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Topic: Deoxycytidine

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	DCK - deoxycytidine kinase
		Metabolism of deoxycytidine to dCTP inhibits phosphorylation of cytosine arabinoside (araC), fludarabine (FaraA) and 2-chlorodeoxyadenosine (CdA) by deoxycytidine kinase.
		Deoxycytidine kinase (NTP:deoxycytidine 5'-phosphotransferase, EC 2.7.1.74) is an enzyme that catalyzes phosphorylation of deoxyribonucleosides and a number of nucleoside analogs that are important in antiviral and cancer chemotherapy.
		DCK is a homologue of DCK (deoxycytidine kinase) from Pan troglodytes.
	www.ihop-net.org /UniPub/iHOP/gi/87645.html (4173 words)

	Characterization, development, and localization of the deoxycytidine phosphorylating systems in mammalian brain. (Site not responding. Last check: 2007-10-13)
		The accumulation of deoxycytidine by rabbit and mouse brain was studied in vitro.
		After homogenization and subcellular fractionation of the brain slices incubated in [3H]deoxycytidine for 30 min, the highest percentage of [3H]deoxycytidine phosphates plus [3H]DNA was present in the nuclear and mitochondrial fractions of all brain regions.
		Deoxycytidine phosphates were synthesized from deoxycytidine in all brain regions tested into middle age.
	www.arclab.org /medlineupdates/abstract_6834071.html (182 words)

	BioMed Central \| Full text \| The relation between deoxycytidine kinase activity and the radiosensitising effect of ...
		In the present study, the relation between deoxycytidine kinase (dCK) activity and the radiosensitising effect of gemcitabine was investigated in eight different human tumour cell lines.
		Gemcitabine (2',2'-difluorodeoxycytidine, dFdC) is a synthetic pyrimidine nucleoside analogue that has a structure very similar to that of deoxycytidine and cytosine arabinoside (Ara-C) In clinical use, gemcitabine is active against a variety of solid tumours such as cancers of the pancreas, lung, head and neck, bladder, breast, and ovary.
		Stegmann AP, Honders MW, Hagemeijer A, Hoebee B, Willemze R, Landegent JE: In vitro-induced resistance to the deoxycytidine analogues cytarabine (AraC) and 5-aza-2'-deoxycytidine (DAC) in a rat modelfor acute myeloid leukemia is mediated by mutations in the deoxycytidine kinase (dck) gene.
	www.biomedcentral.com /1471-2407/6/142 (5061 words)

	Clinical Trial: High-Dose Cytarabine Plus Deoxycytidine in Treating Patients With Acute Myelogenous Leukemia or Other ...
		Deoxycytidine may protect patients from the side effects of high-dose cytarabine.
		OBJECTIVES: I. Estimate the lowest dose of deoxycytidine (dC) that can be given as a host protective agent in conjunction with high dose cytarabine (HD ARA-C) in patients with refractory acute myelogenous leukemia or other hematologic malignancies.
		Cohorts of 3-6 patients receive escalating doses of deoxycytidine and high dose cytarabine until the maximum tolerated dose (MTD) is determined.
	clinicaltrials.gov /show/NCT00002818 (587 words)

	Metabolism of 2',3'-Dideoxy-2',3'-Didehydro-beta -L(-)-5-Fluorocytidine and Its Activity in Combination with Clinically ...
		)Fd4C was not a substrate for deoxycytidine deaminase.
		Human liver deoxycytidine deaminase was partially purified as previously described (17).
		analog catabolized to a deoxyuridine analog by deoxycytidine deaminase
	aac.asm.org /cgi/content/full/42/7/1799 (3456 words)

	Genetic analysis of 2',3'-dideoxycytidine incorporation into cultured human T lymphoblasts.
		In order to analyze the cellular determinants that mediate the action of 2',3'-dideoxycytidine, the growth inhibitory and cytotoxic effects and the metabolism of the dideoxynucleoside were examined in wild type human CEM T lymphoblasts and in mutant populations of CEM cells that were genetically deficient in either nucleoside transport or deoxycytidine kinase activity.
		Whereas 2',3'-dideoxycytidine at a concentration of 5 microM inhibited growth of the wild type CEM parental strain by 50%, two nucleoside transport-deficient clones were 4-fold resistant to the pyrimidine analog.
		The deoxycytidine kinase-deficient cell line was virtually completely resistant to growth inhibition by the dideoxynucleoside at a concentration of 1024 microM.
	www.aegis.com /aidsline/1988/dec/M88C0120.html (471 words)

	The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus ...
		The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2',3'-dideoxycytidine.
		Thymidine (dThd), one of the substrates of mitochondrial deoxypyrimidine kinase (dPyd kinase), was not able to reverse the mitochondrial toxicity of ddC in CEM cells.
		Furthermore, the cytoplasmic deoxycytidine kinase (dCyd kinase)-deficient CEM cells were highly resistant to the mitochondrial toxicity of ddC.
	www.aegis.com /aidsline/1992/may/M9250128.html (478 words)

	Anti-herpes simplex virus activity of 5-alkoxymethyl-2'-deoxycytidimes and their 5-monophosphates - Patent 4990499
		A composition comprising a 5-alkoxymethyl-2'-deoxycytidine, wherein the alkoxy group contains up to 4 carbon atoms, or a 5'-monophosphate thereof, or a pharmaceutically acceptable salt or N.sup.4 -acylated prodrug thereof, wherein the acyl group is derived from an alkanoic acid having 3 to 7 carbon atoms, together with a suitable diluent or carrier.
		A composition according to claim 13, wherein said deoxycytidine is 5-methoxymethyl-2'-deoxycytidine.
		Since MMdCyd is a structural analog of deoxycytidine, the effect of dCyd was further investigated and results are shown in FIG.
	www.freepatentsonline.com /4990499.html (7556 words)

	Pretreatment Deoxycytidine Kinase Levels Predict in Vivo Gemcitabine Sensitivity -- Kroep et al. 1 (6): 371 -- ...
		CDA (EC 3.5.4.5) catalyzes the deamination of cytidine, deoxycytidine,
		be deaminated in contrast to deoxycytidine (36, 37).
		studies using deoxycytidine as a substrate (28, 30).
	mct.aacrjournals.org /cgi/content/full/1/6/371 (4233 words)

	BioMed Central \| Full text \| Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial ...
		Gemcitabine is an analogue of deoxycytidine with activity against several solid tumors.
		Gemcitabine is an analogue of deoxycytidine with activity against several solid tumors (reviewed in [1]).
		Gemcitabine enters the cell via a facilitated nucleoside transport mechanism [2,3] and is phosphorylated into gemcitabine 5'-monophosphate (dFd-CMP) by deoxycytidine kinase (dCK) [4].
	www.biomedcentral.com /1471-2210/4/8 (5859 words)

	Intrinsic Conformational Properties of Deoxyribonucleosides: Implicated Role for Cytosine in the Equilibrium Among the ...
		The right-hand diagrams correspond to deoxycytidine, and the left-hand diagrams correspond to the other nucleosides, as noted.
		A more appropriate comparison of the energetics of deoxycytidine and deoxythymidine would be in the context of a B versus
		Z DNA conformation for deoxycytidine) and the B DNA-like conformation.
	www.biophysj.org /cgi/content/full/76/6/3206 (6566 words)

	Delayed Addition of Deoxycytidine Protects Normal CD34+ Cells against Cytotoxicity of Gemcitabine without Compromising ...
		Deoxycytidine protects normal bone marrow progenitors against Ara-C and gemcitabine cytotoxicity without compromising their activity against cisplatin-resistant human ovarian cancer cells.
		Deoxycytidine preferentially protects normal versus leukemic myeloid progenitor cells from cytosine arabinoside-mediated cytotoxicity.
		Reduction of ara-C cytotoxicity in HL-60 cells by addition of deoxycytidine, cytidine or increased level of cytidine deaminase.
	stemcells.alphamedpress.org /cgi/content/full/21/3/266 (2794 words)

	Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours -- Hubeek et al. ...
		Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours -- Hubeek et al.
		Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours
		Role of deoxycytidine kinase in an in vitro model for AraC- and DAC-resistance: substrate–enzyme interactions with deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-aza-2'-deoxycytidine.
	jcp.bmj.com /cgi/content/full/58/7/695 (2676 words)

	UniProtKB/Swiss-Prot entry P27707 [DCK_HUMAN] Deoxycytidine kinase
		Eriksson S. Cederlund E. Bergman T. Joernvall H. Bohman C. "Characterization of human deoxycytidine kinase.
		Johansson M. Brismar S. Karlsson A. "Human deoxycytidine kinase is located in the cell nucleus.";
		Molecular function: deoxycytidine kinase activity (traceable author statement from ProtInc).
	www.expasy.org /uniprot/P27707 (346 words)

	Mechanisms of Uptake and Resistance to Troxacitabine, a Novel Deoxycytidine Nucleoside Analogue, in Human Leukemic and ...
		Mechanisms of Uptake and Resistance to Troxacitabine, a Novel Deoxycytidine Nucleoside Analogue, in Human Leukemic and Solid Tumor Cell Lines -- Gourdeau et al.
		(2, 35), phosphorylation of deoxycytidine by dCK was greatly
		Ullman B. Dideoxycytidine metabolism in wild type and mutant CEM cells deficient in nucleoside transport or deoxycytidine kinase.
	cancerres.aacrjournals.org /cgi/content/full/61/19/7217 (5982 words)

	Pharmacology of {beta}-L-Thymidine and {beta}-L-2'-Deoxycytidine in HepG2 Cells and Primary Human Hepatocytes: ...
		that deoxycytidine deaminase may be enantioselective, as previous
		-dC, was not a substrate for deoxycytidine deaminase.
		Deoxycytidine deaminase-resistant stereoisomer is the active form of (ß)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.
	aac.asm.org /cgi/content/full/46/6/1728 (2419 words)

	Deoxycytidine triphosphate - Wikipedia, the free encyclopedia
		If a more appropriate WikiProject or portal exists, please adjust this template accordingly.
		Deoxycytidine triphosphate (dCTP) is a cytidine nucleotide triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction.
		A chemical equation can be written that represents the process:
	en.wikipedia.org /wiki/Deoxycytidine_triphosphate (130 words)

	BTP - Graduate Students - Rebecca Selzer (Site not responding. Last check: 2007-10-13)
		In this study, the adducts formed in the reaction between BM and deoxycytidine are identified as diastereomeric pairs of N
		Adduct formation under decreasing BM concentrations resulted in a roughly linear dependency on BM concentration for all adducts.
		Chemical modification of deoxycytidine at different sites yields adducts of different stabilities: Characterization of the N
	www.bact.wisc.edu /Biotech/gradstudents/RebeccaSelzer/profile.htm (289 words)

	EC 2.7.1.74 (Site not responding. Last check: 2007-10-13)
		Other name(s): deoxycytidine kinase (phosphorylating); 2'-deoxycytidine kinase; Ara-C kinase; arabinofuranosylcytosine kinase; deoxycytidine-cytidine kinase
		Kessel, D. Properties of deoxycytidine kinase partially purified from L1210 cells.
		Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside.
	www.chem.qmul.ac.uk /iubmb/enzyme/EC2/7/1/74.html (98 words)

	Human deoxycytidine kinase is located in the cell nucleus -- Johansson et al. 94 (22): 11941 -- Proceedings of the ...
		Human deoxycytidine kinase is located in the cell nucleus -- Johansson et al.
		Arabinosylguanine Is Phosphorylated by Both Cytoplasmic Deoxycytidine Kinase and Mitochondrial Deoxyguanosine Kinase
		Phosphorylation of Deoxycytidine Analog Monophosphates by UMP-CMP Kinase: Molecular Characterization of the Human Enzyme
	www.pnas.org /cgi/content/abstract/94/22/11941 (780 words)

	American Radiolabeled Chemicals, Inc. - Deoxycytidine, [5-3H]
		Place the links you want here in the helpbox topic using the admin site.
		Deoxycytidine, [5-3H] M.W. Specific Activity 20-40 Ci/mmol 0.74-1.48 TBq/mmol
		Deoxycytidine, [5-3H] ART 0238-1 mCi / 37 MBq
	www.arc-inc.com /pc-5108-1-deoxycytidine-5-3h.aspx (92 words)

	Tumor Uptake and Elimination of 2',2'-Difluoro-2'-deoxycytidine (Gemcitabine) after Deoxycytidine Kinase Gene Transfer: ...
		Tumor Uptake and Elimination of 2',2'-Difluoro-2'-deoxycytidine (Gemcitabine) after Deoxycytidine Kinase Gene Transfer: Correlation with in Vivo Tumor Response -- Blackstock et al.
		Tumor Uptake and Elimination of 2',2'-Difluoro-2'-deoxycytidine (Gemcitabine) after Deoxycytidine Kinase Gene Transfer
		Copyright © 2001 by the American Association for Cancer Research.
	clincancerres.aacrjournals.org /cgi/content/abstract/7/10/3263 (679 words)

	Product :: 24014 DEOXYCYTIDINE - 5' - TRIPHOSPHATE, [5 - 3H]
		Product :: 24014 DEOXYCYTIDINE - 5' - TRIPHOSPHATE, [5 - 3H]
		[24014] DEOXYCYTIDINE - 5' - TRIPHOSPHATE, [5 - 3H]
		DEOXYCYTIDINE - 5' - TRIPHOSPHATE, [5 - 3H]
	www.mpbio.com /product_info.php?products_id=24014 (59 words)

	Deoxycytidine kinase, Homo sapiens - UniGene Hs.709
		Homo sapiens full open reading frame cDNA clone RZPDo834F0322D for gene DCK, deoxycytidine kinase; complete cds, incl.
		Homo sapiens deoxycytidine kinase, mRNA (cDNA clone MGC:117410 IMAGE:6472612), complete cds
		Homo sapiens deoxycytidine kinase, mRNA (cDNA clone MGC:138632 IMAGE:40032871), complete cds
	www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Hs&CID=709 (217 words)

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