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Topic: Deoxyadenosine

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Adenine

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	Deoxyadenosine-resistant human T lymphoblasts with elevated 5'-nucleotidase activity.
		Other enzymes of potential importance for deoxyadenosine metabolism were indistinguishable in the two cell types.
		In medium supplemented with the adenosine deaminase inhibitor deoxycoformycin, the T cells with increased 5'-nucleotidase accumulated less nucleotides from exogenously added deoxyadenosine, or 9-beta-D-arabinofuranosyladenine, than did parental T lymphocytes.
		These metabolic changes were associated with resistance to the growth inhibitory effects of these nucleosides, and also to deoxyguanosine and to 9-beta-D-arabinofuranosylguanine.
	www.aegis.com /aidsline/1991/may/M9150268.html (434 words)

	Purine Excretion by Mouse Peritoneal Macrophages Lacking Adenosine Deaminase Activity -- Chan 76 (2): 925 -- ...
		Deoxyadenosine, a cytotoxic purine nucleoside, is excreted in large amounts by patients with severe combined immunodeficiency disease associated with deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4).
		Furthermore, phagocytosis of nucleated erythrocytes augmented the excretion of deoxyadenosine.
		A hypothesis is proposed that macrophages of the reticuloendothelial system are a source of deoxyadenosine, which is one of the two cytotoxic purine nucleosides (the other is adenosine) apparently responsible for the suppression of immune functions in patients with adenosine deaminase deficiency.
	www.pnas.org /cgi/content/abstract/76/2/925 (320 words)

	2-choloro-2'-deoxyadenosine induces apoptosis in human breast cancer cell lines, MDA-MB468 and MCF-7 (Site not responding. Last check: 2007-10-10)
		Cladribine, an analogue of deoxyadenosine, is highly toxic for both non-dividing and proliferating cells and has shown activity in the treatment of several malignancies.
		All aspects of apoptosis are now under intense investigation, from the effects of drugs in both cultured and primary cancer cells of all types, to the study of specific genetic pathways controlling the process.
		One such drug is 2-chloro-2¢-deoxyadenosine (cladribine), an analogue of deoxyadenosine, which is resistant to degradation by adenosine deaminase [4-7].
	ibj.pasteur.ac.ir /ibj21/html/Karami.htm (2782 words)

	Wintersun Chemical
		Deoxyadenosine (dA) : a purine nucleoside composed of adenine linked by its N9 nitrogen to the C1 carbon of deoxyribose.
		Deoxyadenosine monophosphate (dAMP) : a nucleotide, 5'-phosphate of deoxyadenosine, occurring in deoxyribonucleic acid.
		Deoxyadenosine triphosphate (dATP): a nucleotide, the 5’-triphosphate of deoxyadenosine; activated precursor in DNA synthesis.
	www.wintersunchem.com /A/Adenosine.htm (517 words)

	Adagen Pharmacology, Pharmacokinetics, Studies, Metabolism - Pegademase Bovine - RxList Monographs
		It is imperative that treatment with ADAGEN® (pegademase bovine) Injection be carefully monitored by measurement of the level of ADA activity in plasma.
		Monitoring of the level of deoxyadenosine triphosphate (dATP) in erythrocytes is also helpful in determining that the dose of ADAGEN® (pegademase bovine) Injection is adequate.
		In patients with ADA deficiency, inadequate elimination of 2'-deoxyadenosine caused a marked elevation in dATP and a decrease in SAHase level in red blood cells.
	www.rxlist.com /cgi/generic2/pegademase_cp.htm (737 words)

	Biochemical correlates of the differential sensitivity of subtypes of human leukemia to deoxyadenosine and ...
		Biochemical correlates of the differential sensitivity of subtypes of human leukemia to deoxyadenosine and deoxycoformycin
		deoxyadenosine kinase, and poorly with adenosine deaminase and
		Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
	www.bloodjournal.org /cgi/content/abstract/60/5/1096 (338 words)

	American Radiolabeled Chemicals, Inc. - Deoxyadenosine 5'-triphosphate (tetra triethylammonium salt), [a-32P]
		Deoxyadenosine 5'-triphosphate (tetra triethylammonium salt), [a-32P] ARP 0118-1 mCi / 37 MBq
		Deoxyadenosine 5'-triphosphate (tetra triethylammonium salt), [a-32P] ARP 0118-250 µCi / 9.25 MBq
		Deoxyadenosine 5'-triphosphate (tetra triethylammonium salt), [a-32P] ARP 0118B-250 µCi / 9.25 MBq
	www.arc-inc.com /pc-5099-13-deoxyadenosine-5-triphosphate-tetra-triethylammonium-salt-a-32p.aspx (312 words)

	My Favorite Site 3
		DDI also known as didanosine is a purine nucleoside that is the structural analogue to deoxyadenosine.
		However, DDI differes from deoxyadenosine in DNA by one single 3’-hydroxyl group the DDI group contains a hydrogen substituent [2].
		The greater the amount of creatinine clearance results in a smaller half-life quantity for didanosine, as result patients with advanced to moderate renal failure have a greater chance of missing out on the antiviral benefits of DDI.
	www.arches.uga.edu /~bradr/DDI1.htm (397 words)

	Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP ...
		To confirm the assertion that adenosine and deoxyadenosine are
		Smith, C.M., and Henderson, J.F. Deoxyadenosine triphosphate accumulation in erythrocytes of deoxycoformycin-treated mice.
		Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease.
	www.jci.org /cgi/content/full/110/3/395 (4575 words)

	[No title]
		[1] Didanosine is a synthetic analogue of deoxyadenosine, a naturally occurring purine nucleoside.
		Didanosine differs from deoxyadenosine in that the 3'-hydroxyl group on the ribose moiety is replaced with hydrogen.
		Didanosine was approved by the FDA on October 9, 1991, and enteric-coated didanosine was approved by the FDA on October 31, 2000.
	aidsinfo.nih.gov /drugs/htmldrug_tech.asp?int_id=0016 (3094 words)

	The Effect of Nucleosides and Deoxycoformycin on Adenosine and Deoxyadenosine Inhibition of Human Lymphocyte Activation ...
		The Effect of Nucleosides and Deoxycoformycin on Adenosine and Deoxyadenosine Inhibition of Human Lymphocyte Activation -- Uberti et al.
		Articles by Uberti, J. Articles by Johnson, R. The Effect of Nucleosides and Deoxycoformycin on Adenosine and Deoxyadenosine Inhibition of Human Lymphocyte Activation
		reverse deoxyadenosine toxicity but do not alter adenosine toxicity.
	www.jimmunol.org /cgi/content/abstract/123/1/189 (212 words)

	Directory of open access journals
		Adenosine deaminase (ADA) is an enzyme present in all organisms that catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine.
		Both adenosine and deoxyadenosine are biologically active purines that can have a deep impact on cellular physiology; notably, ADA deficiency in humans causes severe combined immunodeficiency.
		We have established a Drosophila model to study the effects of altered adenosine levels in vivo by genetic elimination of adenosine deaminase-related growth factor-A (ADGF-A), which has ADA activity and is expressed in the gut and hematopoietic organ.
	www.doaj.org /doaj?func=abstract&id=121874&recNo=19&toc=1 (235 words)

	Apoptosis - Adenosine and deoxyadenosine induced apoptosis in human breast c...
		Apoptosis - Adenosine and deoxyadenosine induced apoptosis in human breast c...
		Adenosine and deoxyadenosine induced apoptosis in human breast cancer
		Adenosine (Ado) and deoxyadenosine (dAdo) were used to induce apoptosis in estrogen receptor-positive and -negative human breast cancer cells.
	www.newsrx.com /newsletters/World-Disease-Weekly/2005-12-06/1206200533368WDW.html (179 words)

	genome.gov \| Candotti Lab
		ADA is a key enzyme in the purine salvage pathway that catalyzes the deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively.
		Genetic loss of ADA causes a significant increase in adenosine and deoxyadenosine levels, with toxic effects on lymphocytes.
		Most Individuals with this disorder develop severe combined immune deficiency (SCID) soon after birth due to the absence of T and B lymphocytes and consequent lack of immune protection.
	www.genome.gov /10000349 (641 words)

	2-Chlorodeoxyadenosine: A Newer Purine Analog Active in the Treatment of Indolent Lymphoid Malignancies -- Saven and ...
		Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.
		Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.
		Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.
	www.annals.org /cgi/content/full/120/9/784 (4678 words)

	High Adenosine and Deoxyadenosine Concentrations in Mononuclear Cells of Hemodialyzed Patients -- SAMPOL et al. 12 (8): ...
		The accumulation of d-Ado increases the amount of nucleoside phosphorylated by adenosine kinase, producing high concentrations of deoxyadenosine triphosphates (d-ATP) in both B and T lymphocytes.
		Ullman B, Gudas LJ, Cohen A, Martin DW Jr: Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: A model for immunodeficiency disease.
		Matsumoto SS, Yu J, Yu AL: The effect of deoxyadenosine plus deoxycoformycin on replicative and repair synthesis of DNA in human lymphoblasts and isolated nuclei.
	www.jasn.org /cgi/content/full/12/8/1721 (4488 words)

	Dorlands Medical Dictionary
		monophosphate (dAMP) a nucleotide, the 5′-phosphate of deoxyadenosine, occurring in deoxyribonucleic acid.
		(de-ok”se-ə-den´o-səl) the radical formed from deoxyadenosine on loss of an H or OH group.
		(de-ok”se-ad”ə-nil´il) the radical formed by removal of OH from the phosphate group of deoxyadenosine monophosphate.
	www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_d_09zPzhtm (1794 words)

	deoxyadenosine Information from Drugs.com
		The 5′ derivative is also an important component of one form of vitamin B12.
		Deoxyadenosine accumulates in people with severe combined immunodeficiency disease.
		Click here to see what benefits you can get by joining our FREE membership programme.
	www.drugs.com /dict/deoxyadenosine.html (164 words)

	eMedicine - Combined B-Cell and T-Cell Disorders : Article by Hanan Makhoul, MD
		Adenosine deaminase (ADA) is an enzyme of the purine salvage pathway responsible for adenosine and deoxyadenosine deamination to inosine and deoxyinosine, respectively.
		Its deficiency leads to the accumulation of deoxyadenosine triphosphate (dATP) and 2'-deoxyadenosine.
		Pegademase bovine (Adagen) -- ADA is an enzyme of the purine salvage pathway responsible for adenosine and deoxyadenosine deamination to inosine and deoxyinosine, respectively.
	www.emedicine.com /med/topic3538.htm (5145 words)

	Cloning and Expression of the Heterodimeric Deoxyguanosine Kinase/Deoxyadenosine Kinase of Lactobacillus acidophilus ...
		Present address: Dept. of Biochemistry, Molecular and Cellular Biology, Northwestern University, Evanston, IL Present address: Dept. of Biochemistry, State University of New York at Buffalo, Buffalo, NY To whom correspondence should be addressed: Dept. of Biochemistry, The Ohio State University, 484 W. 12th Ave., Columbus, OH 43210-1292.
		The abbreviations used are: TK, thymidine kinase; dCK, deoxycytidine kinase; dAK, deoxyadenosine kinase; dGK, deoxyguanosine kinase; PCR, polymerase chain reaction; ORF, open reading frame; BisTris, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-propane-1,3-diol; TES, 2-{[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino}ethanesulfonic acid; bp, base pair(s); kb, kilobase pairs (kb).
		cis-Active Ras G2-like Sequence Implicated in the Heterotropic Activation of the Deoxyadenosine Kinase of Lactobacillus acidophilus R-26
	www.jbc.org /cgi/content/abstract/270/12/6595 (657 words)

	deoxyadenosine (Site not responding. Last check: 2007-10-10)
		% deoxyadenosine config(deoxyadenosine,[ substituent(adenyl), substituent('D-1-dehydroxy-2-deoxy-5-oxy-ribofuranosyl'), linkage(from('D-1-dehydroxy-2-deoxy-5-oxy-ribofuranosyl',car(1)), to(adenyl,nit(9)), up,single)]).
		Doug Markham of the Institute for Cancer Research, Fox Chase Cancer Center,Philadelphia, PA, has contributed the following structure for deoxyadenosine.
		He computed this structure in sdf format using MacroModel, a molecular mechanics program.
	www.biocheminfo.org /klotho/html/deoxyadenosine.html (135 words)

	The effect of deoxyadenosine plus deoxycoformycin on replicative and repair synthesis of DNA in human lymphoblasts and ...
		The effect of deoxyadenosine plus deoxycoformycin on replicative and repair synthesis of DNA in human lymphoblasts and isolated nuclei -- Matsumoto et al.
		The effect of deoxyadenosine plus deoxycoformycin on replicative and repair synthesis of DNA in human lymphoblasts and isolated nuclei
		Deoxyadenosine plus deoxycoformycin (dCf) causes increased DNA breaks in
	www.jbc.org /cgi/content/abstract/263/15/7153 (346 words)

	Deoxyadenosine monophosphate - Wikipedia, the free encyclopedia
		You can discuss the issue on the talk page.
		Deoxyadenosine monophosphate is a derivative of the common nucleic acid ATP, or adenosine triphosphate, in which the -OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose has been removed (hence the deoxy- part of the name).
		Additionally, the diphosphate of the name indicates that two of the phosphoryl groups of GTP have been removed, most likely by hydrolysis.
	en.wikipedia.org /wiki/Deoxyadenosine_monophosphate (126 words)

	The Antileukemia Drug 2-Chloro-2'-deoxyadenosine: An Intrinsic Transcriptional Antagonist -- Hartman and Hentosh 65 ...
		Carrera CJ, Terai C, Lotz M, Curd JG, Piro LD, Beutler E, and Carson DA (1990) Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo.
		Carrera CJ, Yamanaka H, Piro LD, Lotz M, and Carson DA (1989) Profound toxicity of deoxyadenosine and 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo.
		Tondini C, Balzarotti M, Rampinelli I, Valagussa P, Luoni M, De Paoli A, Santoro A, and Bonadonna G (2000) Fludarabine and cladribine in relapsed/refractory low-grade non-Hodgkin's lymphoma: a phase II randomized study.
	molpharm.aspetjournals.org /cgi/content/full/65/1/227 (4744 words)

	PRODORIC Release 2 (Site not responding. Last check: 2007-10-10)
		deoxyadenosine methyltransferase (Dam) mutant - aerobic and logarithmic phase
		deoxyadenosine methyltransferase (Dam) mutant - aerobic and stationary phase
		deoxyadenosine methyltransferase (Dam) mutant - low aerobic and stationary phase
	prodoric.tu-bs.de /profile_search.php (434 words)

	Synthesis and characterization of 8-methoxy-2'- deoxyadenosine- containing oligonucleotides to probe the syn glycosidic ...
		Synthesis and characterization of 8-methoxy-2'- deoxyadenosine- containing oligonucleotides to probe the syn glycosidic conformation of 2'-deoxyadenosine within DNA -- Eason et al.
		8-Bromo-2'-deoxyadenosine, (see Scheme 1) (1), prepared by reaction of deoxyadenosine with bromine water (29), was then converted to moA (2) in 52% yield on treatment with sodium methoxide in methanol for 1 h at 45
		Employing longer reaction times as given in the literature (18 h) we were unable to obtain the desired product and over-substitution of the adenine by methoxide was apparent.
	nar.oxfordjournals.org /cgi/content/full/24/5/890 (5097 words)

	Escherichia coli deoxyadenosine deaminase / adenosine deaminase
		2,3-dideoxyadenosine [Nygaard78]', STICKY, NOCLOSE);" onmouseout="return nd();">Comment 1 ]: deoxyadenosine
		Adenosine deaminase is part of a pathway which converts adenine, adenosine and deoxyadenosine to guanine nucleotides.
		Page generated by SRI International Pathway Tools version 11.0 on Sat Jun 2, 2007, biocyc09.
	biocyc.org /getid?id=EcoCyc:ADENODEAMIN-MONOMER (181 words)

	Pegademase Bovine Drug Information, Professional
		Pegademase bovine reduces elevated deoxyadenosine triphosphate (dATP) in erythrocytes and increases diminished levels of S-adenosylhomocysteine hydrolase (SAHase)
		Dosage of pegademase bovine injection should be individualized on the basis of plasma ADA activity and red blood cell deoxyadenosine nucleotide (dATP) concentrations
		Until an improvement in immune function has been confirmed, patients should receive appropriate care to protect against infection and other related illnesses
	www.drugs.com /MMX/Pegademase_Bovine.html (1306 words)

	Directed Mutagenesis of Deoxyguanosine Site at Arginine 79 Up-regulates Turnover on Deoxyadenosine Kinase Subunit of ...
		Directed Mutagenesis of Deoxyguanosine Site at Arginine 79 Up-regulates Turnover on Deoxyadenosine Kinase Subunit of Heterodimeric Enzyme from Lactobacillus acidophilus R26 -- Hong et al.
		Present address: Dept. of Biochemistry, Molecular and Cellular Biology, Northwestern University, Evanston, IL To whom correspondence should be addressed: Dept. of Biochemistry, The Ohio State University, 484 W. 12th Ave., Columbus, OH 43210-1292.
		The abbreviations used are: TK, thymidine kinase; dGK, deoxyguanosine kinase; dAK, deoxyadenosine kinase; dCK, deoxycytidine kinase; UMCE, unmodified cloned enzyme; HSV, herpes simplex virus.
	www.jbc.org /cgi/content/abstract/270/12/6602 (551 words)

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