| | Osteogenesis and Dentinogenesis Abnormalities in Constitutively Active PTH/PTHrP Receptor Model (Site not responding. Last check: 2007-10-20) |
 | | Objectives: We characterized osteogenesis and dentinogenesis abnormalities in transgenic mice with constitutively active human PTH/PTHrP receptor (PPR) under the control of the mouse bone specific a1(I) collagen promoter (Col1-caPPR), which is expressed in osteoblasts and odontoblasts. |
 | | Methods: Osteogenesis and dentinogenesis abnormalities were evaluated by Alcian blue and Alizarin red staining, X-ray, histological section and immunohistochemistry. |
 | | This model will be useful for characterization of the downstream effects of the constitutively active PTH/PTHrP receptor during development and growth in the craniofacial region are formed by epithelial-mesenchymal interactions, and as a potential model for human diseases with similar characteristics. |
| iadr.confex.com /iadr/2005Balt/techprogram/abstract_63983.htm (348 words) |