prevention of cancer.
The Dendritic Cell itself is an immune cell whose role is the recognition, processing and presentation of foreign antigens to the T-cells in the effector arm of the immune system.
Dendritic Cell Therapy thus involves the harvesting of blood cells (ie monocytes or macrophages) from a patient and processing them in the laboratory to produce Dendritic Cells which are then given back to a patient in order to allow massive Dendritic participation in optimally activating the immune system.
www.dendritic.info   (361 words)

  
 Biologictherapy.Org: Renal Cell Carcinoma: Dendritic Cells   (Site not responding. Last check: 2007-11-06)
Dendritic cells are a form of white blood cell that act as natural immune response stimulators within the human immune system.
Dendritic cells ingest the cancer proteins, break these proteins into small pieces, and transport them to the dendritic cell surface where they form unique images to which T cells bind.
The results suggested that cultured blood dendritic cells can be a potent vaccine for the antigen-specific immunization of patients with advanced kidney cancer and that Th type-1-dominant immune responses involving DTH reaction are required for the induction of tumor regression.
www.biologictherapy.org /renalcell/renal_treatment_den.html   (563 words)

  
 Information Sheet: Dendritic Cell Therapy   (Site not responding. Last check: 2007-11-06)
Their usual function is to identify foreign substances, such as cancer cells, process these foreign substances, and then jumpstart the immune response by bringing these foreign substances to the attention of T cells.
It is then hoped that these dendritic cells will be able to specifically train T cells to attack and kill all prostate cancer cells that also have the same foreign material on their surface.
Blood cells are removed from your body by a procedure called apheresis which involves removal of your blood through a catheter from an IV in your arm into a machine where cells called mononuclear cells will be separated from the other blood cells and saved.
cc.ucsf.edu /clinical/uro_dendritic.html   (927 words)

  
 Dendritic Cell Therapy : Alternative Cancer Treatment
Dendritic cells are found in all tissues of the body, and many of them began as macrophages.
Dendritic cells were isolated from the bone marrow of these mice, cultured with some growth factors, and exposed to tumor peptides (information about the tumor cell membranes).
The dendritic cells were given using vein injections on 4 occasions; subcutaneous (under the skin) injections of the tumor antigen and a protein that helps stimulate an immune response were injected two weeks after each dendritic cell injection.
www.immunemedicine.com /dendritic-cell-therapy.asp   (3240 words)

  
 Encyclopedia: White blood cell
White blood cells (also called leukocytes or immune cells) are a component of blood.
As well as in the blood, white cells are also found in large numbers in the lymphatic system, the spleen, and in other body tissues.
Red blood cells (erythrocytes) are present in the blood and help carry oxygen to the rest of the cells in the body Blood is a circulating tissue composed of fluid plasma and cells (red blood cells, white blood cells, platelets).
www.nationmaster.com /encyclopedia/White-blood-cell   (449 words)

  
 Dendritic Cell Vaccines
Dendritic cells are antigen presenting cells that have been incorporated into several vaccine strategies over the past decade.
Dendritic cells are CD34+ cells collected from the peripheral blood, usually after the administration of Neupogen®.
The fused cells are described as unique with dendritic cell markers.One problem highlighted was the potential lack of activity of this vaccine in non-HLA identical patients.
professional.cancerconsultants.com /conference_jwci_2003.aspx?id=84   (1097 words)

  
 CancerGuide: How the German Dendritic Cell − Tumor Cell Fusion Vaccine Works   (Site not responding. Last check: 2007-11-06)
Dendritic cells are a type of antigen presenting cell.
These dendritic cells then are seen by the patient's immune system as foreign in their own right and attract T-Cells which respond to the foreign antigen.
Dendritic cells specialize in antigen presentation and are thought to be more effective than B cells.
cancerguide.org /fused_cell_vaccine.html   (1743 words)

  
 Dendritic cell vaccines allow rapid response   (Site not responding. Last check: 2007-11-06)
The approach, in which dendritic cells are engineered to carry peptide antigens on their surfaces, could allow people to gain protection from diseases in just one short and do away with the need for booster injections — given over an extended period - to provide effective immunity.
Badovinac et al show in their study that mice vaccinated with dendritic cells coated with peptides from the bacterium Listeria monocytogenes could mobilise an effective, long-lasting immune response faster than mice who were given a vaccine based on killed bacteria.
Dendritic cells patrol the body for pathogens such as bacteria or viruses.
drugresearcher.com /news/news-ng.asp?n=61170-dendritic-cell-vaccines   (513 words)

  
 mouse Dendritic Cell Marker (33D1) antibody: purified antibody
Bone marrow dendritic cells require GM-CSF to express the 33D1 antigen and this expression is down regulated in the presence of IL-4.
Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice.
Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii.
www.ebioscience.com /ebioscience/specs/antibody_14/14-5884.htm   (400 words)

  
 Encyclopedia article on Dendritic cell [EncycloZine]   (Site not responding. Last check: 2007-11-06)
Then there are plasmacytoid dendritic cells (PDC) which appear to be another kind of myeloid cell that look like plasma cells, but have certain characteristics similar to myeloid dendritic cells.
This infection of dendritic cells by HIV explains why the virus will persist even when the supply of helper T-cells is exhausted, e.g.
However, the principal function of dendritic cells as known to date is always to act as the 'library' or 'encyclopedia' of the immune system.
encyclozine.com /Dendritic_cell   (950 words)

  
 Epidermal dendritic (Langerhans) cells: Immunologic Sentinels of infection
Epidermal dendritic (Langerhans) cells: Immunologic Sentinels of infection
These cells are reminiscent of dendritic cells, such as the Langerhans cell, a species of dendritic cell resident in skin.
Dendritic cells (DC) are the principle APC involved in primary immune responses; their major function is to obtain Ag in tissues, migrate to lymphoid organs, and activate T cells.
cmmg.biosci.wayne.edu /asg/dendritic.html   (1090 words)

  
 HON Allergy Glossary Antigen-presenting cell (APC)
Dendritic cells are the principle APC involved in primary immune responses.
Their major function is to obtain antigen in tissues, migrate to lymphoid organs and activate T cells.
Cell required for, but not actually mediating, a specific immune response.
www.hon.ch /Library/Theme/Allergy/Glossary/apc.html   (195 words)

  
 Dendritic cell definition - Medical Dictionary definitions of popular medical terms
Dendritic cell: A special type of cell that is a key regulator of the immune system, acting as a professional antigen-presenting cell (APC) capable of activating naïve T cells and stimulating the growth and differentiation of B cells.
Dendritic cells are found, for example, in the lymph nodes and spleen.
As an APC, a dendritic cell can retain antigen for long periods on its surface, present the antigen to a T or B cell and so influence their behavior.
www.medterms.com /script/main/art.asp?articlekey=19035   (219 words)

  
 QIMR Website - Dendritic Cell & Cancer Laboratory
Dendritic Cells (DC) are the key initiators and organizers of the immune response.
These cells are smaller than DC and have a fairly reduced antigen presentation capacity, as measured by stimulation of CD8, CD4 T-cells, Th2 balance of cytokine induction upon lymphocyte stimulation and reduced antigen uptake.
Research projects for students are available within the Dendritic Cell and Cancer Laboratory for BSc Honours, MMedSci and PhD students interested in working on the function of DC in Cancer.
www.qimr.edu.au /research/labs/alejl   (1447 words)

  
 Howstuffworks "How Cancer Vaccines Will Work"
Dendritic cells break the antigens on the cancer cell surfaces into smaller pieces.
This combination of dendritic cells and antigens is then injected into the patient, and the dendritic cells work to program the T cells.
While the cells are dead, the antigens are still recognized by the the immune system, which responds by attacking the dead cells.
health.howstuffworks.com /cancer-vaccine2.htm   (722 words)

  
 Drug Discovery & Development   (Site not responding. Last check: 2007-11-06)
A cell that recognizes an antigen to be neutralized, processes it, and incorporates the resulting peptides into the major histocompatibility complex (MHC) molecules on the cell surface.
A plasma membrane region of epithelial cells that faces the lumen and is involved in transport.
A programmed or controlled form of cell death characterized by the loss of cell junctions and microvilli, condensation of the cytoplasm, margination of the nuclear chromatin, and fragmentation of the nucleus.
dddmag.com /scripts/Glossary.asp?...&SEARCHWORD=Dendritic+cell   (2452 words)

  
 Interdigitating Dendritic Cell Sarcoma
The FDC sarcoma comprised swirling fascicles of spindly cells with indistinct cell borders.
Extranodal follicular dendritic cell (FDC) sarcoma of the head and neck region is uncommon, with 16 well-documented cases previously reported (four in the tonsil, four in the pharynx, two in the palate, five in the soft tissue, and one in the thyroid).
Interdigitating dendritic cell sarcoma is an extremely rare neoplasm that mainly occurs in the lymph nodes.
www.thedoctorsdoctor.com /diseases/interdigitating_cell_sarcoma.htm   (3581 words)

  
 Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation -- Rissoan et al. 283 (5405): 1183 -- Science   (Site not responding. Last check: 2007-11-06)
Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand.
Dendritic Cells Are Responsible for the Capacity of CpG Oligodeoxynucleotides to Act as an Adjuvant for Protective Vaccine Immunity Against Leishmania major in Mice.
Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors.
www.sciencemag.org /cgi/content/abstract/283/5405/1183   (4653 words)

  
 The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria -- Stagg et al. 52 (10): ...
Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans.
C-type lectin receptors on dendritic cells and Langerhans cells.
Characterization of antigen-presenting dendritic cells in the peripheral blood and colonic mucosa of patients with ulcerative colitis.
gut.bmjjournals.com /cgi/content/full/52/10/1522   (5397 words)

  
 EMDS - European Macrophage and Dendritic Cell Society
EMDS - European Macrophage and Dendritic Cell Society
The European Macrophage and Dendritic Cell Society (EMDS) has emerged from the activities of the former European Macrophage Study Group (EMSG), a loose association of scientists interested in basic and clinical aspects of monocytes, macrophages, dendritic cells and other myleoid cells in man and experimental animal models.
At the end of year 2000, the members of the EMS decided to rename the society as European Macrophage and Dendritic Cell Society (EMDS) in order to better emphasize the two main streams of research within the Society.
www.macrophage.de   (159 words)

  
 Aastrom Biosciences Completes Second CE Marked Dendritic Cell Therapy Product
This approach can be used to form a tumor-specific vaccine, by first producing a specific class of dendritic cells using cell culture, and then loading these cells with antigen that is specific to a patient's tumor.
Once administered to cancer patients, these dendritic cell vaccines are intended to work by triggering a T-cell immune system response against the patient's tumor cells.
The Company's other CE Marked dendritic cell product, the DC-I, also provides a robust cultured dendritic cell that may then be utilized in a separate mechanical or chemical process to transfer tumor antigens.
www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/02-14-2002/0001669185&EDATE=   (885 words)

  
 Dendritic Cell-Tumor Fusion Vaccines for Renal Cell Carcinoma -- Avigan 10 (18): 6347S -- Clinical Cancer Research
Dendritic Cell-Tumor Fusion Vaccines for Renal Cell Carcinoma
Dendritic cells (DCs) are antigen-presenting cells that are
Boczkowski D, Nair SK, Snyder D, Gilboa E Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.
clincancerres.aacrjournals.org /cgi/content/full/10/18/6347S   (3671 words)

  
 Dendritic cell isolation - BioForum
The cells would be harvested and culture in IL-4 and GM-CSF for the dendritic lineaged out.
I have also noticed that a lot of monocytes and lymphocytes are left in my dendritic cell culture.
Remove the non-adherent cells and wash the adherent cells at least three times with PBS in order to eliminate the small cells.
www.protocol-online.org /forums/index.php?showtopic=1331   (553 words)

  
 Cancer and Dendritic Cell Therapy   (Site not responding. Last check: 2007-11-06)
The evolving role of dendritic cell therapy in urologic oncology.
The recognition that dendritic cells, the most potent antigen-presenting cells, play a pivotal role in the induction of antitumor immunity has reshaped the development of tumor vaccines in clinical medicine.
Although the development of dendritic cell-based vaccines is still in its infancy, the prospects of ultimately generating clinically effective cancer vaccines have become more realistic.
www.cancerresourcecenter.com /articles/alt054.html   (120 words)

  
 Title page for ETD etd-04162004-111040 ( Browse | Search ) All Available ETDs
Murine CD8alpha+ dendritic cells (DC) are antigen-presenting cells with tolerogenic properties, including ability to prolong allograft survival.
We also used this assay with the addition of endothelial cell layers, to assess the adhesion molecules that facilitate DC transendothelial migration.
In these studies we compared the ability of DC subsets to migrate to T cell areas of wild type and specific chemokine-deficient mice.
etd.library.pitt.edu /ETD/available/etd-04162004-111040   (356 words)

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