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Topic: Desflurane

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	MedlinePlus Drug Information: Desflurane (Inhalation-Systemic) (Site not responding. Last check: 2007-10-19)
		Desflurane (DES-flure-ane) belongs to the group of medicines known as general anesthetics (an-ess-THET-iks).
		Desflurane is used to cause general anesthesia (loss of consciousness) before and during surgery.
		However, desflurane caused other unwanted effects in the animal fetus when given for many days in a row in amounts that were large enough to cause harmful effects in the mother.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202685.html (967 words)

	Winterlude Symposium 1994 - Variable-Bypass Vaporizers and the Desflurane Vaporizer
		Winterlude Symposium 1994 - Variable-Bypass Vaporizers and the Desflurane Vaporizer
		The heated sump assembly serves as a reservoir of desflurane vapor.
		The spring seals the bottle until it is engaged in the filler port of the vaporizer.
	www.anesthesia.org /winterlude/wl94/wl94_9.html (1626 words)

	Desflurane ( Suprane ) (Site not responding. Last check: 2007-10-19)
		Desflurane is resistant to chemical degradation and undergoes negligible metabolism (approximately equal to 10% of that seen with isoflurane).
		Desflurane 'wash-out' is approximately equal to 2 to 2.5 times faster than that of isoflurane in the first 2 hours after discontinuation of anaesthesia.
		Comparative studies of desflurane and propofol, and other inhalation agents, indicate that the times to toleration of oral fluids, sitting and discharge from recovery room are similar, regardless of the general anaesthetic agent administered.
	www.general-anaesthesia.com /desflurane.html (419 words)

	Data Sheet
		Desflurane is one of a family of halogenated methylethylethers which is administered by inhalation producing a dose-related, reversible loss of consciousness and of pain sensations, suppression of voluntary motor activity, modification of autonomic reflexes and sedation of respiration and the cardiovascular system.
		Desflurane is not recommended for use as an inhalational induction agent in paediatric patients because of the frequent occurrence of cough, breath holding, apnoea, laryngospasm and increased secretions in children under 12 years.
		Desflurane appears to produce coronary vasodilation at arteriolar level in selected animal models, in a similar fashion to that of isoflurane.
	www.medsafe.govt.nz /Profs/datasheet/s/Supraneliq.htm (2216 words)

	TheMediWeb (Site not responding. Last check: 2007-10-19)
		Desflurane produces concentration related respiratory and cardiovascular depression in spontaneously breathing patients and hypotension in ventilated patients with hypercarbia and hypoxia.
		Administration of desflurane should be stopped, the airway should be checked to ensure it is open and assisted or controlled ventilation with pure oxygen should be maintained along with adequate haemodynamics.
		Concentrations of 1-4% of desflurane in a mixture of nitrous oxide and oxygen havebeen used successfully in patients with chronic renal/hepatic impairment and duringrenal transplantation surgery.
	www.themediweb.net /pharmacy/Desflurane.htm (884 words)

	Physiologic Effects of Anesthesic and Analgesic Agents
		Desflurane differs from isoflurane by the substitution of a chloride atom with a fluoride atom at the alpha-ethyl component of the molecule.
		Desflurane is extremely volatile, a characteristic that necessitated the development of a new vaporizer for its use.
		Desflurane causes a dose-dependent increase in heart rate at deep levels while isoflurane increases rate at all levels of anesthesia.
	info.med.yale.edu /yarc/vcs/anesthesiaeffect.htm (11447 words)

	Economic value of Desflurane in comparison to Isoflurane in Low Flow Anesthesia (Site not responding. Last check: 2007-10-19)
		Desflurane is one of the new anesthetics characterized by a low blood solubility, which allows a rapid saturation of the blood.
		If Desflurane is used in high fresh gas flows, the high concentrations require large amounts of the volatile anesthetic, and therefore -depending upon the fresh gas flow- entail high expenses.
		From theoretical considerations of the pharmacokinetics of Desflurane an economic advantage is postulated in closed circle systems [3,6], but also in low flow anesthesia with fresh gas flows of 1 l/min and less an economical advantage should be possible [5].
	gasnet.med.yale.edu /esia/1998/may/economic.html (1566 words)

	Desflurane and isoflurane have similar effects on cerebral blood flow in patients with intracranial mass lesions.
		Desflurane and isoflurane have similar effects on cerebral blood flow in patients with intracranial mass lesions.
		Desflurane and isoflurane have similar effects on cerebral blood flow in patients with intracranial mass lesions.In 15 patients, an additional measurement at 1.25 MAC was made before closure.
		BACKGROUND: Before desflurane is advocated for patients undergoing neurosurgical procedures, it is necessary to determine the effect of desflurane on cerebral blood flow (CBF).
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/7658796.html (303 words)

	High concentrations of isoflurane do not block the sympathetic nervous system activation from desflurane -- Ebert et ...
		DESFLURANE is one of the new potent volatile anesthetics with
		FIGURE 3 This is a tracing from one of the three subjects with an intact nerve recording during the transition from isoflurane to desflurane anesthesia.
		Rapid increase in desflurane concentration is associated with greater transient cardiovascular stimulation than with rapid increase in isoflurane concentration in humans.
	www.cja-jca.org /cgi/content/full/48/2/133 (2008 words)

	DESFLURANE - (Organic Method #106) (Site not responding. Last check: 2007-10-19)
		Desflurane was not included in Method 103 because it required different analytical conditions.
		Desflurane is a new organic anesthetic gas and may be found in operating rooms, teaching hospitals, dental offices, and veterinary hospitals.
		The amount of desflurane per sample is obtained from the appropriate calibration curve in terms of micrograms per sample, uncorrected for desorption efficiency.
	www.skcinc.com /nioshdbs/oshameth/org106/org106.htm (4037 words)

	Review Of Currently Used Inhalation Anesthetics
		Desflurane is therefore known to be an airway irritant.
		Because the metabolism of enflurane, isoflurane or desflurane is much less than the one of halothane, fulminant hepatic necrosis occurs to a much lesser extent.
		Desflurane may cause coughing during induction and should therefore be combined with intravenous anesthetics.
	www.ispub.com /ostia/index.php?xmlFilePath=journals/ija/vol3n3/inhal2.xml (2302 words)

	Newsletter (Site not responding. Last check: 2007-10-19)
		Desflurane is a newer anaesthetic which may reduce recovery time, but because of its novelty, any potential benefits may be offset by its cost.
		The purpose of this study is to determine whether desflurane- and isoflurane-based anaesthesia differ in cost, and if so, if there are any benefits associated with using one agent over the other.
		Thus, the primary objective of this study is to determine the intraoperative and postoperative drug costs associated with desflurane anaesthesia compared to isoflurane anaesthesia in daycare patients undergoing arthroscopic menisectomy.
	www.cpro.ubc.ca /OldCpro/newslettera99cost.html (557 words)

	Desflurane does not accelerate recovery from operations of short duration: a practice audit: [Le desflurane n'accelere ...
		Desflurane does not accelerate recovery from operations of short duration: a practice audit: [Le desflurane n'accelere pas la recuperation apres une operation de courte duree : un audit clinique] -- Tessler et al.
		DESFLURANE is advocated to be a superior inhalation anesthetic
		Kinetics and potency of desflurane (I-653) in volunteers.
	www.cja-jca.org /cgi/content/full/51/3/222 (1799 words)

	bibliographie s...
		The role of desflurane in the practice of anesthesia [editorial].
		An overview of induction and emergence characteristics of desflurane in pediatric, adult, and geriatric patients.
		Metabolism of desflurane and isoflurane to fluoride ion in surgical patients.
	www.sitanest.net /bibliohalo/s.htm (891 words)

	Desflurane, compared to halothane, augments phenylephrine-induced contraction in isolated rat aorta smooth muscle -- ...
		Desflurane, compared to halothane, augments phenylephrine-induced contraction in isolated rat aorta smooth muscle -- Griffin et al.
		Desflurane is a relatively new volatile anesthetic agent.
		and catecholamine release in response to rapidly increased desflurane
	www.cja-jca.org /cgi/content/full/48/4/361 (2898 words)

	Sito dedicato allo studio ed alla divulgazione dell'anestesia inalatoria
		La potenza del desflurane inoltre permette la somministrazione di alte concentrazioni di ossigeno, permettendo così il suo uso in pazienti con funzionalità polmonare limitata, tra cui quelli che richiedono il collassamento di un polmone.
		Il desflurane può essere utile in neurochirurgia perchè le concentrazioni solitamente usate in clinica causano solo un modico aumento del flusso ematico cerebrale e della pressione intracranica similmente all’isoflurane.
		Desflurane and isoflurane produce similar alterations in systemic and pulmonary hemodynamics and arterial oxygenation in patients undergoing one-lung ventilation during thoracotomy.Anesth Analg 1998;84(1):800-7.
	www.desflurane.it /12.html (4598 words)

	Drug Discovery & Development (Site not responding. Last check: 2007-10-19)
		Researchers at The Children's Hospital used desflurane, an anesthetic gas, on piglets that underwent a low-flow type of cardiopulmonary bypass at one week of age.
		Studies showed that the animals that received desflurane were better able to walk and feed, and had less injury to brain tissue, compared to piglets that received a combination of the liquid anesthetics fentanyl and droperidol.
		Desflurane is a medication routinely used as an anesthetic, but now has been shown to also function as a neurological protector as well.
	www.dddmag.com /PRArchivebyIssue.aspx?RELTYPE=BRK&YEAR=2003&MONTH=03 (767 words)

	SSM Online - News
		The Children’s Hospital of Philadelphia used desflurane, an anesthesia gas, on piglets that underwent a low-flow type of cardiopulmonary bypass at one week of age.
		The animals that received desflurane were better able to walk and feed and had less injury to brain tissue than piglets that received liquid anesthesia medications, a combination of fentanyl and droperidol.
		The researchers remain uncertain about the process by which desflurane improved neurologic outcomes in their study, although they speculate that it may decrease the amount and effects of deleterious amino acids in the brain.
	www.ssmonline.org /News/ViewRelease.asp?ReleaseID=2867 (471 words)

	WSAVA 2001 - CARDIORESPIRATORY EFFECTS OF DESFLURANE ANESTHESIA IN HYPOVOLEMIC DOGS
		Procedure: Desflurane was delivered by face mask until endotracheal intubation could be performed.
		CVP decreased after hypovolemia and was not affected by desflurane.
		Both Ht and Hb were below normal values and decreased during desflurane anesthesia; pH and K+ were lower at induction reaching normal values at M2.
	www.vin.com /VINDBPub/SearchPB/Proceedings/PR05000/PR00544.htm (218 words)

	ASA: Desflurane at High Concentrations Appears to Have More Adverse Events Than Sevoflurane
		Investigator Hariharan Shankar, MD, Pain Management Fellow, Department of Anesthesiology Medical College of Wisconsin in Milwaukee, Milwaukee, Wisconsin, said that the genesis of the study was a report last year that the two drugs had equivalent and minimal effects on airway irritation, at least at relatively low concentrations.
		But after the mask cuff was re-inflated and the anesthetic concentration was increased to a MAC equivalent of 2, desflurane patients showed significantly more responses.
		He concluded that desflurane irritates the airway enough so that its use could be a problem in some patients, especially at higher concentrations.
	www.docguide.com /dg.nsf/PrintPrint/DC21F61F124E035485256F3A00680CB2 (486 words)

	Larsen
		Before the induction of anesthesia, the patients of the desflurane and sevoflurane groups received fentanyl 2 microg/kg.
		In all groups, anesthesia was induced with propofol and maintained either with remifentanil 0.25 microg x kg(-1) x min(-1), desflurane, or sevoflurane 0.85 MAC with 65% nitrous oxide in oxygen.
		Thirty min after anesthesia administration, patients in the remifentanil-propofol and in the desflurane groups gave significantly more correct responses in the DSST compared with sevoflurane (remifentanil 87%, desflurane 83%, sevoflurane 56%), the impairment in the sevoflurane patients corresponding to the effects of a blood alcohol level of approximately 0.1% and, thus, being of clinical importance.
	www.sivauk.org /Education/Larsen1.htm (378 words)

	Government and academic resources on DESFLURANE (Site not responding. Last check: 2007-10-19)
		DESFLURANE - (Organic Method #106): The recoveries of desflurane from samples used in the 18- and 16-day...
		Michael Wilson's Abstracts: The remaining four molecules - cyclopropane, nitrous oxide, isoflurane and desflurane - are non-amphiphilic and polar or weakly polar.
		Virtual Mass Spectrometry Laboratory: Desflurane, C 3 H 2 F 6 O. Like sevoflurane, the amount of time that it takes for a patient to awaken from desflurane induced anesthesia is quite small.
	drugs.mongabay.com /ingredients/DESFLURANE.html (585 words)

	Suprane Online, Description, Chemistry, Ingredients - Desflurane - RxList Monographs
		SUPRANE® (desflurane, USP), a nonflammable liquid administered via vaporizer, is a general inhalation anesthetic.
		Desflurane is nonflammable as defined by the requirements of International Electrotechnical Commission 601-2-13.
		Desflurane is a colorless, volatile liquid below 22.8°C. Data indicate that desflurane is stable when stored under normal room lighting conditions according to instructions.
	www.rxlist.com /cgi/generic2/desflurane.htm (168 words)

	eriksson
		We studied the effect of combining prophylactic ondansetron (4 mg intravenously [IV]) to desflurane-based anesthesia in 90 ASA grade I or 11 women undergoing outpatient gynecological laparoscopy.
		Control groups received a similar desflurane anesthetic (placebo) or a propofol-infusion-based (active control) anesthetic.
		The total incidence of PONV in the desflurane-only group was 80% (P < 0.01), compared to 40% and 20% in the desflurane group receiving ondansetron and the propofol group, respectively.
	www.sivauk.org /Education/eriksson.htm (254 words)

	Inhaled anaesthetics: desflurane and sevoflurane (Site not responding. Last check: 2007-10-19)
		However, in contrast to desflurane, at concentrations exceeding 1 MAC sevoflurane has little or no respiratory irritant properties and may be used to rapidly induce anesthesia.
		Neither anesthetic seems to materially affect heart rate at concentrations lower than MAC, but at higher concentrations desflurane, but not sevoflurane, may increase heart rate.
		Desflurane strongly resists biodegradation and degradation by soda lime, whereas sevoflurane is vulnerable to degradation and the degradation by soda lime or Baralyme produces a toxic product.
	www.ether.org /inhaled-anaesthetic.html (175 words)

	DARE abstract952015 (Site not responding. Last check: 2007-10-19)
		To estimate the mean decrease in time to following commands during awakening when desflurane was used instead of isoflurane or propofol and to examine the mean decrease in time to hospital discharge after ambulatory surgery where desflurane was compared to propofol.
		Patients who received desflurane followed commands a mean of 4.4 minutes (95% CI 3.3 to 5.4 minutes) earlier than patients who received isoflurane.
		The studies comparing desflurane to isoflurane differed in a number of ways; however, the results of the studies were still pooled.
	nhscrd.york.ac.uk /online/dare/952015.htm (521 words)

	CiteULike: A rapid increase in the inspired concentration of desflurane is not associated with epileptiform ... (Site not responding. Last check: 2007-10-19)
		CiteULike: A rapid increase in the inspired concentration of desflurane is not associated with epileptiform encephalogram.
		A rapid increase in the inspired concentration of desflurane is not associated with epileptiform encephalogram.
		It is not known whether this is associated with epileptiform EEG similar to S. We studied EEG and heart rate (HR) during rapidly increased concentrations of S or D in 31 females during the postintubation period of anesthesia.
	www.citeulike.org /user/Terkko/article/272115 (344 words)

	ELECTROENCEPHALOGRAPHIC EFFECTS OF DESFLURANE DURING SURGICAL STIMULATION (Site not responding. Last check: 2007-10-19)
		To obtain clinical relevant data, we examined the effect of desflurane on several univariate EEG parameters during surgery.
		Between opening and closure of the peritoneum desflurane vapor settings were randomly varied between 0.5 and 1.6 MAC, as long as a clinically adequate depth of anesthesia was maintained.
		Cortical activity was monitored with a 3 lead EEG, which was analyzed to yield the median and the 95% quantile of the power spectrum (SEF 95) and the bispectral index (BIS; Aspect A-1000).
	www.meb.uni-bonn.de /kai/paper/hr1.htm (313 words)

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