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Topic: Dexamphetamine

	Dextroamphetamine - Wikipedia, the free encyclopedia
		Dextroamphetamine (also known as dextroamphetamine sulfate, dexamphetamine, dexedrine, Dexampex, Ferndex, Oxydess II, Robese, Spancap #1, and, informally, Dex), a stereoisomer of amphetamine, is an indirect-acting stimulant that releases norepinephrine from nerve terminals, thus promoting nerve impulse transmission.
		Certain studies have been performed regarding possible alternate use for antidepressant treatment for HIV patients with depression and debilitating fatigue, early stage physiotherapy for severe stroke victims and treatment for those with methamphetamine (speed) addiction.
		Possible adverse effects of dexamphetamine include insomnia, reduced appetite, dependence, nervousness, restlessness, irritability, and euphoria that may be followed by fatigue and depression.
	en.wikipedia.org /wiki/Dexamphetamine (514 words)

	Data Sheet
		Dexamphetamine, the dextrorotatory isomer of amphetamine, is an indirect-acting sympathomimetic amine with central stimulant and anorectic activity.
		Dexamphetamine sulphate is readily absorbed from the gastro-intestinal tract and rapidly distributed into most of the body tissues with high concentrations in the brain and CSF.
		The side-effects of dexamphetamine are commonly symptoms of overstimulation of the central nervous system and include insomnia, nervousness, restlessness, irritability, and euphoria that may be followed by fatigue and depression.
	www.medsafe.govt.nz /Profs/Datasheet/d/Dexamphetaminesulphatetab.htm (1132 words)

	Attract
		We found a RCT that aimed to establish the efficacy of dexamphetamine in adult attention deficit hyperactivity disorder (ADHD) in a naturalistic setting.
		"A randomised, double-blind, placebo-controlled study of dexamphetamine was conducted by two psychiatrists in private practice who saw a total of 68 consecutive referrals of patients thought to have ADHD by their referring general practitioners.
		One patient on dexamphetamine discontinued the trial because of an event possibly related to the medication.
	www.attract.wales.nhs.uk /question_answers.cfm?question_id=1279 (372 words)

	ADHD Articles and News
		The biphasic nature of the response is seen in humans as well, and the commonly used clinical dose of dexamphetamine (0.2 to 0.6 mg Kg-1) is in the same range as that in the hypolocomotor animal model.
		Methylphenidate and dexamphetamine, like cocaine, block the dopamine transporter leading to an increase in dopamine in the synaptic cleft, and dexamphetamine additionally has a direct dopamine releasing action [20].
		Dexamphetamine typically takes 2-3 hours to reach peak concentration after a single oral dose [48], but its half-life (approximately 7 hours) is considerably longer than that of methylphenidate.
	www.addconsults.com /articles/full.php3?id=1037 (4287 words)

	ADHD
		Dexamphetamine is licensed for use in children down to 3 years which indicates both the manufacturer’s and the licensing authority’s confidence in the use of this drug in young children.
		Dexamphetamine is licensed in adults for narcolepsy despite society’s disapproval of illicit amphetamine usage (e.g.
		Ritalin and dexamphetamine are gentle drugs as indicated by being licensed for use in young children.
	www.althealth.co.uk /services/info/misc/adhd3.php (8199 words)

	eMJA: Licit psychostimulant consumption in Australia, 1984–2000: international and jurisdictional comparison
		The centrally acting psychostimulant drugs methylphenidate and dexamphetamine are the preferred pharmacotherapies for ADHD in children in North America,1 the United Kingdom2 and Australia.
		The aims of this study are to compare trends from 1994 to 2000 in the rates of consumption of dexamphetamine and methylphenidate in Australia with nine other developed countries, and to compare the rates of their consumption between Australia's jurisdictions (States and Territories) from 1984 to 2000.
		Annual data from 1984 to 2000 on dexamphetamine sulfate 5 mg tablets and methylphenidate 10 mg tablets were obtained from the TMU and standardised to defined daily doses (DDDs) per 1000 population per day using interpolations of end-year national and Australian jurisdictional populations.
	www.mja.com.au /public/issues/177_10_181102/ber10505_fm.html (2992 words)

	The World Today - WA crackdown on dexamphetamine
		The stimulant is usually prescribed for Attention Deficit and Hyperactivity Disorder, but it has been revealed that around one-fifth of the 16 and 17 old boys in state schools in WA use dexamphetamine for non-medical reasons.
		Dexamphetamine is sometimes referred to by its older trademark name, Dexedrine.
		Police have seized quantities of the drug from school students who are selling it to or stealing it from their fellows.
	www.abc.net.au /worldtoday/stories/s684652.htm (684 words)

	[No title] (Site not responding. Last check: 2007-09-11)
		This study determined whether dexamphetamine improved symptoms and quality of life in patients with chronic fatigue syndrome.
		Ten patients were randomly assigned to dexamphetamine, and 10 were assigned to placebo.
		Dexamphetamine may be useful in the management of chronic fatigue syndrome; a larger and longer trial is justified by these results.
	www.fibromyalgiasupport.com /library/print.cfm?ID=4222 (205 words)

	Medication for Attention Deficit/Hyperactivity Disorder (ADHD): and analysis by Federal Electorate (200103)
		Although the use of medication for the treatment of ADHD continues to be controversial in the public arena, the safety and efficacy, particularly in the short term, of psycho-stimulants such as dexamphetamine sulfate and Ritalin is well established.
		Broadly speaking, some witnesses have argued that higher prescription rates for dexamphetamine sulfate in Western Australia are a result of misdiagnosis and/or over-prescription, while others have argued that there is no evidence to suggest that the rates are anything other than appropriate.
		Evidence such as this would appear to indicate the higher rates of prescription of dexamphetamine sulfate in Western Australia may not simply be a result of the (often-claimed) better understanding of ADHD among practitioners in that State.
	www.aph.gov.au /library/pubs/rb/2004-05/05rb02.htm (5083 words)

	eMJA: Serotonin toxicity with therapeutic doses of dexamphetamine and venlafaxine
		Therapy with dexamphetamine and venlafaxine was ceased, and cyproheptadine (8 mg doses up to a total of 32 mg over three hours) was given.
		Dexamphetamine therapy was restarted three days later and citalopram therapy was commenced one week after discharge.
		Dexamphetamine causes psychostimulation and increased peripheral sympathomimetic activity.
	www.mja.com.au /public/issues/176_05_040302/prior_letter_fm.html (741 words)

	NHMRC - Publications - (Site not responding. Last check: 2007-09-11)
		Dexamphetamine and methylphenidate (Ritalin¨) act on dopaminergic and noradrenergic neurotransmitter pathways and appear to influence mainly prefrontal, frontal and limbic systems with benefits on disruptive behavioural inhibition, impulse control, selective attention, active working memory and executive functioning.
		The majority of studies evaluate methylphenidate, as dexamphetamine is much less used in the United States where prescribing and manufacturing are more restricted and associations with Îstreet speedâ and other substance abuse are strong.
		Dexamphetamine may theoretically predispose to slightly more noticeable side-effects as confirmed in an Australian crossover study of the two stimulants.
	www.nhmrc.gov.au /publications/adhd/part2.htm (5839 words)

	U.S. Medicine Information Central
		Schmidt and Umbach's medical defense, officials said that the use of dexamphetamine is safe and efficacious, backed by decades of research and a perfect safety record.
		The use of dexamphetamine is only one part of the overall fatigue management program, which includes schedule control, environment control, rest control and the avoidance of any abrupt circadian rhythm movements whenever possible, he said.
		Regarding the safety of dexamphetamine, Dr. Michaud emphasized that the drug is commonly prescribed to schoolchildren for Attention Deficit and Hyperactivity Disorder and is completely safe when used correctly.
	www.usmedicine.com /article.cfm?articleID=587&issueID=47 (1158 words)

	pregnancy.htm (Site not responding. Last check: 2007-09-11)
		The student was suspended originally for one day but that was increased to five days after the Cannington district office learnt of the severity of the teacher's injuries.
		AMA senior psychiatrist Paul Skerritt said the effects of dexamphetamine or Ritalin were not long-lasting, which made it difficult to medicate schoolchildren.
		"The problem with dexamphetamine is it has a fairly short half-life which is nonsense for school kids because they have to take a dose to school and it is possible for the effects to wear off," Dr Skerritt said.
	www.parenting101.netfirms.com /news9.htm (426 words)

	sixthseal.com: Incoming! 100 x 5 mg dexamphetamine tablets! =D (Site not responding. Last check: 2007-09-11)
		I therefore substituted the dex with meth and being ADHD was a prime candidate for the lures of IV drug use and fell of the rails completely as my social circle changed from the recreational types to the fanatical, 'junky' type, and I went through a horifying 6 yrs of heroin addiction.
		Dexamphetamine in non add will make you wanna go out and party more and that sort of thing, as I mentioned it increases their motor activity...talking, moving etc..that doesn't mean they can sit still and use their brain better.
		Dexamphetamine releases dopamine in people with adhd and makes use of it in the brain, this makes them focus and concentrate as much as a normal person does.
	www.sixthseal.com /000512.html (9531 words)

	AM - Concern over level of 'kiddie speed' prescription
		The prescription of dexamphetamine, known as "kiddie speed", is increasing and Democrats Senator Lyn Allison says while the drug does solve an immediate problem, by calming children down, she's concerned so many children are being prescribed the drug.
		ALEXANDRA KIRK: The prescription of dexamphetamine to children diagnosed with attention deficit disorder is on the increase, and Democrats Senator Lyn Allison says the figures she's just obtained seem high and concerning.
		LYN ALLISON: We're seeing various studies being done around the world that are starting to question the growth of the use of this drug, and I think there's also a case to be made for other factors to be involved in attention deficit disorder, which is what this drug is used for.
	www.abc.net.au /am/content/2004/s1086220.htm (477 words)

	Erowid Experience Vaults: Amphetamines - Dexamphetamine Sulphate - Dillusions
		Until now, I thought I was the only one on Earth mad enough to be addicted to something as horrible as Dexamphetamine.
		At age 13, I was diagnosed with ADHD — The inattentive type.
		I was easily distracted and very tuned out in class, until the day I was given a little white pill called Dexamphetamine Sulphate.
	www.erowid.org /experiences/exp.php?ID=34239 (356 words)

	A Pilot Randomized Controlled Trial of Dexamphetamine in Patients With Chronic Fatigue Syndrome -- Olson et al. 44 (1): ...
		A Pilot Randomized Controlled Trial of Dexamphetamine in Patients With Chronic Fatigue Syndrome -- Olson et al.
		Dexamphetamine treatment was associated with a lessened severity
		symptoms of chronic fatigue syndrome, and the capacity of dexamphetamine
	psy.psychiatryonline.org /cgi/content/full/44/1/38 (2364 words)

	Fed/ Australia falls short in ADHD drug treatment : Epilepsy.com
		The degree of difference between individual federal electorates and across the states and territories is unlikely to be in the best interests of Australia's children and their families, the report's author Luke Buckmaster said.
		Between 1984 and 2000, consumption of dexamphetamine rose by a national average of 31 per cent a year, a rate of increase unrivalled by any nation other than the United States, Mr Buckmaster found.
		The report found dexamphetamine was used more heavily in Western Australia than any other state, with 86,980 prescriptions in 2003, while the Northern Territory had the lowest number of users, at 708 last year.
	www.epilepsy.com /newsfeed/pr_1101306608.html (477 words)

	Stimulants
		Since almost all crack cocaine abusers are cigarette smokers as well and since rapid smoking aversion therapy is the most effective stop smoking technique, I would think that rapid-smoking treatment of tobacco cigarettes by crack cocaine abusers in the presence of cocaine cues might be a useful form of therapy.
		Dexamphetamine Sustained Release Helps in DB: A 128-patient 12-week DB PC study started with 15 or 30 mg and increased to 30 or 60 mg at 5 weeks.
		Perhaps, the high dose is why the dexamphetamine studies have found benefit but the methylphenidate studies below have not.
	www.modern-psychiatry.com /new_page_49.htm (2898 words)

	Pilbara Division of General Practice (Site not responding. Last check: 2007-09-11)
		The "Dexamphetamine and Teenagers" project was recently launched by the Minister for Health.
		The project aims to address the inappropriate supply and use of dexamphetamine by WA school students.
		The information is in the form of an A5 tear off pad that can be provided to parents at either the time of prescription, or having the prescription filled.
	www.pdgp.com.au /gpinfo.asp?ID=49 (255 words)

	Teknoscape Forums - WA top State for 'dexies' (Site not responding. Last check: 2007-09-11)
		Mr Kucera said dexamphetamines were over-prescribed in WA and he hoped to set up a policy to tackle the problem.
		Dexamphetamine is used in the treatment of children with attention deficit and hyperactivity disorder but there is concern that it is getting increasingly into the hands of young people who do not have the condition.
		A 1999 Australian school students alcohol and drug survey found 20 per cent of WA male students aged 16 and 17 and 17 per cent of female students of the same age had used amphetamines for non-medical reasons in the year before the survey.
	www.teknoscape.com.au /forums/showthread.php?t=3840 (1442 words)

	ADD/ADHD - F.A.Q. ADDults
		It means that the tablet (such as Ritalin and Dexamphetamine) makes more dopamine available for active duty in that part of the brain just behind the forehead.
		When a patient is tolerating Ritalin or Dexamphetamine, they think he or she is getting more and more addicted.
		Tolerance is when a person on Ritalin or Dexamphetamine needs progressively increasing numbers of tablets to keep the beneficial effect of the treatment the same.
	www.adders.org /info28.htm (1117 words)

	Bozarth (ed., 1987): Assessing Drug Reinforcement, Chapter 11
		This was conducted with dexamphetamine sulfate as the reinforcer at a dose of 0.015 mg/kg; 100 pairing trials were given on Day 2, and the test for conditioned reinforcement was on Day 6 rather than Day 3.
		Parallel studies performed with dexamphetamine sulfate and AMT (Davis and Smith, 1973b), as with morphine, gave results also parallel to those for morphine.
		Further application of the conditioned reinforcement paradigm was directed to the possible discrimination between noradrenergic and dopaminergic components in the effects of AMT on reward from both morphine and dexamphetamine.
	www.addictionscience.net /MARPADc11.htm (4001 words)

	Crime and Misconduct Commission - Fighting crime / (Site not responding. Last check: 2007-09-11)
		As methylphenidate and dexamphetamine are the exclusive treatment options in about 90 per cent of all cases of ADHD, this bulletin will refer to these stimulants or their compounds only.
		While there may be an oversupply of methylphenidate and dexamphetamine and the potential to abuse these drugs is evident, a problem as extreme as the current amphetamine market would probably not develop.
		Although there is still the potential for methylphenidate and dexamphetamine to become the entry-level drugs for a much larger stimulant abuse problem, the CMC considers that the illicit diversion and abuse of ADHD prescription drugs currently poses a low crime risk to the Queensland public.
	www.cmc.qld.gov.au /CRIMEBULLETIN4.html (3583 words)

	Swinburne Centre for Neuropsychology: Staff (Site not responding. Last check: 2007-09-11)
		Thesis Title: The effects of sleep deprivation and dexamphetamine on neuropsychological function, driving performance and brain activity in professional drivers.
		Description: This study is investigating mechanisms which might lead to accidents in professional drivers by evaluating neuropsychological and driving performance after 24 hours of acute sleep deprivation.
		This study will also assess whether dexamphetamine reverses all the acute effects of sleep deprivation on performance and brain activity, and examine how well drivers perceive sleepiness and performance impairment when sleep deprived and using dexamphetamine.
	www.swin.edu.au /bioscieleceng/neuropsych/jackson.htm (104 words)

	Medication for Attention Deficit/Hyperactivity Disorder (ADHD): an Analysis by Federal Electorate (Current Issues Brief ...
		It should be stressed also that while dexamphetamine sulfate represents the majority (72 per cent) of prescriptions for the treatment of ADHD, it is not the only such drug.
		An analysis of PBS data for 1999-2000 indicates that the number of prescriptions dispensed for dexamphetamine sulfate was highest in Western Australia and lowest in the Northern Territory.
		If this is the case, the one conclusion that does appear to be sustainable is that the interests of Australia's children and their families are unlikely to be well served by such variation between electorates.
	www.aph.gov.au /library/pubs/cib/2000-01/01cib11.htm (3870 words)

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