
	Where results make sense

Topic: Deoxyuridine

Related Topics

Uridine

Piezoelectricity

Ben Ali

British Medical Journal

Operation Castle

Year of the Four Emperors

Operation Renntier

Joan Clos

Operation Enduring Freedom

Constance Bennett

Grand Duke of Tuscany

	Patent 6,020,146
		fibroblast cells to said suspected carcinogen, agglomerating the treated cells; incubating the agglomerated cells with a deoxyuridine analog; labeling the cells which have incorporated the deoxyuridine analog with an antibody to the deoxyuridine analog; and quantitating the amount of cells incorporating the deoxyuridine analog.
		By deoxyuridine analog is meant a derivative of a deoxyuridine, which is incorporated by a cell transformed by a carcinogen but not incorporated by untransformed spheroid cells.
		(c) administrating a deoxyuridine analog and a thymidilate synthetase inhibitor to said agglomerated cell sample, wherein said deoxyuridine analog is a halogenated deoxyuridine which is incorporated by cells transformed by a carcinogen and is not incorporated byuntransformed spheroid cells;
	www.pharmcast.com /Patents/020100OG/6020146_carcinogen020100.htm (1973 words)

	Anti-herpes simplex virus activity of 5-alkoxymethyl-2'-deoxycytidimes and their 5-monophosphates - Patent 4990499
		In contrast, deoxyuridine analogues are rapidly catabolized to pyrimidine bases by thymidine phosphorylase (Veres et al., 1986).
		The cytotoxicity of deoxyuridine analogues is due to inhibition of thymidylate synthase by their corresponding monophosphates (DeClercq et al., 1982).
		Penetration of MMdCyd in the CNS should be greater than its corresponding deoxyuridine derivative, 5-methoxymethyl-2'-deoxyuridine, because of its greater lipid solubility.
	www.freepatentsonline.com /4990499.html (7556 words)

	The Phosphodiester Bond 3' to a Deoxyuridine Residue Is Crucial for Substrate Binding for Uracil DNA N-Glycosylase
		The rate of uracil excision from duplex DNA containing a pyrophosphate bond 3' or 5' to the uracil residue was also reduced, being 0.1% and 1% the rate of uracil removal from the corresponding duplex DNA control.
		Kinetic measurements showed that the pyrophosphate bond placed adjacent to the deoxyuridine residue drastically reduced the affinity of UDG toward the modified DNA substrate, with the greatest effect occurring when the pyrophosphate bond was 3' adjacent to the deoxyuridine.
		The effect of the pyrophosphate bond on the substrate susceptibility of oligonucleotides containing deoxyuridine is discussed with respect to the mechanism of action of UDG.
	pubs.acs.org /cgi-bin/abstract.cgi/bichaw/1996/35/i51/abs/bi961774o.html (334 words)

	Deoxyuridine Is Generated Preferentially in the Nontranscribed Strand of DNA from Cells Expressing Activation-Induced ...
		Deoxyuridine Is Generated Preferentially in the Nontranscribed Strand of DNA from Cells Expressing Activation-Induced Cytidine Deaminase -- Martomo et al.
		Deoxyuridine Is Generated Preferentially in the Nontranscribed Strand of DNA from Cells Expressing Activation-Induced Cytidine Deaminase
		to deoxyuridine in DNA in vitro, there is no physical evidence
	www.jimmunol.org /cgi/content/abstract/174/12/7787 (333 words)

	A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil -- Greagg et al. 96 (16): ...
		The position of the full-length product obtained from primer-extension against the T template (not shown) was consistent with termination at the end of the 119-base template.
		of deoxyuridine and is not involved in detection and stalling
		(b) In the read-ahead model, specific stalling of a running polymerase at a deoxyuridine upstream in the single-stranded segment of the template would give a gap between the last incorporated nucleotide (arrowed) and the template deoxyuridine (U), smaller than the "footprint" of the polymerase, as is observed.
	www.pnas.org /cgi/content/full/96/16/9045 (4496 words)

	Absence of deoxyuridine and 5-hydroxymethyldeoxyuridine in the DNA from three tissues of mice of various ages. (Site not responding. Last check: 2007-10-12)
		Absence of deoxyuridine and 5-hydroxymethyldeoxyuridine in the DNA from three tissues of mice of various ages.
		Mutational damage to DNA may modulate the aging process as well as contribute to the high incidence of cancer in older animals.
		Neither deoxyuridine (dU) nor 5-hydroxymethyldeoxyuridine (dHMU) were found in hydrolysates of DNA samples from brain, liver or small intestinal mucosa of mice of different ages.
	www.arclab.org /medlineupdates/abstract_2426529.html (169 words)

	Cancer Spectrum: Wells et al., pp. 675-682.
		on plasma concentrations of deoxyuridine and thymidine (14).
		The increase in the retention of the thymidine tracer in tumors
		in plasma is derived from an intracellular deoxyuridine monophosphate
	jncicancerspectrum.oxfordjournals.org /cgi/content/full/jnci;95/9/675 (4161 words)

	2.7 dUTPases
		Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a ubiquitous enzyme.
		It has been discovered in organisms ranging from viruses to high eukaryotes, including humans.
		Its role is the degradation of deoxyuridine triphosphate (dUTP) to deoxyuridine monophosphate (dUMP): this is a necessary step in the cellular biosynthesis of thymidine.
	www.ysbl.york.ac.uk /projects/2/2.7.htm (546 words)

	deoxyuridine (Site not responding. Last check: 2007-10-12)
		% deoxyuridine config(deoxyuridine,[ substituent(uracyl), substituent('D-1-dehydroxy-2-deoxy-5-oxy-ribofuranosyl'), linkage(from('D-1-dehydroxy-2-deoxy-5-oxy-ribofuranosyl',car(1)), to(uracyl,nit(1)), up,single)]).
		Doug Markham of the Institute for Cancer Research, Fox Chase Cancer Center,Philadelphia, PA, has contributed the following structure for deoxyuridine.
		He computed this structure in sdf format using MacroModel, a molecular mechanics program.
	www.biocheminfo.org /klotho/html/deoxyuridine.html (127 words)

	5-Fluoro-2'-Deoxyuridine-Induced cdc25A Accumulation Correlates with Premature Mitotic Entry and Clonogenic Death in ...
		The occurrence and consequences of deoxyuridine in DNA.
		Canman C, Lawrence T, Shewach D, Tang H, Maybaum J. Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.
		Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331.
	cancerres.aacrjournals.org /cgi/content/full/64/18/6588 (5639 words)

	Suicide Prodrugs Activated by Thymidylate Synthase: Rationale for Treatment and Noninvasive Imaging of Tumors with ...
		Suicide Prodrugs Activated by Thymidylate Synthase: Rationale for Treatment and Noninvasive Imaging of Tumors with Deoxyuridine Analogues -- Collins et al.
		dose of the deoxyuridine analogue was tagged with an isotope,
		to therapy with deoxyuridine analogues as suicide prodrugs.
	clincancerres.aacrjournals.org /cgi/content/full/5/8/1976 (2894 words)

	[No title] (Site not responding. Last check: 2007-10-12)
		72 2e-12 pdb1DUPA Chain A, Deoxyuridine 5'-Triphosphate Nucleotido...
		spP06968DUT_ECOLI DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE (DUTPASE) (DUTP PYROPHOSPHATASE) >gi67802pirWPECDU dUTP pyrophosphatase (EC 3.6.1.23) - Escherichia coli >gi41297embCAA25859
		(Z81097) Similarity to Human deoxyuridine 5'-triphosphate nucleotidohydrolase (SW:P33316); cDNA EST EMBL:M75928 comes from this gene; cDNA EST EMBL:C07581 comes from this gene; cDNA EST EMBL:C08967 comes from this gene; cDNA...
	spock.jouy.inra.fr /NCBI/dut.html (606 words)

	Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice -- Jansen et al. ... (Site not responding. Last check: 2007-10-12)
		Mutagenic replication of deoxyuridine, or of its abasic derivative,
		of cytosine residues opposite deoxyuridine residues and abasic
		Deoxyuridine and abasic sites are essential triggers for somatic
	www.jem.org /cgi/content/full/203/2/319 (2585 words)

	Deoxyuridine triphosphatase, Rattus norvegicus - UniGene Rn.6102
		sp:P33316 - DUT_HUMAN Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor
		Tissues and development stages from this gene's sequences survey gene expression.
		Rattus norvegicus deoxyuridine triphosphatase (Dut), transcript variant 1, mRNA
	www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Rn&CID=6102 (151 words)

	Chlorella Virus-Encoded Deoxyuridine Triphosphatases Exhibit Different Temperature Optima -- Zhang et al. 79 (15): 9945 ...
		Chlorella Virus-Encoded Deoxyuridine Triphosphatases Exhibit Different Temperature Optima -- Zhang et al.
		Chlorella Virus-Encoded Deoxyuridine Triphosphatases Exhibit Different Temperature Optima
		A putative deoxyuridine triphosphatase (dUTPase) gene from chlorella
	jvi.asm.org /cgi/content/abstract/79/15/9945 (266 words)

	UniProtKB/Swiss-Prot entry P33316 [DUT_HUMAN] Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
		UniProtKB/Swiss-Prot entry P33316 [DUT_HUMAN] Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
		Ladner R.D. McNulty D.E. Carr S.A. Roberts G.D. Caradonna S.J. "Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase.";
		You may not see all the information available for this page (More information).
	www.expasy.org /uniprot/P33316 (591 words)

	Deoxyuridine triphosphatase, Mus musculus - UniGene Mm.282499
		Mus musculus deoxyuridine triphosphatase, mRNA (cDNA clone MGC:62538 IMAGE:6485182), complete cds
		Mus musculus deoxyuridine triphosphatase, mRNA (cDNA clone MGC:28500 IMAGE:4187559), complete cds
		EST sequences (10 of 333) [Show all sequences]
	www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Mm&CID=282499 (324 words)

	Binding of non-natural 3'-nucleotides to ribonuclease A -- Jenkins et al. 272 (3): 744 -- FEBS Journal (Site not responding. Last check: 2007-10-12)
		We find that both non-natural 3'-nucleotides have significantly
		more affinity for wild-type RNase A than do deoxyuridine 3'-phosphate
		The syntheses of deoxyuridine 3'-phosphate (dUMP, 5a) and 2'-fluoro-2'-deoxyuridine
	content.febsjournal.org /cgi/content/full/272/3/744 (5053 words)

Try your search on: Qwika (all wikis)