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Topic: Deoxyguanosine

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	Arch Neurol -- Hepatocerebral Mitochondrial DNA Depletion Syndrome Caused by Deoxyguanosine Kinase (DGUOK) Mutations, ...
		The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA [letter].
		A novel mutation in the deoxyguanosine kinase gene causing depletion of mitochondrial DNA.
		Deoxyguanosine kinase mutations and combined deficiencies of the mitochondrial respiratory chain in patients with hepatic involvement.
	archneur.ama-assn.org /cgi/content/full/63/8/1129 (2558 words)

	Guanine nucleosides and Jurkat cell death: roles of ATP depletion and accumulation of deoxyribonucleotides -- Batiuk ...
		Jurkat cells were incubated with 500 µM guanosine or deoxyguanosine for 8, 16, or 24 h.
		Cells treated with guanosine or deoxyguanosine showed a mixture of necrotic features (yellow stain indicating inability to exclude propidium iodide due to damaged cell membrane, arrowheads) and apoptotic features (exclusion of propidium iodide and condensed and fragmented nuclei staining green with Hoechst 33343, arrows).
		Effects of 8-aminoguanosine on the toxicity of guanosine and deoxyguanosine for malignant and normal lymphoid cells.
	ajpcell.physiology.org /cgi/content/full/281/6/C1776 (4365 words)

	Interaction between 3-(p-tolylamino)-1,5-azulenequinone and the deoxyguanosine residue various oligonucleotides upon ... (Site not responding. Last check: )
		Cleavage of these single- and double-stranded oligodeoxyribonucleotides selectively at the deoxyguanosine residue was accomplished by use of 3-(p-tolylamino)-1,5-azulenequinone 1 upon irradiation with 350 mn UV light.
		For the helices containing a deoxyguanosine residue at a bulge, at a hairpin loop or toward the end, the cleaving efficiency was increased.
		By possessing an [(AT)4]^sub 2^ stem individually and one deoxyguanosine nucleotide in the middle of the loop, oligodeoxyribonucleotides H3 and HS (see entries 10 and 11 in Table 1) could form two hairpins.
	www.findarticles.com /p/articles/mi_qa3931/is_200111/ai_n9009226 (880 words)

	Deoxyguanosine Kinase (DGUOK) Gene Sequencing - Mitochondrial DNA Analysis
		Two primary enzymes: deoxyguanosine kinase (DGUOK, MIM601465) and thymidine kinase (TK2, MIM 188250), are responsible for the salvage biosynthesis of dNTPs necessary to maintain the balance of mitochondrial deoxynucleotide pools.
		Mandel H, Szargel R, Labay V, Elpeleg O, Saada A, Shalata A, Anbinder Y, Berkowitz D, Hartman C, Barak M, Eriksson S, Cohen N. (2001) The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA.
		Taanman JW, Kateeb I, Muntau AC, Jaksch M, Cohen N, Mandel H. (2002) A novel mutation in the deoxyguanosine kinase gene causing depletion of mitochondrial DNA.
	www.bcm.edu /geneticlabs/tests/mito/DGUOK.html (311 words)

	Anti-herpes simplex virus activity of 5-alkoxymethyl-2'-deoxycytidimes and their 5-monophosphates - Patent 4990499
		A method according to claim 4, wherein there is also administered to the patient an amount of deoxyguanosine effective to potentiate the 5-methoxymethyl-2'-deoxycytidine.
		A method according to claim 5, wherein there is also administered to the patient an amount of deoxyguanosine effective to potentiate the 5-methoxymethyl-2'-deoxycytidine.
		Tetrahydrodeoxyuridine and deoxyguanosine were devoid of cytotoxicity up to 1 mM and 250.mu.M respectively against rapidly dividing Vero cells (Table 12).
	www.freepatentsonline.com /4990499.html (7556 words)

	CiteULike: Structural characterization of G-quadruplexes in deoxyguanosine clusters using ion mobility mass ...
		The aggregation and conformation of deoxyguanosine (dG) in an ammonium acetate buffer solution were examined using mass spectrometry, ion mobility, and molecular mechanics/dynamics calculations.
		All of the other clusters in the mass spectrum (14, 16, and 17 dGs with 3 NH4+ and 23 dGs with 4 NH4+) only had one peak in their ATDs and in all cases the theoretical structures in a quadruplex arrangement agreed with the experimental cross sections.
		SN - 1044-0305 N2 - The aggregation and conformation of deoxyguanosine (dG) in an ammonium acetate buffer solution were examined using mass spectrometry, ion mobility, and molecular mechanics/dynamics calculations.
	www.citeulike.org /group/2058/article/1605908 (922 words)

	Mitochondrial Basis for Immune Deficiency: Evidence from Purine Nucleoside Phosphorylase-deficient Mice -- Arpaia et ...
		Effect of Bcl2 overexpression on thymocyte apoptosis induced by deoxyguanosine in the presence of a PNP inhibitor.
		Thymocytes from C57BL/6 mice were incubated in RPMI 1640 medium with 10% FCS in the presence or absence of 60 µM deoxyguanosine and 20 µM of the PNP inhibitor CI-1000 (2-amino 3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d]-pyrimidin-4-one HCl) as indicated for 12 h.
		The accumulated deoxynucleosides are phosphorylated by the mitochondrial enzymes deoxyguanosine kinase (GdR kinase; reference 47) or thymidine kinase (TdR kinase; reference (61)), resulting in the accumulation of dGTP and dTTP, respectively.
	www.jem.org /cgi/content/full/191/12/2197 (5143 words)

	GUANINE (2-AMINO-6-HYDROXYPURINE)
		Its action is similar to that of cyclic adenosine monophosphate, but the two cyclic nucleotides activate different protein kinases and usually produce opposite effects on cell function.
		Deoxyguanosine monophosphate (dGMP) : a nucleotide, the 5'-phosphate of deoxyguanosine, occurring in deoxyribonucleic acid.
		Chemically modified nucleotides substituted or attached by special chemical groups or elements are studied and used to inactivate the normal biological operation in the living organism, the function of important enzymes, and cytobiology research.
	www.chemicalland21.com /lifescience/phar/GUANINE.htm (826 words)

	UniProtKB/Swiss-Prot entry Q16854 [DGUOK_HUMAN] Deoxyguanosine kinase, mitochondrial
		Johansson M. Karlsson A. "Cloning and expression of human deoxyguanosine kinase cDNA.";
		Wang L. Limongelli A. Vila M.R. Carrara F. Zeviani M. Eriksson S. "Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.";
		Molecular function: deoxyguanosine kinase activity (traceable author statement from ProtInc).
	www.expasy.org /uniprot/Q16854 (599 words)

	Mitochondrial DNA depletion can be prevented by dGMP and dAMP supplementation in a resting culture of deoxyguanosine ...
		in the gene for deoxyguanosine kinase (DGUOK; OMIM 601465) (11),
		(2001) The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA.
		Taanman, J.-W., Kateeb, I., Muntau, A.C., Jaksch, M., Cohen, N. and Mandel, H. (2002) A novel mutation in the deoxyguanosine kinase gene causing depletion of mitochondrial DNA.
	hmg.oxfordjournals.org /cgi/content/full/12/15/1839 (4265 words)

	Metabolism in Human Cells of the D and L Enantiomers of the Carbocyclic Analog of 2'-Deoxyguanosine: Substrate Activity ...
		Metabolism in Human Cells of the D and L Enantiomers of the Carbocyclic Analog of 2'-Deoxyguanosine: Substrate Activity with Deoxycytidine Kinase, Mitochondrial Deoxyguanosine Kinase, and 5'-Nucleotidase -- Bennett et al.
		Enantiomers of the Carbocyclic Analog of 2'-Deoxyguanosine: Substrate Activity with Deoxycytidine Kinase, Mitochondrial Deoxyguanosine Kinase, and 5'-Nucleotidase
		In hepatocytes infected with duck hepatitis B virus, the template for viral RNA synthesis is amplified by an intracellular pathway.
	aac.asm.org /cgi/content/full/42/5/1045 (3724 words)

	Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver -- Chaudhary et al. 265 (5178): 1580 -- ...
		DNA from disease-free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens.
		Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells.
		Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct.
	www.sciencemag.org /cgi/content/abstract/265/5178/1580 (1255 words)

	Intranuclear Distribution of 8-hydroxy-2'-deoxyguanosine: An Immunocytochemical Study -- Toyokuni et al. 47 (6): 833 -- ...
		Kasai H (1997) Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis.
		Kasai H, Nishimura S (1984) Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents.
		Lindahl T (1993) Instability and decay of the primary structure of DNA.
	www.jhc.org /cgi/content/full/47/6/833 (1163 words)

	Rizzo Homepage
		A Stereocontrolled Route to Deoxyguanosine Adducts of alpha,beta-Unsaturated Aldehydes.
		Kris H. Franklin, M.S.2004, Vanderbilt University, Thesis: "Amino Acid and Peptide Promoted Catalysis of 1,N2 Hydroxypropano Adducts of Deoxyguanosine: A Biomimetic Model for the Interaction of ±,&Mac178;-Unsaturated Aldehydes With DNA." Currently employed at Merck and Co., Rahway, NJ Angela Brock, B.S.,2000, Knox College.; Ph.
		A Stereocontrolled Route to Deoxyguanosine Adducts of ±,<-Unsaturated Aldehydes.
	www.vanderbilt.edu /AnS/Chemistry/Rizzo/Rizzo.htm (3220 words)

	Biochem. J. (2007) 402, 377-385 - B. Mousson de Camaret and others - Mutant deoxyguanosine kinase in reversible mtDNA ...
		DGUOK [dG (deoxyguanosine) kinase] is one of the two mitochondrial deoxynucleoside salvage pathway enzymes involved in precursor synthesis for mtDNA (mitochondrial DNA) replication.
		DGUOK is responsible for the initial rate-limiting phosphorylation of the purine deoxynucleosides, using a nucleoside triphosphate as phosphate donor.
		Abbreviations used: dA, deoxyadenosine; dCK, deoxycytidine kinase; dG, deoxyguanosine, DGUOK, dG kinase; mtDNA, mitochondrial DNA; MDS, mtDNA depletion syndrome; MRI, magnetic resonance imaging; qPCR, quantitative PCR; RT, reverse transcriptase; TK2, thymidine kinase 2.
	www.biochemj.org /bj/402/bj4020377.htm (516 words)

	Deoxyguanosine kinase, Homo sapiens - UniGene Hs.469022
		PREDICTED: similar to Deoxyguanosine kinase, mitochondrial precursor (dGK)
		Homo sapiens deoxyguanosine kinase (DGUOK), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA
		Homo sapiens deoxyguanosine kinase (DGUOK), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA
	www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Hs&CID=469022 (228 words)

	deoxyguanosine
		% deoxyguanosine config(deoxyguanosine,[ substituent(guanyl), substituent('D-1-dehydroxy-2-deoxy-5-oxy-ribofuranosyl'), linkage(from('D-1-dehydroxy-2-deoxy-5-oxy-ribofuranosyl',car(1)), to(guanyl,nit(9)), up,single)]).
		Doug Markham of the Institute for Cancer Research, Fox Chase Cancer Center,Philadelphia, PA, has contributed the following structure for deoxyguanosine.
		He computed this structure in sdf format using MacroModel, a molecular mechanics program.
	www.biocheminfo.org /klotho/html/deoxyguanosine.html (135 words)

	Nelarabine : Nature Reviews Drug Discovery (Site not responding. Last check: )
		Patients lacking PNP, which catabolizes deoxyguanosine, show a profound deoxyguanosine triphosphate (dGTP)-mediated T-cell lymphopaenia without a concomitant decrease in B cells, indicating that deoxyguanosine analogues could be particularly useful for treating T-cell malignancies such as T-ALL
		Indeed, ara-G was found to be selectively toxic to T cells compared with B cells, and a water-soluble prodrug of ara-G, nelarabine (also known as compound 506U78), was subsequently developed
		Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells.
	www.nature.com /nrd/journal/v5/n1/full/nrd1933.html (1372 words)

	Department of Chemistry at Vanderbilt University
		The adduction of IQ with DNA also gives a minor N2-adduct of deoxyguanosine, which has not been extensively studied.
		Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy.
		Wang, Hao; Marnett, Lawrence J.; Harris, Thomas M.; Rizzo, Carmelo J. A Novel Synthesis of Malondialdehyde Adducts of Deoxyguanosine, Deoxyadenosine and Deoxycytidine.
	www.vanderbilt.edu /AnS/Chemistry/faculty/bio.php?ID=36 (1134 words)

	Purine Nucleoside Phosphorylase Inhibitor BCX-1777-a Novel Potent Immunosuppressive Agent: The Role of dGTP in ...
		BACKGROUND: BCX-1777 is a potent PNP inhibitor and in the presence of deoxyguanosine (dGuo) inhibits proliferation of lymphocytes effectively.
		The present study was to understand the mechanism of in vitro T cell inhibition and the role of deoxyguanosine triphosphate (dGTP) in this inhibition process.
		Also, in vivo efficacy of BCX-1777 and cyclosporin was compared.
	gateway.nlm.nih.gov /MeetingAbstracts/102267662.html (244 words)

	UniProtKB/TrEMBL entry Q9A1S5 [Q9A1S5_STRP1] Putative deoxyguanosine kinase/deoxyadenosine kinase(I) subunit
		Molecular function: deoxyadenosine kinase activity (inferred from electronic annotation from EC).
		Molecular function: deoxyguanosine kinase activity (inferred from electronic annotation from EC).
		Molecular function: phosphotransferase activity, alcohol group as acceptor (inferred from electronic annotation from InterPro).
	ca.expasy.org /uniprot/Q9A1S5 (299 words)

	Environmental Health Perspectives 105, Number 7, July 1997: Article by Hong et al.
		The effects of magnesium carbonate on the cytotoxicity and genotoxicity induced by nickel subsulfide were examined with respect to the inhibition of cell proliferation, micronuclei formation, DNA-protein cross-link formation, and intranuclear nickel concentration.
		The generation of reactive oxygen by nickel chloride was also analyzed by observing 8-hydroxy-deoxyguanosine formation from deoxyguanosine in the presence and absence of magnesium chloride.
		The suppression of up to 64% of the proliferation of BALB/3T3 fibroblasts by nickel subsulfide (1 µg/ml) was reversed by magnesium.
	www.ehponline.org /docs/1997/105-7/hong.html (357 words)

	1,N2-Deoxyguanosine Adducts of Acrolein, Crotonaldehyde, and trans-4-Hydroxynonenal Cross-link to Peptides via Schiff ...
		A, shown is the sequence of the 12-bp oligonucleotide used in this study.
		The position of the adducted deoxyguanosine is denoted by an asterisk on the upper stand, and the position of the
		B, shown are the structures of the ring-open (species 1) and ring-closed (species 2) forms of the acrolein-derived
	www.jbc.org /cgi/content/full/278/8/5970 (4892 words)

	A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method ...
		We found using NaI that the ratio of oxo8dG/10
		deoxyguanosine (dG) in nDNA isolated from mouse tissues ranged
		10 Kasai,H. and Nishimura,S. (1984) Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents.
	nar.oxfordjournals.org /cgi/content/full/29/10/2117 (6705 words)

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