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Desmopressin - Wikipedia, the free encyclopedia Desmopressin (1-desamino-8-d-arginine vasopressin) is a modified form of the normal human hormone arginine vasopressin, an octapeptide (a chain of eight amino acids). Desmopressin is used to reduce urine production in central diabetes insipidus patients and to promote the release of von Willebrand factor and factor VIII in patients with coagulation disorders such as type I von Willebrand disease, mild hemophilia A, and thrombocytopenia. Desmopressin is not effective in the treatment of hemophilia B or severe hemophilia A. It may also be prescribed to reduce frequent bedwetting episodes in children by decreasing noctural urine production. en.wikipedia.org /wiki/Desmopressin   (287 words)

Desmopressin Acetate Injection Drug Information Desmopressin Acetate Injection DESMOPRESSIN ACETATE has been shown to be more potent than arginine vasopressin in increasing plasma levels of factor VIII activity in patients with hemophilia and von Willebrand's disease Type I. Dose-response studies were performed in healthy persons, using doses of 0.1 to 0.4 µg/kg body weight, infused over a 10-minute period. DESMOPRESSIN ACETATE is not indicated for the treatment of hemophilia A with factor VIII coagulant activity levels equal to or less than 5%, or for the treatment of hemophilia B, or in patients who have factor VIII antibodies. DESMOPRESSIN ACETATE Injection 4 µg/mL should not be used in infants less than three months of age in the treatment of hemophilia A or von Willebrand's disease; safety and effectiveness in pediatric patients under 12 years of age with diabetes insipidus have not been established. www.drugs.com /PDR/Desmopressin_Acetate_Injection.html   (2687 words)

Journal of Family Practice: How effective is desmopressin for primary nocturnal enuresis? - Clinical inquiries: from ...   (Site not responding. Last check: 2007-11-06) Desmopressin reduces the number of nights of primary noctural enuresis by at least 1 per week, and increases the likelihood of "cure" (defined as 14 consecutive dry nights) while treatment is continued (number needed to treat [NNT]=5-6) (strength of recommendation [SOR]: A, based on meta-analysis). Desmopressin is an analogue of the natural pituitary hormone vasopressin acetate. Desmopressin at doses of 20 [micro]g, 40 [micro]g, and 60 [micro]g similarly increased the likelihood of a cure (14 consecutive dry nights during treatment) in 3 trials reporting this outcome (relative risk for failure to achieve 14 dry nights with 20 [micro]g=0.84; NNT for cure=5.6). www.findarticles.com /p/articles/mi_m0689/is_7_52/ai_106026465   (447 words)

desmopressin oral and injectable - [Medication] Desmopressin is used to treat hemophilia A, von Willebrand's disease (Type I), and cranial diabetes insipidus. Desmopressin is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Desmopressin should not be used to treat von Willebrand's disease or hemophilia A in children younger than 3 months of age. www.peacehealth.org /kbase/multum/d00583a1.htm   (956 words)

Desmopressin for bed-wetting - [Medication] - Quest Diagnostics Patient Health Library   (Site not responding. Last check: 2007-11-06) Desmopressin is used in the treatment of bed-wetting (primary nocturnal enuresis) in children age 6 and older. Desmopressin may be used for some children when other treatments have been unsuccessful; it is usually not used until other treatments have been tried first. Desmopressin is usually effective when used for a short period of time, such as during times of emotional stress or during overnight trips or camping trips. www.questdiagnostics.com /kbase/topic/detail/drug/hw211361/detail.htm   (544 words)

Health Library -   (Site not responding. Last check: 2007-11-06) Desmopressin nasal is used to treat bed-wetting, central cranial diabetes insipidus, and increased thirst and urination resulting from head surgery or head trauma. Desmopressin nasal is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Desmopressin nasal is available with a prescription generically and under the brand name DDAVP as a nasal spray and as a rhinal tube. www.coxnet.org /library/healthguide/en-us/drugguide/topic.asp?hwid=d00583n1   (1172 words)

MedlinePlus Drug Information: Desmopressin Desmopressin is a chemical that is similar to a hormone found naturally in your body. Desmopressin is used to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions, allowing you to sleep through the night without awakening to urinate. Desmopressin comes in a liquid that is administered into the nose and as a nasal spray. www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682876.html   (812 words)

MedlinePlus Drug Information: Desmopressin (Systemic)   (Site not responding. Last check: 2007-11-06) Desmopressin (des-moe-PRES-in) is a hormone taken through the nose, by mouth, or given by injection to prevent or control the frequent urination, increased thirst, and loss of water associated with diabetes insipidus (water diabetes). Desmopressin works by acting on the kidneys to reduce the flow of urine. Desmopressin is also given by injection to treat some patients with certain bleeding problems such as hemophilia or von Willebrand's disease. www.nlm.nih.gov /medlineplus/druginfo/uspdi/202186.html   (1477 words)

Desmopressin - Drugs & Vitamins - Drug Library - DrugDigest DESMOPRESSIN (DDAVP®, Stimate™) is a man-made form of vasopressin (antidiuretic hormone, or ADH). Desmopressin (Stimate™) also can be used treat or prevent bleeding in patients with mild hemophilia A or certain types of von Willebrand's disease. Desmopressin nasal spray is only for use in the nose; do not take by mouth. www.drugdigest.org /DD/DVH/Uses/0,3915,194|Desmopressin,00.html   (895 words)

Ferring Pharmaceuticals - Other Products Desmopressin Acetate Rhinal Tube is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. Desmopressin acetate is also available as a solution for injection when the intranasal route may be compromised. Desmopressin acetate should be used with caution in patients with conditions associated with fluid and electrolyte imbalance, such as cystic fibrosis, because these patients are prone to hyponatremia. www.ferringusa.com /other_products/desmopression_tube.htm   (1884 words)

Desmopressin (DDAVP®) - PetPlace.com Desmopressin acetate is used for replacement of deficient ADH. Desmopressin should not be used in animals with known hypersensitivity or The dose for desmopressin is one to two drops of the nasal spray administered in the conjunctival sac (eyes) or in each nostril once or twice daily. www.petplace.com /drug-library/desmopressin-ddavp/page1.aspx   (560 words)

Desmopressin acetate for hemophilia - SJMMC, Ann Arbor, Michigan MI   (Site not responding. Last check: 2007-11-06) Desmopressin can be used by people who have mild to moderate hemophilia to help increase clotting factors when they have certain medical or dental procedures done. Desmopressin is used before dental and minor surgical procedures for people who have mild to moderate hemophilia A. It is also used to treat mild bleeding episodes. Desmopressin does not carry infectious diseases, and it is safe for treatment of adults. www.sjmercyhealth.org /13377.cfm   (279 words)

Surgical Outcome In Cushing’s Disease - Desmopressin Test   (Site not responding. Last check: 2007-11-06) This study was formulated to investigate the effect of desmopressin administration on ACTH and cortisol secretion in patients with Cushing’s disease. The rise of cortisol level after desmopressin administration was also significant reaching a peak at 45 minutes and the mean cortisol levels at 15, 30, 45 and 60 minutes were significantly higher than the basal level. The authors conclude that desmopressin administration is associated with a significant rise of ACTH and cortisol levels in majority of the patients with Cushing’s disease and there was good (non complete) concordance between the response to desmopressin test and surgical outcome. www.indegene.com /End/Jour/indJour_CEND_Sum_01-07-2001_2.asp   (472 words)

Desmopressin (DDAVP) in the Treatment of Bleeding Disorders: The First 20 Years -- Mannucci 90 (7): 2515 -- Blood Additional evidence of the HIV-sparing effect of desmopressin stems from the comparison of the prevalence of HIV infection in Italian patients with mild hemophilia A to the corresponding patients from other countries where the compound was used later. Desmopressin is a possible treatment for patients with liver cirrhosis and prolonged bleeding time who need invasive diagnostic procedures such as liver biopsies. Preoperative desmopressin failed to reduce blood loss in patients undergoing debridement and grafting of burn wounds, a procedure in which extreme blood loss is a frequent occurrence. www.bloodjournal.org /cgi/content/full/90/7/2515   (5998 words)

DESMOPRESSIN Desmopressin is the synthetic version of vasopressin, a peptide hormone found naturally in the brain and partly responsible for ‘inserting’ memories in the hippocampus, the region of the brain where memories are stored. Desmopressin is sometimes used for the treatment of diabetes insipidus, a condition of frequent urination and extreme thirst. Desmopressin is more potent than Vasopressin and should be used in lower doses. www.antiaging-systems.com /a2z/desmopressin.htm   (360 words)

Replacing Blood Factors and Desmopressin Therapy   (Site not responding. Last check: 2007-11-06) Desmopressin is a medication used to treat mild cases of hemophilia. Although desmopressin does not affect blood factor IX, the medication does increase the levels of blood factor VIII, making desmopressin useful in the treatment of hemophilia A. Desmopressin is based on the hormone DDAVP. Unlike blood factor replacement, which usually requires intravenous administration, a single shot of desmopressin is injected slowly into a blood vein for mild cases of hemophilia. www.causes-of-hemophilia.com /html/treating-hemophilia.php3   (588 words)

Desmopressin acetate for von Willebrand's disease - [Medication] - Quest Diagnostics Patient Health Library Desmopressin increases the amount of clotting factor VIII, which helps blood to clot. Desmopressin is usually injected, but a nasal spray is also available. Desmopressin is used for people with mild to moderate von Willebrand's disease. www.questdiagnostics.com /kbase/topic/detail/drug/ue4013/detail.htm   (221 words)

Desmopressin: Facts and details from Encyclopedia Topic   (Site not responding. Last check: 2007-11-06) Desmopressin is a modified form of the hormal human vasopressin antidiuretic hormone quick summary: Desmopressin is used to reduce urine urine quick summary: Urine is liquid waste excreted by the kidneys and eventually expelled from the body in a process known as urination.... www.absoluteastronomy.com /encyclopedia/d/de/desmopressin.htm   (1094 words)

DDAVP/Desmopressin Intranasal Solution , SPC from the eMC Desmopressin should not be prescribed to patients over the age of 65 for the treatment of nocturia associated with multiple sclerosis. Results from analyses of milk from nursing mothers receiving high dose Desmopressin (300 micrograms intranasally) indicate that the amounts of Desmopressin that may be transferred to the child are considerably less than the amounts required to influence diuresis. Desmopressin is a structural analogue of vasopressin, with two chemical changes namely desamination of the N-terminal and replacement of the 8-L-Arginine by 8-D-Arginine. emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?documentid=660   (1040 words)

Desmopressin in the treatment of daytime urinary frequency in patients with multiple sclerosis -- Hoverd and Fowler 65 ... Desmopressin in the treatment of daytime urinary frequency in patients with multiple sclerosis Desmopressin is a synthetic vasopressin analogue with a duration of action of 9.5-13 hours. Desmopressin in the treatment of nocturia and enuresis in patients with multiple sclerosis. jnnp.bmjjournals.com /cgi/content/full/65/5/778   (1431 words)

Desmopressin for nocturnal enuresis in children Desmopressin is a drug that increases water reabsorption from the kidneys. In one small trial, desmopressin resulted in more wet nights, compared to alarms, toward the end of treatment (weighted mean difference (WMD) 1.4; 95% CI 0.14 to 2.66), and the chance of failure or relapse after alarms was lower (RR 9.17; 95% CI 1.28 to 65.90). Desmopressin rapidly reduced the number of wet nights per week experienced by children, but there was some evidence that this was not sustained after treatment stopped. www.cochrane.org /reviews/en/ab002112.html   (641 words)

National MS Society | DDAVP Tablets (Desmopressin) Desmopressin is a synthetic analogue of the natural pituitary hormone 8-arginine vasopression (ADH), that works on the kidneys to control urination. It is not known whether desmopressin passes into breast milk and should therefore be used with caution by women who are breatfeeding. Side effects that typically go away as your body adjusts to the medication and do not require medical attention unless they continue for several weeks or are bothersome: runny or stuffy nose; abdominal or stomach cramps; flushing of the skin; headache; nausea; pain in the vulva. www.nationalmssociety.org /Meds-Desmopressin_ac.asp   (311 words)

NEJM -- A trial of desmopressin (1-desamino-8-D-arginine vasopressin) to reduce blood loss in uncomplicated cardiac ...   (Site not responding. Last check: 2007-11-06) Previous studies have suggested that desmopressin may reduce the bleeding diathesis that often complicates open-heart surgery. To pursue this question further, we performed a double-blind, randomized, placebo-controlled trial to determine whether the previously reported beneficial effect of desmopressin on hemostasis during complex cardiac surgery was applicable to all elective cardiac surgical procedures involving cardiopulmonary bypass. Desmopressin is believed to exert its hemostatic effect by releasing von Willebrand factor. content.nejm.org /cgi/content/abstract/321/21/1437   (530 words)

Desmopressin for bedwetting - [Medication] Desmopressin is used in the treatment of bedwetting (primary nocturnal enuresis) in children age 6 and older. Once treatment with desmopressin is stopped, 50% to 90% relapse into their usual pattern of bedwetting. Desmopressin often is used along with behavioural training to treat accidental wetting. www.bchealthguide.org /kbase/topic/detail/drug/hw211361/detail.htm   (533 words)

Osmoregulation and Desmopressin Pharmacokinetics in Enuretic Children -- Nevéus et al. 103 (1): 65 -- Pediatrics The plasma desmopressin concentrations in the children are depicted in Fig 1. Stenberg A, Läckgren G Desmopressin tablets in the treatment of severe nocturnal enuresis in adolescents. Janknegt RA, Zweers HM, Delaere KP, Kloet AG, Khoe SG, Arendsen HJ Oral desmopressin as a new treatment modality for primary nocturnal enuresis in adolescents and adults: a double-blind, randomized, multicenter study. pediatrics.aappublications.org /cgi/content/full/103/1/65   (2845 words)

ImmInst.org -> Vasopressin's(Desmopressin) duration of effect?   (Site not responding. Last check: 2007-11-06) Diapid was less expensive than desmopressin; if I remember correctly, about $10,- for one bottle which contained 3 times more than a bottle of desmopressin. In contrast to vasopressin, desmopressin does not induce the release of adrenocorticotropic hormone or increase plasma cortisol concentrations, and desmopressin has slight structural variations that reduce its vasopressive activity and contractile action on visceral smooth muscle. Desmopressin increases plasma factor VIII and plasminogen activator to a greater extent than equivalent weights of vasopressin. www.imminst.org /forum/index.php?act=ST&f=169&t=6505&s=   (1260 words)

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