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Topic: Derivatized

	United States Patent Application: 0050089840
		An isolated, derivatized peptide consisting of the sequence of SEQ ID NO: 3, wherein the peptide is modified by replacing glutamic acid at position 13 with a lysine and attaching a coupling group to the lysine, or derivatized by conjugating a coupling group to a lysine added at the C-terminus.
		The derivatized peptide of claim 7, wherein the coupling group is selected from the group consisting of: (a) a maleimido group; (b) a succinimidyl group; (c) a hydrazine group; and (d) a carbonyl group.
		The derivatized peptide of claim 13, wherein the maleimido group is 3'-maleimidopropionate connected to the epsilon amino group of lysine by [2-(2-amino)ethoxyl]ethoxy acetic acid.
	appft1.uspto.gov /netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=2&u=/netahtml/PTO/search-bool.html&r=51&f=G&l=50&co1=AND&d=PG01&s1=condom&OS=condom&RS=condom (11740 words)

	World Intellectual Property Organization (Site not responding. Last check: 2007-10-15)
		Further surprising in conjunction with the derivatization of a mixture of malto-oligosaccharides is the discovery that the change in DP profile of the mixture upon oxidation, and, it is believed, other derivatization, is smaller in conjunction with reduced malto- oligosaccharides as compared with unmodified malto- oligosaccharides.
		The scope of derivatization encompassed by the invention is not contemplated to be limited, and thus, for example, the hydrogenated malto- oligosaccharides may be derivatized via oxidation, esterification, etherification, or other suitable derivatization reaction.
		For example, with respect to derivatization the oxidation of the malto-oligosaccharide in one or more primary alcohol positions to form carboxylic acids, a variety of oxidation reactions are known in the art and are applicable for use in conjunction with the invention.
	www.wipo.int /ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/14394.010301&ELEMENT_SET=DECL (5179 words)

	Patent 5098977: Methods and compositions for providing articles having improved biocompatability characteristics
		The aliphatic extensions employed for derivatizing the are preferably of the type having from 12 to 22 carbon atoms, such as aliphatic hydrocarbons or acyls, in that such structures are generally found to adsorb to albumin.
		The degree of derivatization, e.g., the density of derivatization in terms of the ratio of derivatized to underivatized aromatic structures, will generally be determined by the length of time the reaction is allowed to proceed.
		For the step of aliphatic derivatization, it is generally necessary to perform a solvent exchange to remove the polymer from its aqueous environment and replace it with polar aprotic solvent such as dry dimethylacetamide, dimethyl sulfoxide, tetrahydrofuran or dimethyl formamide.
	www.freepatentsonline.com /5098977.html (7778 words)

	Analysis of diacylglycerols
		Derivatized DAG are purified by TLC on silica gel with petroleum ether/diethyl ether (75/25, v/v) as solvent system.
		The Rf of derivatized alkenyl-, alkylacyl- and diacyl-DAG are 0.82, 0.75 and 0.67, respectively.
		The same derivatization procedure is used for the analysis of the molecular species of free diradylglycerols or of phospholipids after their hydrolysis with phospholipase C. Each sub-class, purified by TLC, is analyzed by HPLC.
	www.cyberlipid.org /acylglyt/acyl0005.htm (1037 words)

	World Intellectual Property Organization (Site not responding. Last check: 2007-10-15)
		Therefore, the biomolecule is derivatized with one component of a Diels-Alder reaction, i.
		The maleimide derivatized surfaces are detected by staining with a thiol-fluorescein reagent, which reacts with the maleimide via a Michael-addition as illustrated in Scheme 9.
		The diene derivatized surfaces are detected by Diels-Alder reaction with a fluorescein maleimide as illustrated in Scheme 11.
	www.wipo.int /ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/84234.011108&ELEMENT_SET=DECL (7074 words)

	A high-performance liquid chromatographic assay for the determination of desbutylhalofantrine enantiomers in rat plasma
		For the nonstereospecific assay of DHF used in the determination of recovery and derivatization yield, the mobile phase consisted of a 25:75 mixture of [25 mM potassium phosphate:3 mM sulfuric acid:3.6 mM triethylamine]:acetonitrile containing sodium dodecyl sulfate (1.5 g/L).
		The derivatization yield of DHF was estimated by calculating the difference in the mean underivatized DHT:HF peak height ratios between the derivatized and underivatized samples.
		We chose to use the latter conditions for derivatization, since a.) the reaction was faster, b.) the peaks at 4 and 6 min eluted at a time where potentially interfering peaks from endogenous were co-eluting, and c.) heat was not required which could potentially lead to inadvertent racemization of the DHF enantiomers.
	www.ualberta.ca /~csps/JPPS4(1)/D.Brocks/antimalarial.htm (4178 words)

	Patent 6,268,335
		When the derivatized protein is precipitated or crystallized, the rate at which the insulin derivative dissolves from the solid form is greatly reduced compared with the rate at which similar solid forms comprised of un-derivatized protein dissolve.
		Accordingly, in its broadest aspect, the present invention provides insoluble compositions comprising a derivatized protein selected from the group consisting of insulin derivatives, insulin analog derivatives, and proinsulin derivatives, wherein the derivatives are less soluble than the underivatized insulin, insulin analog, or proinsulin.
		Also part of the present invention are amorphous precipitates, comprising, in their broadest aspect, a derivatized protein selected from the group consisting of derivatized insulin, derivatized insulin analog, and derivatized proinsulin, protamine, a phenolic preservative, and zinc, wherein the derivatized protein is less soluble than the underivatized protein.
	www.pharmcast.com /Patents/Yr2001/July2001/073101/6268335_Insulin073101.htm (736 words)

	Patent 6,531,448
		Accordingly, in its broadest aspect, the present invention provides insoluble compositions comprising a derivatized protein selected from the group consisting of insulin derivatives, insulin analog derivatives, and proinsulin derivatives, a protein selected from the group consisting of insulin, insulin analogs, and proinsulins, a complexing compound, a hexamer-stabilizing compound, and a divalent metal cation.
		The derivatized protein is either less soluble in an aqueous solvent than is the un-derivatized protein, is more lipophilic than un-derivatized insulin, or produces a complex with zinc and protamine that is less soluble than the corresponding complex with the un-derivatized protein.
		Hybrid hexamers are believed to be formed when a protein and a derivatized protein are first mixed together under conditions that strongly favor dissolution into lower states of aggregation than the hexameric state, and second, the conditions are changed to strongly favor the hexameric aggregation state.
	www.pharmcast.com /Patents/Yr2003/Mar2003/031103/6531448_Glucose031103.htm (1170 words)

	Amino Acid Analysis
		Derivatization is performed automatically on the amino acid analyzer by reacting the free amino acids, under basic conditions, with phenylisothiocyanate (PITC) to produce phenylthiocarbamyl (PTC) amino acid derivatives (see Figure 1 and Figure 2).
		Following derivatization, a methanol solution containing the PTC-amino acids is transferred to a narrow bore HPLC system for separation.
		The PTC-amino acids are separated on a reverse phase C18 silica column and the PTC chromophore is detected at 254 nm.
	www.biotech.iastate.edu /facilities/protein/aaa.html (1093 words)

	Structural and Functional Consequences of Antigenic Modulation of Red Blood Cells With Methoxypoly(Ethylene Glycol) -- ...
		Stored RBC were found to be readily derivatized even after storage at 4°C for 0, 7, and 45 days (Fig 2).
		RBC were derivatized with 1.2 mmol/L cyanuric chloride-activated mPEG at 4°C for 30 minutes in PBS (pH 9.2).
		Finally, as shown in Fig 6, extensive derivatization of murine cells did result in foreshortened in vivo survival.
	www.bloodjournal.org /cgi/content/full/93/6/2121 (4063 words)

	Derivatized reduced malto-oligosaccharides
		In agreement with the described development, a malto-oligosaccharide is hydrogenated to thus get a hydrogenated malto-oligosaccharide, and the resultant hydrogenated malto-oligosaccharide is derivatized, suсh as through oxidаtion, esterification, etherification, оr enzymatic modification.
		The derivatization of suсh hydrogenated malto-oligosaccharides outcome in a amazingly small height of a formаtion of by-рrоduсts and рrоduсts of degradation.
		The resultant malto-oligosaccharide miхture next is derivatized to form a derivatized malto-oligosaccharide miхture.
	www.patentalert.com /docs/000/z00034901.shtml (126 words)

	The evaluation of 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) as a derivatizing reagent for fumonisin B(1) ... (Site not responding. Last check: 2007-10-15)
		The evaluation of 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) as a derivatizing reagent for fumonisin B(1) determination.
		HPLC procedures using derivatization of FB(1) and fluorescence detection are most commonly used.
		Studies on derivatization conditions indicated good derivative yields with AQC over a pH range of 8.0 to 10.0.
	www.aaccnet.org /meetings/2000/Abstracts/a00ma069.htm (284 words)

	Distinguishing amphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine from other sympathomimetic amines ...
		Misidentification of ephedrine and pseudoephedrine as methamphetamine has been reported because of similar retention times of their derivatives in gas chromatography as well as very similar mass spectral fragmentation patterns in the conventional electron impact mode of analysis.
		The derivatization is easily accomplished at room temperature by adding the derivatizing reagent in the extraction solvent because the reagent is stable in the presence of water.
		The electron impact mass spectrum of derivatized methamphetamine (base peak, m/z 144, other peaks at m/z 102, 58) is similar to the electron impact mass spectrum of both derivatized pseudoephedrine (base peak, m/z 144, other peaks, m/z 102, 58), and ephedrine (base peak, m/z 144, other peaks, m/z 102, 58).
	www.astm.org /JOURNALS/FORENSIC/PAGES/2609.htm (385 words)

	DERIVATIZED GOLD CLUSTERS AND ANTIBODY-GOLD CLUSTER CONJUGATES (Site not responding. Last check: 2007-10-15)
		In this invention, the derivatized Au and Au13 clusters are used to prepare antibody or antibody fragment conjugates potentially useful in diagnostic and therapeutic applications.
		Antibodies or active antibody fragments are covalently combined with a stable derivatized gold cluster.
		These antibody gold cluster conjugates retain the antibody specificity and activity, and may be useful in any electron microscopy study, diagnostic technique, antigen localization study or therapy that relies upon the delivery of an effective dose to a targeted site.
	www.bnl.gov /TECHXFER/tech_briefs/netlic8.html (345 words)

	Selenium derivatization and crystallization of DNA and RNA oligonucleotides for X-ray crystallography using multiple ...
		Selenium derivatization and crystallization of DNA and RNA oligonucleotides for X-ray crystallography using multiple anomalous dispersion -- Carrasco et al.
		for the halogen derivatization of DNA and RNA oligonucleotides
		Derivatization of DNA and RNA with selenium represents a new
	nar.oxfordjournals.org /cgi/content/full/32/5/1638 (4525 words)

	Session J7.8 (Site not responding. Last check: 2007-10-15)
		We review the results of spectral studies of the ultrafast excited-state absorption in fullerenes and derivatized fullerenes, which allow determination of both the spectral response of reverse saturable absorption (RSA) nonlinearities in these compounds, as well as the dynamical response for different morphologies.
		We find that by appropriate pretreatment, the optical limiting response of derivatized fullerene sol-gels can be enhanced to approach that of the same molecules in solution while significantly enhancing the damage threshold.
		The ultrafast absorption and optical limiting of these derivatived fullerenes will be compared with that of various porphyrin and phthalocyanine molecules as well as new broadband limiting materials which consist of phthalocyanines derivatized directly onto the fullerene molecule.
	www.mrs.org /meetings/fall97/abstract_book/J/node52.html (181 words)

	Monolayer and Epi-Flourescence Microscopy Studies of Amino Acid Derivatized Diacetylene Lipids (Site not responding. Last check: 2007-10-15)
		Examination of the amino acid derivatized diacetylene lipids showed a wide variety of surface characteristics with many novel properties.
		Decrease of pH results in attenuation of LE–LC phase transition in Gln-PDA monolayers due to charge screening, while temperature affects the monolayers through regular thermal agitation, and the effect is opposite to the thermal anomaly observed for the non-derivatized diacetylene lipids.
		EFM studies reveal that only the lipids derivatized with hydrophilic headgroups exhibit phase transition and domain formation, while those with hydrophobic headgroups do not easily form polymerizable matrices.
	stevens.scripps.edu /publications/62.htm (222 words)

	Chromatographia online - August 56 abstracts
		Many sulfoxide enantiomers could be baseline resolved using the derivatized cyclodextrin stationary phases in the reverse phase mode.The most important factor influencing enantioselectivity is the presence of steric bulk alpha to the chiral center.
		The derivatization products were injected directly into the liquid chromatograph and separated on an amino-functionalized silica gel column.T he performance of the method (detection limit, quantification limit, linearity, and relative standard deviation) was studied and the results obtained showed the method was suitable for routine analysis of glyphosate and AMPA.
		Thermal derivatization in the injection system was used for the identification and quantification of bis-GMA.Clean-up is not necessary using SIM mode.
	www.chromatographia.de /daten/august_56_abstracts.htm (2876 words)

	Structure and function in rhodopsin: Mass spectrometric identification of the abnormal intradiscal disulfide bond in ...
		Derivatizations as expected for ID cysteines in correctly folded (A) and misfolded (B) rhodopsins.
		Derivatization of Sulfhydryl Groups in Free Cysteines in Denatured Rhodopsin with NEM.
		Rhodopsins were derivatized at cysteines as in the strategy outlined above.
	www.pnas.org /cgi/content/full/98/9/4872 (3280 words)

	1ppacc
		These peptides were derivatized using the novel, fluorescent derivatizing agent, 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate.
		Derivatized peptides were detected using fluorescence and ultraviolet absorption signals, and underivatized peptides were detected using ultraviolet absorbance at 185 nm.
		Data are presented which compare the analysis of the derivatized and underivatized peptides.
	www.waters.com /WatersDivision/contentd.asp?ref=JDRS-5LWKMN (118 words)

	Early organization of pre-mRNA during spliceosome assembly - Nature Structural & Molecular Biology (Site not responding. Last check: 2007-10-15)
		We also prepared a pre-mRNA derivatized with Fe-BABE proximal to the 3' splice site (position 179), as well as two pre-mRNAs modified at position 148 in which elements required for splicing, the pyrimidine tract and the branch region were mutated to disrupt spliceosome assembly.
		This suggests that these regions are either positioned distal to one another throughout assembly of the spliceosome or they are occluded from one another by bound protein or RNA components of the pre-spliceosome and spliceosome.
		In contrast, E complex formation and 5' splice site cleavage are still observed in substrates derivatized in an analogous position but lacking a functional branch sequence (Fig.
	www.nature.com /cgi-taf/DynaPage.taf?file=/nsmb/journal/v9/n8/full/nsb822.html (4238 words)

	Dansyl Chloride Derivatization of Methamphetamine: A Method with Advantages for Screening and Analysis of ... (Site not responding. Last check: 2007-10-15)
		Urinary MP derivatized with DNC could be detected by visual observation of the fluorescence in a solid-phase extraction column such as a Sep-Pak® C18 cartridge to which the whole reaction solution was applied.
		MP derivatized with DNC could be determined by HPLC with ultraviolet detection.
		The intensity of the cartridge fluorescence due to DNC-derivatized MP was approximately related to the urinary content of MP determined by HPLC or GC–MS, although a false positive in the visual fluorescence was observed in some urinary specimens from healthy volunteers.
	www.jatox.com /abstracts/2002/jan-feb/17-oguri.htm (360 words)

	Methylation and carbamylation of human {gamma}-crystallins -- Lapko et al. 12 (8): 1762 -- Protein Science
		The expected y- and b-fragments for the peptide with both cysteines derivatized are given at the top.
		and 2-year-old lenses, and derivatization of the cysteines with
		B-crystallin from the nucleus of a 19-year-old lens after derivatization with 4-vinylpyridine and isolation by reversed-phase HPLC.
	www.proteinscience.org /cgi/content/full/12/8/1762 (4946 words)

	Derivatized biotin compounds and methods of use (US6242610)
		The derivatized biotin acts as a stable analog of the carboxyphosphate intermediate in naturally-occurring biotin-mediated CO2 transfer.
		Amspacher, D. et al., "The Synthesis of a Slow-Binding Inhibitor of Biotin Carboxylase via a Selective Derivatization of Biotin," Poster presented at 216th American Chemical Society National Meeting (Boston, Aug. 23-27, 1998).
		Amspacher, D. et al., "The Synthesis of a Slow-Binding Inhibitor of Biotin Carboxylase via a Selective Derivatization of Biotin," Newsletter and Abstracts, 216th American Chemical Society National Meeting (Boston, Aug. 23-27, 1998).
	www.delphion.com /details?&pn=US06242610__ (452 words)

	Biological Activity of Reducing-End-Derivatized Oligogalacturonides in Tobacco Tissue Cultures -- Spiro et al. 116 (4): ...
		Oligogalacturonides derivatized with tyramine or biotin-x-hydrazide (6-[biotinoylamino] caproic acid hydrazide) at C-1 of
		We determined the effect of derivatized and underivatized oligogalacturonides on TCL explants cultured in transition medium
		Derivatization or modification of the reducing end of oligogalacturonides significantly reduced their biological activity
	www.plantphysiol.org /cgi/content/full/116/4/1289 (4292 words)

	CAAT: 1997-1998 Grants - Streilein (Site not responding. Last check: 2007-10-15)
		For hapten-specificity control, some fresh PBMC were derivatized with 0.1% oxazolone; negative control cells were treated with acetone alone.
		Autologous mixed lymphocyte reactions (AMLR) were then set up using purified T cells as responder cells (10,000 cells/well) and fresh or cultured PBMC that had been derivatized or not, and irradiated (2000 rads) were used as stimulator cells.
		Whether derivatized or not, they can significantly activate autologous naive T cells.
	caat.jhsph.edu /programs/grants/97-98grants/streilein.htm (490 words)

	Southern blotting & hybridization (Site not responding. Last check: 2007-10-15)
		In Southern blotting, denatured DNA is transferred from an electrophoresis gel to a sheet of nitrocellulose or derivatized nylon.
		The exploded view at left shows that transfer is accomplished by the flow of buffer through wick, gel, sheet and into adsorbent paper layers.
		DNA is retained by the derivatized nylon or nitrocellulose.
	opbs.okstate.edu /~melcher/MG/MGW4/MG423.html (255 words)

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