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Topic: Dermatofibrosarcoma protuberans

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	Dermatofibrosarcoma Protuberans (DFSP) - Dr Sampurna Roy MD
		Dermatofibrosarcoma protuberans is a fibrohistiocytic tumour of intermediate malignancy,characterized by a distinctive storiform growth pattern and frequent local recurrences.
		Dermatofibrosarcoma protuberans with fibrosarcomatous areas: a clinico-pathologic and immunohistochemic study in four cases.
		Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma Group.
	www.histopathology-india.net /DFSP.htm (871 words)

	Dermatofibrosarcoma Protuberans
		Dermatofibrosarcoma protuberans is genetically characterized by the unbalanced chromosomal t(17;22)(q21;q13), usually in the form of a supernumerary ring chromosome.
		Dermatofibrosarcoma protuberans (DFSP) is a dermal and subcutaneous tumor categorized as a tumor of intermediate malignancy, and its progression in some cases to fibrosarcoma is well known.
		Dermatofibrosarcoma protuberans (DFSP) is a fibrohistiocytic tumor of intermediate malignancy characterized by a distinctive storiform growth pattern and frequent local recurrences.
	www.thedoctorsdoctor.com /diseases/dfsp.htm (6720 words)

	Dermatofibrosarcoma Protuberans
		Dermatofibrosarcoma protuberans is a rare type of malignant tumor that occurs in the dermis, the second layer of the skin.
		Dermatofibrosarcoma protuberans is a slow-growing tumor that is most commonly seen on the trunk of the body (chest, abdomen, and back), but can also occur on the arms, legs, head, neck, hands, or feet.
		Dermatofibrosarcoma protuberans has a high recurrence rate because the tumor has many projections beyond the main mass that may be left behind when the tumor is removed.
	www.hmc.psu.edu /healthinfo/d/dermatofibrosarcomaprotuberans.htm (547 words)

	Dermatofibrosarcoma Protuberans
		Dermatofibrosarcoma protuberans (DFSP) is a rare variety of mesenchymal tumour arising from dermis.
		Dermatofibrosarcoma protuberans (DFSP) is a relatively unusual, highly invasive locally aggressive cutaneous tumour of intermediate malignancy.
		Dermatofibrosarcoma protuberans metastatic to a regional lymph node.
	www.bhj.org /journal/2003_4502_april/dermatofibrosarcoma_370.htm (1002 words)

	[No title] (Site not responding. Last check: 2007-10-08)
		Dermatofibrosarcoma protuberans is a rare cutaneous soft tissue neoplasm with the potential for intermediate malignancy, and is characterized by local invasion and recurrence.
		Dermatofibrosarcoma protuberans mimicking a primary breast lesion has not previously been reported in Korea.
		We report on the case of a 28-year-old female patient with dermatofibrosarcoma protuberans on one of her breasts, which is a very unusual site.
	www.radiology.or.kr /journal/view.php?page=&number=5412&year=2004&vol=51&page=103&mode_title=1 (126 words)

	Medical Dictionary: Dermatofibrosarcoma protuberans - WrongDiagnosis.com
		Dermatofibrosarcoma protuberans: An intermediate cutaneous fibrohistiocytic neoplasm, presenting as a nodular cutaneous mass, most often on the trunk and the proximal extremities.
		Dermatofibrosarcoma protuberans is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Dermatofibrosarcoma protuberans, or a subtype of Dermatofibrosarcoma protuberans, affects less than 200,000 people in the US population.
	www.wrongdiagnosis.com /medical/dermatofibrosarcoma_protuberans.htm (310 words)

	[No title]
		Dermatofibrosarcoma protuberans of the scalp is a very rare but well known clinical entity.
		Dermatofibrosarcoma protuberans: a clinicopathological study in an African population.
		Dermatofibrosarcoma protuberans: an analysis of 86 cases--five with metastasis.
	www.ispub.com /ostia/index.php?xmlPrinter=true&xmlFilePath=journals/ijs/vol4n2/scalp.xml (2225 words)

	Dermatofibrosarcoma protuberans of scalp : a case report., Sinha VD, Dharker SR, Kalra GS: Neurol India
		Dermatofibrosarcoma protuberans of scalp : a case report., Sinha VD, Dharker SR, Kalra GS: Neurol India
		Dermatofibrosarcoma protuberans of scalp : a case report.
		A case of dermatofibrosarcoma protuberans of scalp involving the underlying bone, operated after recurrence by taking safety margin of 3 cm and skin deficit covered by transposition flap, is being reported.
	www.neurologyindia.com /article.asp?issn=0028-3886;year=2001;volume=49;issue=1;spage=81;epage=3;aulast=Sinha;type=0 (82 words)

	Cancer Resources—Cancer News, Cancer Conferences, Cancer Causes, Cancer Prevention
		NEW YORK (Reuters Health) - Therapy with imatinib mesylate (Gleevec; Novartis Pharmaceuticals) led to a "dramatic response" in a patient with metastatic dermatofibrosarcoma protuberans, according to a case report in the September 1st issue of the Journal of Clinical Oncology.
		Dermatofibrosarcoma protuberans is caused by activation of the platelet-derived growth factor B receptor, a transmembrane tyrosine kinase, Dr. Rubin, of the University of Washington Medical Center, Seattle, and colleagues note.
		The investigators therefore treated their patient, a 25-year-old man with unresectable metastatic dermatofibrosarcoma protuberans, with the tyrosine kinase inhibitor imatinib mesylate.
	www.oncolink.upenn.edu /resources/article.cfm?c=3&s=8&ss=23&id=8879&month=09&year=2002 (358 words)

	eMedicine - Dermatofibrosarcoma Protuberans : Article by Chih-Shan Jason Chen, MD, PhD (Site not responding. Last check: 2007-10-08)
		Dermatofibrosarcoma protuberans manifests as an irregular plaque on the chest.
		Gisselsson D, Hoglund M, O'Brien KP, et al: A case of dermatofibrosarcoma protuberans with a ring chromosome 5 and a rearranged chromosome 22 containing amplified COL1A1 and PDGFB sequences.
		Naeem R, Lux ML, Huang SF, et al: Ring chromosomes in dermatofibrosarcoma protuberans are composed of interspersed sequences from chromosomes 17 and 22.
	www.emedicine.com /derm/topic97.htm (2395 words)

	Recurrent dermatofibrosarcoma protuberans treated with Mohs micrographic surgery
		We present the case of a 68-year-old woman with a recurrent dermatofibrosarcoma protuberans on the neck and the upper back, surgically treated four times over a yearlong period.
		The dermatofibrosarcoma protuberans is a locally aggressive and highly recurrent malignant neoplasm of dermal origin.
		A 68-year-old woman was affected by dermatofibrosarcoma protuberans extending from the posterior cervical region to the left upper part of the back (Fig.
	www.mf.uni-lj.si /acta-apa/acta-apa-00-4/kodric.html (1262 words)

	Dissertations from Karolinska Institutet - Published by Karolinska Institutet Karolinska Institutet - ki.se
		Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are rare invasive tumors of the dermis.
		A case of dermatofibrosarcoma protuberans with a ring chromosome 5 and a rearranged chromosome 22 containing amplified COL1A1 and PDGFB sequences.
		A case of dermatofibrosarcoma protuberans of the vulva with a COL1A1/PDGFB fusion identical to a case of giant cell fibroblastoma.
	diss.kib.ki.se /2000/91-628-4017-7 (790 words)

	Congenital dermatofibrosarcoma protuberans with fibrosarcomatous and myxoid change -- Gu et al. 58 (9): 984 -- Journal ...
		Congenital dermatofibrosarcoma protuberans with fibrosarcomatous and myxoid change -- Gu et al.
		Fibrosarcomatous ("high-grade") dermatofibrosarcoma protuberans: clinicopathologic and immunohistochemical study of a series of 41 cases with emphasis on prognostic significance.
		Involvement of chromosomes 17 and 22 in dermatofibrosarcoma protuberans.
	jcp.bmjjournals.com /cgi/content/full/58/9/984 (991 words)

	Dermatofibrosarcoma protuberans in two patients with acquired immunodeficiency syndrome.
		Dermatofibrosarcoma protuberans in two patients with acquired immunodeficiency syndrome.
		Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive cutaneous tumor of intermediate malignancy.
		Dermatofibrosarcoma protuberans was confirmed in both cases by the histopathologic and immunohistochemical findings.
	www.aegis.com /aidsline/2000/may/A0051666.html (356 words)

	Arch Dermatol -- Abstract: Dermatofibrosarcoma protuberans with lymph node and pulmonary metastases, April 1978, Kahn ... (Site not responding. Last check: 2007-10-08)
		Arch Dermatol -- Abstract: Dermatofibrosarcoma protuberans with lymph node and pulmonary metastases, April 1978, Kahn et al.
		Dermatofibrosarcoma protuberans with lymph node and pulmonary metastases
		Dermatofibrosarcoma protuberans is a locally aggressive histiocytic tumor
	archderm.ama-assn.org /cgi/content/abstract/114/4/599 (113 words)

	TelePathology Consultants, PC - Diagnosis of Forum Case 2
		Giant cell fibroblastomas vary in cellularity from those resembling dermatofibrosarcoma protuberans to those that are hypocellular with a predominant myxoid or hyaline stroma.
		Dermatofibrosarcoma protuberans may share some of the myxoid changes and the presence of giant atypical cells as seen in giant cell fibroblastoma.
		Based on similarities found on morphological studies, tumor recurrence and immunohistochemical markers, of both dermatofibrosarcoma protuberans and giant cell fibroblastoma, some authors have raised the possibility of a common origin.
	www.telepathology.com /cases/forum/dxcase2.htm (578 words)

	2004 Society for Ultrastructural Pathology Handout #2
		Dermatofibrosarcoma protuberans and its fibrosarcomatous variant with areas of myoid differentiation: a report of three cases.
		Translocation, t(1722)(q22q13), in dermatofibrosarcoma protuberans: a new tumor-associated chromosome rearrangement.
		Supernumerary ring chromosome in a Bednar tumor (pigmented dermatofibrosarcoma protuberans) is composed of interspersed sequences from chromosomes 17 and 22: a fluorescence in situ hybridization and comparative genomic hybridization analysis.
	www.uscap.org /site~/93rd/companion22h2.htm (10793 words)

	dermatofibrosarcoma protuberans, polymophic, page1 (Site not responding. Last check: 2007-10-08)
		There is evidence that dermatofibrosarcoma protuberans (DFSP) is composed of some type of spindle cell of the peripheral nerve unit rather than of ordinary fibroblasts.
		Diverse mophologic patterns are encountered in other tumors of such derivation (malignant peripheral nerve sheath tumors, malignant schwannomas, Triton tumors, ossifying fibromyxoid tumors, etc.), so it is not surprising that diverse patterns are found in occasional examples of dermatofibrosarcoma protuberans.
		The usual degree of dermal thickening is seen to the right of the 'atrophic' area.The pattern of infiltration of the fat (honeycomb pattern) is very characteristic of DFSP but can be seen in fibrous hamartomas of infancy and a few other tumors.
	www.bweems.com /dfsppolypg1.html (416 words)

	Letters to the Editor - September 15, 2000 - American Family Physician
		Dermatofibrosarcoma protuberans (DFSP) is an uncommon, but not rare, aggressive soft tissue sarcoma arising in the dermis, with a high recurrence rate and a low metastatic potential.
		The tumor usually presents in young to middle-aged adults (20 to 50 years of age) and is rare in childhood or at birth.
		Lopes JM, Paiva ME. Dermatofibrosarcoma protuberans: a histological and ultrastructural study of 11 cases with emphasis on the study of recurrences and histogenesis.
	www.aafp.org /afp/20000915/letters.html (1558 words)

	dermatofibrosarcoma protuberans
		In April of this year, Hickey was diagnosed with dermatofibrosarcoma protuberans, a locally aggressive and extremely rare form of skin cancer.
		Dermatofibrosarcoma protuberans [24,25] t(17;22) Platelet-derived growth factor b-chain (PDGFB) gene on chromosome 17 and collagen type I alpha 1 (COL1A1) on...
		Cancer.gov - Dictionary...dermatofibrosarcoma protuberans (DER-ma-toe-FI-bro-sar-KO-ma pro-TOO-ber-anz) A type of tumor that begins as a hard nodule and grows slowly.
	www.cancer-help.org /cancer/0604/dermatofibrosarcoma_protuberans.html (413 words)

	Article : Dermatofibrosarcoma Protuberans (DFSP) — CT Findings in DFSP — A Rare Skin Tumour ; Author : R Shrimali ; ... (Site not responding. Last check: 2007-10-08)
		Taylar HB, Helwig EB, Dermatofibrosarcoma protuberans – A Study of 115 cases.
		Rutgers E, Kroon BBR, Albus-lutter CE, Gortzak E, Dermatofibrosarcoma protuberans: treatment and prognosis, European Journal of Surgical Oncology 1992; 18:241-248.
		Miyakawa E, Fujimoto H, Miyakawa K, Nemoto K et al, Dermatofibrosarcoma protuberans – CT findings with pathologic correlation in 6 cases.
	www.ijri.org /articles/archives/2002-12-3/abdominal_357.htm (670 words)

	Bioline International Official Site (site up-dated regularly)
		Dermatofibrosarcoma protuberans (DFSP) is a rare, slow growing, locally aggressive dermal tumor of disputed histogenesis with a marked tendency for local recurrence.
		Histopathologically, dermatofibrosarcoma protuberans has a monomorphous appearance with thin spindle cells, no or mild nuclear atypia with fewer secondary elements like giant and inflammatory cells than either benign or malignant fibrohistiocytoma.
		The atrophic variant of dermatofibrosarcoma protuberans in childhood: A report of six cases.
	www.bioline.org.br /request?dv04106 (1102 words)

	eMedicine - Dermatofibrosarcoma Protuberans : Article Excerpt by: Chih-Shan Jason Chen, MD, PhD (Site not responding. Last check: 2007-10-08)
		Background: Dermatofibrosarcoma protuberans (DFSP) is a relatively uncommon soft tissue neoplasm with intermediate-to-low grade malignancy.
		Although DFSP may have been reported in the literature as early as 1890, Darier and Ferrand first described it in 1924 as a distinct cutaneous disease entity called progressive and recurring dermatofibroma.
		Hoffman officially coined the term dermatofibrosarcoma protuberans in 1925.
	www.emedicine.com /derm/byname/dermatofibrosarcoma-protuberans.htm (444 words)

	Transformed dermatofibrosarcoma protuberans: a clinicopathological study of eight cases -- Szollosi and Nemes 58 (7): ...
		(B) Fibrosarcomatous transformation of dermatofibrosarcoma protuberans; the transition to fibrosarcomatous area was gradual and subtle (case 2).
		Dermatofibrosarcoma protuberans: an analysis of 86 cases—five with metastasis.
		Dowd JO, Laidler P. Progression of dermatofibrosarcoma protuberans to malignant fibrous histiocytoma: report of a case with implications for tumor histogenesis.
	jcp.bmjjournals.com /cgi/content/full/58/7/751 (2816 words)

	Dermatofibrosarcoma - Outcome of patients with primary or recurrent dermatof...
		Dermatofibrosarcoma - Outcome of patients with primary or recurrent dermatof...
		Outcome of patients with primary or recurrent dermatofibrosarcoma protuberans analyzed
		The outcome of patients with primary or recurrent dermatofibrosarcoma protuberans (DFSP) was analyzed.
	www.newsrx.com /newsletters/Cancer-Weekly/2006-01-10/01102006333171CW.html (344 words)

	Dermatofibrosarcoma Protuberans: Reappraisal of Wide Local Excision and Impact of Inadequate Initial Treatment -- ...
		Dermatofibrosarcoma Protuberans: Reappraisal of Wide Local Excision and Impact of Inadequate Initial Treatment -- Khatri et al.
		Dermatofibrosarcoma Protuberans: Reappraisal of Wide Local Excision and Impact of Inadequate Initial Treatment
		Dermatofibrosarcoma Protuberans Treated at a Single Institution: A Surgical Disease With a High Cure Rate
	www.annalssurgicaloncology.org /cgi/content/abstract/10/9/1118 (378 words)

	Recurrent Dermatofibrosarcoma Protuberans of the Scalp
		Lopez JI, Elizalde JM, Fernandez Larrinoa A. Pigmented dermatofibrosarcoma protuberans (Bednar tumour).
		Das L, Grover SB, Chand K, Dawson L. Intracranial extension of a dermatofibrosarcoma protuberans of the scalp: a case report with brief review of literature.
		Revision surgery in dermatofibrosarcoma protuberans of the trunk and extremities.
	www.ispub.com /ostia/index.php?xmlFilePath=journals/ijs/vol4n2/scalp.xml (2201 words)

	Article
		Abstract: Dermatofibrosarcoma protuberans (DFSP) is a highly recurrent low-grade soft tissue sarcoma, which is usually located on the trunk.
		In a review of the literature there were several reports of patients with dermatofibrosarcoma with histologically documented metastasis.
		We present a case of dermatofibrosarcoma protuberans first time reported in the literature with metastasis to the testis evaluated by Colour Doppler sonography.
	dx.doi.org /10.2298/AOO0201033C (113 words)

	derma.de \| Das Informationsangebot der deutschsprachigen Dermatologie
		Das lokale infiltrative Wachstum des Dermatofibrosarcoma protuberans ist gekennzeichnet durch asymmetrische, subklinische Ausläufer, besonders häufig langstreckig (bis mehrere cm, in einem Fall bis 7 cm) in horizontaler Richtung.
		Parker TL, Zitelli JA (1995) Surgical margins for excision of dermatofibrosarcoma protuberans.
		Schmoeckel C, Albini A, Krieg T, Stets R (1985) The fibroblastic nature of dermatofibrosarcoma protuberans: morphological investigations in vivo and in vitro.
	www.derma.de /84.0.html (1187 words)

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